Page last updated: 2024-10-16

adenine and Multiple Myeloma

adenine has been researched along with Multiple Myeloma in 31 studies

Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.

Research Excerpts

ExcerptRelevanceReference
"We evaluated ibrutinib, a once-daily inhibitor of Bruton's tyrosine kinase, combined with bortezomib and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma who had received 1-3 prior therapies."9.34A phase 2 study of ibrutinib in combination with bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma. ( Anagnostopoulos, A; Briso, EM; Cascavilla, N; Dobkowska, E; García Sanz, R; Hajek, R; Hauns, B; Lee, Y; Martin Sánchez, J; Oriol, A; Ozcan, M; Pour, L; Špička, I; Terjung, A, 2020)
"This phase 1, dose-finding study investigated ibrutinib and carfilzomib ± dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma (≥2 lines of therapy including bortezomib and an immunomodulatory agent)."9.27Phase 1 trial of ibrutinib and carfilzomib combination therapy for relapsed or relapsed and refractory multiple myeloma. ( Anderson, LD; Bilotti, E; Chang, L; Chari, A; Chhabra, S; Cornell, RF; Gasparetto, C; Graef, T; Holkova, B; Karanes, C; Larson, S; Lee, Y; Lunning, M; Matous, JV; Niesvizky, R; Pak, Y; Salman, Z; Usmani, SZ; Valent, J, 2018)
"Resveratrol, a natural compound extracted from the skins of grapes, berries, or other fruits, has been shown to have anti-tumor effects against multiple myeloma (MM) via promoting apoptosis and inhibiting cell viability."8.02Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells. ( Cheng, T; Lai, W; Lu, Y; Ma, R; Peng, Y; Shi, B; Shi, J; Wang, Y; Wu, X; Yang, G; Yi, H; Yu, D, 2021)
"Patients with multiple myeloma (MM) inevitably relapse on initial treatment regimens, and novel combination therapies are needed."6.94Final analysis of a phase 1/2b study of ibrutinib combined with carfilzomib/dexamethasone in patients with relapsed/refractory multiple myeloma. ( Anderson, LD; Chari, A; Chhabra, S; Cornell, RF; Gasparetto, C; Girnius, S; Karanes, C; Lee, Y; Liu, E; Lunning, M; Matous, JV; Niesvizky, R; Salman, Z; Shustik, C; Stuart, R; Usmani, SZ; Valent, J, 2020)
"Fatal lactic acidosis has been reported while on the treatment with Nucleoside/nucleotide analogues (NA) for the treatment of hepatitis B, C and HIV."5.48Tenofovir alafenamide associated fatal lactic acidosis in an autologous hematopoietic stem cell transplant recipient. ( Alsunaid, SR; Ashraf, H; Soubani, AO, 2018)
"We evaluated ibrutinib, a once-daily inhibitor of Bruton's tyrosine kinase, combined with bortezomib and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma who had received 1-3 prior therapies."5.34A phase 2 study of ibrutinib in combination with bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma. ( Anagnostopoulos, A; Briso, EM; Cascavilla, N; Dobkowska, E; García Sanz, R; Hajek, R; Hauns, B; Lee, Y; Martin Sánchez, J; Oriol, A; Ozcan, M; Pour, L; Špička, I; Terjung, A, 2020)
"This phase 1, dose-finding study investigated ibrutinib and carfilzomib ± dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma (≥2 lines of therapy including bortezomib and an immunomodulatory agent)."5.27Phase 1 trial of ibrutinib and carfilzomib combination therapy for relapsed or relapsed and refractory multiple myeloma. ( Anderson, LD; Bilotti, E; Chang, L; Chari, A; Chhabra, S; Cornell, RF; Gasparetto, C; Graef, T; Holkova, B; Karanes, C; Larson, S; Lee, Y; Lunning, M; Matous, JV; Niesvizky, R; Pak, Y; Salman, Z; Usmani, SZ; Valent, J, 2018)
"Resveratrol, a natural compound extracted from the skins of grapes, berries, or other fruits, has been shown to have anti-tumor effects against multiple myeloma (MM) via promoting apoptosis and inhibiting cell viability."4.02Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells. ( Cheng, T; Lai, W; Lu, Y; Ma, R; Peng, Y; Shi, B; Shi, J; Wang, Y; Wu, X; Yang, G; Yi, H; Yu, D, 2021)
" In this study we report for the first time that ibrutinib is cytotoxic to malignant plasma cells from patients with multiple myeloma (MM) and furthermore that treatment with ibrutinib significantly augments the cytotoxic activity of bortezomib and lenalidomide chemotherapies."3.79BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB. ( Barrera, LN; Bowles, KM; MacEwan, DJ; Murray, MY; Rushworth, SA; Zaitseva, L, 2013)
"The proteasome inhibitor Bortezomib has been approved for the treatment of relapsed/refractory multiple myeloma (MM), thanks to its ability to induce MM cell apoptosis."3.76Bortezomib induces autophagic death in proliferating human endothelial cells. ( Belloni, D; Caligaris-Cappio, F; Dell'Antonio, G; Ferrarini, M; Ferrero, E; Foglieni, C; Veschini, L, 2010)
"Patients with multiple myeloma (MM) inevitably relapse on initial treatment regimens, and novel combination therapies are needed."2.94Final analysis of a phase 1/2b study of ibrutinib combined with carfilzomib/dexamethasone in patients with relapsed/refractory multiple myeloma. ( Anderson, LD; Chari, A; Chhabra, S; Cornell, RF; Gasparetto, C; Girnius, S; Karanes, C; Lee, Y; Liu, E; Lunning, M; Matous, JV; Niesvizky, R; Salman, Z; Shustik, C; Stuart, R; Usmani, SZ; Valent, J, 2020)
"Fatal lactic acidosis has been reported while on the treatment with Nucleoside/nucleotide analogues (NA) for the treatment of hepatitis B, C and HIV."1.48Tenofovir alafenamide associated fatal lactic acidosis in an autologous hematopoietic stem cell transplant recipient. ( Alsunaid, SR; Ashraf, H; Soubani, AO, 2018)
" We here compare bortezomib with carfilzomib and LU-102 in MM and MCL in vitro with regard to their effects on pIκB/NF-κB signaling and their cytotoxic activity in combination with ibrutinib."1.42The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells. ( Bader, J; Besse, L; de Bruin, G; Driessen, C; Geurink, PP; Kisselev, AF; Kraus, J; Kraus, M; Liu, N; Overkleeft, H, 2015)
"We show here that treatment of human multiple myeloma (MM) cells with 17DMAG induces mTOR inhibition and microtubule-associated protein light chain 3 (LC3) conversion (LC3-I to LC3-II), an indicator of autophagy."1.36Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis. ( López-Pérez, AI; López-Rivas, A; Martín-Pérez, R; Palacios, C; Pandiella, A, 2010)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.23)18.7374
1990's1 (3.23)18.2507
2000's1 (3.23)29.6817
2010's22 (70.97)24.3611
2020's6 (19.35)2.80

Authors

AuthorsStudies
Santoni, G1
Amantini, C1
Maggi, F1
Marinelli, O1
Santoni, M1
Morelli, MB1
Hajek, R1
Pour, L1
Ozcan, M1
Martin Sánchez, J1
García Sanz, R1
Anagnostopoulos, A1
Oriol, A1
Cascavilla, N1
Terjung, A1
Lee, Y3
Briso, EM1
Dobkowska, E1
Hauns, B1
Špička, I1
Li, A1
Li, X1
Chen, X2
Zeng, C1
Wang, Z1
Li, Z1
Chen, J1
Chari, A2
Cornell, RF2
Gasparetto, C2
Karanes, C2
Matous, JV2
Niesvizky, R2
Lunning, M2
Usmani, SZ2
Anderson, LD3
Chhabra, S2
Girnius, S1
Shustik, C1
Stuart, R1
Salman, Z3
Liu, E1
Valent, J2
Dou, R1
Qian, J1
Wu, W1
Zhang, Y2
Yuan, Y1
Guo, M2
Wei, R1
Yang, S1
Jurczyszyn, A1
Janz, S2
Beksac, M1
Gu, C1
Yang, Y3
Ma, R1
Yu, D1
Peng, Y1
Yi, H1
Wang, Y3
Cheng, T1
Shi, B1
Yang, G2
Lai, W1
Wu, X1
Lu, Y1
Shi, J2
Ma, J1
Gong, W1
Liu, S1
Li, Q2
Wang, J1
Wang, S1
Chen, N1
Liu, Q1
Zhao, H1
Richardson, PG1
Bensinger, WI1
Huff, CA1
Costello, CL1
Lendvai, N1
Berdeja, JG1
Siegel, DS1
Lebovic, D1
Jagannath, S1
Laubach, JP1
Stockerl-Goldstein, KE1
Kwei, L1
Clow, F1
Elias, L2
Graef, T2
Bilotti, E2
Vij, R1
Larson, S1
Holkova, B1
Chang, L1
Pak, Y1
Gertz, MA1
Ito, T1
Ando, T1
Suzuki-Karasaki, M1
Tokunaga, T1
Yoshida, Y1
Ochiai, T1
Tokuhashi, Y1
Suzuki-Karasaki, Y1
Alsunaid, SR1
Ashraf, H1
Soubani, AO1
Cameron, F1
Sanford, M1
Zhang, Q1
Xia, B1
Qu, F1
Yuan, T1
Guo, S1
Zhao, W1
Yang, H1
Murray, MY2
Zaitseva, L2
Auger, MJ1
Craig, JI1
MacEwan, DJ2
Rushworth, SA2
Bowles, KM2
Gu, Z1
Salama, ME1
Das, S1
Wendlandt, E1
Xu, H1
Huang, J1
Tao, Y1
Hao, M1
Franqui, R1
Levasseur, D1
Tricot, G1
Zhan, F1
Kraus, J1
Kraus, M1
Liu, N1
Besse, L1
Bader, J1
Geurink, PP1
de Bruin, G1
Kisselev, AF1
Overkleeft, H1
Driessen, C1
Berglöf, A1
Hamasy, A1
Meinke, S1
Palma, M1
Krstic, A1
Månsson, R1
Kimby, E1
Österborg, A1
Smith, CI1
Smith, LL1
Hoang, B1
Benavides, A1
Shi, Y1
Frost, P1
Lichtenstein, A1
Belloni, D1
Veschini, L1
Foglieni, C1
Dell'Antonio, G1
Caligaris-Cappio, F1
Ferrarini, M1
Ferrero, E1
Palacios, C1
Martín-Pérez, R1
López-Pérez, AI1
Pandiella, A1
López-Rivas, A1
Pan, Y1
Gao, Y1
Chen, L2
Gao, G1
Dong, H1
Dong, B1
Tai, YT2
Chang, BY1
Kong, SY1
Fulciniti, M1
Calle, Y1
Hu, Y1
Lin, J1
Zhao, JJ1
Cagnetta, A1
Cea, M1
Sellitto, MA1
Zhong, MY1
Wang, Q1
Acharya, C1
Carrasco, DR1
Buggy, JJ1
Treon, SP1
Matsui, W1
Richardson, P1
Munshi, NC1
Anderson, KC2
Zhao, S1
Ma, CM1
Liu, CX1
Wei, W1
Sun, Y1
Yan, H1
Wu, YL1
Edwards, CM1
Barrera, LN1
Gao, LS1
Zhang, XH1
Zhang, H1
Zhang, YY1
Fu, JX1
Hanson, KH1
Crowley, J1
Salmon, SE1
Keppen, M1
Braun, TJ1
Bonnet, JD1
Volkman, LE1
Krueger, RG1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Autologous Cells Derived Anti-CD19 CAR-Engineered T Cells With Concurrent BTK Inhibitor for B Cell Lymphoma:a Single-center, Open-label, Pragmatic Clinical Trial[NCT05020392]Phase 324 participants (Anticipated)Interventional2021-09-14Recruiting
A Phase I Study of Ibrutinib (PCI-32765) in Combination With Revlimid/Dexamethasone (Rd) in Relapsed/Refractory Multiple Myeloma[NCT03702725]Phase 114 participants (Actual)Interventional2019-08-29Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for adenine and Multiple Myeloma

ArticleYear
Ibrutinib: first global approval.
    Drugs, 2014, Volume: 74, Issue:2

    Topics: Adenine; Antineoplastic Agents; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular

2014
Targets for Ibrutinib Beyond B Cell Malignancies.
    Scandinavian journal of immunology, 2015, Volume: 82, Issue:3

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Atrial Fibrillation; Humans; Leukemia, Lympho

2015

Trials

5 trials available for adenine and Multiple Myeloma

ArticleYear
A phase 2 study of ibrutinib in combination with bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma.
    European journal of haematology, 2020, Volume: 104, Issue:5

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bortezomib;

2020
Final analysis of a phase 1/2b study of ibrutinib combined with carfilzomib/dexamethasone in patients with relapsed/refractory multiple myeloma.
    Hematological oncology, 2020, Volume: 38, Issue:3

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dexamethaso

2020
Ibrutinib alone or with dexamethasone for relapsed or relapsed and refractory multiple myeloma: phase 2 trial results.
    British journal of haematology, 2018, Volume: 180, Issue:6

    Topics: Adenine; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Dis

2018
Phase 1 trial of ibrutinib and carfilzomib combination therapy for relapsed or relapsed and refractory multiple myeloma.
    Leukemia & lymphoma, 2018, Volume: 59, Issue:11

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dexamethaso

2018
Evaluation of amonafide in refractory and relapsing multiple myeloma: a Southwest Oncology Group study.
    Anti-cancer drugs, 1991, Volume: 2, Issue:3

    Topics: Adenine; Adult; Aged; Antineoplastic Agents; Blood Cell Count; Drug Resistance; Female; Granulocytes

1991

Other Studies

24 other studies available for adenine and Multiple Myeloma

ArticleYear
The Mucolipin TRPML2 Channel Enhances the Sensitivity of Multiple Myeloma Cell Lines to Ibrutinib and/or Bortezomib Treatment.
    Biomolecules, 2022, 01-09, Volume: 12, Issue:1

    Topics: Adenine; Apoptosis; Bortezomib; Cell Line, Tumor; Cell Proliferation; Humans; Multiple Myeloma; Pipe

2022
NUPR1 Silencing Induces Autophagy-Mediated Apoptosis in Multiple Myeloma Cells Through the PI3K/AKT/mTOR Pathway.
    DNA and cell biology, 2020, Volume: 39, Issue:3

    Topics: Adenine; Apoptosis; Autophagy; Basic Helix-Loop-Helix Transcription Factors; Bone Marrow Cells; Cell

2020
Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma.
    Cell death & disease, 2021, 02-24, Volume: 12, Issue:2

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Adenine; Animals; Antineoplasti

2021
Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells.
    Acta biochimica et biophysica Sinica, 2021, May-21, Volume: 53, Issue:6

    Topics: Adenine; Adenosine Monophosphate; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; A

2021
Ibrutinib targets microRNA-21 in multiple myeloma cells by inhibiting NF-κB and STAT3.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2018, Volume: 40, Issue:1

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Aged; Cell Line, Tumor; Cell Proliferation; Female; Ge

2018
Multiple myeloma - a cure within reach.
    Leukemia & lymphoma, 2018, Volume: 59, Issue:11

    Topics: Adenine; Humans; Multiple Myeloma; Oligopeptides; Piperidines; Pyrazoles; Pyrimidines

2018
Cold PSM, but not TRAIL, triggers autophagic cell death: A therapeutic advantage of PSM over TRAIL.
    International journal of oncology, 2018, Volume: 53, Issue:2

    Topics: A549 Cells; Adenine; Autophagosomes; Autophagy; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation

2018
Tenofovir alafenamide associated fatal lactic acidosis in an autologous hematopoietic stem cell transplant recipient.
    Transplant infectious disease : an official journal of the Transplantation Society, 2018, Volume: 20, Issue:5

    Topics: Acidosis, Lactic; Adenine; Aged; Alanine; Antiviral Agents; Fatal Outcome; Hematopoietic Stem Cell T

2018
[Effect of PI3Kδ inhibitor CAL-101 on myeloma cell lines and preliminary study of synergistic effects with other new drugs].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2014, Volume: 35, Issue:10

    Topics: Adenine; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Humans; M

2014
Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.
    Cell cycle (Georgetown, Tex.), 2015, Volume: 14, Issue:14

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Bortezomib; Cell Survival; Drug Resistance, Neoplasm;

2015
Bruton tyrosine kinase is a therapeutic target in stem-like cells from multiple myeloma.
    Cancer research, 2015, Feb-01, Volume: 75, Issue:3

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents; beta Catenin; Bone Mar

2015
The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells.
    Cancer chemotherapy and pharmacology, 2015, Volume: 76, Issue:2

    Topics: Adenine; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Drug Resistance, Neopla

2015
58th American Society of Hematology Annual Meeting.
    The Lancet. Haematology, 2017, Volume: 4, Issue:1

    Topics: ADAMTS13 Protein; Adenine; Antibodies, Monoclonal; Antineoplastic Agents; Central Venous Catheters;

2017
Effect of autophagy on multiple myeloma cell viability.
    Molecular cancer therapeutics, 2009, Volume: 8, Issue:7

    Topics: Adenine; Antifungal Agents; Antimalarials; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Pr

2009
Bortezomib induces autophagic death in proliferating human endothelial cells.
    Experimental cell research, 2010, Apr-01, Volume: 316, Issue:6

    Topics: Adenine; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Autophagy; Boronic Acids; Bortezom

2010
Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis.
    Leukemia research, 2010, Volume: 34, Issue:11

    Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Benzoquinones; HSP90 Heat-Shock Proteins; Huma

2010
Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, May-15, Volume: 17, Issue:10

    Topics: Adenine; Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Line, Tumor; DNA D

2011
Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.
    Blood, 2012, Aug-30, Volume: 120, Issue:9

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Bone Marrow; Cell Line, Tumor; Cell Prolifera

2012
Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells.
    International journal of molecular medicine, 2012, Volume: 30, Issue:4

    Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cells

2012
BTK inhibition in myeloma: targeting the seed and the soil.
    Blood, 2012, Aug-30, Volume: 120, Issue:9

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Bone Marrow; Humans; Multiple Myeloma; Piperi

2012
BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB.
    Cellular signalling, 2013, Volume: 25, Issue:1

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Amides; Antineoplastic Agents; Boronic Acids; Bortezom

2013
Bruton's tyrosine kinase: oncotarget in myeloma.
    Oncotarget, 2012, Volume: 3, Issue:9

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Cell Growth Processes; Disease Models, Animal

2012
[The influence of induced autophagy in vitro on proliferation of multiple myeloma cells].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2012, Volume: 33, Issue:11

    Topics: Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Humans; Multipl

2012
Characterization of C-type particles produced by a tissue culture-adapted murine myeloma.
    Journal of virology, 1973, Volume: 12, Issue:6

    Topics: Adenine; Animals; Cells, Cultured; Centrifugation, Density Gradient; Ethyl Ethers; Gammaretrovirus;

1973