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adenine and Lupus Erythematosus, Systemic

adenine has been researched along with Lupus Erythematosus, Systemic in 16 studies

Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Research Excerpts

ExcerptRelevanceReference
"Systemic lupus erythematosus is a polymorphic and multigenic inflammatory autoimmune disease."1.38Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor. ( Bourguignon, JJ; Gazi, L; Keravis, T; Lugnier, C; Monneaux, F; Muller, S; Yougbaré, I, 2012)
"Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens."1.38Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus. ( Bashmakov, A; Buggy, JJ; Chang, BY; Du, Y; Grewal, S; Hutcheson, J; Mohan, C; Sajitharan, D; Satterthwaite, AB; Vanarsa, K; Zhou, XJ, 2012)
"Renal involvement in patients with systemic lupus erythematosus (SLE) varies from none to full-blown disease."1.31The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE. ( Chung, JH; Kim, HL; Kim, S; Kim, YS; Lee, DS; Lee, JS; Lim, CS; Yang, SH, 2002)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's2 (12.50)18.2507
2000's2 (12.50)29.6817
2010's9 (56.25)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Yougbare, I3
Keravis, T2
Lugnier, C3
Zheng, F1
Tang, D1
Xu, H1
Xu, Y1
Dai, W1
Zhang, X1
Hong, X1
Liu, D1
Dai, Y1
Tardif, V1
Manenkova, Y1
Berger, M1
Hoebe, K1
Zuo, JP1
Yuan, C1
Kono, DH1
Theofilopoulos, AN1
Lawson, BR1
Boire, G1
Roy, M1
Rouseau, E1
Wang, Y1
Zhang, L1
Wei, P1
Zhang, H1
Liu, C1
Paley, MA1
Strand, V1
Kim, AH1
Monneaux, F1
Gazi, L1
Bourguignon, JJ1
Muller, S1
Kil, LP1
de Bruijn, MJ1
van Nimwegen, M1
Corneth, OB1
van Hamburg, JP1
Dingjan, GM1
Thaiss, F1
Rimmelzwaan, GF1
Elewaut, D1
Delsing, D1
van Loo, PF1
Hendriks, RW1
Leroy, V1
Kihara, M1
Baudino, L1
Brighouse, G1
Evans, LH1
Izui, S1
Hutcheson, J1
Vanarsa, K1
Bashmakov, A1
Grewal, S1
Sajitharan, D1
Chang, BY1
Buggy, JJ1
Zhou, XJ1
Du, Y1
Satterthwaite, AB1
Mohan, C1
Kim, HL1
Lee, DS1
Yang, SH1
Lim, CS1
Chung, JH1
Kim, S1
Lee, JS1
Kim, YS1
Burzynski, M1
Duriagin, S1
Mostowska, M1
Wudarski, M1
Chwalinska-Sadowska, H1
Jagodzinski, PP1
Batova, IN1
Kyurkchiev, SD1
Kehayov, IR1
Ahmad, J1
Ashok, BT1
Ali, R1
Alarcón-Segovia, D1
Fishbein, E1
Lightfoot, RW1
Redecha, PB1
Levesanos, N1

Reviews

1 review available for adenine and Lupus Erythematosus, Systemic

ArticleYear
From mechanism to therapies in systemic lupus erythematosus.
    Current opinion in rheumatology, 2017, Volume: 29, Issue:2

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antibodies, Monoclonal; Antibodies, Monoclonal, Humani

2017

Other Studies

15 other studies available for adenine and Lupus Erythematosus, Systemic

ArticleYear
NCS 613, a PDE4 inhibitor, by increasing cAMP level suppresses systemic inflammation and immune complexes deposition in kidney of MRL/lpr lupus- prone mice.
    Biochimica et biophysica acta. Molecular basis of disease, 2021, 03-01, Volume: 1867, Issue:3

    Topics: Adenine; Animals; Anti-Inflammatory Agents; Antigen-Antibody Complex; Cyclic AMP; Female; Inflammati

2021
Genomewide analysis of 6-methyladenine DNA in peripheral blood mononuclear cells of systemic lupus erythematosus.
    Lupus, 2019, Volume: 28, Issue:3

    Topics: Adenine; Adult; Blood Sedimentation; Case-Control Studies; Complement C3; Complement C4; DNA Methyla

2019
Critical role of transmethylation in TLR signaling and systemic lupus erythematosus.
    Clinical immunology (Orlando, Fla.), 2013, Volume: 147, Issue:2

    Topics: Adenine; Animals; Antigen-Presenting Cells; Autoantibodies; B-Lymphocytes; Butyrates; CD4-Positive T

2013
NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:5

    Topics: Adenine; Adult; Aged; Anti-Inflammatory Agents; Cell Nucleus; Cyclic Nucleotide Phosphodiesterases,

2013
Inhibition of PI3Kδ improves systemic lupus in mice.
    Inflammation, 2014, Volume: 37, Issue:3

    Topics: Adenine; Animals; Antibodies, Antinuclear; Chemokine CCL2; Class I Phosphatidylinositol 3-Kinases; C

2014
Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor.
    PloS one, 2012, Volume: 7, Issue:1

    Topics: Adenine; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Progression; Fem

2012
Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice.
    Blood, 2012, Apr-19, Volume: 119, Issue:16

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Autoimmunity; B-Lymphocytes; Cell Lineage; Ge

2012
Sgp3 and TLR7 stimulation differentially alter the expression profile of modified polytropic retroviruses implicated in murine systemic lupus.
    Journal of autoimmunity, 2012, Volume: 38, Issue:4

    Topics: Adenine; Animals; DNA Replication; Endogenous Retroviruses; Female; Gene Expression Regulation; Geno

2012
Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.
    Arthritis research & therapy, 2012, Nov-08, Volume: 14, Issue:6

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Autoantibodies; Autoimmunity; Enzyme-Linked I

2012
The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 40, Issue:6

    Topics: 5' Flanking Region; Adenine; Adult; Chemokine CCL2; Disease Progression; Female; Gene Expression Reg

2002
MTR 2756 A > G polymorphism is associated with the risk of systemic lupus erythematosus in the Polish population.
    Lupus, 2007, Volume: 16, Issue:6

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenine; Adult; Gene Frequency; Genetic P

2007
Base specificity and binding of anti-ss/dsDNA monoclonal antibody. Application to the determination of ssDNA.
    Biochemistry and molecular biology international, 1993, Volume: 29, Issue:3

    Topics: Adenine; Animals; Antibodies, Antinuclear; Antibodies, Monoclonal; Antibody Specificity; Base Sequen

1993
Reactive oxygen species modified thymine and poly(dT) present unique epitope for human anti-DNA autoantibodies.
    Immunology letters, 1997, Volume: 58, Issue:2

    Topics: Adenine; Animals; Antibodies, Antinuclear; Antibody Specificity; Autoimmune Diseases; Cattle; Enzyme

1997
Immunochemical characterization of the anti-RNA antibodies found in scleroderma and systemic lupus erythematosus. I. Differences in reactivity with Poly (U) and Poly-(A) Poly (U).
    Journal of immunology (Baltimore, Md. : 1950), 1975, Volume: 115, Issue:1

    Topics: Adenine; Antibody Formation; Epitopes; Hemagglutination Inhibition Tests; Humans; Immune Sera; Immun

1975
Longitudinal studies of anti-DNA antibody levels in SLE.
    Scandinavian journal of rheumatology. Supplement, 1975, Volume: 11

    Topics: Adenine; Antibodies, Antinuclear; Binding Sites, Antibody; Complement System Proteins; DNA; Humans;

1975