adenine has been researched along with Lupus Erythematosus, Systemic in 16 studies
Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Systemic lupus erythematosus is a polymorphic and multigenic inflammatory autoimmune disease." | 1.38 | Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor. ( Bourguignon, JJ; Gazi, L; Keravis, T; Lugnier, C; Monneaux, F; Muller, S; Yougbaré, I, 2012) |
| "Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens." | 1.38 | Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus. ( Bashmakov, A; Buggy, JJ; Chang, BY; Du, Y; Grewal, S; Hutcheson, J; Mohan, C; Sajitharan, D; Satterthwaite, AB; Vanarsa, K; Zhou, XJ, 2012) |
| "Renal involvement in patients with systemic lupus erythematosus (SLE) varies from none to full-blown disease." | 1.31 | The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE. ( Chung, JH; Kim, HL; Kim, S; Kim, YS; Lee, DS; Lee, JS; Lim, CS; Yang, SH, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Yougbare, I | 3 |
| Keravis, T | 2 |
| Lugnier, C | 3 |
| Zheng, F | 1 |
| Tang, D | 1 |
| Xu, H | 1 |
| Xu, Y | 1 |
| Dai, W | 1 |
| Zhang, X | 1 |
| Hong, X | 1 |
| Liu, D | 1 |
| Dai, Y | 1 |
| Tardif, V | 1 |
| Manenkova, Y | 1 |
| Berger, M | 1 |
| Hoebe, K | 1 |
| Zuo, JP | 1 |
| Yuan, C | 1 |
| Kono, DH | 1 |
| Theofilopoulos, AN | 1 |
| Lawson, BR | 1 |
| Boire, G | 1 |
| Roy, M | 1 |
| Rouseau, E | 1 |
| Wang, Y | 1 |
| Zhang, L | 1 |
| Wei, P | 1 |
| Zhang, H | 1 |
| Liu, C | 1 |
| Paley, MA | 1 |
| Strand, V | 1 |
| Kim, AH | 1 |
| Monneaux, F | 1 |
| Gazi, L | 1 |
| Bourguignon, JJ | 1 |
| Muller, S | 1 |
| Kil, LP | 1 |
| de Bruijn, MJ | 1 |
| van Nimwegen, M | 1 |
| Corneth, OB | 1 |
| van Hamburg, JP | 1 |
| Dingjan, GM | 1 |
| Thaiss, F | 1 |
| Rimmelzwaan, GF | 1 |
| Elewaut, D | 1 |
| Delsing, D | 1 |
| van Loo, PF | 1 |
| Hendriks, RW | 1 |
| Leroy, V | 1 |
| Kihara, M | 1 |
| Baudino, L | 1 |
| Brighouse, G | 1 |
| Evans, LH | 1 |
| Izui, S | 1 |
| Hutcheson, J | 1 |
| Vanarsa, K | 1 |
| Bashmakov, A | 1 |
| Grewal, S | 1 |
| Sajitharan, D | 1 |
| Chang, BY | 1 |
| Buggy, JJ | 1 |
| Zhou, XJ | 1 |
| Du, Y | 1 |
| Satterthwaite, AB | 1 |
| Mohan, C | 1 |
| Kim, HL | 1 |
| Lee, DS | 1 |
| Yang, SH | 1 |
| Lim, CS | 1 |
| Chung, JH | 1 |
| Kim, S | 1 |
| Lee, JS | 1 |
| Kim, YS | 1 |
| Burzynski, M | 1 |
| Duriagin, S | 1 |
| Mostowska, M | 1 |
| Wudarski, M | 1 |
| Chwalinska-Sadowska, H | 1 |
| Jagodzinski, PP | 1 |
| Batova, IN | 1 |
| Kyurkchiev, SD | 1 |
| Kehayov, IR | 1 |
| Ahmad, J | 1 |
| Ashok, BT | 1 |
| Ali, R | 1 |
| Alarcón-Segovia, D | 1 |
| Fishbein, E | 1 |
| Lightfoot, RW | 1 |
| Redecha, PB | 1 |
| Levesanos, N | 1 |
1 review available for adenine and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
From mechanism to therapies in systemic lupus erythematosus.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antibodies, Monoclonal; Antibodies, Monoclonal, Humani | 2017 |
15 other studies available for adenine and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
NCS 613, a PDE4 inhibitor, by increasing cAMP level suppresses systemic inflammation and immune complexes deposition in kidney of MRL/lpr lupus- prone mice.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Antigen-Antibody Complex; Cyclic AMP; Female; Inflammati | 2021 |
Genomewide analysis of 6-methyladenine DNA in peripheral blood mononuclear cells of systemic lupus erythematosus.
Topics: Adenine; Adult; Blood Sedimentation; Case-Control Studies; Complement C3; Complement C4; DNA Methyla | 2019 |
Critical role of transmethylation in TLR signaling and systemic lupus erythematosus.
Topics: Adenine; Animals; Antigen-Presenting Cells; Autoantibodies; B-Lymphocytes; Butyrates; CD4-Positive T | 2013 |
NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production.
Topics: Adenine; Adult; Aged; Anti-Inflammatory Agents; Cell Nucleus; Cyclic Nucleotide Phosphodiesterases, | 2013 |
Inhibition of PI3Kδ improves systemic lupus in mice.
Topics: Adenine; Animals; Antibodies, Antinuclear; Chemokine CCL2; Class I Phosphatidylinositol 3-Kinases; C | 2014 |
Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor.
Topics: Adenine; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Progression; Fem | 2012 |
Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Autoimmunity; B-Lymphocytes; Cell Lineage; Ge | 2012 |
Sgp3 and TLR7 stimulation differentially alter the expression profile of modified polytropic retroviruses implicated in murine systemic lupus.
Topics: Adenine; Animals; DNA Replication; Endogenous Retroviruses; Female; Gene Expression Regulation; Geno | 2012 |
Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Autoantibodies; Autoimmunity; Enzyme-Linked I | 2012 |
The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE.
Topics: 5' Flanking Region; Adenine; Adult; Chemokine CCL2; Disease Progression; Female; Gene Expression Reg | 2002 |
MTR 2756 A > G polymorphism is associated with the risk of systemic lupus erythematosus in the Polish population.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenine; Adult; Gene Frequency; Genetic P | 2007 |
Base specificity and binding of anti-ss/dsDNA monoclonal antibody. Application to the determination of ssDNA.
Topics: Adenine; Animals; Antibodies, Antinuclear; Antibodies, Monoclonal; Antibody Specificity; Base Sequen | 1993 |
Reactive oxygen species modified thymine and poly(dT) present unique epitope for human anti-DNA autoantibodies.
Topics: Adenine; Animals; Antibodies, Antinuclear; Antibody Specificity; Autoimmune Diseases; Cattle; Enzyme | 1997 |
Immunochemical characterization of the anti-RNA antibodies found in scleroderma and systemic lupus erythematosus. I. Differences in reactivity with Poly (U) and Poly-(A) Poly (U).
Topics: Adenine; Antibody Formation; Epitopes; Hemagglutination Inhibition Tests; Humans; Immune Sera; Immun | 1975 |
Longitudinal studies of anti-DNA antibody levels in SLE.
Topics: Adenine; Antibodies, Antinuclear; Binding Sites, Antibody; Complement System Proteins; DNA; Humans; | 1975 |