Page last updated: 2024-10-16

adenine and Liver Failure

adenine has been researched along with Liver Failure in 24 studies

Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)

Research Excerpts

ExcerptRelevanceReference
"A randomized, open-label comparative study of entecavir versus adefovir therapy was performed in subjects with chronic hepatitis B who had hepatic decompensation (Child-Turcotte-Pugh score ≥7)."9.15Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study. ( Beebe, S; Bialkowska, J; Brown, RS; Cheinquer, H; Cooney, E; Jeffers, L; Leung, N; Liaw, YF; Myers, RP; Peng, CY; Raptopoulou-Gigi, M; Sarin, SK; Tang, S; Tanwandee, T; Tsai, N, 2011)
"Lamivudine treatment in patients with chronic hepatitis B virus (HBV) infection may improve clinical state and suppress viral replication before liver transplantation."9.11Liver transplantation for chronic hepatitis B with lamivudine-resistant YMDD mutant using add-on adefovir dipivoxil plus lamivudine. ( Chan, SC; Fan, ST; Lau, GK; Liu, CL; Lo, CM; Ng, IO, 2005)
"The aims of this study were to select the patients with a potential for progression to hepatic failure due to lamivudine-resistant HBV and to standardize the treatment for patients with lamivudine-resistant HBV."7.74Predictive factors associated with the progression to hepatic failure caused by lamivudine-resistant HBV. ( Hino, T; Hisamochi, A; Ide, T; Koga, H; Koga, Y; Kumashiro, R; Kuwahara, R; Ogata, K; Sata, M; Takao, Y; Tanaka, K, 2008)
"We determined the clinical outcome of hepatitis e antigen (HBeAg)-negative chronic hepatitis B patients treated with long-term nucleos(t)ide analog therapy starting with lamivudine."7.73Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine. ( Dimakopoulos, K; Dimou, E; Hadziyannis, SJ; Kitis, G; Manesis, E; Manolakopoulos, S; Papatheodoridis, GV; Rapti, I; Tzourmakliotis, D, 2005)
"The susceptibility of adefovir-resistant hepatitis B virus (HBV) mutants is only reduced by 3-10-fold in in vitro studies, suggesting that virologic breakthrough and clinical deterioration are unlikely."7.73Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation. ( Andreone, P; Cursaro, C; Fung, SK; Han, SH; Hussain, M; Keeffe, EB; Lok, AS; Marrero, JA; Rajender Reddy, K; Regev, A; Richtmyer, P, 2005)
"Lamivudine is a treatment option for the therapy of chronic hepatitis B with an excellent safety profile."7.72Severe exacerbation of chronic hepatitis B after emergence of lamivudine resistance in a cirrhotic patient: immediate switch to adefovir dipivoxil appears to be indicated. ( Flemming, P; Klempnauer, J; Manns, MP; Nashan, B; Niemann, P; Rohde, P; Tillmann, HL; Tischendorf, JJ; Trautwein, C; Wiegand, J, 2004)
" Hepatitis B immunoglobulin and adefovir dipivoxil were initiated."7.70Fulminant hepatic failure resulting from lamivudine-resistant hepatitis B virus in a renal transplant recipient: durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin. ( Gibbs, CS; Howard, T; Jacobsmeyer, S; Lamy, P; Murray, A; Peters, MG; Singer, G; Xiong, X, 1999)
"In patients with hepatitis B-related HCC, adefovir antiviral therapy reduced late HCC recurrence and significantly improved overall survival after R0 hepatic resection."5.20Antiviral therapy improves postoperative survival in patients with hepatocellular carcinoma: a randomized controlled trial. ( Huang, G; Lau, WY; Pan, ZY; Shen, F; Wang, ZG; Wu, MC; Yuan, SX; Zhou, WP, 2015)
"A randomized, open-label comparative study of entecavir versus adefovir therapy was performed in subjects with chronic hepatitis B who had hepatic decompensation (Child-Turcotte-Pugh score ≥7)."5.15Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study. ( Beebe, S; Bialkowska, J; Brown, RS; Cheinquer, H; Cooney, E; Jeffers, L; Leung, N; Liaw, YF; Myers, RP; Peng, CY; Raptopoulou-Gigi, M; Sarin, SK; Tang, S; Tanwandee, T; Tsai, N, 2011)
"Lamivudine treatment in patients with chronic hepatitis B virus (HBV) infection may improve clinical state and suppress viral replication before liver transplantation."5.11Liver transplantation for chronic hepatitis B with lamivudine-resistant YMDD mutant using add-on adefovir dipivoxil plus lamivudine. ( Chan, SC; Fan, ST; Lau, GK; Liu, CL; Lo, CM; Ng, IO, 2005)
"The aims of this study were to select the patients with a potential for progression to hepatic failure due to lamivudine-resistant HBV and to standardize the treatment for patients with lamivudine-resistant HBV."3.74Predictive factors associated with the progression to hepatic failure caused by lamivudine-resistant HBV. ( Hino, T; Hisamochi, A; Ide, T; Koga, H; Koga, Y; Kumashiro, R; Kuwahara, R; Ogata, K; Sata, M; Takao, Y; Tanaka, K, 2008)
"We determined the clinical outcome of hepatitis e antigen (HBeAg)-negative chronic hepatitis B patients treated with long-term nucleos(t)ide analog therapy starting with lamivudine."3.73Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine. ( Dimakopoulos, K; Dimou, E; Hadziyannis, SJ; Kitis, G; Manesis, E; Manolakopoulos, S; Papatheodoridis, GV; Rapti, I; Tzourmakliotis, D, 2005)
"The susceptibility of adefovir-resistant hepatitis B virus (HBV) mutants is only reduced by 3-10-fold in in vitro studies, suggesting that virologic breakthrough and clinical deterioration are unlikely."3.73Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation. ( Andreone, P; Cursaro, C; Fung, SK; Han, SH; Hussain, M; Keeffe, EB; Lok, AS; Marrero, JA; Rajender Reddy, K; Regev, A; Richtmyer, P, 2005)
"3%) patients developed hepatitis B virus DNA breakthrough 47 and 53 months, respectively, after transplantation, but they remained well after treatment with adefovir."3.72Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure. ( Fan, ST; Lai, CL; Liu, CL; Lo, CM; Wei, WI; Wong, J; Yong, BH, 2003)
"Lamivudine is a treatment option for the therapy of chronic hepatitis B with an excellent safety profile."3.72Severe exacerbation of chronic hepatitis B after emergence of lamivudine resistance in a cirrhotic patient: immediate switch to adefovir dipivoxil appears to be indicated. ( Flemming, P; Klempnauer, J; Manns, MP; Nashan, B; Niemann, P; Rohde, P; Tillmann, HL; Tischendorf, JJ; Trautwein, C; Wiegand, J, 2004)
"Hepatitis B virus (HBV) recurrence following liver transplantation (LTx) has been controllable primarily with the use of hepatitis B immune globulin (HBIg) and lamivudine (LAM)."3.72Outcomes in liver transplant recipients with hepatitis B virus: resistance and recurrence patterns from a large transplant center over the last decade. ( De Medina, M; Madariaga, J; Montalbano, M; Neff, GW; Nery, C; Nery, J; O'brien, CB; Ruiz, P; Safdar, K; Schiff, ER; Shire, N; Tzakis, AG, 2004)
" Hepatitis B immunoglobulin and adefovir dipivoxil were initiated."3.70Fulminant hepatic failure resulting from lamivudine-resistant hepatitis B virus in a renal transplant recipient: durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin. ( Gibbs, CS; Howard, T; Jacobsmeyer, S; Lamy, P; Murray, A; Peters, MG; Singer, G; Xiong, X, 1999)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.17)18.2507
2000's12 (50.00)29.6817
2010's10 (41.67)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Malek, AE1
Nieto, Y1
Szvalb, AD1
Siddiqui, S1
Shafi, MA1
Hwang, JP1
Raad, II1
Torres, HA1
Price, J1
Rao, W1
Xie, M1
Shen, Z1
Huang, G1
Lau, WY1
Wang, ZG1
Pan, ZY1
Yuan, SX1
Shen, F1
Zhou, WP1
Wu, MC1
Jiao, M1
Ren, F1
Zhou, L1
Zhang, X2
Zhang, L1
Wen, T1
Wei, L1
Wang, X1
Shi, H1
Bai, L1
Zheng, S1
Zhang, J1
Chen, Y1
Han, Y1
Zhao, C1
Duan, Z1
Kim, SK1
Kim, SR1
Imoto, S1
Tohyama, M1
Otono, Y1
Tamura, T1
Kuwahara, R2
Kumashiro, R2
Ide, T2
Koga, Y2
Hino, T2
Hisamochi, A1
Tanaka, K1
Ogata, K1
Koga, H1
Takao, Y1
Sata, M2
Muñoz Bertrán, E1
Pérez Ceballos, E1
Gómez Espín, R1
Ortega González, I1
Liaw, YF1
Raptopoulou-Gigi, M1
Cheinquer, H1
Sarin, SK1
Tanwandee, T1
Leung, N1
Peng, CY1
Myers, RP1
Brown, RS1
Jeffers, L1
Tsai, N1
Bialkowska, J1
Tang, S1
Beebe, S1
Cooney, E1
Kohler, JJ1
Hosseini, SH1
Cholongitas, E1
Papatheodoridis, GV2
Qayyum, S1
Dong, H1
Kovacic, D1
Sohail, S1
Waters, B1
Thornton, C1
Corbett, CE1
Liu, CL2
Fan, ST2
Lo, CM2
Wei, WI1
Yong, BH1
Lai, CL1
Wong, J1
Wiegand, J1
Tischendorf, JJ1
Nashan, B1
Klempnauer, J1
Flemming, P1
Niemann, P1
Rohde, P1
Manns, MP1
Trautwein, C1
Tillmann, HL1
Inoue, H1
Tanabe, R1
Tanaka, E1
Hatano, E1
Tanaka, A1
Kanazawa, A1
Tsuyuki, S1
Tsunekawa, S1
Iwata, S1
Takahashi, R1
Chance, B1
Yamaoka, Y1
Neff, GW1
O'brien, CB1
Nery, J1
Shire, N1
Montalbano, M1
Ruiz, P1
Nery, C1
Safdar, K1
De Medina, M1
Tzakis, AG1
Schiff, ER1
Madariaga, J1
Dimou, E1
Dimakopoulos, K1
Manolakopoulos, S1
Rapti, I1
Kitis, G1
Tzourmakliotis, D1
Manesis, E1
Hadziyannis, SJ1
Lau, GK1
Chan, SC1
Ng, IO1
Fung, SK1
Andreone, P1
Han, SH1
Rajender Reddy, K1
Regev, A1
Keeffe, EB1
Hussain, M1
Cursaro, C1
Richtmyer, P1
Marrero, JA1
Lok, AS1
Masiá, M1
Gutiérrez, F1
Padilla, S1
Ramos, JM1
Pascual, J1
Bruno, R1
Sacchi, P1
Filice, G1
Matthews, GV1
Cooper, DA1
Dore, GJ1
Peters, MG1
Singer, G1
Howard, T1
Jacobsmeyer, S1
Xiong, X1
Gibbs, CS1
Lamy, P1
Murray, A1

Reviews

4 reviews available for adenine and Liver Failure

ArticleYear
An update on hepatitis B, D, and E viruses.
    Topics in antiviral medicine, 2014, Volume: 21, Issue:5

    Topics: Adenine; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Hepatitis D, Chronic; Hepatitis E

2014
[Hepatitis B reactivation in an HbsAg-negative/anti-HBc-positive patient with B-cell non-Hodgkin lymphoma receiving chemotherapy with rituximab].
    Gastroenterologia y hepatologia, 2010, Volume: 33, Issue:5

    Topics: Adenine; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antibody

2010
High genetic barrier nucleos(t)ide analogue(s) for prophylaxis from hepatitis B virus recurrence after liver transplantation: a systematic review.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2013, Volume: 13, Issue:2

    Topics: Adenine; Antiviral Agents; DNA, Viral; Guanine; Hepatitis B; Hepatitis B virus; Humans; Immunoglobul

2013
Severe toxicity associated with the combination of tenofovir and didanosine: case report and review.
    International journal of STD & AIDS, 2005, Volume: 16, Issue:9

    Topics: Acidosis, Lactic; Acute Disease; Adenine; Anti-HIV Agents; Didanosine; Drug Therapy, Combination; Fe

2005

Trials

3 trials available for adenine and Liver Failure

ArticleYear
Antiviral therapy improves postoperative survival in patients with hepatocellular carcinoma: a randomized controlled trial.
    Annals of surgery, 2015, Volume: 261, Issue:1

    Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Hepatitis

2015
Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study.
    Hepatology (Baltimore, Md.), 2011, Volume: 54, Issue:1

    Topics: Adenine; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Fem

2011
Liver transplantation for chronic hepatitis B with lamivudine-resistant YMDD mutant using add-on adefovir dipivoxil plus lamivudine.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2005, Volume: 11, Issue:7

    Topics: Adenine; Adult; Aged; Antiviral Agents; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Vi

2005

Other Studies

17 other studies available for adenine and Liver Failure

ArticleYear
Hepatitis B Virus-associated Liver Failure in a Patient With B-cell Non-Hodgkin Lymphoma After Anti-cancer Therapy Including Ibrutinib.
    Clinical lymphoma, myeloma & leukemia, 2020, Volume: 20, Issue:3

    Topics: Adenine; Aged; Aged, 80 and over; Hepatitis B virus; Humans; Liver Failure; Lymphoma, Non-Hodgkin; M

2020
Tenofovir disoproxil fumarate rescue therapy for HBV recurrence in two liver transplant recipients with previous multiple nucleo(s/t)ide treatment failures.
    Transplant international : official journal of the European Society for Organ Transplantation, 2014, Volume: 27, Issue:10

    Topics: Adenine; Aged; Follow-Up Studies; Graft Rejection; Graft Survival; Hepatitis B; Humans; Liver Failur

2014
Peroxisome proliferator-activated receptor α activation attenuates the inflammatory response to protect the liver from acute failure by promoting the autophagy pathway.
    Cell death & disease, 2014, Aug-28, Volume: 5

    Topics: Acute Disease; Adenine; Adult; Animals; Autophagy; Autophagy-Related Protein 7; Cells, Cultured; Che

2014
Rhabdomyolysis due to lamivudine re-administration in a patient with HBV-related hepatic failure caused by interruption of lamivudine and adefovir.
    Journal of gastrointestinal and liver diseases : JGLD, 2015, Volume: 24, Issue:4

    Topics: Adenine; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B, Chr

2015
Predictive factors associated with the progression to hepatic failure caused by lamivudine-resistant HBV.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:11

    Topics: Adenine; Adult; Antiviral Agents; Bilirubin; Disease Progression; Drug Resistance, Viral; Female; Fo

2008
Subcellular renal proximal tubular mitochondrial toxicity with tenofovir treatment.
    Methods in molecular biology (Clifton, N.J.), 2011, Volume: 755

    Topics: Adenine; Animals; Cardiomyopathies; Cell Separation; DNA, Mitochondrial; Female; HIV Infections; HIV

2011
Combination therapy efavirenz/emtricitabine/tenofovir disoproxil fumarate associated with hepatic failure.
    Current drug safety, 2012, Nov-01, Volume: 7, Issue:5

    Topics: Adenine; Adult; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fum

2012
Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure.
    Transplantation, 2003, Oct-27, Volume: 76, Issue:8

    Topics: Acute Disease; Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Follow-Up Studies; Graft Surviv

2003
Severe exacerbation of chronic hepatitis B after emergence of lamivudine resistance in a cirrhotic patient: immediate switch to adefovir dipivoxil appears to be indicated.
    Zeitschrift fur Gastroenterologie, 2004, Volume: 42, Issue:1

    Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Hep

2004
Adefovir dipivoxil as a treatment for hepatic failure caused by lamivudine-resistant HBV strains.
    Digestive diseases and sciences, 2004, Volume: 49, Issue:2

    Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance; Hepatitis B; Hepatitis B virus; Humans; Lami

2004
Inhibition of tumor necrosis factor-induced apoptosis in transgenic mouse liver expressing creatine kinase.
    Liver international : official journal of the International Association for the Study of the Liver, 2004, Volume: 24, Issue:4

    Topics: Adenine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Caspase 3; Caspases; Creatine Kinas

2004
Outcomes in liver transplant recipients with hepatitis B virus: resistance and recurrence patterns from a large transplant center over the last decade.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2004, Volume: 10, Issue:11

    Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Graft Survival; Hepatitis B;

2004
Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine.
    Hepatology (Baltimore, Md.), 2005, Volume: 42, Issue:1

    Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; Female; Hepatitis B e

2005
Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation.
    Journal of hepatology, 2005, Volume: 43, Issue:6

    Topics: Adenine; Adult; Aged; Antiviral Agents; Disease Progression; Drug Resistance, Viral; Hepatitis B; He

2005
Could tenofovir modify the model end-stage liver disease (MELD) score in patients with end-stage liver disease eligible for liver transplantation?
    Journal of acquired immune deficiency syndromes (1999), 2007, May-01, Volume: 45, Issue:1

    Topics: Adenine; Anti-HIV Agents; Humans; Liver Failure; Liver Transplantation; Organophosphonates; Severity

2007
Improvements in parameters of end-stage liver disease in patients with HIV/HBV-related cirrhosis treated with tenofovir.
    Antiviral therapy, 2007, Volume: 12, Issue:1

    Topics: Adenine; CD4 Lymphocyte Count; DNA, Viral; Follow-Up Studies; Hepatitis B; Hepatitis B e Antigens; H

2007
Fulminant hepatic failure resulting from lamivudine-resistant hepatitis B virus in a renal transplant recipient: durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin.
    Transplantation, 1999, Dec-27, Volume: 68, Issue:12

    Topics: Adenine; Adult; Antiviral Agents; Carrier State; DNA-Directed DNA Polymerase; Drug Resistance; Femal

1999