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adenine and Leukocytopenia

adenine has been researched along with Leukocytopenia in 13 studies

Research Excerpts

ExcerptRelevanceReference
"Twenty-eight patients with advanced breast cancer refractory to prior hormone and/or first-line chemotherapy (with or without anthracycline drugs) were treated with the investigational agent amonafide at a dose of 800 mg/m2 intravenously over 3 hours repeated every 4 weeks."9.07Phase II study of amonafide in advanced breast cancer. ( Depisch, D; Dittrich, C; Gisslinger, H; Haider, K; Kornek, G; Linkesch, W; Scheithauer, W, 1991)
" For illustration, a pharmacodynamic model for leukopenia was constructed by stepwise linear regression from data of 41 patients with cancer treated with the drug amonafide."5.07Bootstrap validation of pharmacodynamic models defined via stepwise linear regression. ( Mick, R; Ratain, MJ, 1994)
"Twenty-eight patients with advanced breast cancer refractory to prior hormone and/or first-line chemotherapy (with or without anthracycline drugs) were treated with the investigational agent amonafide at a dose of 800 mg/m2 intravenously over 3 hours repeated every 4 weeks."5.07Phase II study of amonafide in advanced breast cancer. ( Depisch, D; Dittrich, C; Gisslinger, H; Haider, K; Kornek, G; Linkesch, W; Scheithauer, W, 1991)
"To determine if variability in toxicity of amonafide during phase II trials could be correlated with pharmacokinetic variability."2.68Population pharmacodynamic study of amonafide: a Cancer and Leukemia Group B study. ( Allen, SL; Costanza, M; Henderson, IC; Ratain, MJ; Rosner, G; Schilsky, RL; Van Echo, DA, 1995)
" The goal of this study was to construct and validate a pharmacodynamic model-based dosing strategy for amonafide, to try to further decrease inter-patient variability in leukopenia."1.29Individualized dosing of amonafide based on a pharmacodynamic model incorporating acetylator phenotype and gender. ( Berezin, F; Janisch, L; Kut, M; Mick, R; Ratain, MJ; Schilsky, RL; Vogelzang, NJ, 1996)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19904 (30.77)18.7374
1990's9 (69.23)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
YANASE, T1
KASAI, A1
YAMANAKA, J1
OWAN, T1
Ratain, MJ4
Rosner, G1
Allen, SL1
Costanza, M1
Van Echo, DA1
Henderson, IC1
Schilsky, RL3
Mick, R3
Xiwen, B1
Lixin, Y1
Junjie, M1
Janisch, L2
Berezin, F2
Vogelzang, NJ1
Kut, M1
Asbury, R1
Blessing, JA1
Podczaski, E1
Ball, H1
Lu, W1
Hanson, KH1
Crowley, J1
Salmon, SE1
Keppen, M1
Braun, TJ1
Bonnet, JD1
Scheithauer, W1
Dittrich, C1
Kornek, G1
Haider, K1
Linkesch, W1
Gisslinger, H1
Depisch, D1
Williams, SF1
Smiddy, J1
Muto, T1
Ebisawa, I1
Mitsui, G1
Rusanov, AM1
Novoselova, GS1
Smirnova, GA1

Trials

6 trials available for adenine and Leukocytopenia

ArticleYear
Population pharmacodynamic study of amonafide: a Cancer and Leukemia Group B study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:3

    Topics: Acetylation; Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Femal

1995
Bootstrap validation of pharmacodynamic models defined via stepwise linear regression.
    Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:2

    Topics: Acetylation; Adenine; Aging; Female; Humans; Imides; Isoquinolines; Leukocyte Count; Leukopenia; Mal

1994
A phase II trial of amonafide in patients with mixed mesodermal tumors of the uterus: a Gynecologic Oncology Group study.
    American journal of clinical oncology, 1998, Volume: 21, Issue:3

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Imides; Isoquinoline

1998
[Clinical investigation on treatment of integrated traditional and Western medicine in hyperthyroidism with leukocytopenia induced by sulfourea drugs].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1998, Volume: 18, Issue:1

    Topics: Adenine; Adolescent; Adult; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Hypert

1998
Evaluation of amonafide in refractory and relapsing multiple myeloma: a Southwest Oncology Group study.
    Anti-cancer drugs, 1991, Volume: 2, Issue:3

    Topics: Adenine; Adult; Aged; Antineoplastic Agents; Blood Cell Count; Drug Resistance; Female; Granulocytes

1991
Phase II study of amonafide in advanced breast cancer.
    Breast cancer research and treatment, 1991, Volume: 20, Issue:1

    Topics: Adenine; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Cardiomyopathies; Drug Evaluation; Fe

1991

Other Studies

7 other studies available for adenine and Leukocytopenia

ArticleYear
[Clinical experiences with adociron in the treatment of radioleukopenia in carcinoma of the cervix].
    [Sanfujinka no shinpo] Advances in obstetrics and gynecology, 1962, Volume: 14

    Topics: Adenine; Carcinoma; Female; Humans; Leukocyte Disorders; Leukopenia; Radiation Injuries; Radiotherap

1962
[The effects of adenine on the leukopenia after x-irradiation. I].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 1962, Mar-25, Volume: 21

    Topics: Adenine; Humans; Leukocyte Disorders; Leukopenia; Radiation Effects; X-Rays

1962
Treatment of peripheral leukopenia after cadaveric kidney transplantation.
    Transplantation proceedings, 1996, Volume: 28, Issue:3

    Topics: Adenine; Adult; Azathioprine; Blood Transfusion; Cadaver; Drug Therapy, Combination; Female; Glycery

1996
Individualized dosing of amonafide based on a pharmacodynamic model incorporating acetylator phenotype and gender.
    Pharmacogenetics, 1996, Volume: 6, Issue:1

    Topics: Acetylation; Adenine; Adult; Antineoplastic Agents; Drug Administration Schedule; Female; Humans; Im

1996
Paradoxical relationship between acetylator phenotype and amonafide toxicity.
    Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:5 Pt 1

    Topics: Acetylation; Adenine; Antineoplastic Agents; Body Weight; Female; Humans; Imides; Isoquinolines; Leu

1991
Malaria in Laos. II. Peripheral leucocyte counts during long-term administration of combined folic inhibitors (pyrimethamine with sulformethoxine or sulfamonomethoxine).
    The Japanese journal of experimental medicine, 1971, Volume: 41, Issue:5

    Topics: Adenine; Administration, Oral; Aniline Compounds; Asian People; Drug Combinations; Folic Acid Antago

1971
[Treatment of experimental radiation leukopenia with Etaden].
    Meditsinskaia radiologiia, 1967, Volume: 12, Issue:7

    Topics: Adenine; Animals; Leukopenia; Mice; Radiation Injuries, Experimental; Radiation-Protective Agents; R

1967