adenine has been researched along with Leukemia L 1210 in 44 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The acyclic nucleotide analogue (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)-adenine [(S)-HPMPA], which contains a phosphonate-substituted aliphatic chain, is a potent and selective inhibitor of the replication of various DNA viruses, including herpes simplex virus type 1 (HSV-1)." | 3.67 | Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis. ( Bernaerts, R; De Clercq, E; Holý, A; Merta, A; Rosenberg, I; Sakuma, T; Votruba, I, 1987) |
| " Adenine derivative 2a is a substrate for adenosine deaminase whereas both 2a and 2b exhibit 50% inhibition of the growth of murine leukemia L 1210 cell culture at 1 mM concentration." | 3.67 | Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogues of neplanocin A. ( Phadtare, S; Zemlicka, J, 1987) |
| "The use of the aqueous extracts of Eleutherococcus senticosus in combination with either cytarabine or N6-(delta 2-isopentenyl)-adenosine gave additive antiproliferative effects against L1210 murine leukemia." | 1.27 | Cytotoxic effects of Eleutherococcus senticosus aqueous extracts in combination with N6-(delta 2-isopentenyl)-adenosine and 1-beta-D-arabinofuranosylcytosine against L1210 leukemia cells. ( Hacker, B; Medon, PJ, 1984) |
| "Hydroxyurea is an inhibitor of ribonucleotide reductase and is specifically directed at the non-heme iron subunit (which contains the free radical) of this enzyme." | 1.27 | Cross-resistance patterns in hydroxyurea-resistant leukemia L1210 cells. ( Carter, GL; Cory, JG, 1988) |
| " The activity of 9-beta-D-arabinofuranosyladenine 5'-monophosphate, alone or in combination with either of the two inhibitors of adenosine deaminase, was comparable to that of 9-beta-D-arabinofuranosyladenine (ara-A), apparently reflecting the rapid conversion of 9-beta-D-arabinofuranosyladenine 5'-monophosphate to ara-A by L1210/C2 cells." | 1.26 | Antiproliferative effects of 9-beta-D-arabinofuranosyladenine 5'-monophosphate and related compounds in combination with adenosine deaminase inhibitors against mouse leukemia L1210/C2 cells in culture. ( Cass, CE; Selner, M; Tan, TH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (70.45) | 18.7374 |
| 1990's | 13 (29.55) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DYER, E | 1 |
| REITZ, JM | 1 |
| FARRIS, RE | 1 |
| HIRSCHBERG, E | 1 |
| BRINDLE, SD | 1 |
| SEMENTE, G | 1 |
| MEAD, JA | 1 |
| GREENBERG, NH | 1 |
| SCHRECKER, AW | 1 |
| SEEGER, DR | 1 |
| TOMCUFCIK, AS | 1 |
| BROCKMAN, RW | 3 |
| CHUMLEY, S | 1 |
| Burchenal, JH | 1 |
| Dollinger, M | 1 |
| Butterbaugh, J | 1 |
| Stoll, D | 1 |
| Giner-Sorolla, A | 1 |
| Bennett, LL | 1 |
| Smithers, D | 1 |
| Rose, LM | 1 |
| Adamson, DJ | 1 |
| Cybulski, RL | 2 |
| Fry, DW | 2 |
| Goldman, ID | 2 |
| Sato, A | 2 |
| Carter, GL | 3 |
| Bacon, PE | 2 |
| Cory, JG | 4 |
| Hacker, B | 1 |
| Medon, PJ | 1 |
| Heimer, R | 1 |
| Goldberg, D | 1 |
| Cadman, E | 1 |
| Huennekens, FM | 2 |
| Suresh, MR | 2 |
| Vitols, KS | 1 |
| Henderson, GB | 2 |
| Leyva, A | 1 |
| Appel, H | 1 |
| Pinedo, HM | 1 |
| Adachi, T | 1 |
| Arai, Y | 1 |
| Inoue, I | 1 |
| Saneyoshi, M | 1 |
| Dutta, SP | 2 |
| Mittelman, A | 1 |
| Chheda, GB | 2 |
| Xu, ZQ | 1 |
| Qiu, YL | 1 |
| Chokekijchai, S | 1 |
| Mitsuya, H | 1 |
| Zemlicka, J | 3 |
| Azuma, A | 1 |
| Nakajima, Y | 1 |
| Nishizono, N | 1 |
| Minakawa, N | 1 |
| Suzuki, M | 1 |
| Hanaoka, K | 1 |
| Kobayashi, T | 1 |
| Tanaka, M | 1 |
| Sasaki, T | 2 |
| Matsuda, A | 1 |
| Kessel, D | 2 |
| Braña, MF | 1 |
| Castellano, JM | 1 |
| Morán, M | 1 |
| Emling, F | 1 |
| Kluge, M | 1 |
| Schlick, E | 1 |
| Klebe, G | 1 |
| Walker, N | 1 |
| Balzarini, J | 2 |
| Hatse, S | 2 |
| Naesens, L | 2 |
| De Clercq, E | 3 |
| Cass, CE | 3 |
| Tan, TH | 1 |
| Selner, M | 1 |
| Vengris, VE | 1 |
| Pitha, PM | 1 |
| Sensenbrenner, LL | 1 |
| Hong, CI | 1 |
| Tritsch, GL | 1 |
| Cox, C | 1 |
| Parthasarthy, R | 1 |
| Merta, A | 4 |
| Votruba, I | 4 |
| Jindrich, J | 1 |
| Holý, A | 4 |
| Cihlár, T | 1 |
| Rosenberg, I | 4 |
| Otmar, M | 1 |
| Herve, TY | 1 |
| Vijayalakshmi, D | 1 |
| Dagnino, L | 1 |
| Belt, JA | 1 |
| Gati, WP | 1 |
| Paterson, AR | 2 |
| Ishida, K | 1 |
| Ishibashi, M | 1 |
| Shigemori, H | 1 |
| Kobayashi, J | 1 |
| Veselý, J | 2 |
| Revankar, GR | 1 |
| Hanna, NB | 1 |
| Imamura, N | 1 |
| Lewis, AF | 1 |
| Larson, SB | 1 |
| Finch, RA | 1 |
| Avery, TL | 1 |
| Robins, RK | 1 |
| Matsumoto, M | 1 |
| Weckbecker, G | 1 |
| Fathi-Afshar, R | 1 |
| Allen, TM | 1 |
| Krueger, CA | 1 |
| Cook, DA | 1 |
| Clanachan, AS | 1 |
| Vriend, R | 1 |
| Baer, HP | 1 |
| Bernaerts, R | 1 |
| Sakuma, T | 1 |
| Phadtare, S | 1 |
| Lee, KH | 1 |
| Rice, GK | 1 |
| Hall, IH | 1 |
| Amarnath, V | 1 |
| Hill, DL | 1 |
| Wingo, R | 1 |
| Smith, CM | 1 |
| Fontenelle, LJ | 1 |
| Muzik, H | 1 |
| Unger, H | 1 |
| Brox, LW | 1 |
| Henderson, JF | 1 |
| Montgomery, JA | 1 |
| Thomas, HJ | 1 |
| Dodd, DC | 1 |
| Chao, DL | 1 |
| Kimball, AP | 1 |
| Shaddix, S | 1 |
| Laster, WR | 1 |
| Schabel, FM | 1 |
44 other studies available for adenine and Leukemia L 1210
| Article | Year |
|---|---|
CARBAMATES DERIVED FROM AMINOPURINES.
Topics: 2-Aminopurine; Adenine; Animals; Antineoplastic Agents; Carbamates; Chemistry, Pharmaceutical; Leuke | 1963 |
DEVELOPMENT AND PROPERTIES OF MOUSE LEUKEMIA L1210 RESISTANT TO MIRACIL D.
Topics: Adenine; Animals; Azaguanine; Cyclophosphamide; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; | 1964 |
THE PHARMACOLOGICAL AND BIOCHEMICAL ACTIVITY OF 4-AMINO-4-DEOXY-10-METHYLPTEROYLASPARTIC ACID.
Topics: Adenine; Amino Acids; Animals; Aspartic Acid; Enzyme Inhibitors; Folic Acid; Formates; Kinetics; Leu | 1965 |
INHIBITION OF FORMYLGLYCINAMIDE RIBONUCLEOTIDE SYNTHESIS IN NEOPLASTIC CELLS BY PURINES AND ANALOGS.
Topics: Adenine; Animals; Antimetabolites; Antineoplastic Agents; Azaserine; Carcinoma, Squamous Cell; Glyci | 1965 |
Studies of 6-N-hydroxylamino-9-beta-D-ribofuranosylpurine in mouse leukemia.
Topics: Adenine; Animals; Body Weight; Cytarabine; Drug Antagonism; Drug Synergism; Fluorouracil; Guanine; L | 1967 |
Mode of action of 2-amino-6-chloro-1-deazapurine.
Topics: 2-Aminopurine; Adenine; AMP Deaminase; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cel | 1984 |
Approaches to the measurement of intracellular adenine and the discrimination between adenine transport and metabolism in L1210 leukemia cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Animals; Azides; Biological Transport; Glucose; Hypoxanthine; | 1982 |
Effects of biochemical modulation of drug combinations directed at the ribonucleotide reductase site on leukemia L1210 cell growth in culture.
Topics: Adenine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cells, Cultured; De | 1983 |
Cytotoxic effects of Eleutherococcus senticosus aqueous extracts in combination with N6-(delta 2-isopentenyl)-adenosine and 1-beta-D-arabinofuranosylcytosine against L1210 leukemia cells.
Topics: Adenine; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; | 1984 |
Effects of combinations of drugs having different modes of action at the ribonucleotide reductase site on growth of L1210 cells in culture.
Topics: Adenine; Animals; Antineoplastic Agents; Deferoxamine; Deoxyadenosines; Hydroxyurea; Kinetics; Leuke | 1982 |
Modulation of fluoropyrimidine metabolism in L1210 cells by L-alanosine.
Topics: Adenine; Alanine; Animals; Aspartic Acid; Cells, Cultured; Clone Cells; Deoxyuridine; Leukemia L1210 | 1983 |
Adenosine stimulation of uphill adenine transport in L1210 leukemia cells. Evidence for a novel countertransport mechanism.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Biological Transport; Coformycin; Dipyr | 1981 |
Transport of folate compounds, pterins and adenine in L1210 mouse leukemia cells.
Topics: Adenine; Animals; Biological Transport; Energy Metabolism; Folic Acid; Leukemia L1210; Membranes; Me | 1982 |
Purine modulation of thymidine activity in L1210 leukemia cells in vitro.
Topics: Adenine; Animals; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyribonuc | 1982 |
Synthesis and antitumor activity of cytosine and adenine nucleosides of unsaturated 5-(aminoacyl)aminopentofuranoses.
Topics: Adenine; Amino Acids; Animals; Antineoplastic Agents; Cytosine; Leukemia L1210; Mice; Sarcoma 180 | 1980 |
Metabolism of 1,N6-ethenoadenosine.
Topics: Adenine; Adenosine; Animals; Cells, Cultured; Leukemia L1210; Male; Mice; Rats; Sarcoma 180 | 1980 |
Unsaturated acyclic analogues of 2'-deoxyadenosine and thymidine containing fluorine: synthesis and biological activity.
Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cattle; Deoxyadenosines; HIV; Humans; Hyd | 1995 |
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.
Topics: Adenine; Animals; Antineoplastic Agents; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; L | 1993 |
Accumulation and metabolism of adenallene by murine leukemia L1210 cells.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Biological Transport; Biotransformation; Cytosine; Ki | 1994 |
Synthesis, structure and antitumor activity of new benz[d,e]isoquinoline-1,3-diones.
Topics: Adenine; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Crystallography, X | 1995 |
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Biological | 1998 |
N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties.
Topics: Adenine; Adenosine Deaminase; Adenosine Triphosphate; AMP Deaminase; Animals; Antineoplastic Agents; | 1999 |
Antiproliferative effects of 9-beta-D-arabinofuranosyladenine 5'-monophosphate and related compounds in combination with adenosine deaminase inhibitors against mouse leukemia L1210/C2 cells in culture.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Arabinonucleotides; Cell Division; Cells, Cultured | 1979 |
Folate uptake in L1210 cells: mediation by an adenine transport system.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Animals; Biological Transport, Active; Folic Acid; Kinetics; L | 1979 |
Polymeric drugs: direct compared with indirect inhibition of leukemia virus replication in mice.
Topics: Adenine; Animals; Depression, Chemical; Female; Friend murine leukemia virus; Hematopoiesis; Immunit | 1978 |
Synthesis and biological activities of some N6- and N9-carbamoyladenines and related ribonucleosides.
Topics: Adenine; Adenosine; Animals; Cell Division; Cell Line; Chemical Phenomena; Chemistry; Leukemia L1210 | 1977 |
Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells.
Topics: Adenine; Adenylate Kinase; Animals; Creatine Kinase; Isoelectric Point; Leukemia L1210; Mice; Molecu | 1992 |
L1210/B23.1 cells express equilibrative, inhibitor-sensitive nucleoside transport activity and lack two parental nucleoside transport activities.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Biological Transport; Carrier Proteins; Cell Membrane | 1992 |
Agelasine G, a new antileukemic alkaloid from the Okinawan marine sponge Agelas sp.
Topics: Adenine; Animals; Antineoplastic Agents; Diterpenes; Leukemia L1210; Magnetic Resonance Spectroscopy | 1992 |
Phosphorylation of acyclic nucleotide analogs HPMPA and PMEA in L1210 mouse leukemia cell extracts.
Topics: Adenine; Adenosine Triphosphate; Animals; Antiviral Agents; Guanylate Kinases; Hydrogen-Ion Concentr | 1990 |
Synthesis and in vivo antitumor activity of 2-amino-9H-purine-6-sulfenamide, -sulfinamide, and -sulfonamide and related purine ribonucleosides.
Topics: 2-Aminopurine; Adenine; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Female; Leuke | 1990 |
The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L1210 mouse leukemia cells.
Topics: Adenine; Animals; Antiviral Agents; Cell Division; DNA; Leukemia L1210; Male; Mice; Mice, Inbred DBA | 1990 |
Antineoplastic effect of the combination of 2,3-dihydro-1H-pyrazole[2,3a]imidazole plus deoxyadenosine/erythro-9-(2-hydroxyl-3-nonyl)adenine in mice with L1210 leukemia cells.
Topics: Adenine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; | 1990 |
Some pharmacological activities of novel adenine-related compounds isolated from a marine sponge Agelas mauritiana.
Topics: Adenine; Adenosine; Animals; Aorta; Cell Cycle; Erythrocytes; In Vitro Techniques; Kinetics; Leukemi | 1989 |
Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis.
Topics: Adenine; Animals; Antiviral Agents; DNA, Viral; Herpes Simplex; Leukemia L1210; Organophosphonates; | 1987 |
Cross-resistance patterns in hydroxyurea-resistant leukemia L1210 cells.
Topics: Adenine; Animals; Cell Line; Drug Resistance; Electron Spin Resonance Spectroscopy; Guanidines; Hydr | 1988 |
Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogues of neplanocin A.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Antibiotics, Antineoplastic; Guanine; I | 1987 |
Antitumor agents. 86. Synthesis and cytotoxicity of alpha-methylene-gamma-lactone-bearing purines.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Survival; Guanine; Humans; Hypoxanthines; Indicators a | 1987 |
Nonspecific inhibition of precursor uptake by alkyl-substituted purines and prednisolone.
Topics: Acetates; Adenine; Adenocarcinoma; Animals; Carbon Radioisotopes; Cell Division; Cell Line; Choline; | 1974 |
Inhibitors of inosinate dehydrogenase activity in Ehrlich ascites tumor cells in vitro.
Topics: Adenine; Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, D | 1974 |
Nucleosides of 2-azapurines and certain ring analogs.
Topics: Adenine; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cells, Cultured; Deoxyadenosines; | 1972 |
Effects of persantin on several transport systems of murine leukemias.
Topics: Adenine; Adenosine; Amino Acids; Animals; Biological Transport; Cell Line; Cyclopentanes; Cytidine; | 1972 |
Deamination of arabinosyladenine by adenosine deaminase and inhibition by arabinosyl-6-mercaptopurine.
Topics: Adenine; Adenosine; Aminohydrolases; Animals; Antibiotics, Antineoplastic; Arabinose; Cell Fractiona | 1972 |
Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole.
Topics: Adenine; Animals; Azaguanine; Carbon Isotopes; Carcinoma, Squamous Cell; Culture Techniques; DNA, Ne | 1970 |