adenine and Innate Inflammatory Response studies

Research Excerpts

Excerpt	Relevance	Reference
"This prospective randomized pilot study was conducted in Lok Nayak Hospital, New Delhi, involving 30 patients of chronic hepatitis B (both e antigen positive and negative); 15 were randomly selected to receive either adefovir or lamivudine for a period of 6 months."	9.15	Evaluation of adefovir & lamivudine in chronic hepatitis B: correlation with HBV viral kinetic, hepatic-necro inflammation & fibrosis. ( Asim, M; Das, BC; Gondal, R; Kar, P; Medhi, S; Pradeep Kumar, S, 2011)
"Colchicine inhibited tubulin polymerization and caspase-1 activation and attenuated kidney inflammation and fibrosis in a mouse model of adenine-induced KI."	8.31	Beneficiary Effects of Colchicine on Inflammation and Fibrosis in a Mouse Model of Kidney Injury. ( Arazi, E; Landau, D; Segev, Y; Shukri, N; Tobar, A, 2023)
"These findings demonstrate that simvastatin inhibits airway inflammation and airway remodelling through an activated autophagic process in BSMCs."	7.85	Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma. ( Cui, R; Ding, T; Gu, W; Guo, X; Han, F; Li, X; Peng, J; Xu, W, 2017)
" In this study, we found that β-mangostin from seedcases of Garcinia mangostana inhibited α-melanocyte-stimulating hormone (α-MSH)-mediated melanogenesis in B16F10 melanoma cells and a three-dimensional human skin model."	7.85	Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy. ( Kim, KD; Lee, KW; Madhi, H; Oh, SS; Park, KH; Park, S; Ryu, HW; Yoo, J, 2017)
"While body weight was decreased, kidney weight increased in DEP+adenine versus saline+adenine or DEP."	7.83	Prolonged Pulmonary Exposure to Diesel Exhaust Particles Exacerbates Renal Oxidative Stress, Inflammation and DNA Damage in Mice with Adenine-Induced Chronic Renal Failure. ( Ali, BH; Beegam, S; Hamadi, NK; Karaca, T; Nemmar, A; Yasin, J; Yuvaraju, P, 2016)
" The negative impact of inflammation in this CKD model was overcome by the marked anti-inflammatory effects of thalidomide, promoting renal protection."	7.79	Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice. ( Blanco, P; Catanozi, S; de Sá Lima, L; Degaspari, S; Dellê, H; Noronha, IL; Santana, AC; Scavone, C; Silva, C; Solez, K, 2013)
"Tetracycline exerts neuroprotection via suppressing the local inflammation induced by cerebral ischemia."	7.78	Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy. ( Dai, J; Jiang, Y; Liu, X; Wu, L; Xu, G; Zhu, J, 2012)
" This study assessed changes in bone-turnover markers, osteoprotegerin (OPG), soluble receptor activator for nuclear factor-κβ ligand (sRANKL), and inflammation in subjects initiating TDF- versus non-TDF-containing regimens, and determined the relationship between bone turnover, OPG/sRANKL and inflammation."	7.77	Bone turnover, osteoprotegerin/RANKL and inflammation with antiretroviral initiation: tenofovir versus non-tenofovir regimens. ( Brown, TT; Labbato, D; McComsey, GA; Ross, AC; Storer, N, 2011)
" In this study, we showed elevated HMGB1 expression in renal granulomas in rats with crystal-induced granulomatous nephritis caused by feeding an adenine-rich diet."	7.76	High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy. ( Biswas, KK; Hashiguchi, T; Kawahara, K; Lotz, M; Maruyama, I; Nitanda, T; Oyama, Y; Tancharoen, S; Taniguchi, N; Uchimura, T; Umekita, Y, 2010)
"Exposure to nonoxynol-9 (N-9) or cellulose sulfate (CS), but not 9-[2-(phosphonomethoxy)propyl]adenine (also referred to as tenofovir) or PRO2000, resulted in a rapid and sustained reduction in TER and a marked increase in HIV infection of T cells cultured in the lower chamber."	7.75	Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety. ( Cheshenko, N; Fakioglu, E; Guzman, E; Herold, BC; Keller, MJ; Mesquita, PM; Mhatre, M; Wilson, SS, 2009)
"Members of a group of substituted 9-benzyladenines have been identified as effective inhibitors of inflammatory aspects of the delayed hypersensitivity skin reaction in the guinea-pig."	7.65	Substituted 9-benzyladenines: inhibitors of inflammation associated with the delayed hypersensitivity skin reaction. ( Brittain, RJ; Wojnar, RJ, 1975)
"This prospective randomized pilot study was conducted in Lok Nayak Hospital, New Delhi, involving 30 patients of chronic hepatitis B (both e antigen positive and negative); 15 were randomly selected to receive either adefovir or lamivudine for a period of 6 months."	5.15	Evaluation of adefovir & lamivudine in chronic hepatitis B: correlation with HBV viral kinetic, hepatic-necro inflammation & fibrosis. ( Asim, M; Das, BC; Gondal, R; Kar, P; Medhi, S; Pradeep Kumar, S, 2011)
"Colchicine inhibited tubulin polymerization and caspase-1 activation and attenuated kidney inflammation and fibrosis in a mouse model of adenine-induced KI."	4.31	Beneficiary Effects of Colchicine on Inflammation and Fibrosis in a Mouse Model of Kidney Injury. ( Arazi, E; Landau, D; Segev, Y; Shukri, N; Tobar, A, 2023)
" Adenine treatment reduced body weight, creatinine renal clearance, and increased water intake and urine output, as well as the plasma concentrations of urea and creatinine, neutrophil gelatinase-associated lipocalin, and N-acetyl-β-D-glucosaminidase activity, and albumin in urine."	3.88	The effect of sildenafil on rats with adenine-Induced chronic kidney disease. ( Adham, SA; Al Kalbani, J; Al Suleimani, Y; Al Za'abi, M; Ali, BH; Karaca, T; Manoj, P; Nemmar, A; Yasin, J, 2018)
" Drugs currently used against HBV include IFN-α that decreases viremia, inflammation and the growth of liver fibrosis, and adefovir that decreases the viral load."	3.88	Chronic hepatitis B virus and liver fibrosis: A mathematical model. ( Friedman, A; Siewe, N, 2018)
" In this study, we found that β-mangostin from seedcases of Garcinia mangostana inhibited α-melanocyte-stimulating hormone (α-MSH)-mediated melanogenesis in B16F10 melanoma cells and a three-dimensional human skin model."	3.85	Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy. ( Kim, KD; Lee, KW; Madhi, H; Oh, SS; Park, KH; Park, S; Ryu, HW; Yoo, J, 2017)
"These findings demonstrate that simvastatin inhibits airway inflammation and airway remodelling through an activated autophagic process in BSMCs."	3.85	Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma. ( Cui, R; Ding, T; Gu, W; Guo, X; Han, F; Li, X; Peng, J; Xu, W, 2017)
"Chronic lung inflammation is accepted as being associated with the development of lung cancer caused by nickel exposure."	3.83	Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells. ( Che, X; Chen, LC; Gao, J; Gu, J; Huang, C; Huang, H; Jin, H; Li, J; Li, Y; Lyu, J; Xie, Q; Zhang, L; Zhu, J, 2016)
" Here, we studied whether a specific inhibitor of the Nlrp3 inflammasome, CP-456,773, can prevent kidney fibrosis in a murine model of crystal nephropathy induced by diets rich in oxalate or adenine."	3.83	An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice. ( Bartok, E; Boor, P; Dhana, E; Evers, BD; Franklin, BS; Hall, JP; Hartmann, G; Hornung, V; Knolle, PA; Kurts, C; Latz, E; Ludwig-Portugall, I; Primiano, MJ, 2016)
"While body weight was decreased, kidney weight increased in DEP+adenine versus saline+adenine or DEP."	3.83	Prolonged Pulmonary Exposure to Diesel Exhaust Particles Exacerbates Renal Oxidative Stress, Inflammation and DNA Damage in Mice with Adenine-Induced Chronic Renal Failure. ( Ali, BH; Beegam, S; Hamadi, NK; Karaca, T; Nemmar, A; Yasin, J; Yuvaraju, P, 2016)
"The adenine-treated animals exhibited marked azotemia, impaired urinary concentrating capacity, intense tubular and glomerular damage, interstitial inflammation and fibrosis."	3.79	Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy. ( Aminzadeh, MA; Nicholas, SB; Norris, KC; Vaziri, ND, 2013)
" The negative impact of inflammation in this CKD model was overcome by the marked anti-inflammatory effects of thalidomide, promoting renal protection."	3.79	Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice. ( Blanco, P; Catanozi, S; de Sá Lima, L; Degaspari, S; Dellê, H; Noronha, IL; Santana, AC; Scavone, C; Silva, C; Solez, K, 2013)
" To find out whether suppressed autophagy was linked to inflammation we used the autophagy inhibitor, 3-methyladenine, to inhibit autophagy."	3.78	Autophagy regulates inflammation in adipocytes. ( Kashiwagi, A; Kondo, M; Kume, S; Kusunoki, C; Maegawa, H; Morino, K; Nishio, Y; Sekine, O; Ugi, S; Uzu, T; Yasuda, M; Yoshizaki, T, 2012)
"Tetracycline exerts neuroprotection via suppressing the local inflammation induced by cerebral ischemia."	3.78	Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy. ( Dai, J; Jiang, Y; Liu, X; Wu, L; Xu, G; Zhu, J, 2012)
" This study assessed changes in bone-turnover markers, osteoprotegerin (OPG), soluble receptor activator for nuclear factor-κβ ligand (sRANKL), and inflammation in subjects initiating TDF- versus non-TDF-containing regimens, and determined the relationship between bone turnover, OPG/sRANKL and inflammation."	3.77	Bone turnover, osteoprotegerin/RANKL and inflammation with antiretroviral initiation: tenofovir versus non-tenofovir regimens. ( Brown, TT; Labbato, D; McComsey, GA; Ross, AC; Storer, N, 2011)
" In this study, we showed elevated HMGB1 expression in renal granulomas in rats with crystal-induced granulomatous nephritis caused by feeding an adenine-rich diet."	3.76	High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy. ( Biswas, KK; Hashiguchi, T; Kawahara, K; Lotz, M; Maruyama, I; Nitanda, T; Oyama, Y; Tancharoen, S; Taniguchi, N; Uchimura, T; Umekita, Y, 2010)
"Exposure to nonoxynol-9 (N-9) or cellulose sulfate (CS), but not 9-[2-(phosphonomethoxy)propyl]adenine (also referred to as tenofovir) or PRO2000, resulted in a rapid and sustained reduction in TER and a marked increase in HIV infection of T cells cultured in the lower chamber."	3.75	Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety. ( Cheshenko, N; Fakioglu, E; Guzman, E; Herold, BC; Keller, MJ; Mesquita, PM; Mhatre, M; Wilson, SS, 2009)
"Adenine phosphoribosyltransferase (APRT) deficiency in humans is an autosomal recessive syndrome characterized by the urinary excretion of adenine and the highly insoluble compound 2,8-dihydroxyadenine (DHA) that can produce kidney stones or renal failure."	3.69	Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. ( Boivin, G; Chen, J; Davies, PM; Engle, SJ; Sahota, A; Simmonds, HA; Stambrook, PJ; Stockelman, MG; Tischfield, JA; Ying, MY; Yum, MN, 1996)
"Members of a group of substituted 9-benzyladenines have been identified as effective inhibitors of inflammatory aspects of the delayed hypersensitivity skin reaction in the guinea-pig."	3.65	Substituted 9-benzyladenines: inhibitors of inflammation associated with the delayed hypersensitivity skin reaction. ( Brittain, RJ; Wojnar, RJ, 1975)
"The adenine-containing diet caused renal failure, characterized by crystal deposits, cystic dilatation of tubules, and micro-abscesses."	3.01	Functional and histological effects of Anthurium schlechtendalii Kunth extracts on adenine-induced kidney damage of adult Wistar rats. ( Ajibola, OO; Barradas-Dermitz, DM; Calderón-Garcidueñas, AL; Carvajal-Zarrabal, O; López-Amador, N; Nolasco-Hipolito, C, 2023)
" Furthermore, the nanoformulations studied to increase ibrutinib bioavailability are reported."	2.72	Btk Inhibitors: A Medicinal Chemistry and Drug Delivery Perspective. ( Brullo, C; Russo, E; Spallarossa, A; Tasso, B; Villa, C, 2021)
"Airway inflammation is a key factor in the mechanisms of asthma."	2.42	Mechanisms of asthma. ( Busse, WW; Rosenwasser, LJ, 2003)
"FSTL1 promotes CS-induced COPD by modulating autophagy, therefore targeting FSTL1 and autophagy may shed light on treating cigarette smoke-induced COPD."	1.62	FSTL1 aggravates cigarette smoke-induced airway inflammation and airway remodeling by regulating autophagy. ( Cao, L; Dong, L; Huang, S; Liu, T; Liu, X; Liu, Y; Pan, Y; Wang, J; Wu, J; Xu, J; Zhao, J; Zou, M, 2021)
"Cardiorenal syndrome is a major cause of mortality in patients with chronic kidney disease (CKD)."	1.56	The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease. ( Abe, T; Akiyama, Y; Asaji, K; Fukuda, S; Ho, HJ; Ito, S; Iwasaki, T; Kanemitsu, Y; Kikuchi, K; Kure, S; Matsuhashi, T; Mishima, E; Nanto-Hara, F; Oikawa, Y; Owada, Y; Saigusa, D; Soga, T; Suzuki, C; Suzuki, T; Tomioka, Y; Tsukimi, T, 2020)
"Systemic sclerosis is a multisystem inflammatory and vascular lesion leading to extensive tissue fibrosis."	1.51	DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models. ( Fan, C; Feng, C; Li, H; Lu, H; Niu, L; Qi, Q; Tang, W; Wu, B; Wu, Y; Zhang, Z; Zuo, J, 2019)
"Inflammation has been implicated in the pathogenesis of type 2 diabetes (T2D), which is a progressive disease characterized by pancreatic β‑cell dysfunction and apoptosis with consequential insufficient insulin secretion."	1.51	Role of autophagy in LPS‑induced inflammation in INS‑1 cells. ( Cao, MM; Jiang, W; Li, YB; Liu, GD; Su, Y; Wang, J; Zhu, LB, 2019)
"Atherosclerosis is a progressive, chronic inflammation in arterial walls."	1.51	The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling. ( Bai, HL; Dai, XY; Guo, FX; Hu, YW; Kang, CM; Li, P; Lu, JB; Lu, ZF; Wang, Q; Wu, Q; Xiao, L; Xu, BM; Xu, YJ; Ye, S; Zheng, L, 2019)
" When CCP dosage reached 200mg/kg/day, the area of renal pathological damage was decreased by 59."	1.48	Renoprotective effect of Chinese chive polysaccharides in adenine-induced chronic renal failure. ( Chena, HR; Li, QM; Lu, CQ; Luo, JP; Pan, LH; Zha, XQ, 2018)
"Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease with high mortality rate."	1.48	Ibrutinib Exacerbates Bleomycin-Induced Pulmonary Fibrosis via Promoting Inflammation. ( Gu, Y; Huang, B; Li, H; Lu, G; Qi, M; Xia, D; Yang, Y, 2018)
"Obesity is a major current public health problem worldwide due to the severe co-morbid conditions that this disease entails."	1.48	Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes. ( Bravo-Sagua, R; Breitwieser, G; Cifuentes, M; Fuentes, C; Lavandero, S; Mattar, P; Tobar, N; Troncoso, R, 2018)
"Type 2 diabetes is a chronic inflammatory disease."	1.46	Endoplasmic reticulum stress induced by lipopolysaccharide is involved in the association between inflammation and autophagy in INS‑1 cells. ( Cao, MM; Li, YB; Liu, GD; Liu, H; Su, Y; Yin, JJ, 2017)
"Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear."	1.46	Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. ( Blanco, P; Bolen, CR; Chang, J; Daburon, S; Davis, MM; Déchanet-Merville, J; Dekker, CL; Douchet, I; Faustin, B; Fragiadakis, GK; Furman, D; Ganio, EA; Gaudilliere, B; Haddad, F; Jojic, V; Kuo, CJ; Lartigue, L; Moreau, JF; Nolan, GP; Spitzer, MH, 2017)
" The FDA-recommended rabbit vaginal irritation (RVI) model serves as a first line selection tool for vaginal products; however, for decades it has been limited to histopathology scoring, insufficient to select safe anti-HIV microbicides."	1.42	A quantitative multiplex nuclease protection assay reveals immunotoxicity gene expression profiles in the rabbit model for vaginal drug safety evaluation. ( Chandra, N; Doncel, GF; Fichorova, RN; Mendonca, K; Murray, R; Yamamoto, HS, 2015)
"Chrysin did not cause any overt adverse effect on the treated rats."	1.42	Ameliorative effect of chrysin on adenine-induced chronic kidney disease in rats. ( Adham, SA; Al Za'abi, M; Ali, BH; Nemmar, A; Schupp, N; Waly, MI; Yasin, J, 2015)
"Malnutrition and inflammation are also closely linked to an increased risk of cardiovascular death in CKD."	1.40	Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia. ( Kitazono, T; Masutani, K; Nakano, T; Noguchi, H; Ooboshi, H; Taniguchi, M; Tatsumoto, N; Tokumoto, M; Tsuruya, K; Yamada, S, 2014)
"If abacavir or didanosine increase cardiovascular risk, it is likely not through the direct endothelial activation pathways tested in these experiments."	1.37	Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in coronary endothelial cells. ( Clauss, M; Desta, Z; Deuter-Reinhard, M; Green, L; Gupta, SK; Kim, C; Taylor, BM, 2011)
"Renal failure is associated with aortic valve calcification (AVC)."	1.35	Uraemic hyperparathyroidism causes a reversible inflammatory process of aortic valve calcification in rats. ( Abedat, S; Beeri, R; Ben-Dov, IZ; Danenberg, HD; Lotan, C; Meir, K; Planer, D; Shuvy, M; Sosna, J, 2008)

Research

Studies (135)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Number of Participants Who Received the Influenza Vaccine

Change in Fat mtDNA Content

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (1.48)	18.7374
1990's	1 (0.74)	18.2507
2000's	14 (10.37)	29.6817
2010's	87 (64.44)	24.3611
2020's	31 (22.96)	2.80

Authors	Studies
Saunders, MJ	1
Edwards, BS	1
Zhu, J	6
Sklar, LA	1
Graves, SW	1
Gao, Y	2
Luo, C	1
Rui, T	1
Fan, Y	3
Yao, Y	4
Shen, H	2
Gao, C	2
Wang, T	3
Wang, H	4
Chen, X	6
Zhang, J	6
Li, D	3
Xia, C	1
Li, LL	1
Wang, Z	3
Zhang, M	4
Tao, L	1
Melekoglu, E	1
Cetinkaya, MA	1
Kepekci-Tekkeli, SE	1
Kul, O	1
Samur, G	1
Yang, Y	6
Ha, S	2
Jeong, S	1
Jang, CW	1
Kim, J	4
Im, DS	1
Chung, HY	2
Chung, KW	2
Li, Z	3
Xu, Q	1
Huangfu, N	1
Ito, S	3
Manabe, E	1
Dai, Y	1
Ishihara, M	1
Tsujino, T	1
Dong, H	1
Hong, X	1
He, Y	3
Bao, Z	1
Zhang, Y	11
Shen, S	1
Wang, G	1
Mo, R	1
Tölle, M	1
Henkel, C	1
Herrmann, J	1
Daniel, C	1
Babic, M	1
Xia, M	1
Schulz, AM	1
Amann, K	1
van der Giet, M	1
Schuchardt, M	1
Li, X	8
Peng, X	2
Qiao, B	1
Peng, M	2
Deng, N	1
Yu, R	1
Tan, Z	1
Luo, T	1
Zhou, X	3
Qin, M	1
Lin, Y	1
Lin, J	1
Chen, G	1
Liu, A	1
Ouyang, D	1
Chen, D	6
Pan, H	1
Landau, D	2
Shukri, N	1
Arazi, E	1
Tobar, A	1
Segev, Y	2
Moellmann, J	1
Krueger, K	1
Wong, DWL	1
Klinkhammer, BM	1
Buhl, EM	1
Dehairs, J	1
Swinnen, JV	1
Noels, H	1
Jankowski, J	1
Lebherz, C	1
Boor, P	2
Marx, N	1
Lehrke, M	1
Son, M	1
Kim, D	2
Kim, MJ	2
Kim, B	1
Calderón-Garcidueñas, AL	1
Barradas-Dermitz, DM	1
Nolasco-Hipolito, C	1
López-Amador, N	1
Ajibola, OO	1
Carvajal-Zarrabal, O	1
Wu, TT	1
Chen, CC	2
Lin, JT	2
Young, GH	2
Wang, HC	1
Chen, HM	2
Nanto-Hara, F	1
Kanemitsu, Y	1
Fukuda, S	1
Kikuchi, K	1
Asaji, K	1
Saigusa, D	1
Iwasaki, T	1
Ho, HJ	1
Mishima, E	1
Suzuki, T	2
Suzuki, C	1
Tsukimi, T	1
Matsuhashi, T	1
Oikawa, Y	1
Akiyama, Y	1
Kure, S	1
Owada, Y	1
Tomioka, Y	1
Soga, T	1
Abe, T	1
Sadeghi, A	1
Shabani, M	1
Alizadeh, S	1
Meshkani, R	1
Zhang, Z	3
Wu, Y	4
Wu, B	1
Qi, Q	1
Li, H	7
Lu, H	1
Fan, C	1
Feng, C	1
Zuo, J	1
Niu, L	1
Tang, W	1
Su, JT	1
Simpson, SM	1
Sung, S	1
Tfaily, EB	1
Veazey, R	1
Marzinke, M	1
Qiu, J	1
Watrous, D	1
Widanapathirana, L	1
Pearson, E	1
Peet, MM	1
Karunakaran, D	1
Grasperge, B	1
Dobek, G	1
Cain, CM	1
Hope, T	1
Kiser, PF	1
Singh, SB	1
Carroll-Portillo, A	1
Coffman, C	1
Ritz, NL	1
Lin, HC	1
Halim, AA	1
Alsayed, B	1
Embarak, S	1
Yaseen, T	1
Dabbous, S	1
Fontaine, O	1
Dueluzeau, R	1
Raibaud, P	1
Chabanet, C	1
Popoff, MR	1
Badoual, J	1
Gabilan, JC	1
Andremont, A	1
Gómez, L	1
Andrés, S	1
Sánchez, J	1
Alonso, JM	1
Rey, J	1
López, F	1
Jiménez, A	1
Yan, Z	1
Zhou, L	2
Zhao, Y	4
Wang, J	9
Huang, L	2
Hu, K	1
Liu, H	7
Guo, Z	2
Song, Y	1
Huang, H	5
Yang, R	1
Owen, TW	1
Al-Kaysi, RO	1
Bardeen, CJ	1
Cheng, Q	1
Wu, S	1
Cheng, T	1
Wang, B	5
Zhang, Q	4
Wu, X	3
Ochiai, T	1
Ishiguro, H	2
Nakano, R	2
Kubota, Y	2
Hara, M	1
Sunada, K	1
Hashimoto, K	2
Kajioka, J	1
Fujishima, A	1
Jiao, J	3
Gai, QY	3
Wang, W	2
Zang, YP	2
Niu, LL	2
Fu, YJ	4
Wang, X	6
Yao, LP	1
Qin, QP	1
Wang, ZY	1
Liu, J	4
Aleksic Sabo, V	1
Knezevic, P	1
Borges-Argáez, R	1
Chan-Balan, R	1
Cetina-Montejo, L	1
Ayora-Talavera, G	1
Sansores-Peraza, P	1
Gómez-Carballo, J	1
Cáceres-Farfán, M	1
Jang, J	1
Akin, D	1
Bashir, R	1
Yu, Z	1
Jiang, H	1
He, C	2
Xiao, Z	1
Xu, J	3
Sun, Q	1
Han, D	1
Lei, H	1
Zhao, K	2
Zhu, L	1
Fu, H	2
Wilson, BK	1
Step, DL	1
Maxwell, CL	1
Gifford, CA	1
Richards, CJ	1
Krehbiel, CR	1
Warner, JM	1
Doerr, AJ	1
Erickson, GE	1
Guretzky, JA	1
Rasby, RJ	1
Watson, AK	1
Klopfenstein, TJ	1
Sun, Y	5
Liu, Z	5
Pham, TD	1
Lee, BK	1
Yang, FC	1
Wu, KH	1
Lin, WP	1
Hu, MK	1
Lin, L	3
Shao, J	1
Sun, M	1
Xu, G	2
Zhang, X	10
Xu, N	1
Wang, R	1
Liu, S	1
He, H	1
Dong, X	2
Yang, M	2
Yang, Q	1
Duan, S	1
Yu, Y	3
Han, J	3
Zhang, C	3
Chen, L	2
Yang, X	3
Li, W	3
Campbell, DA	1
Gao, K	1
Zager, RA	1
Johnson, ACM	1
Guillem, A	1
Keyser, J	1
Singh, B	1
Steubl, D	1
Schneider, MP	1
Meiselbach, H	1
Nadal, J	1
Schmid, MC	1
Saritas, T	1
Krane, V	1
Sommerer, C	1
Baid-Agrawal, S	1
Voelkl, J	1
Kotsis, F	1
Köttgen, A	1
Eckardt, KU	1
Scherberich, JE	1
Yao, L	2
Sun, L	3
Zhu, Z	1
Naren, N	1
Zhang, XX	2
Gentile, GL	1
Rupert, AS	1
Carrasco, LI	1
Garcia, EM	1
Kumar, NG	1
Walsh, SW	1
Jefferson, KK	1
Guest, RL	1
Samé Guerra, D	1
Wissler, M	1
Grimm, J	1
Silhavy, TJ	1
Lee, JH	3
Yoo, JS	1
Kim, Y	2
Kim, JS	2
Lee, EJ	1
Roe, JH	1
Delorme, M	1
Bouchard, PA	1
Simon, M	1
Simard, S	1
Lellouche, F	1
D'Urzo, KA	1
Mok, F	1
D'Urzo, AD	1
Koneru, B	1
Lopez, G	1
Farooqi, A	1
Conkrite, KL	1
Nguyen, TH	1
Macha, SJ	1
Modi, A	1
Rokita, JL	1
Urias, E	1
Hindle, A	1
Davidson, H	1
Mccoy, K	1
Nance, J	1
Yazdani, V	1
Irwin, MS	1
Yang, S	1
Wheeler, DA	1
Maris, JM	1
Diskin, SJ	1
Reynolds, CP	1
Abhilash, L	1
Kalliyil, A	1
Sheeba, V	1
Hartley, AM	2
Meunier, B	2
Pinotsis, N	1
Maréchal, A	2
Xu, JY	1
Genko, N	1
Haraux, F	1
Rich, PR	1
Kamalanathan, M	1
Doyle, SM	1
Xu, C	2
Achberger, AM	1
Wade, TL	1
Schwehr, K	1
Santschi, PH	1
Sylvan, JB	1
Quigg, A	1
Leong, W	1
Xu, W	3
Gao, S	1
Zhai, X	1
Wang, C	2
Gilson, E	1
Ye, J	1
Lu, Y	1
Yan, R	1
Hu, Z	1
You, Q	1
Cai, Q	1
Yang, D	1
Gu, S	1
Dai, H	1
Zhao, X	1
Gui, C	1
Gui, J	1
Wu, PK	1
Hong, SK	1
Starenki, D	1
Oshima, K	1
Shao, H	1
Gestwicki, JE	1
Tsai, S	1
Park, JI	1
Wang, Y	9
Zhao, R	1
Gu, Z	1
Dong, C	2
Guo, G	1
Li, L	5
Barrett, HE	1
Meester, EJ	1
van Gaalen, K	1
van der Heiden, K	1
Krenning, BJ	1
Beekman, FJ	1
de Blois, E	1
de Swart, J	1
Verhagen, HJ	1
Maina, T	1
Nock, BA	1
Norenberg, JP	1
de Jong, M	1
Gijsen, FJH	1
Bernsen, MR	1
Martínez-Milla, J	1
Galán-Arriola, C	1
Carnero, M	1
Cobiella, J	1
Pérez-Camargo, D	1
Bautista-Hernández, V	1
Rigol, M	1
Solanes, N	1
Villena-Gutierrez, R	1
Lobo, M	1
Mateo, J	1
Vilchez-Tschischke, JP	1
Salinas, B	1
Cussó, L	1
López, GJ	1
Fuster, V	1
Desco, M	1
Sanchez-González, J	1
Ibanez, B	1
van den Berg, P	1
Schweitzer, DH	1
van Haard, PMM	1
Geusens, PP	1
van den Bergh, JP	1
Zhu, X	2
Huang, X	2
Xu, H	3
Yang, G	2
Lin, Z	1
Salem, HF	1
Nafady, MM	1
Kharshoum, RM	1
Abd El-Ghafar, OA	1
Farouk, HO	1
Domiciano, D	1
Nery, FC	1
de Carvalho, PA	1
Prudente, DO	1
de Souza, LB	1
Chalfun-Júnior, A	1
Paiva, R	1
Marchiori, PER	1
Lu, M	2
An, Z	1
Jiang, J	2
Li, J	9
Du, S	1
Zhou, H	1
Cui, J	1
Wu, W	1
Liu, Y	9
Song, J	1
Lian, Q	1
Uddin Ahmad, Z	1
Gang, DD	1
Konggidinata, MI	1
Gallo, AA	1
Zappi, ME	1
Yang, TWW	1
Johari, Y	1
Burton, PR	1
Earnest, A	1
Shaw, K	1
Hare, JL	1
Brown, WA	1
Kim, GA	1
Han, S	1
Choi, GH	1
Choi, J	2

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effects of 2 Initial Standard Antiretroviral Combinations Therapies on Lipid Metabolism in ARV-naive HIV-infected Subjects[NCT00759070]	Phase 4	50 participants (Anticipated)	Interventional	2008-09-30	Active, not recruiting
Residual Immune Activation in HIV-infected Patients on Successful cART: Association Between Inflammasome Activation in Monocytes by Circulating Metabolites and Non AIDS Defining Comorbidities[NCT03191175]		55 participants (Actual)	Observational	2017-07-03	Completed
Immune Senescence in the Elderly: Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages[NCT01827462]	Phase 4	136 participants (Actual)	Interventional	2007-10-31	Completed
Reversibility of Mitochondrial Toxicity in HIV Lipoatrophy[NCT00119379]	Phase 2	50 participants (Actual)	Interventional	2005-04-30	Completed
Potential Role of Gum Arabic as Antioxidant and Anti-inflammatory Agent in Hemodialysis Patients[NCT03214692]		50 participants (Anticipated)	Interventional	2017-07-31	Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	Participants (Count of Participants)
18-30 Years Old at Enrollment	59
60-79 Years Old at Enrollment	37
80-100 Years Old at Enrollment	40

Subcutaneous abdominal fat mitochondrial DNA (mtDNA) (NCT00119379)
Timeframe: Baseline to Week 48

Change in Hip Bone Mineral Density (BMD)

Intervention	copies/cell (Median)
Uridine Supplementation	-169
Switch to TDF	321

Change in hip bone mineral density (BMD) as measured by dual-energy x-ray absorbtiometry (DEXA) scan (NCT00119379)
Timeframe: Baseline to Week 48

Change in Limb Fat

Intervention	hip BMD, g/cm^2 (Median)
Uridine Supplementation	0.45
Switch to TDF	-3.3

Change in limb fat as measured by dual-energy x-ray absorbtiometry (DEXA) scan (NCT00119379)
Timeframe: Baseline to Week 48

Change in Lumbar Spine Bone Mineral Density (BMD)

Intervention	limb fat (kg) (Median)
Uridine Supplementation	0.1
Switch to TDF	0.4

Change in lumbar spine bone mineral density (BMD) as measured by dual-energy x-ray absorbtiometry (DEXA) scan (NCT00119379)
Timeframe: Baseline to Week 48

Change in PBMC mtDNA

Intervention	lumbar spine BMD, g/cm^2 (Median)
Uridine Supplementation	0.39
Switch to TDF	0.0

Peripheral blood mononuclear cell (PBMC) mitochondrial DNA (mtDNA), measured in copies/cell (NCT00119379)
Timeframe: Baseline to Week 48

Change in Trunk Fat

Intervention	copies/cell (Median)
Uridine Supplementation	-24
Switch to TDF	-52

Change in trunk fat as measured by dual-energy x-ray absorbtiometry (DEXA) scan (NCT00119379)
Timeframe: Baseline to Week 48

Article	Year
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. Current protocols in cytometry, 2010, Volume: Chapter 13 Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr	2010
Autophagy inhibition facilitates wound closure partially dependent on the YAP/IL-33 signaling in a mouse model of skin wound healing. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:10 Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagy; Disease Models, Animal; Inflammat	2021
Effects of prebiotic oligofructose-enriched inulin on gut-derived uremic toxins and disease progression in rats with adenine-induced chronic kidney disease. PloS one, 2021, Volume: 16, Issue:10 Topics: Adenine; Animals; Blood Urea Nitrogen; Cresols; Disease Models, Animal; Dysbiosis; Humans; Indican;	2021
Comparison of two different toxin-induced kidney fibrosis models in terms of inflammatory responses. Toxicology, 2021, Volume: 463 Topics: Adenine; Animals; Cytokines; Disease Models, Animal; Fibrosis; Folic Acid; Inflammation; Male; Mice;	2021
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling. Journal of clinical laboratory analysis, 2022, Volume: 36, Issue:1 Topics: Adenine; Animals; Atherosclerosis; Humans; Inflammation; Lipoproteins, LDL; Macrophages; Methyltrans	2022
Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation. Journal of pharmacological sciences, 2022, Volume: 148, Issue:1 Topics: Adenine; Administration, Oral; Animals; Disease Models, Animal; Disease Progression; Drugs, Chinese	2022
A carrier-free metal-organic hybrid nanoassembly with combination anti-viral and hepato-protective activity for hepatitis B treatment. Biomaterials science, 2022, Jul-26, Volume: 10, Issue:15 Topics: Adenine; Animals; Antiviral Agents; DNA Replication; DNA, Viral; Hepatitis B; Hepatitis B virus; Inf	2022
Uremic mouse model to study vascular calcification and "inflamm-aging". Journal of molecular medicine (Berlin, Germany), 2022, Volume: 100, Issue:9 Topics: Adenine; Aging; Animals; Disease Models, Animal; Inflammation; Kidney Failure, Chronic; Mice; Rats;	2022
Gut-Kidney Impairment Process of Adenine Combined with Cells, 2022, 10-17, Volume: 11, Issue:20 Topics: Acetic Acid; Adenine; Animals; Bacteroides; Colitis; Creatinine; Diarrhea; Disease Models, Animal; F	2022
Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation. Oxidative medicine and cellular longevity, 2022, Volume: 2022 Topics: Adenine; Adenosine Triphosphate; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Caspase 1	2022
Beneficiary Effects of Colchicine on Inflammation and Fibrosis in a Mouse Model of Kidney Injury. Nephron, 2023, Volume: 147, Issue:11 Topics: Adenine; Animals; Anti-Inflammatory Agents; Caspase 1; Colchicine; Disease Models, Animal; Fibrosis;	2023
2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function. Biochimica et biophysica acta. Molecular basis of disease, 2024, Volume: 1870, Issue:1 Topics: Adenine; Animals; Fibrosis; Inflammation; Kidney; Mice; Mice, Inbred C57BL; Mitochondria; Renal Insu	2024
TLR7 activation by miR-21 promotes renal fibrosis by activating the pro-inflammatory signaling pathway in tubule epithelial cells. Cell communication and signaling : CCS, 2023, 08-18, Volume: 21, Issue:1 Topics: Adenine; Animals; Epithelial Cells; Fibrosis; Inflammation; Kidney Diseases; Mice; MicroRNAs; NF-kap	2023
The anti-inflammatory function of adenine occurs through AMPK activation and its downstream transcriptional regulation in THP-1 cells. Bioscience, biotechnology, and biochemistry, 2019, Volume: 83, Issue:12 Topics: Adenine; AMP-Activated Protein Kinases; Anti-Inflammatory Agents; Cytokines; Enzyme Activation; Gene	2019
The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020, 02-01, Volume: 35, Issue:2 Topics: Adenine; Animals; Cardio-Renal Syndrome; Disease Models, Animal; Disease Progression; Fibrosis; Gast	2020
Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells. Cytokine, 2020, Volume: 125 Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chloroquine; Cytokines; Free Radical Scaveng	2020
DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models. Arthritis research & therapy, 2019, 12-16, Volume: 21, Issue:1 Topics: Adenine; Animals; Bleomycin; Butyrates; Cell Line; Cells, Cultured; Dermis; Disease Models, Animal;	2019
A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques. Antimicrobial agents and chemotherapy, 2020, 02-21, Volume: 64, Issue:3 Topics: Adenine; Alanine; Animals; Anti-HIV Agents; Delayed-Action Preparations; Drug Implants; Female; Fuma	2020
Intestinal Alkaline Phosphatase Exerts Anti-Inflammatory Effects Against Lipopolysaccharide by Inducing Autophagy. Scientific reports, 2020, 02-20, Volume: 10, Issue:1 Topics: Adenine; Alkaline Phosphatase; Animals; Autophagy; Autophagy-Related Protein 5; Cattle; Cell Line, T	2020
BTK Inhibitors in Cancer Patients with COVID-19: "The Winner Will be the One Who Controls That Chaos" (Napoleon Bonaparte). Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 07-15, Volume: 26, Issue:14 Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Anti-Inflammatory Agents; Antineoplastic Agents; Benza	2020
Dietary Fermented Soy Extract and Oligo-Lactic Acid Alleviate Chronic Kidney Disease in Mice via Inhibition of Inflammation and Modulation of Gut Microbiota. Nutrients, 2020, Aug-08, Volume: 12, Issue:8 Topics: Adenine; Animals; Biomarkers; Cecum; Clostridium; Cystatin C; Cytokines; Dietary Supplements; Diseas	2020
Autophagy inhibition protects from alveolar barrier dysfunction in LPS-induced ALI mice by targeting alveolar epithelial cells. Respiratory physiology & neurobiology, 2021, Volume: 283 Topics: Acute Lung Injury; Adenine; Alveolar Epithelial Cells; Animals; Autophagy; Bronchoalveolar Lavage Fl	2021
Characterization of total adenosine deaminase activity (ADA) and its isoenzymes in saliva and serum in health and inflammatory conditions in four different species: an analytical and clinical validation pilot study. BMC veterinary research, 2020, Oct-12, Volume: 16, Issue:1 Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Automation; Biomarkers; Cattl	2020
Bruton's Tyrosine Kinase Inhibitor Attenuates Warm Hepatic Ischemia/Reperfusion Injury via Modulation of the NLR Family Pyrin Domain Containing 3 Inflammasome. Transplantation proceedings, 2020, Volume: 52, Issue:10 Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Inflammasomes; Inflammation; Liver; Male; Mic	2020
TLR9 deficiency alleviates doxorubicin-induced cardiotoxicity via the regulation of autophagy. Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:18 Topics: Adenine; Animals; Apoptosis; Autophagy; Cardiomyopathies; Doxorubicin; Inflammation; MAP Kinase Sign	2020
NCS 613, a PDE4 inhibitor, by increasing cAMP level suppresses systemic inflammation and immune complexes deposition in kidney of MRL/lpr lupus- prone mice. Biochimica et biophysica acta. Molecular basis of disease, 2021, 03-01, Volume: 1867, Issue:3 Topics: Adenine; Animals; Anti-Inflammatory Agents; Antigen-Antibody Complex; Cyclic AMP; Female; Inflammati	2021
Renal Aging Resembles a Continuum Between Normal and Diseased Kidneys That Potentiates Inflammatory Response to Injury. The journals of gerontology. Series A, Biological sciences and medical sciences, 2021, 02-25, Volume: 76, Issue:3 Topics: Adenine; Aging; Animals; Cytokines; Disease Models, Animal; Inflammation; Kidney Diseases; Male; Mic	2021
FSTL1 aggravates cigarette smoke-induced airway inflammation and airway remodeling by regulating autophagy. BMC pulmonary medicine, 2021, Jan-28, Volume: 21, Issue:1 Topics: Adenine; Adult; Airway Remodeling; Animals; Autophagy; Biomarkers; Bronchoalveolar Lavage Fluid; Cig	2021
Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease. Aging cell, 2021, Volume: 20, Issue:3 Topics: Adenine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition; Cyclin-Dependent Kinas	2021
Ibrutinib-related uveitis: A report of two severe cases. European journal of ophthalmology, 2022, Volume: 32, Issue:4 Topics: Adenine; Aged; Female; Humans; Hyphema; Inflammation; Male; Middle Aged; Piperidines; Uveitis; Uveit	2022
Experimental modulation of Interleukin 1 shows its key role in chronic kidney disease progression and anemia. Scientific reports, 2021, 03-18, Volume: 11, Issue:1 Topics: Adenine; Anemia; Animals; Antibodies, Monoclonal; Disease Models, Animal; Disease Progression; Immun	2021
Narciclasine attenuates sepsis-induced myocardial injury by modulating autophagy. Aging, 2021, 05-25, Volume: 13, Issue:11 Topics: Adenine; Amaryllidaceae Alkaloids; Animals; Autophagy; Inflammation; Lipopolysaccharides; Male; MAP	2021
Effects of growth hormone treatment on growth plate, bone, and mineral metabolism of young rats with uremia induced by adenine. Pediatric research, 2017, Volume: 82, Issue:1 Topics: Adenine; Animals; Blood Urea Nitrogen; Chondrocytes; Female; Fibroblast Growth Factors; Growth Hormo	2017
Renoprotective effect of Chinese chive polysaccharides in adenine-induced chronic renal failure. International journal of biological macromolecules, 2018, Volume: 106 Topics: Adenine; Animals; Antioxidants; Blood Urea Nitrogen; Chive; Creatinine; Humans; Inflammation; Kidney	2018
Endoplasmic reticulum stress induced by lipopolysaccharide is involved in the association between inflammation and autophagy in INS‑1 cells. Molecular medicine reports, 2017, Volume: 16, Issue:5 Topics: Activating Transcription Factor 4; Adenine; Animals; Apoptosis; Autophagy; Caspase 1; Cell Count; Ce	2017
Erhuang Formula ameliorates renal damage in adenine-induced chronic renal failure rats via inhibiting inflammatory and fibrotic responses. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 95 Topics: Adenine; Animals; Blood Urea Nitrogen; Chromatography, High Pressure Liquid; Creatinine; Drugs, Chin	2017
Autophagy inhibitors suppress environmental particulate matter-induced airway inflammation. Toxicology letters, 2017, Oct-05, Volume: 280 Topics: Adenine; Animals; Autophagy; Benzylamines; Cell Line; Cytokines; Environmental Pollutants; Gene Expr	2017
[TLR2 modulates Staphylococcus aureus-induced inflammatory response and autophagy in macrophages through PI3K signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2017, Volume: 33, Issue:9 Topics: Adenine; Animals; Autophagy; Cells, Cultured; Inflammation; Macrophages; Mice; Phosphatidylinositol	2017
Anti-inflammatory effects of low-level laser therapy on human periodontal ligament cells: in vitro study. Lasers in medical science, 2018, Volume: 33, Issue:3 Topics: Adenine; Anti-Inflammatory Agents; Cell Death; Cell Survival; Cyclic AMP; Cytokines; Gene Expression	2018
Ibrutinib Exacerbates Bleomycin-Induced Pulmonary Fibrosis via Promoting Inflammation. Inflammation, 2018, Volume: 41, Issue:3 Topics: Adenine; Animals; Apoptosis; Bleomycin; Disease Models, Animal; Epithelial Cells; Humans; Idiopathic	2018
Gum Acacia Improves Renal Function and Ameliorates Systemic Inflammation, Oxidative and Nitrosative Stress in Streptozotocin-Induced Diabetes in Rats with Adenine-Induced Chronic Kidney Disease. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 45, Issue:6 Topics: Acacia; Adenine; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Gum Arabic; Infla	2018
Regulation of Autophagy Affects the Prognosis of Mice with Severe Acute Pancreatitis. Digestive diseases and sciences, 2018, Volume: 63, Issue:10 Topics: Adenine; Animals; Autophagy; Caspase 1; Disease Models, Animal; Inflammation; Interleukin-1beta; Mic	2018
Chronic hepatitis B virus and liver fibrosis: A mathematical model. PloS one, 2018, Volume: 13, Issue:4 Topics: Adenine; Computer Simulation; Diffusion; Drug Delivery Systems; Hepatic Stellate Cells; Hepatitis B	2018
Dietary Fermentable Fibers Attenuate Chronic Kidney Disease in Mice by Protecting the Intestinal Barrier. The Journal of nutrition, 2018, 04-01, Volume: 148, Issue:4 Topics: Adenine; Animals; Cecum; Colon; Diet; Dietary Fiber; Dysbiosis; Fatty Acids, Volatile; Fermentation;	2018
Phosphatidyl-Inositol-3 Kinase Inhibitors Regulate Peptidoglycan-Induced Myeloid Leukocyte Recruitment, Inflammation, and Neurotoxicity in Mouse Brain. Frontiers in immunology, 2018, Volume: 9 Topics: Adenine; Animals; Autophagy; Brain; Chemotaxis, Leukocyte; Enzyme Inhibitors; Inflammation; Male; Mi	2018
Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice. Journal of neuroinflammation, 2018, Sep-19, Volume: 15, Issue:1 Topics: Adenine; Animals; Animals, Newborn; Anti-Inflammatory Agents; Cell Line, Transformed; Cells, Culture	2018
The effect of sildenafil on rats with adenine-Induced chronic kidney disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 108 Topics: Adenine; Animals; Biomarkers; Blood Pressure; Body Weight; Creatinine; Cytokines; Fibrosis; Inflamma	2018
Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes. Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:11 Topics: Adenine; Adipocytes; Adipose Tissue; Autophagy; Calcimimetic Agents; Cell Line; Cinacalcet; Gene Kno	2018
The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling. Cell death and differentiation, 2019, Volume: 26, Issue:9 Topics: Adenine; Animals; Atherosclerosis; Autophagosomes; Autophagy; Autophagy-Related Protein 7; Chromatin	2019
Inhibition of miR-155 reduces impaired autophagy and improves prognosis in an experimental pancreatitis mouse model. Cell death & disease, 2019, 04-03, Volume: 10, Issue:4 Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagosomes; Autophagy; Ceruletide; Disea	2019
MiR-135-5p-p62 Axis Regulates Autophagic Flux, Tumorigenic Potential, and Cellular Interactions Mediated by Extracellular Vesicles During Allergic Inflammation. Frontiers in immunology, 2019, Volume: 10 Topics: Adenine; Animals; Autophagy; Carcinogenesis; Cell Communication; Cell Line; Disease Models, Animal;	2019
Protective effect of Tenuifolin against Alzheimer's disease. Neuroscience letters, 2019, 07-13, Volume: 705 Topics: Adenine; Alzheimer Disease; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Amyloid beta-Prote	2019
Role of autophagy in LPS‑induced inflammation in INS‑1 cells. Molecular medicine reports, 2019, Volume: 19, Issue:6 Topics: Acetylcysteine; Adenine; Animals; Apoptosis; Autophagy; Caspase 1; Cell Line; Inflammasomes; Inflamm	2019
Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2013, Volume: 28, Issue:8 Topics: Adenine; Animals; Arachidonate 12-Lipoxygenase; Blotting, Western; Catalase; Chronic Disease; Cycloo	2013
NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production. Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:5 Topics: Adenine; Adult; Aged; Anti-Inflammatory Agents; Cell Nucleus; Cyclic Nucleotide Phosphodiesterases,	2013
Comparison of cardiovascular disease risk markers in HIV-infected patients receiving abacavir and tenofovir: the nucleoside inflammation, coagulation and endothelial function (NICE) study. Antiviral therapy, 2014, Volume: 19, Issue:2 Topics: Adenine; Adult; Anti-HIV Agents; Biomarkers; Blood Coagulation; Cardiovascular Diseases; Dideoxynucl	2014
Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway. Autophagy, 2013, Volume: 9, Issue:12 Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Autophagy; Carbazoles; Cyclic AMP; Endothel	2013
Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia. American journal of physiology. Renal physiology, 2014, Jun-15, Volume: 306, Issue:12 Topics: Acute-Phase Proteins; Adenine; Animals; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dos	2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis. Autophagy, 2014, Volume: 10, Issue:7 Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; CD4-Positive T-Lymphocytes; Ce	2014
PI3K inhibitors LY294002 and IC87114 reduce inflammation in carrageenan-induced paw oedema and down-regulate inflammatory gene expression in activated macrophages. Basic & clinical pharmacology & toxicology, 2015, Volume: 116, Issue:1 Topics: Adenine; Animals; Carrageenan; Chemokine CCL2; Chromones; Down-Regulation; Edema; Enzyme Inhibitors;	2015
Effect of antiretroviral HIV therapy on hepatitis B virus replication and pathogenicity. Intervirology, 2014, Volume: 57, Issue:3-4 Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Coinfection; Deoxycytidine; Emtrici	2014
Peroxisome proliferator-activated receptor α activation attenuates the inflammatory response to protect the liver from acute failure by promoting the autophagy pathway. Cell death & disease, 2014, Aug-28, Volume: 5 Topics: Acute Disease; Adenine; Adult; Animals; Autophagy; Autophagy-Related Protein 7; Cells, Cultured; Che	2014
Phosphate binders prevent phosphate-induced cellular senescence of vascular smooth muscle cells and vascular calcification in a modified, adenine-based uremic rat model. Calcified tissue international, 2015, Volume: 96, Issue:4 Topics: Adenine; Animal Feed; Animals; Calcinosis; Calcium Carbonate; Cellular Senescence; Disease Models, A	2015
Hypoxia induces microglia autophagy and neural inflammation injury in focal cerebral ischemia model. Experimental and molecular pathology, 2015, Volume: 98, Issue:2 Topics: Adenine; Animals; Autophagy; Brain; Cell Hypoxia; Cerebral Arteries; Disease Models, Animal; Infarct	2015
Lycium barbarum polysaccharide improves bipolar pulse current-induced microglia cell injury through modulating autophagy. Cell transplantation, 2015, Volume: 24, Issue:3 Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Caspase 7; Cell Line; Drugs, Chinese Herbal; Elec	2015
Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult. Molecular and cellular biochemistry, 2015, Volume: 403, Issue:1-2 Topics: Acetylglucosaminidase; Adenine; Adenosine Deaminase; Adenosine Kinase; Animals; Animals, Newborn; Bl	2015
A quantitative multiplex nuclease protection assay reveals immunotoxicity gene expression profiles in the rabbit model for vaginal drug safety evaluation. Toxicology and applied pharmacology, 2015, Jun-15, Volume: 285, Issue:3 Topics: Adenine; Animals; Anti-HIV Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Co	2015
Ameliorative effect of chrysin on adenine-induced chronic kidney disease in rats. PloS one, 2015, Volume: 10, Issue:4 Topics: Acetylglucosaminidase; Adenine; Animals; Antioxidants; Creatinine; Disease Models, Animal; Fibrosis;	2015
Citrate Attenuates Adenine-Induced Chronic Renal Failure in Rats by Modulating the Th17/Treg Cell Balance. Inflammation, 2016, Volume: 39, Issue:1 Topics: Adenine; Animals; Anti-Inflammatory Agents; Blood Urea Nitrogen; Cell Survival; Citric Acid; Creatin	2016
The Role of Autophagy in Kidney Inflammatory Injury via the NF-κB Route Induced by LPS. International journal of medical sciences, 2015, Volume: 12, Issue:8 Topics: Acute Kidney Injury; Adenine; Animals; Autophagy; Disease Models, Animal; Immunohistochemistry; Infl	2015
Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages. Journal of leukocyte biology, 2016, Volume: 99, Issue:2 Topics: Adenine; Adenine Nucleotides; Animals; beta-N-Acetylhexosaminidases; Cell Cycle; Cell Division; Cell	2016
The Effect of Autophagy on Inflammation Cytokines in Renal Ischemia/Reperfusion Injury. Inflammation, 2016, Volume: 39, Issue:1 Topics: Acute Kidney Injury; Adenine; Animals; Anti-Inflammatory Agents; Autophagy; Beclin-1; Enzyme Activat	2016
Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress. Thorax, 2016, Volume: 71, Issue:1 Topics: Adenine; Animals; Aspergillosis, Allergic Bronchopulmonary; Biomarkers; Blotting, Western; Bronchoal	2016
Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells. PloS one, 2015, Volume: 10, Issue:11 Topics: Adenine; Adenine Phosphoribosyltransferase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase	2015
Calcitonin gene-related peptide mediates an inflammatory response in Schwann cells via cAMP-dependent ERK signaling cascade. Life sciences, 2016, Jan-01, Volume: 144 Topics: Adenine; Calcitonin Gene-Related Peptide; Cell Line; Cyclic AMP; Cytokines; Dose-Response Relationsh	2016
The case of an APDS patient: Defects in maturation and function and decreased in vitro anti-mycobacterial activity in the myeloid compartment. Clinical immunology (Orlando, Fla.), 2017, Volume: 178 Topics: Adenine; B-Lymphocytes; Cell Differentiation; Class I Phosphatidylinositol 3-Kinases; Dendritic Cell	2017
Alcohol Decreases Organic Dust-Stimulated Airway Epithelial TNF-Alpha Through a Nitric Oxide and Protein Kinase-Mediated Inhibition of TACE. Alcoholism, clinical and experimental research, 2016, Volume: 40, Issue:2 Topics: ADAM Proteins; ADAM17 Protein; Adenine; Bronchi; Cell Line; Cyclic AMP-Dependent Protein Kinases; Du	2016
Prolonged Pulmonary Exposure to Diesel Exhaust Particles Exacerbates Renal Oxidative Stress, Inflammation and DNA Damage in Mice with Adenine-Induced Chronic Renal Failure. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 38, Issue:5 Topics: Adenine; Animals; Antioxidants; Blood Pressure; Body Weight; Catalase; Creatinine; DNA Damage; Femal	2016
Inflammation increases oxidative DNA damage repair and stimulates preneoplastic changes in colons of newborn rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2016, Volume: 67, Issue:2 Topics: Adenine; Animals; Animals, Newborn; Arachidonate 12-Lipoxygenase; Colon; Colonic Neoplasms; Cyclooxy	2016
Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses. The Journal of biological chemistry, 2016, 07-22, Volume: 291, Issue:30 Topics: Adenine; Animals; Astrocytes; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Fact	2016
An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice. Kidney international, 2016, Volume: 90, Issue:3 Topics: Adenine; Adoptive Transfer; Animals; Cells, Cultured; Dendritic Cells; Disease Models, Animal; Fibro	2016
Activation of volume-sensitive Cl- channel mediates autophagy-related cell death in myocardial ischaemia/reperfusion injury. Oncotarget, 2016, Jun-28, Volume: 7, Issue:26 Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Proliferation; Chloride Channels; Cytokines; Hydrogen-I	2016
Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells. Autophagy, 2016, 10-02, Volume: 12, Issue:10 Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Bronchi; Cell Line, Tumo	2016
Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy. Experimental dermatology, 2017, Volume: 26, Issue:7 Topics: Adenine; alpha-MSH; Animals; Autophagy; Cell Survival; Garcinia mangostana; Humans; Inflammation; Me	2017
Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma. Respirology (Carlton, Vic.), 2017, Volume: 22, Issue:3 Topics: Adenine; Airway Remodeling; Animals; Asthma; Autophagosomes; Autophagy; Autophagy-Related Protein 5;	2017
Effects of ibrutinib treatment on murine platelet function during inflammation and in primary hemostasis. Haematologica, 2017, Volume: 102, Issue:3 Topics: Adenine; Adenosine Diphosphate; Animals; Blood Platelets; Collagen; Crotalid Venoms; Gene Expression	2017
Protease-activated receptor 2 exacerbates adenine-induced renal tubulointerstitial injury in mice. Biochemical and biophysical research communications, 2017, 01-29, Volume: 483, Issue:1 Topics: Adenine; Animals; Enzyme-Linked Immunosorbent Assay; Factor V; Factor Xa; Fibrin; Fibrosis; Gene Exp	2017
Defective autophagy is associated with neuronal injury in a mouse model of multiple sclerosis. Bosnian journal of basic medical sciences, 2017, May-20, Volume: 17, Issue:2 Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Caspase 3; Disease Models, Animal; Encephalomyelit	2017
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature medicine, 2017, Volume: 23, Issue:2 Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;	2017
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature medicine, 2017, Volume: 23, Issue:2 Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;	2017
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature medicine, 2017, Volume: 23, Issue:2 Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;	2017
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature medicine, 2017, Volume: 23, Issue:2 Topics: Adenine; Adult; Aged; Aged, 80 and over; Aging; Animals; Blood Platelets; Blood Pressure; Caffeine;	2017
Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination. Cell death and differentiation, 2017, Volume: 24, Issue:4 Topics: Adenine; Animals; Autophagy; Beclin-1; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chaperonin 60;	2017
Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjugate chemistry, 2009, Volume: 20, Issue:6 Topics: Adenine; Animals; Antibody Formation; Cell Line; Cytokines; Female; Humans; Inflammation; Kinetics;	2009
Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety. The Journal of infectious diseases, 2009, Aug-15, Volume: 200, Issue:4 Topics: Adenine; Anti-HIV Agents; Anti-Infective Agents; Cell Line; Cellulose; Electric Impedance; Epithelia	2009
Regulation of the autophagic machinery in human neutrophils. European journal of immunology, 2010, Volume: 40, Issue:5 Topics: Adenine; Autophagy; Cadaverine; Chromones; Coloring Agents; Escherichia coli; Guanosine; Humans; Hyd	2010
High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy. Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:6 Topics: Adenine; Animals; Blood Urea Nitrogen; Chemokine CCL2; Creatinine; Epithelial Cells; Granuloma; HMGB	2010
Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. Journal of medicinal chemistry, 2010, Apr-08, Volume: 53, Issue:7 Topics: Adenine; Animals; Carboxylic Acids; Cell Line; Drug Stability; Humans; Hypersensitivity; Immunothera	2010
Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation. The Journal of biological chemistry, 2010, Sep-10, Volume: 285, Issue:37 Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Cells, Cultur	2010
An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. Journal of immunology (Baltimore, Md. : 1950), 2011, Jun-01, Volume: 186, Issue:11 Topics: Adenine; Adenosylhomocysteinase; Animals; Blotting, Western; Butyrates; Cell Line, Tumor; Colitis; C	2011
Effect of antiviral therapy on the immunohistochemical expression of bcl-xL and bax protein in patients with HBeAg-negative chronic hepatitis B. Journal of medical virology, 2011, Volume: 83, Issue:7 Topics: Adenine; Adult; Antiviral Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Biopsy; Fema	2011
Bone turnover, osteoprotegerin/RANKL and inflammation with antiretroviral initiation: tenofovir versus non-tenofovir regimens. Antiviral therapy, 2011, Volume: 16, Issue:7 Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Biomarkers; Bone Density; Bone Remodeling; CD4 Lymphocy	2011
Autophagy regulates inflammation in adipocytes. Biochemical and biophysical research communications, 2012, Jan-06, Volume: 417, Issue:1 Topics: 3T3-L1 Cells; Adenine; Adipocytes; Animals; Autophagy; Endoplasmic Reticulum Stress; Gene Expression	2012
Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in coronary endothelial cells. Antiviral therapy, 2011, Volume: 16, Issue:8 Topics: Adenine; Anti-HIV Agents; Apoptosis; Cardiovascular Diseases; Cell Adhesion Molecules; Coronary Vess	2011
Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis. PloS one, 2011, Volume: 6, Issue:12 Topics: Adenine; Allopurinol; Animals; Diet; Disease Progression; Inflammasomes; Inflammation; Kidney Tubule	2011
L-selectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:6 Topics: Adenine; Animals; Anti-Infective Agents; Benzalkonium Compounds; Biomarkers; Carboxymethylcellulose	2012
Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy. PloS one, 2012, Volume: 7, Issue:11 Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Inflammation;	2012
Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2013, Volume: 28, Issue:5 Topics: Adenine; Animals; Blotting, Western; Cytokines; Disease Models, Animal; Electrophoretic Mobility Shi	2013
Effect of gum arabic on oxidative stress and inflammation in adenine-induced chronic renal failure in rats. PloS one, 2013, Volume: 8, Issue:2 Topics: Adenine; Animals; Creatinine; Gum Arabic; Histones; Immunohistochemistry; Inflammation; Interleukin-	2013
Selective role of PI3K delta in neutrophil inflammatory responses. Biochemical and biophysical research communications, 2003, Sep-05, Volume: 308, Issue:4 Topics: Adenine; Androstadienes; Animals; Anti-Inflammatory Agents; Chromones; Class I Phosphatidylinositol	2003
Effects of spinally administered adenine on dorsal horn neuronal responses in a rat model of inflammation. Neuroscience letters, 2004, Feb-19, Volume: 356, Issue:3 Topics: Adenine; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Electric St	2004
Detection of chlorinated DNA and RNA nucleosides by HPLC coupled to tandem mass spectrometry as potential biomarkers of inflammation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Nov-15, Volume: 827, Issue:1 Topics: Adenine; Biomarkers; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytosine; Deoxyadenosin	2005
Inhibition of mRNA deadenylation and degradation by different types of cell stress. Biological chemistry, 2006, Volume: 387, Issue:3 Topics: Adenine; Cytokines; Electrophoresis, Polyacrylamide Gel; Gene Expression; Heat-Shock Response; HeLa	2006
The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages. Free radical research, 2006, Volume: 40, Issue:8 Topics: Adenine; Adenosine Diphosphate; Animals; Cell Line; Enzyme Activation; Inflammation; Macrophages, Al	2006
Uraemic hyperparathyroidism causes a reversible inflammatory process of aortic valve calcification in rats. Cardiovascular research, 2008, Aug-01, Volume: 79, Issue:3 Topics: Adenine; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aortic Valve; Blotting, W	2008
TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization. Biochimica et biophysica acta, 2008, Volume: 1779, Issue:11 Topics: Adenine; Animals; Argonaute Proteins; Base Sequence; Cytoplasmic Structures; Eukaryotic Initiation F	2008
Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. Proceedings of the National Academy of Sciences of the United States of America, 1996, May-28, Volume: 93, Issue:11 Topics: Adenine; Adenine Phosphoribosyltransferase; Alleles; Animals; Erythrocytes; Fibrosis; Homozygote; Hu	1996
Adrenomedullin suppresses fMLP-induced upregulation of CD11b of human neutrophils. Inflammation, 2001, Volume: 25, Issue:3 Topics: Adenine; Adenylyl Cyclase Inhibitors; Adrenomedullin; Calcitonin Gene-Related Peptide; Calcitonin Ge	2001
Protection from reperfusion injury after cardiac transplantation by inhibition of adenosine metabolism and nucleotide precursor supply. Circulation, 2001, Sep-18, Volume: 104, Issue:12 Suppl 1 Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals;	2001
Structure-activity profile of substituted purines and inflammation in the delayed hypersensitivity skin reaction. Agents and actions, 1975, Volume: 5, Issue:2 Topics: Adenine; Animals; Anti-Inflammatory Agents; Antimetabolites; Benzyl Compounds; Guinea Pigs; Hypersen	1975
Substituted 9-benzyladenines: inhibitors of inflammation associated with the delayed hypersensitivity skin reaction. Agents and actions, 1975, Volume: 5, Issue:2 Topics: Adenine; Animals; Benzyl Compounds; Dermatitis, Contact; Guinea Pigs; Hypersensitivity, Delayed; Inf	1975

adenine and Innate Inflammatory Response