adenine has been researched along with Infarction, Middle Cerebral Artery in 14 studies
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Importantly, the neuron-protective effect of MDL-28170 on ischemic insult was reversed by cotreatment with either class III-PI3K (phosphatidylinositol 3-kinase) inhibitor 3-methyladenine or lysosomal inhibitor chloroquine (chloroquine), suggesting that CAPN1 activation-mediated impairment of autophagic flux is crucial for cerebral ischemia-induced neuronal damage." | 8.02 | CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage. ( Cai, R; Che, X; Fu, X; Liu, Y; Luo, J; Yang, J; Yang, Y; Yao, Y; Yu, X; Zhang, H; Zhou, MS, 2021) |
| " Importantly, the neuron-protective effect of MDL-28170 on ischemic insult was reversed by cotreatment with either class III-PI3K (phosphatidylinositol 3-kinase) inhibitor 3-methyladenine or lysosomal inhibitor chloroquine (chloroquine), suggesting that CAPN1 activation-mediated impairment of autophagic flux is crucial for cerebral ischemia-induced neuronal damage." | 4.02 | CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage. ( Cai, R; Che, X; Fu, X; Liu, Y; Luo, J; Yang, J; Yang, Y; Yao, Y; Yu, X; Zhang, H; Zhou, MS, 2021) |
| "We used a cerebral ischemia mouse model (middle cerebral artery occlusion, MCAO) to evaluate the effects of inhibiting autophagy in ischemic brain pathology." | 1.62 | Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke. ( Doran, SJ; Li, J; McCullough, LD; Moruno-Manchon, JF; O'Keefe, LM; Patel, AR; Patrizz, AN; Tsvetkov, AS; Venna, VR, 2021) |
| "Focal cerebral ischemia was induced in aged rats by middle cerebral artery occlusion (MCAO)." | 1.51 | Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion. ( Bi, J; Han, D; Liang, J; Lu, Y; Ren, L; Wang, P, 2019) |
| "Focal cerebral ischemia was induced by permanent middle cerebral artery occlusion (pMCAO) in rats." | 1.36 | Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia. ( Hong, LZ; Liu, CF; Liu, J; Qin, AP; Qin, YY; Qin, ZH; Xu, M; Yang, L; Zhang, HL, 2010) |
| "Focal cerebral ischemia was introduced by permanent middle cerebral artery occlusion (pMCAO)." | 1.35 | Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. ( Fukunaga, K; Han, F; Han, R; Qin, ZH; Sheng, R; Wen, YD; Zhang, LS; Zhang, X; Zhang, XD, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, P | 3 |
| Lu, Y | 1 |
| Han, D | 1 |
| Ren, L | 1 |
| Bi, J | 1 |
| Liang, J | 1 |
| Liu, Y | 1 |
| Che, X | 1 |
| Zhang, H | 1 |
| Fu, X | 1 |
| Yao, Y | 1 |
| Luo, J | 1 |
| Yang, Y | 1 |
| Cai, R | 1 |
| Yu, X | 1 |
| Yang, J | 1 |
| Zhou, MS | 1 |
| Patrizz, AN | 1 |
| Moruno-Manchon, JF | 1 |
| O'Keefe, LM | 1 |
| Doran, SJ | 1 |
| Patel, AR | 1 |
| Venna, VR | 1 |
| Tsvetkov, AS | 1 |
| Li, J | 1 |
| McCullough, LD | 1 |
| Guo, D | 1 |
| Ma, J | 1 |
| Yan, L | 1 |
| Li, T | 1 |
| Li, Z | 1 |
| Han, X | 1 |
| Shui, S | 1 |
| Li, Y | 1 |
| Zhang, Y | 1 |
| Fu, H | 1 |
| Huang, H | 2 |
| Lu, Q | 1 |
| Qin, H | 1 |
| Wu, Y | 1 |
| Mao, G | 1 |
| Wei, Z | 1 |
| Liao, P | 1 |
| Li, WL | 1 |
| Yu, SP | 1 |
| Chen, D | 1 |
| Yu, SS | 1 |
| Jiang, YJ | 1 |
| Genetta, T | 1 |
| Wei, L | 1 |
| Xingyong, C | 1 |
| Xicui, S | 1 |
| Huanxing, S | 1 |
| Jingsong, O | 1 |
| Yi, H | 1 |
| Xu, Z | 1 |
| Ruxun, H | 1 |
| Zhong, P | 1 |
| Guo, Z | 1 |
| Cao, G | 1 |
| Yang, H | 1 |
| Zhou, H | 1 |
| Li, L | 1 |
| Cao, Z | 1 |
| Yu, B | 1 |
| Kou, J | 1 |
| Yang, Z | 1 |
| Zhong, L | 1 |
| Zhong, S | 1 |
| Xian, R | 1 |
| Yuan, B | 1 |
| Wen, YD | 1 |
| Sheng, R | 1 |
| Zhang, LS | 1 |
| Han, R | 1 |
| Zhang, X | 1 |
| Zhang, XD | 1 |
| Han, F | 1 |
| Fukunaga, K | 1 |
| Qin, ZH | 2 |
| Qin, AP | 1 |
| Liu, CF | 1 |
| Qin, YY | 1 |
| Hong, LZ | 1 |
| Xu, M | 1 |
| Yang, L | 1 |
| Liu, J | 1 |
| Zhang, HL | 1 |
| Guan, YF | 1 |
| Du, H | 1 |
| Zhai, QW | 1 |
| Su, DF | 1 |
| Miao, CY | 1 |
| Lee, EJ | 1 |
| Wu, TS | 1 |
| Chang, GL | 1 |
| Li, CY | 1 |
| Chen, TY | 1 |
| Lee, MY | 1 |
| Chen, HY | 1 |
| Maynard, KI | 1 |
| Zhang, L | 1 |
| Himi, T | 1 |
| Murota, S | 1 |
14 other studies available for adenine and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Glucose; Infarction, Middle Cerebral Artery; Ischemic A | 2019 |
CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Beclin-1; Brain Ischemia; Calpain; Dipepti | 2021 |
Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Protein-1 Homolog; Becli | 2021 |
Down-Regulation of Lncrna MALAT1 Attenuates Neuronal Cell Death Through Suppressing Beclin1-Dependent Autophagy by Regulating Mir-30a in Cerebral Ischemic Stroke.
Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Cells, Cultured; Cerebral Cortex; Disease Models, | 2017 |
Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Topics: Activating Transcription Factor 4; Adenine; Animals; Apoptosis; Brain; eIF-2 Kinase; Endoplasmic Ret | 2020 |
The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice.
Topics: Adenine; Animals; Autophagy; Blood-Brain Barrier; Cerebral Cortex; Infarction, Middle Cerebral Arter | 2013 |
Upregulation of myeloid cell leukemia-1 potentially modulates beclin-1-dependent autophagy in ischemic stroke in rats.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain; Disease Models, Animal; | 2013 |
A combination of four active compounds alleviates cerebral ischemia-reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK/mTOR and JNK pathways.
Topics: Adenine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autophagy; Brain; Brain | 2014 |
Hypoxia induces microglia autophagy and neural inflammation injury in focal cerebral ischemia model.
Topics: Adenine; Animals; Autophagy; Brain; Cell Hypoxia; Cerebral Arteries; Disease Models, Animal; Infarct | 2015 |
Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Autophagy; Biomarkers; Brain; Brain Ischemia; Cat | 2008 |
Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; Beclin-1; Brain Ischemia; Ca | 2010 |
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Glucose; Infar | 2012 |
Delayed treatment with nicotinamide inhibits brain energy depletion, improves cerebral microperfusion, reduces brain infarct volume, but does not alter neurobehavioral outcome following permanent focal cerebral ischemia in Sprague Dawley rats.
Topics: Adenine; Adenosine Triphosphate; Animals; Behavior, Animal; Brain; Brain Chemistry; Cerebrovascular | 2006 |
Induction of hepatocyte growth factor (HGF) in rat microglial cells by prostaglandin E(2).
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Brain Ischemia; Bucladesine; Cells, Cultured; Cyclic | 2000 |