Page last updated: 2024-10-16

adenine and Idiopathic Parkinson Disease

adenine has been researched along with Idiopathic Parkinson Disease in 26 studies

Research Excerpts

ExcerptRelevanceReference
"Congenital hydrocephalus (CH) is caused by genetic mutations, but whether factors impacting human genetic mutations are disease-specific remains elusive."2.72Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions. ( Hart, C; McKnight, I; Park, IH; Shim, JW, 2021)
"At the molecular level, Parkinson's disease share common molecular signatures with most neurodegenerative diseases including the accumulation of misfolded proteins in the brain."2.61Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease. ( Gonzalez, C; Hetz, C; Lopez, N; Martinez, A, 2019)
"Neurodegenerative diseases are characterized by the aggregation of misfolded proteins in the brain."2.50Prions: generation and spread versus neurotoxicity. ( Halliday, M; Mallucci, GR; Radford, H, 2014)
"Baicalein was administrated from 7 to 12 week."1.46Baicalein Protects against Rotenone-Induced Neurotoxicity through Induction of Autophagy. ( Cao, X; Kuang, L; Lu, Z, 2017)
"L-Dopa, the standard therapeutic for Parkinson's disease, is inactivated by the enzyme catechol-O-methyltransferase (COMT)."1.37Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors. ( Borroni, E; Diederich, F; Ehler, A; Ellermann, M; Jakob-Roetne, R; Lerner, C; Paulini, R; Roth, D; Rudolph, MG; Schlatter, D; Schweizer, WB, 2011)
"Monogenic forms of Parkinson's disease (PD) provide an opportunity to examine mechanisms underlying phenotypic variation."1.34Glutathione S-transferase polymorphisms and onset age in alpha-synuclein A53T mutant Parkinson's disease. ( Athanassiadou, A; Bonifati, V; Di Iorio, G; Golbe, LI; Johnson, WG; Markopoulou, K; Papapetropoulos, S; Spychala, JR; Stenroos, ES; Vance, JM; Watts, RL; Williams, TA, 2007)
"All compounds tested reversed the catalepsy induced by haloperidol."1.33New adenosine A2A receptor antagonists: actions on Parkinson's disease models. ( Cristalli, G; Morelli, M; Pinna, A; Volpini, R, 2005)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.85)18.7374
1990's1 (3.85)18.2507
2000's9 (34.62)29.6817
2010's13 (50.00)24.3611
2020's2 (7.69)2.80

Authors

AuthorsStudies
Pupyshev, AB1
Tenditnik, MV1
Ovsyukova, MV1
Akopyan, AA1
Dubrovina, NI1
Tikhonova, MA1
McKnight, I1
Hart, C1
Park, IH1
Shim, JW1
Kuang, L1
Cao, X1
Lu, Z1
Martinez, A1
Lopez, N1
Gonzalez, C1
Hetz, C1
Yang, F1
Yang, YP1
Mao, CJ1
Liu, L1
Zheng, HF1
Hu, LF1
Liu, CF1
Piersanti, G1
Bartoccini, F1
Lucarini, S1
Cabri, W1
Stasi, MA1
Riccioni, T1
Borsini, F2
Tarzia, G1
Minetti, P1
Endo, K1
Deguchi, K1
Matsunaga, H1
Tomaya, K1
Yamada, K1
Halliday, M1
Radford, H1
Mallucci, GR1
Yakhine-Diop, SM1
Bravo-San Pedro, JM1
Gómez-Sánchez, R1
Pizarro-Estrella, E1
Rodríguez-Arribas, M1
Climent, V1
Aiastui, A1
López de Munain, A1
Fuentes, JM1
González-Polo, RA1
Zhang, Y1
Wu, JY1
Weng, LH1
Li, XX1
Yu, LJ1
Xu, Y1
Volpini, R4
Dal Ben, D1
Lambertucci, C1
Marucci, G2
Mishra, RC1
Ramadori, AT1
Klotz, KN1
Trincavelli, ML1
Martini, C1
Cristalli, G4
Finaurini, S1
Buccioni, M1
Lammi, C1
Kandhavelu, M1
Ricciutelli, M1
Angeli, P1
Commandeur, JN1
Pinna, A4
Tronci, E1
Schintu, N1
Simola, N1
Pontis, S2
Morelli, M3
Oses, JP1
Batassini, C1
Pochmann, D1
Böhmer, AE1
Vuaden, FC1
Silvestrin, RB1
Oliveira, A1
Bonan, CD1
Bogo, MR1
Souza, DO1
Portela, LV1
Sarkis, JJ1
Mello e Souza, T1
Hassin-Baer, S1
Hattori, N1
Cohen, OS1
Massarwa, M1
Israeli-Korn, SD1
Inzelberg, R1
Ellermann, M1
Paulini, R1
Jakob-Roetne, R1
Lerner, C1
Borroni, E1
Roth, D1
Ehler, A1
Schweizer, WB1
Schlatter, D1
Rudolph, MG1
Diederich, F1
Jiang, TF1
Zhang, YJ1
Zhou, HY1
Wang, HM1
Tian, LP1
Liu, J1
Ding, JQ1
Chen, SD1
GOMIRATO, G1
HYDEN, H1
Golbe, LI1
Di Iorio, G1
Markopoulou, K1
Athanassiadou, A1
Papapetropoulos, S1
Watts, RL1
Vance, JM1
Bonifati, V1
Williams, TA1
Spychala, JR1
Stenroos, ES1
Johnson, WG1
Vilar, R1
Coelho, H1
Rodrigues, E1
Gama, MJ1
Rivera, I1
Taioli, E1
Lechner, MC1
Lücking, CB1
Kösel, S1
Mehraein, P1
Graeber, MB1
Loeffler, DA1
Camp, DM1
Juneau, PL1
Harel, E1
LeWitt, PA1
Barbieri, S1
Hofele, K1
Wiederhold, KH1
Probst, A1
Mistl, C1
Danner, S1
Kauffmann, S1
Sommer, B1
Spooren, W1
Tolnay, M1
Bilbe, G1
van der Putten, H1

Reviews

5 reviews available for adenine and Idiopathic Parkinson Disease

ArticleYear
Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions.
    Experimental neurology, 2021, Volume: 335

    Topics: Adenine; Alzheimer Disease; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes; Databases, G

2021
Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease.
    Biology of the cell, 2019, Volume: 111, Issue:6

    Topics: Adenine; Adrenergic alpha-2 Receptor Agonists; Animals; Disease Models, Animal; Endoplasmic Reticulu

2019
Prions: generation and spread versus neurotoxicity.
    The Journal of biological chemistry, 2014, Jul-18, Volume: 289, Issue:29

    Topics: Adenine; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; eIF-2 Kinase; Humans; I

2014
Novel investigational adenosine A2A receptor antagonists for Parkinson's disease.
    Expert opinion on investigational drugs, 2009, Volume: 18, Issue:11

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Clinical Trials, Phase I

2009
Mouse models of alpha-synucleinopathy and Lewy pathology. Alpha-synuclein expression in transgenic mice.
    Advances in experimental medicine and biology, 2001, Volume: 487

    Topics: Adenine; alpha-Synuclein; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Humans; Lewy Bo

2001

Other Studies

21 other studies available for adenine and Idiopathic Parkinson Disease

ArticleYear
Restoration of Parkinson's Disease-Like Deficits by Activating Autophagy through mTOR-Dependent and mTOR-Independent Mechanisms in Pharmacological and Transgenic Models of Parkinson's Disease in Mice.
    Bulletin of experimental biology and medicine, 2021, Volume: 171, Issue:4

    Topics: Adenine; Animals; Autophagy; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Transgenic; MTO

2021
Baicalein Protects against Rotenone-Induced Neurotoxicity through Induction of Autophagy.
    Biological & pharmaceutical bulletin, 2017, Sep-01, Volume: 40, Issue:9

    Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dop

2017
Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein.
    Acta pharmacologica Sinica, 2013, Volume: 34, Issue:5

    Topics: Adenine; alpha-Synuclein; Animals; Autophagy; Cell Survival; Chymotrypsin; Humans; Oligopeptides; Pa

2013
Synthesis and biological evaluation of metabolites of 2-n-butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), a potent antagonist of the A2A adenosine receptor for the treatment of Parkinson's disease.
    Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Behavior, Animal; Binding, Competitive; CHO Cel

2013
8-Substituted 2-alkynyl-N(9)-propargyladenines as A2A adenosine receptor antagonists.
    Bioorganic & medicinal chemistry, 2014, Jun-15, Volume: 22, Issue:12

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Antipsychotic Agents; Cat

2014
G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.
    Toxicology, 2014, Oct-03, Volume: 324

    Topics: 1-Methyl-4-phenylpyridinium; Adenine; Autophagy; Case-Control Studies; Caspases; Cells, Cultured; Do

2014
Valproic acid protects against MPP
    Neuroscience letters, 2017, 01-18, Volume: 638

    Topics: 1-Methyl-4-phenylpyridinium; Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Humans;

2017
Adenosine A2A receptor antagonists: new 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease.
    ChemMedChem, 2009, Volume: 4, Issue:6

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Binding Sites; Computer Simulation; Crystallogr

2009
In vitro metabolism studies of new adenosine A 2A receptor antagonists.
    Drug metabolism letters, 2008, Volume: 2, Issue:4

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Chromatography, High Pressure Liquid; Cytochrom

2008
A new ethyladenine antagonist of adenosine A(2A) receptors: behavioral and biochemical characterization as an antiparkinsonian drug.
    Neuropharmacology, 2010, Volume: 58, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenine; Animals; Antiparkinson Agents; Autoradiograph

2010
The hydrolysis of striatal adenine- and guanine-based purines in a 6-hydroxydopamine rat model of Parkinson's disease.
    Neurochemical research, 2011, Volume: 36, Issue:2

    Topics: 5'-Nucleotidase; Acid Anhydride Hydrolases; Adenine; Adrenergic Agents; Animals; Corpus Striatum; Di

2011
Phenotype of the 202 adenine deletion in the parkin gene: 40 years of follow-up.
    Movement disorders : official journal of the Movement Disorder Society, 2011, Volume: 26, Issue:4

    Topics: Adenine; Adult; Age of Onset; Aged; Disability Evaluation; Disease Progression; Family Health; Femal

2011
Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2011, May-27, Volume: 17, Issue:23

    Topics: Adenine; Catalysis; Catalytic Domain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inh

2011
Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2013, Volume: 8, Issue:1

    Topics: Adenine; alpha-Synuclein; Autophagy; Blotting, Western; Cell Line; Cell Survival; Curcumin; Genetic

2013
A BIOCHEMICAL GLIA ERROR IN THE PARKINSON DISEASE.
    Brain : a journal of neurology, 1963, Volume: 86

    Topics: Adenine; Cytosine; Globus Pallidus; Guanine; Neurochemistry; Neuroglia; Neurons; Nucleic Acids; Park

1963
New adenosine A2A receptor antagonists: actions on Parkinson's disease models.
    European journal of pharmacology, 2005, Apr-11, Volume: 512, Issue:2-3

    Topics: Adenine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Behavior, Anim

2005
Glutathione S-transferase polymorphisms and onset age in alpha-synuclein A53T mutant Parkinson's disease.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2007, Mar-05, Volume: 144B, Issue:2

    Topics: Adenine; Adult; Age of Onset; Aged; Aged, 80 and over; Alleles; alpha-Synuclein; Glutathione Transfe

2007
Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease.
    European journal of neurology, 2007, Volume: 14, Issue:2

    Topics: Adenine; Aged; Aged, 80 and over; Alleles; Cytochrome P-450 CYP2D6; Gene Deletion; Genetic Predispos

2007
Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease.
    Synapse (New York, N.Y.), 2007, Volume: 61, Issue:8

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Dihydroxyphenylalanine; Dopamine Agents; Functi

2007
Absence of the mitochondrial A7237T mutation in Parkinson's disease.
    Biochemical and biophysical research communications, 1995, Jun-15, Volume: 211, Issue:2

    Topics: Adenine; Base Sequence; DNA Primers; DNA, Mitochondrial; Electron Transport Complex IV; Frontal Lobe

1995
Purine-induced alterations of dopamine metabolism in rat pheochromocytoma PC12 cells.
    Brain research bulletin, 2000, Volume: 52, Issue:6

    Topics: Adenine; Adenosine; Animals; Disease Models, Animal; Dopamine; Guanine; Guanosine; Hypoxanthine; Neo

2000