Page last updated: 2024-10-16

adenine and Hypoxia

adenine has been researched along with Hypoxia in 47 studies

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
"We measured the changes in pial arteriolar diameter and CSF concentrations of adenosine, inosine, and hypoxanthine during hypoxia in the absence and presence of topically applied dipyridamole (10(-6) M) and erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA; 10(-5) M)."7.68Changes in pial arteriolar diameter and CSF adenosine concentrations during hypoxia. ( Meno, JR; Ngai, AC; Winn, HR, 1993)
"The survival time of rats and hamsters in lethal hypoxia was measured after a sublethal exposure and a normoxia break, at the beginning of which purines were administered intraperitoneally in the following dosages: 25 mg/kg hypoxanthine, 50 mg/kg allopurinol, 25 mg/kg adenine."7.68Influence of hypoxanthine, allopurinol and adenine on resistance of rats and hamsters to hypobaric hypoxia. ( Brandová, J; Novák, L; Stípek, S; Trojan, S, 1990)
"After the same period of anoxia 50% of the total pool, comprising adenosine, inosine, hypoxanthine and uric acid in approximately equal proportions, was recovered from the coronary perfusate."5.27Adenine pool catabolism in the ischemic, the calcium-depleted ischemic, and the substrate free anoxic isolated rat heart: relationship to contracture development. ( Holliss, DG; Humphrey, SM; Seelye, RN, 1984)
" Therefore, the aim of our study was to use human colorectal cancer HCT116 cells to explore whether inhibition of autophagy by 3-Methyladenine (3-MA, an autophagy inhibitor) is able to enhance hypoxia-induced apoptosis in vitro."3.91Inhibition of autophagy by 3-MA promotes hypoxia-induced apoptosis in human colorectal cancer cells. ( Dong, Y; Wu, Y; Xing, CG; Yang, XD; Ye, ZY; Zhao, GL, 2019)
" Inhibition of autophagy by chloroquine and 3-methyladenine worsened renal ischemia/reperfusion injury, as indicated by renal function, histology, and tubular apoptosis."3.76Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. ( Dong, Z; Jiang, M; Liu, K; Luo, J, 2010)
" We used Langendorff isolated rat heart preparation to test the hypothesis that allopurinol could maintain a level of the adenine nucleotide pool (ATP, ADP, and AMP) that would protect and improve the functional activity of the heart during a period of hypoxia."3.71Allopurinol enhances adenine nucleotide levels and improves myocardial function in isolated hypoxic rat heart. ( El-Migdadi, F; Farah, H; Khatib, SY, 2001)
"We measured the changes in pial arteriolar diameter and CSF concentrations of adenosine, inosine, and hypoxanthine during hypoxia in the absence and presence of topically applied dipyridamole (10(-6) M) and erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA; 10(-5) M)."3.68Changes in pial arteriolar diameter and CSF adenosine concentrations during hypoxia. ( Meno, JR; Ngai, AC; Winn, HR, 1993)
"The effects of 5-amino-4-imidazolecarboxamide riboside (rAICA) on coronary adenosine efflux were examined in blood-free perfused working rat heart preparations subjected to mild (70% O2) and severe hypoxia (45% O2)."3.685-Amino-4-imidazolecarboxamide riboside raises adenosine in perfused hypoxic rat heart. ( Burrier, AC; Jeng, AY; Oei, HH, 1991)
"The administration of allopurinol significantly increased resistance to repeated hypobaric hypoxia, while hypoxanthine decreased it."3.68Plasma xanthine oxidase and resistance to hypoxia: effect of purines and alcohol administration. ( Novák, L; Stípek, S; Trojan, S; Zima, T, 1991)
"The survival time of rats and hamsters in lethal hypoxia was measured after a sublethal exposure and a normoxia break, at the beginning of which purines were administered intraperitoneally in the following dosages: 25 mg/kg hypoxanthine, 50 mg/kg allopurinol, 25 mg/kg adenine."3.68Influence of hypoxanthine, allopurinol and adenine on resistance of rats and hamsters to hypobaric hypoxia. ( Brandová, J; Novák, L; Stípek, S; Trojan, S, 1990)
"Renal fibrosis is the final manifestation of chronic kidney disease (CKD) regardless of etiology."1.91Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model. ( Kim, DA; Kim, M; Kong, KH; Lee, MR; Oh, HJ, 2023)
" These findings indicate that adenine at 50 microM dosage can restore ATP concentrations to the normoxic range after 60 in of anoxia in the nonworking rat heart while raising the adenine dose to 1 mM inhibited the tissue ATP content."1.28Dose effects of adenine on myocardial ATP content in the post-anoxic nonworking rat heart. ( Halle, AA; Kang, ES; Mirvis, DM; Sullivan, JM, 1989)
"After the same period of anoxia 50% of the total pool, comprising adenosine, inosine, hypoxanthine and uric acid in approximately equal proportions, was recovered from the coronary perfusate."1.27Adenine pool catabolism in the ischemic, the calcium-depleted ischemic, and the substrate free anoxic isolated rat heart: relationship to contracture development. ( Holliss, DG; Humphrey, SM; Seelye, RN, 1984)
"[3H]adenine was taken up by a crude hypothalamic synaptosomal fraction and incorporated into mainly nucleotides."1.26Release of 3H-nucleosides from 3H-adenine labelled hypothalamic synaptosomes. ( Fredholm, BB; Vernet, L, 1979)
"In can be concluded that anoxia kidney deterioration is associated with a progressive loss of intracellular oxypurine, and a decreasing ability to regenerate adenylates after reoxygenation, which could be prevented by exogenic addition of adenosine."1.26The postanoxic regeneration of 5'-adenosine nucleotides in rabbit kidney tissue during in vitro perfusion. ( Buhl, MR, 1976)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199011 (23.40)18.7374
1990's15 (31.91)18.2507
2000's5 (10.64)29.6817
2010's13 (27.66)24.3611
2020's3 (6.38)2.80

Authors

AuthorsStudies
Xu, L2
Bi, Y1
Xu, Y2
Wu, Y4
Du, X1
Mou, Y1
Chen, J3
Kim, DA3
Lee, MR3
Oh, HJ3
Kim, M3
Kong, KH3
Halim, AA1
Alsayed, B1
Embarak, S1
Yaseen, T1
Dabbous, S1
Fontaine, O1
Dueluzeau, R1
Raibaud, P1
Chabanet, C1
Popoff, MR1
Badoual, J1
Gabilan, JC1
Andremont, A1
Gómez, L1
Andrés, S1
Sánchez, J1
Alonso, JM1
Rey, J1
López, F1
Jiménez, A1
Yan, Z1
Zhou, L1
Zhao, Y3
Wang, J6
Huang, L2
Hu, K1
Liu, H4
Wang, H3
Guo, Z1
Song, Y1
Huang, H4
Yang, R1
Owen, TW1
Al-Kaysi, RO1
Bardeen, CJ1
Cheng, Q1
Wu, S1
Cheng, T1
Zhou, X1
Wang, B4
Zhang, Q4
Wu, X2
Yao, Y3
Ochiai, T1
Ishiguro, H2
Nakano, R2
Kubota, Y2
Hara, M1
Sunada, K1
Hashimoto, K1
Kajioka, J1
Fujishima, A1
Jiao, J3
Gai, QY3
Wang, W2
Zang, YP2
Niu, LL2
Fu, YJ3
Wang, X6
Yao, LP1
Qin, QP1
Wang, ZY1
Liu, J4
Aleksic Sabo, V1
Knezevic, P1
Borges-Argáez, R1
Chan-Balan, R1
Cetina-Montejo, L1
Ayora-Talavera, G1
Sansores-Peraza, P1
Gómez-Carballo, J1
Cáceres-Farfán, M1
Jang, J1
Akin, D1
Bashir, R1
Yu, Z1
Zhu, J2
Jiang, H1
He, C2
Xiao, Z1
Xu, J2
Sun, Q1
Han, D1
Lei, H1
Zhao, K2
Zhu, L1
Li, X5
Fu, H2
Wilson, BK1
Step, DL1
Maxwell, CL1
Gifford, CA1
Richards, CJ1
Krehbiel, CR1
Warner, JM1
Doerr, AJ1
Erickson, GE1
Guretzky, JA1
Rasby, RJ1
Watson, AK1
Klopfenstein, TJ1
Sun, Y4
Liu, Z3
Pham, TD1
Lee, BK1
Yang, FC1
Wu, KH1
Lin, WP1
Hu, MK1
Lin, L3
Shao, J1
Sun, M1
Xu, G1
Zhang, X7
Xu, N1
Wang, R1
Liu, S1
He, H1
Dong, X2
Yang, M2
Yang, Q1
Duan, S1
Yu, Y2
Han, J3
Zhang, C3
Chen, L2
Yang, X1
Li, W3
Wang, T2
Campbell, DA1
Gao, K1
Zager, RA1
Johnson, ACM1
Guillem, A1
Keyser, J1
Singh, B1
Steubl, D1
Schneider, MP1
Meiselbach, H1
Nadal, J1
Schmid, MC1
Saritas, T1
Krane, V1
Sommerer, C1
Baid-Agrawal, S1
Voelkl, J1
Kotsis, F1
Köttgen, A1
Eckardt, KU2
Scherberich, JE1
Li, H5
Yao, L2
Sun, L3
Zhu, Z1
Naren, N1
Zhang, XX2
Gentile, GL1
Rupert, AS1
Carrasco, LI1
Garcia, EM1
Kumar, NG1
Walsh, SW1
Jefferson, KK1
Guest, RL1
Samé Guerra, D1
Wissler, M1
Grimm, J1
Silhavy, TJ1
Lee, JH2
Yoo, JS1
Kim, Y1
Kim, JS2
Lee, EJ1
Roe, JH1
Delorme, M1
Bouchard, PA1
Simon, M1
Simard, S1
Lellouche, F1
D'Urzo, KA1
Mok, F1
D'Urzo, AD1
Koneru, B1
Lopez, G1
Farooqi, A1
Conkrite, KL1
Nguyen, TH1
Macha, SJ1
Modi, A1
Rokita, JL1
Urias, E1
Hindle, A1
Davidson, H1
Mccoy, K1
Nance, J1
Yazdani, V1
Irwin, MS1
Yang, S1
Wheeler, DA1
Maris, JM1
Diskin, SJ1
Reynolds, CP1
Abhilash, L1
Kalliyil, A1
Sheeba, V1
Hartley, AM2
Meunier, B2
Pinotsis, N1
Maréchal, A2
Xu, JY1
Genko, N1
Haraux, F1
Rich, PR1
Kamalanathan, M1
Doyle, SM1
Xu, C1
Achberger, AM1
Wade, TL1
Schwehr, K1
Santschi, PH1
Sylvan, JB1
Quigg, A1
Leong, W1
Xu, W2
Gao, S1
Zhai, X1
Wang, C2
Gilson, E1
Ye, J1
Lu, Y1
Yan, R1
Zhang, Y6
Hu, Z1
You, Q1
Cai, Q1
Yang, D1
Gu, S1
Dai, H1
Zhao, X1
Gui, C1
Gui, J1
Wu, PK1
Hong, SK1
Starenki, D1
Oshima, K1
Shao, H1
Gestwicki, JE1
Tsai, S1
Park, JI1
Wang, Y7
Zhao, R1
Gu, Z1
Dong, C2
Guo, G1
Li, L4
Barrett, HE1
Meester, EJ1
van Gaalen, K1
van der Heiden, K1
Krenning, BJ1
Beekman, FJ1
de Blois, E1
de Swart, J1
Verhagen, HJ1
Maina, T1
Nock, BA1
Norenberg, JP1
de Jong, M1
Gijsen, FJH1
Bernsen, MR1
Martínez-Milla, J1
Galán-Arriola, C1
Carnero, M1
Cobiella, J1
Pérez-Camargo, D1
Bautista-Hernández, V1
Rigol, M1
Solanes, N1
Villena-Gutierrez, R1
Lobo, M1
Mateo, J1
Vilchez-Tschischke, JP1
Salinas, B1
Cussó, L1
López, GJ1
Fuster, V1
Desco, M1
Sanchez-González, J1
Ibanez, B1
van den Berg, P1
Schweitzer, DH1
van Haard, PMM1
Geusens, PP1
van den Bergh, JP1
Zhu, X1
Huang, X2
Xu, H2
Yang, G2
Lin, Z1
Salem, HF1
Nafady, MM1
Kharshoum, RM1
Abd El-Ghafar, OA1
Farouk, HO1
Domiciano, D1
Nery, FC1
de Carvalho, PA1
Prudente, DO1
de Souza, LB1
Chalfun-Júnior, A1
Paiva, R1
Marchiori, PER1
Lu, M2
An, Z1
Jiang, J2
Li, J7
Du, S1
Zhou, H1
Cui, J1
Wu, W1
Liu, Y8
Song, J1
Lian, Q1
Uddin Ahmad, Z1
Gang, DD1
Konggidinata, MI1
Gallo, AA1
Zappi, ME1
Yang, TWW1
Johari, Y1
Burton, PR1
Earnest, A1
Shaw, K1
Hare, JL1
Brown, WA1
Kim, GA1
Han, S1
Choi, GH1
Choi, J1
Lim, YS1
Gallo, A1
Cancelli, C1
Ceron, E1
Covino, M1
Capoluongo, E1
Pocino, K1
Ianiro, G1
Cammarota, G1
Gasbarrini, A1
Montalto, M1
Somasundar, Y1
Lu, IC1
Mills, MR1
Qian, LY1
Olivares, X1
Ryabov, AD1
Collins, TJ1
Zhao, L1
Doddipatla, S1
Thomas, AM1
Nikolayev, AA1
Galimova, GR1
Azyazov, VN1
Mebel, AM1
Kaiser, RI1
Guo, S1
Yang, P1
Yu, X2
Zhang, H1
Yu, B2
Han, B1
George, MW1
Moor, MB1
Bonny, O1
Langenberg, E1
Paik, H1
Smith, EH1
Nair, HP1
Hanke, I1
Ganschow, S1
Catalan, G1
Domingo, N1
Schlom, DG1
Assefa, MK1
Wu, G2
Hayton, TW1
Becker, B1
Enikeev, D1
Netsch, C1
Gross, AJ1
Laukhtina, E1
Glybochko, P1
Rapoport, L1
Herrmann, TRW1
Taratkin, M1
Dai, W1
Shi, J2
Carreno, J1
Kloner, RA1
Pickersgill, NA1
Vetter, JM1
Kim, EH1
Cope, SJ1
Du, K1
Venkatesh, R1
Giardina, JD1
Saad, NES1
Bhayani, SB1
Figenshau, RS1
Eriksson, J1
Landfeldt, E1
Ireland, S1
Jackson, C1
Wyatt, E1
Gaudig, M1
Stancill, JS1
Happ, JT1
Broniowska, KA1
Hogg, N1
Corbett, JA1
Tang, LF1
Bi, YL1
Fan, Y2
Sun, YB1
Wang, AL1
Xiao, BH1
Wang, LF1
Qiu, SW1
Guo, SW1
Wáng, YXJ1
Sun, J2
Chu, S1
Pan, Q1
Li, D2
Zheng, S2
Ma, L1
Wang, L4
Hu, T1
Wang, F1
Han, Z1
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Ge, X1
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Dias-Santagata, D1
Lennerz, JK1
Sadow, PM1
Frazier, RP1
Govinda Raju, S1
Henry, D1
Chung, T1
Kherani, J1
Rothenberg, SM1
Wirth, LJ1
Marti, CN1
Choi, NG1
Bae, SJ1
Ni, L1
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Dai, T1
Yang, Y3
Lee, R1
Fleischer, AS1
Wemhoff, AP1
Ford, CR1
Kleppinger, EL1
Helms, K1
Bush, AA1
Luna-Abanto, J1
García Ruiz, L1
Laura Martinez, J1
Álvarez Larraondo, M1
Villoslada Terrones, V1
Dukic, L1
Maric, N1
Simundic, AM1
Chogtu, B1
Ommurugan, B1
Thomson, SR1
Kalthur, SG1
Benidir, M1
El Massoudi, S1
El Ghadraoui, L1
Lazraq, A1
Benjelloun, M1
Errachidi, F1
Cassar, M1
Law, AD1
Chow, ES1
Giebultowicz, JM1
Kretzschmar, D1
Salonurmi, T1
Nabil, H1
Ronkainen, J1
Hyötyläinen, T1
Hautajärvi, H1
Savolainen, MJ1
Tolonen, A1
Orešič, M1
Känsäkoski, P1
Rysä, J1
Hakkola, J1
Hukkanen, J1
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Zhou, Z1
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Xu, YM1
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van Hest, JCM1
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Suleiman, K1
Drain, PK1
Ruhwald, M1
Schumacher, S1
Denkinger, CM1
Waning, B1
Van Gemert, W1
Pai, M1
Myers, RK1
Bonsu, JM1
Carey, ME1
Yerys, BE1
Mollen, CJ1
Curry, AE1
Douglas, TA1
Alinezhadbalalami, N1
Balani, N1
Schmelz, EM1
Davalos, RV1
Kamaldinov, T1
Erndt-Marino, J1
Levin, M1
Kaplan, DL1
Hahn, MS1
Heidarimoghadam, R1
Farmany, A1
Lee, JJ1
Kang, J1
Park, S1
Cho, JH1
Oh, S1
Park, DJ1
Perez-Maldonado, R1
Cho, JY1
Park, IH1
Kim, HB1
Song, M1
Mfarrej, B1
Jofra, T1
Morsiani, C1
Gagliani, N1
Fousteri, G1
Battaglia, M1
Giuliano, C1
Levinger, I1
Vogrin, S1
Neil, CJ1
Allen, JD1
Lv, Y1
Yuan, R1
Cai, B1
Bahrami, B1
Chowdhury, AH1
Yang, C2
Qiao, Q1
Liu, SF1
Zhang, WH1
Kolano, L1
Knappe, D1
Volke, D1
Sträter, N1
Hoffmann, R1
Coussens, M1
Calders, P1
Lapauw, B1
Celie, B1
Banica, T1
De Wandele, I1
Pacey, V1
Malfait, F1
Rombaut, L1
Vieira, D1
Angel, S1
Honjol, Y1
Gruenheid, S1
Gbureck, U1
Harvey, E1
Merle, G1
Seo, G1
Lee, G1
Kim, MJ1
Baek, SH1
Choi, M1
Ku, KB1
Lee, CS1
Jun, S1
Park, D1
Kim, HG1
Kim, SJ1
Lee, JO1
Kim, BT1
Park, EC1
Kim, SI1
Ende, M1
Kirkkala, T1
Loitzenbauer, M1
Talla, D1
Wildner, M1
Miletich, R1
Criado, A1
Lavela, P1
Tirado, JL1
Pérez-Vicente, C1
Kang, D1
Feng, D2
Fang, Z1
Wei, F1
De Clercq, E1
Pannecouque, C1
Zhan, P1
Guo, Y1
Shen, Y2
Wang, Q2
Kawazoe, Y1
Jena, P1
Sun, Z1
Li, Z2
Liang, H1
Xu, X2
Ma, G1
Huo, X1
Church, JS1
Chace-Donahue, F1
Blum, JL1
Ratner, JR1
Zelikoff, JT1
Schwartzer, JJ1
Fiseha, T1
Tamir, Z1
Yao, W1
Wang, P1
Mi, K1
Cheng, J1
Gu, C1
Huang, J2
Sun, HB1
Xing, WQ1
Liu, XB1
Zheng, Y1
Yang, SJ1
Wang, ZF1
Liu, SL1
Ba, YF1
Zhang, RX1
Liu, BX1
Fan, CC1
Chen, PN1
Liang, GH1
Yu, YK1
Wang, HR1
Li, HM1
Li, ZX1
Lalani, SS1
Anasir, MI1
Poh, CL1
Khan, IT1
Nadeem, M1
Imran, M1
Khalique, A1
Raspini, B1
Porri, D1
De Giuseppe, R1
Chieppa, M1
Liso, M1
Cerbo, RM1
Civardi, E1
Garofoli, F1
Monti, MC1
Vacca, M1
De Angelis, M1
Cena, H1
Kong, D1
Han, X1
Zhou, Y3
Xue, H1
Zhang, W1
Ruan, Z1
Li, S2
Noer, PR1
Kjaer-Sorensen, K1
Juhl, AK1
Goldstein, A1
Ke, C1
Oxvig, C1
Duan, C1
Kong, F1
Lin, S1
Wang, Z2
Bhattacharya, R1
Mazumder, D1
Yan, X1
Ma, C1
Tang, Y1
Kong, X1
Lu, J1
Zhang, M2
Vital-Jacome, M1
Cazares-Granillo, M1
Carrillo-Reyes, J1
Buitron, G1
Jacob, SI1
Douair, I1
Maron, L1
Ménard, G1
Rusjan, P1
Sabioni, P1
Di Ciano, P1
Mansouri, E1
Boileau, I1
Laveillé, A1
Capet, M1
Duvauchelle, T1
Schwartz, JC1
Robert, P1
Le Foll, B1
Xia, Y2
Chen, S1
Luo, M1
Wu, J1
Cai, S1
He, Y2
Garbacz, P1
Misiak, M1
Jackowski, K1
Yuan, Q1
Sherrell, PC1
Bi, X1
Nutho, B1
Mahalapbutr, P1
Hengphasatporn, K1
Pattaranggoon, NC1
Simanon, N1
Shigeta, Y1
Hannongbua, S1
Rungrotmongkol, T1
Caffrey, PJ1
Kher, R1
Bian, K1
Delaney, S1
Xue, J1
Wu, P1
Yuan, Y2
Luo, J2
Ye, S1
Ustriyana, P1
Wei, B1
Raee, E1
Hu, Y1
Wesdemiotis, C1
Sahai, N1
Kaur, A1
Nigam, K1
Srivastava, S1
Tyagi, A1
Dang, S1
Millar, JE1
Bartnikowski, N1
Passmore, MR1
Obonyo, NG1
Malfertheiner, MV1
von Bahr, V1
Redd, MA1
See Hoe, L1
Ki, KK1
Pedersen, S1
Boyle, AJ1
Baillie, JK1
Shekar, K1
Palpant, N1
Suen, JY1
Matthay, MA1
McAuley, DF1
Fraser, JF1
Settles, JA1
Gerety, GF1
Spaepen, E1
Suico, JG1
Child, CJ1
Oh, BL1
Lee, JS1
Lee, EY1
Lee, HY1
Yu, HG1
Leslie, I1
Boos, LA1
Larkin, J1
Pickering, L1
Lima, HK1
Vogel, K1
Hampel, D1
Wagner-Gillespie, M1
Fogleman, AD1
Ferraz, SL1
O'Connor, M1
Mazzucchelli, TG1
Kajiyama, H1
Suzuki, S1
Shimbo, A1
Utsumi, F1
Yoshikawa, N1
Kikkawa, F1
Javvaji, PK1
Dhali, A1
Francis, JR1
Kolte, AP1
Roy, SC1
Selvaraju, S1
Mech, A1
Sejian, V1
DeSilva, S1
Vaidya, SS1
Mao, C1
Akhatayeva, Z1
Cheng, H1
Zhang, G1
Jiang, F1
Meng, X1
Elnour, IE1
Lan, X1
Song, E1
Rohde, S1
Antonides, CFJ1
Muslem, R1
de Woestijne, PCV1
der Meulen, MHV1
Kraemer, US1
Dalinghaus, M1
Bogers, AJJC1
Pourmand, A1
Ghassemi, M1
Sumon, K1
Amini, SB1
Hood, C1
Sikka, N1
Duan, H1
Chen, WP1
Fan, M1
Wang, WP1
Yu, L1
Tan, SJ1
Xin, S1
Wan, LJ1
Guo, YG1
Tanda, S1
Gingl, K1
Ličbinský, R1
Hegrová, J1
Goessler, W1
Li, ZL1
Zhou, YL1
Yan, W1
Luo, L1
Su, ZZ1
Fan, MZ1
Wang, SR1
Zhao, WG1
Xu, D1
Hassan, HM1
Jiang, Z1
Bachmann, KF1
Haenggi, M1
Jakob, SM1
Takala, J1
Gattinoni, L1
Berger, D1
Bentley, RF1
Vecchiarelli, E1
Banks, L1
Gonçalves, PEO1
Thomas, SG1
Goodman, JM1
Mather, K1
Boachie, R1
Anini, Y1
Panahi, S1
Anderson, GH1
Luhovyy, BL1
Nafie, MS1
Arafa, K1
Sedky, NK1
Alakhdar, AA1
Arafa, RK1
Fan, S1
Hu, H1
Liang, J1
Hu, BC1
Wen, Z1
Hu, D1
Liu, YY1
Chu, Q1
Wu, MC1
Lu, X1
Wang, D1
Hu, M1
Shen, H1
Yao, M1
Dahlgren, RA1
Vysloužil, J1
Kulich, P1
Zeman, T1
Vaculovič, T1
Tvrdoňová, M1
Mikuška, P1
Večeřa, Z1
Stráská, J1
Moravec, P1
Balcar, VJ1
Šerý, O1
Qiao, L1
Xiong, X1
Peng, X1
Zheng, J1
Duan, J1
Xiao, W1
Zhou, HY1
Sui, ZY1
Zhao, FL1
Sun, YN1
Wang, HY1
Han, BH1
Jintao, X1
Shasha, Y1
Jincai, W1
Chunyan, L1
Mengya, Y1
Yongli, S1
Rasoanirina, BNV1
Lassoued, MA1
Miladi, K1
Razafindrakoto, Z1
Chaâbane-Banaoues, R1
Ramanitrahasimbola, D1
Cornet, M1
Sfar, S1
Liang, C1
Xing, Q1
Yi, JL1
Zhang, YQ1
Li, CY1
Tang, SJ1
Gao, C1
Sun, X1
Peng, M1
Sun, XF1
Zhang, T1
Shi, JH1
Liao, CX1
Gao, WJ1
Sun, LL1
Gao, Y1
Cao, WH1
Lyu, J1
Yu, CQ1
Wang, SF1
Pang, ZC1
Cong, LM1
Dong, Z2
Wu, F1
Wu, XP1
Jiang, GH1
Wang, XJ1
Wang, BY1
Li, LM1
Pan, L1
Wan, SP1
Yi, HWL1
He, HJ1
Yong, ZP1
Shan, GL1
Weng, TT1
Yan, SQ1
Gao, GP1
Wei, C1
Tao, FB1
Shao, ZH1
Yao, T1
Dong, S1
Shi, S1
Feng, YL1
Zhang, YW1
Wang, SP1
Shi, AX1
Operario, D1
Zhang, ZH1
Zhu, XF1
Zaller, N1
Gao, P1
Sun, YH1
Zhang, HB1
Xu, S1
Yan, L1
Zhou, P1
Tan, YZ1
Wang, HJ1
Wang, GD1
Dong, Y1
Zhao, GL1
Ye, ZY1
Xing, CG1
Yang, XD1
Papadakis, M1
Hadley, G1
Xilouri, M1
Hoyte, LC1
Nagel, S1
McMenamin, MM1
Tsaknakis, G1
Watt, SM1
Drakesmith, CW1
Chen, R1
Wood, MJ1
Zhao, Z1
Kessler, B1
Vekrellis, K1
Buchan, AM1
Maeda, H1
Nagai, H1
Takemura, G1
Shintani-Ishida, K1
Komatsu, M1
Ogura, S1
Aki, T1
Shirai, M1
Kuwahira, I1
Yoshida, K1
Yan, H1
Gao, J1
Shen, Z1
Cheng, Y1
Wang, RR1
Hu, WW1
Wang, G1
Stepp, MW1
Folz, RJ1
Zelko, IN1
Crean, D1
Bellwon, P1
Aschauer, L1
Limonciel, A1
Moenks, K1
Hewitt, P1
Schmidt, T1
Herrgen, K1
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Xu, R1
Wang, N1
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Mercurio, AM1
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Jiang, M1
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WYBORNY, L1
Kelley, EE1
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Khoo, NK1
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Johnson, KK1
Powell, PC1
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Lancaster, JR1
Tarpey, MM1
Park, WS1
Son, YK1
Kim, N1
Ko, JH1
Kang, SH1
Warda, M1
Earm, YE1
Jung, ID1
Park, YM1
Siess, M1
Delabar, U2
Seifart, HJ1
Humphrey, SM1
Holliss, DG1
Seelye, RN1
Zhu, PJ1
Krnjević, K1
Meno, JR1
Ngai, AC1
Winn, HR1
Mallet, RT1
Lee, SC1
Downey, HF1
Guéron, M1
Morimoto, Y2
Kemmotsu, O1
Alojado, ES1
Gleiter, CH1
Brause, M1
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Giannella, E1
Mochmann, HC1
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Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill : A Multiple Center Randomized Clinical Trial (BICAR-ICU)[NCT02476253]Phase 3400 participants (Anticipated)Interventional2015-05-05Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for adenine and Hypoxia

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016

Trials

1 trial available for adenine and Hypoxia

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016

Other Studies

46 other studies available for adenine and Hypoxia

ArticleYear
Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation.
    Neural plasticity, 2021, Volume: 2021

    Topics: Adenine; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein;

2021
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
    BMB reports, 2023, Volume: 56, Issue:2

    Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H

2023
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
    BMB reports, 2023, Volume: 56, Issue:2

    Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H

2023
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
    BMB reports, 2023, Volume: 56, Issue:2

    Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H

2023
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
    BMB reports, 2023, Volume: 56, Issue:2

    Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H

2023
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
    BMB reports, 2023, Volume: 56, Issue:2

    Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H

2023
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
    BMB reports, 2023, Volume: 56, Issue:2

    Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H

2023
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
    BMB reports, 2023, Volume: 56, Issue:2

    Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H

2023
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
    BMB reports, 2023, Volume: 56, Issue:2

    Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H

2023
Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model.
    BMB reports, 2023, Volume: 56, Issue:2

    Topics: Adenine; Animals; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Fibronectins; Fibrosis; H

2023
The role of RNA m
    Respiratory research, 2021, Apr-26, Volume: 22, Issue:1

    Topics: Adenine; Animals; Animals, Newborn; Arterial Pressure; Disease Models, Animal; Hypertension, Pulmona

2021
Hypoxic preconditioning-induced autophagy enhances survival of engrafted endothelial progenitor cells in ischaemic limb.
    Journal of cellular and molecular medicine, 2017, Volume: 21, Issue:10

    Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Hypoxia; Cell Survival; Cells, Cultured; Endothelial Pr

2017
Inhibition of autophagy by 3-MA promotes hypoxia-induced apoptosis in human colorectal cancer cells.
    European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:3

    Topics: Adenine; Annexin A5; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasm

2019
Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.
    Nature medicine, 2013, Volume: 19, Issue:3

    Topics: Adenine; Animals; Autophagy; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Cells, Cultured; Hypo

2013
Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart.
    Biochimica et biophysica acta, 2013, Volume: 1832, Issue:8

    Topics: Adenine; Animals; Autophagy; Chloroquine; Heart Diseases; Heart Failure; Hypoxia; Lysosomes; Male; M

2013
Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance.
    Autophagy, 2013, Volume: 9, Issue:9

    Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Br

2013
The c10orf10 gene product is a new link between oxidative stress and autophagy.
    Biochimica et biophysica acta, 2014, Volume: 1843, Issue:6

    Topics: Adenine; Animals; Autophagy; Biomarkers; Blotting, Western; Carcinoma, Hepatocellular; Chlorocebus a

2014
Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing.
    Toxicology in vitro : an international journal published in association with BIBRA, 2015, Dec-25, Volume: 30, Issue:1 Pt A

    Topics: Adenine; Cell Line; Epithelium; Gene Expression Regulation; Humans; Hypoxia; Kidney Diseases; Kidney

2015
Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015, Volume: 30, Issue:12

    Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Ca

2015
Activation of volume-sensitive Cl- channel mediates autophagy-related cell death in myocardial ischaemia/reperfusion injury.
    Oncotarget, 2016, Jun-28, Volume: 7, Issue:26

    Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Proliferation; Chloride Channels; Cytokines; Hydrogen-I

2016
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
    The Journal of biological chemistry, 2008, Oct-17, Volume: 283, Issue:42

    Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Membrane; Chloroquine; Culture Media; Endothelium, Vascul

2008
HPLC-UV measurements of metabolites in the supernatant of endothelial cells exposed to oxidative stress.
    Analytical and bioanalytical chemistry, 2010, Volume: 396, Issue:5

    Topics: Adenine; Animals; Aorta; Biomarkers; Cells, Cultured; Chromatography, High Pressure Liquid; Endothel

2010
Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury.
    The American journal of pathology, 2010, Volume: 176, Issue:3

    Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5;

2010
AKT loss in human epithelial cells treated with severe hypoxia.
    Biochimica et biophysica acta, 2010, Volume: 1803, Issue:8

    Topics: Adenine; Autophagy; Calpain; Chromones; Enzyme Inhibitors; Epithelial Cells; HeLa Cells; Humans; Hyp

2010
ADENINE NUCLEOTIDE DEGRADATION IN THE RABBIT HEART.
    The American journal of physiology, 1964, Volume: 207

    Topics: Adenine; Adenine Nucleotides; Adenosine Triphosphate; Aminohydrolases; Animals; Azaguanine; Dicumaro

1964
Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells.
    Free radical biology & medicine, 2006, Mar-15, Volume: 40, Issue:6

    Topics: Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta; Cattle; Endothelium, Vascular

2006
Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels.
    Pflugers Archiv : European journal of physiology, 2007, Volume: 454, Issue:6

    Topics: Acute Disease; Adenine; Animals; Blood Pressure; Carbazoles; Coronary Circulation; Cyclic AMP-Depend

2007
Cardiac synthesis and degradation of pyridine nucleotides and the level of energy-rich phosphates influenced by various precursors.
    Advances in myocardiology, 1983, Volume: 4

    Topics: Adenine; Adenosine Triphosphate; Animals; Glycoside Hydrolases; Guinea Pigs; Hypoxia; Myocardial Con

1983
Adenine pool catabolism in the ischemic, the calcium-depleted ischemic, and the substrate free anoxic isolated rat heart: relationship to contracture development.
    Journal of molecular and cellular cardiology, 1984, Volume: 16, Issue:12

    Topics: Adenine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; C

1984
Endogenous adenosine deaminase does not modulate synaptic transmission in rat hippocampal slices under normoxic or hypoxic conditions.
    Neuroscience, 1994, Volume: 63, Issue:2

    Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Electrophysiology; Hippocampu

1994
Changes in pial arteriolar diameter and CSF adenosine concentrations during hypoxia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1993, Volume: 13, Issue:2

    Topics: Adenine; Adenosine; Animals; Arterioles; Cerebrovascular Circulation; Dipyridamole; Hypoxanthine; Hy

1993
Endogenous adenosine increases O2 utilisation efficiency in isoprenaline-stimulated canine myocardium.
    Cardiovascular research, 1996, Volume: 31, Issue:1

    Topics: Adenine; Adenosine; Adenosine Deaminase; Adrenergic beta-Agonists; Animals; Dogs; Hypoxia; Isoproter

1996
AMP degradation in the perfused rat heart during 2-deoxy-D-glucose perfusion and anoxia. Part II: The determination of the degradation pathways using an adenosine deaminase inhibitor.
    Journal of molecular and cellular cardiology, 1996, Volume: 28, Issue:10

    Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Monophosphate; Animals; Anti

1996
Extracellular acidosis delays cell death against glucose-oxygen deprivation in neuroblastoma x glioma hybrid cells.
    Critical care medicine, 1997, Volume: 25, Issue:5

    Topics: Acidosis; Adenine; Cell Death; Cell Survival; Flow Cytometry; Glioma; Glucose; Hydrogen-Ion Concentr

1997
Evidence against a major role of adenosine in oxygen-dependent regulation of erythropoietin in rats.
    Kidney international, 1997, Volume: 52, Issue:2

    Topics: Adenine; Adenosine; Adenosine Diphosphate; Animals; Antihypertensive Agents; Carbon Monoxide; Dipyri

1997
Ischemic preconditioning prevents the impairment of hypoxic coronary vasodilatation caused by ischemia/reperfusion: role of adenosine A1/A3 and bradykinin B2 receptor activation.
    Circulation research, 1997, Volume: 81, Issue:3

    Topics: Adenine; Adenosine; Animals; Bradykinin; Bradykinin Receptor Antagonists; Coronary Vessels; Guinea P

1997
Adenylate kinase 1 gene deletion disrupts muscle energetic economy despite metabolic rearrangement.
    The EMBO journal, 2000, Dec-01, Volume: 19, Issue:23

    Topics: Adenine; Adenosine Triphosphate; Adenylate Kinase; Animals; Blotting, Northern; Catalysis; Cloning,

2000
Allopurinol enhances adenine nucleotide levels and improves myocardial function in isolated hypoxic rat heart.
    Biochemistry. Biokhimiia, 2001, Volume: 66, Issue:3

    Topics: Adenine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Allopurinol; Animal

2001
Release of 3H-purines from [3H]-adenine labelled rabbit kidney following sympathetic nerve stimulation, and its inhibition by alpha-adrenoceptor blockage.
    British journal of pharmacology, 1978, Volume: 64, Issue:2

    Topics: Adenine; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Electric Stimulation; Female; Hypoxi

1978
Release of 3H-nucleosides from 3H-adenine labelled hypothalamic synaptosomes.
    Acta physiologica Scandinavica, 1979, Volume: 106, Issue:2

    Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Antimycin A; Chromatography, Gel; Chromatograph

1979
The postanoxic regeneration of 5'-adenosine nucleotides in rabbit kidney tissue during in vitro perfusion.
    Scandinavian journal of clinical and laboratory investigation, 1976, Volume: 36, Issue:2

    Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine T

1976
Measurement of rat plasma adenosine levels during normoxia and hypoxia.
    Life sciences, 1992, Volume: 51, Issue:15

    Topics: Adenine; Adenosine; Adenosine Monophosphate; Animals; Blood Pressure; Carbon Dioxide; Chromatography

1992
Evaluation of N-0861, (+-)-N6-endonorbornan-2-yl-9-methyladenine, as an A1 subtype-selective adenosine receptor antagonist in the guinea pig isolated heart.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:3

    Topics: Adenine; Adenosine; Animals; Carrier Proteins; Coronary Vessels; Guinea Pigs; Heart; Heart Conductio

1992
[The oxygen system of an isolated heart during its perfusion with a suspension of human erythrocytes after different periods of their preservation in a solution containing adenine].
    Gematologiia i transfuziologiia, 1991, Volume: 36, Issue:8

    Topics: Adenine; Animals; Anticoagulants; Blood Preservation; Citrates; Cryopreservation; Cryoprotective Age

1991
5-Amino-4-imidazolecarboxamide riboside raises adenosine in perfused hypoxic rat heart.
    European journal of pharmacology, 1991, Oct-29, Volume: 204, Issue:1

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Cardiac Out

1991
Plasma xanthine oxidase and resistance to hypoxia: effect of purines and alcohol administration.
    Drug metabolism and drug interactions, 1991, Volume: 9, Issue:3-4

    Topics: Adenine; Allopurinol; Animals; Cricetinae; Ethanol; Female; Guinea Pigs; Hypoxanthines; Hypoxia; Ino

1991
Effect of propionyl carnitine on energy charge and adenine nucleotide content of cardiac endothelial cells during hypoxia.
    International journal of tissue reactions, 1991, Volume: 13, Issue:1

    Topics: Adenine; Animals; Carnitine; Cells, Cultured; Endothelium, Vascular; Energy Metabolism; Hypoxia; Oxi

1991
Species-dependent effects of adenosine on heart rate and atrioventricular nodal conduction. Mechanism and physiological implications.
    Circulation research, 1990, Volume: 67, Issue:4

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Atrioventricular Node; Bundle of His; D

1990
Influence of hypoxanthine, allopurinol and adenine on resistance of rats and hamsters to hypobaric hypoxia.
    Biomedica biochimica acta, 1990, Volume: 49, Issue:1

    Topics: Adenine; Allopurinol; Animals; Cricetinae; Female; Hypoxanthine; Hypoxanthines; Hypoxia; Rats; Rats,

1990
Dose effects of adenine on myocardial ATP content in the post-anoxic nonworking rat heart.
    General pharmacology, 1989, Volume: 20, Issue:6

    Topics: Adenine; Adenosine Triphosphate; Animals; Heart; Hypoxia; In Vitro Techniques; Male; Myocardium; Rat

1989
Adenosine in cerebral homeostatic role: appraisal through actions of homocysteine, colchicine, and dipyridamole.
    Journal of neurobiology, 1986, Volume: 17, Issue:1

    Topics: Adenine; Adenosine; Animals; Cerebral Cortex; Colchicine; Dipyridamole; Glutamates; Guinea Pigs; Hom

1986
Adenosine triphosphate degradation in specific disease.
    The Journal of laboratory and clinical medicine, 1985, Volume: 106, Issue:2

    Topics: Adenine; Adenosine Triphosphate; Biotransformation; Carnitine O-Palmitoyltransferase; Ethanol; Fruct

1985
Adenosine and hypoxic vasodilatation.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1985, Volume: 5, Issue:4

    Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cerebrovascular Circulation; Coformycin; Dogs; Hyp

1985
Effect of anoxia on sugar transport in avian erythrocytes.
    Biochimica et biophysica acta, 1973, Apr-25, Volume: 307, Issue:1

    Topics: Adenine; Adenosine; Aerobiosis; Anaerobiosis; Animals; Biological Transport; Blood Glucose; Buffers;

1973
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