Page last updated: 2024-10-16

adenine and Hypophosphatemia

adenine has been researched along with Hypophosphatemia in 62 studies

Hypophosphatemia: A condition of an abnormally low level of PHOSPHATES in the blood.

Research Excerpts

ExcerptRelevanceReference
"Hypophosphatemia linked to a decreased proximal tubular reabsorption was frequently observed in HIV-positive adults independently of the use of tenofovir."9.12Is tenofovir involved in hypophosphatemia and decrease of tubular phosphate reabsorption in HIV-positive adults? ( Badiou, S; Baillat, V; Cristol, JP; De Boever, CM; Reynes, J; Terrier, N, 2006)
" He had been receiving low-dose adefovir dipivoxil (ADV) for the treatment of lamivudine-resistant chronic hepatitis B virus infection for eight years and subsequently developed severe hypophosphatemia and proximal renal tubule dysfunction."8.90Hypophosphatemic osteomalacia due to drug-induced Fanconi's syndrome associated with adefovir dipivoxil treatment for hepatitis B. ( Eguchi, H; Hiromatsu, Y; Kuwahara, R; Tani, J; Tsuruta, M, 2014)
"To investigate the clinical features and treatment protocol and prognosis for the hypophosphataemic osteomalacia related to adefovir dipivoxil."8.87[A case of adefovir dipivoxil induced hypophosphataemic osteomalacia and literature review]. ( Li, XP; Meng, XW; Sun, XF; Xia, WB; Xing, XP; Zhang, HB, 2011)
"Adefovir dipivoxil (ADV) is one of the most important nucleostide analogues currently in use for the treatment of chronic hepatitis B virus (HBV) infection."7.91Low-dose adefovir dipivoxil-induced hypophosphatemia osteomalacia in five chronic hepatitis B virus-infected patients. Is low-dose adefovir dipivoxil-induced nephrotoxicity completely reversible? ( Dai, ZJ; Jin, J; Pan, YJ; Qian, YY; Ruan, LY; Shi, MT; Wu, CM; Zhu, YX, 2019)
" He had been receiving adefovir dipivoxil (ADV) for the treatment of entecavir (ETV)-resistant chronic hepatitis B (CHB) for four years in his 8-year treatment of hepatocellular carcinoma (HCC), but was referred to our hospital after increased levels of bone pain in his ribs, knees, and ankles."7.91[Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B]. ( Ikeda, A; Ikeda, F; Kanzaki, H; Kitamura, Y; Makita, T; Murakawa, K; Nishihara, S; Okada, H; Onishi, H; Sendo, T; Shiraha, H; Takaki, A; Takeuchi, Y; Tanaka, Y; Wada, N; Yasunaka, T, 2019)
" She had a 7-year history of taking adefovir at 10 mg/day for chronic hepatitis B."7.88Adefovir-induced Fanconi syndrome associated with osteomalacia. ( Cha, SK; Cho, DH; Kim, HS; Kim, JH; Kim, WI; Kim, YJ; Lee, EY; Lee, JH; Lee, SM; Park, KS; Park, S, 2018)
"To investigate the predictors of hypophosphatemic osteomalacia induced by adefovir dipivoxil (ADV) and to monitor for early detection."7.88Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil. ( Feng, L; Gao, RW; Li, R; Yang, YH; Zhang, B; Zhu, S; Zou, YZ, 2018)
"Retrieval of case reports was based on Pubmed, CNKI, Wan Fang and VIP databases using the key words adefovir dipivoxil, hypophosphatemia, osteomalacia and Fanconi syndrome."7.88Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series. ( Chen, N; Li, LY; Liu, LW; Peng, T; Tang, KX; Yu, F; Yu, X; Zhang, JB; Zhang, Q; Zhao, YP, 2018)
"Adefovir-induced hypophosphatemic osteomalacia in the context of hepatocarcinoma is rare and needs to be differentiated from metastatic hepatocarcinoma."7.85Adefovir-Induced Hypophosphatemic Osteomalacia Mimicking Bone Metastases From Primary Hepatocarcinoma. ( Luo, QY; Qiu, ZL; Shen, CT; Sun, ZK; Wei, WJ, 2017)
"Renal dysfunction and Fanconi's syndrome associated with hypophosphatemia caused by long-term administration of low-dose adefovir dipivoxil (ADV) has been reported in recent years."7.80Renal dysfunction and hypophosphatemia during long-term lamivudine plus adefovir dipivoxil therapy in patients with chronic hepatitis B. ( Akuta, N; Arase, Y; Hara, T; Hosaka, T; Ikeda, K; Kawamura, Y; Kobayashi, M; Kumada, H; Saitoh, S; Seko, Y; Sezaki, H; Suzuki, F; Suzuki, Y; Tanaka, M, 2014)
"In human immunodeficiency virus (HIV)-infected patients, tenofovir disoproxil fumarate (TDF) may cause hypophosphatemia leading to osteomalacia due to renal phosphate wasting."7.80Fibroblast growth factor 23 is elevated in tenofovir-related hypophosphatemia. ( Holmes, DT; Jiang, SY; Kendler, DL; Saeedi, R, 2014)
" Treatment of chronic hepatitis C in patients coinfected with HIV is a complex problem associated with toxicities and drug interactions between HIV antiretrovirals and interferon and ribavirin."7.79Short communication: Interferon/ribavirin treatment for HCV is associated with the development of hypophosphatemia in HIV/hepatitis C virus-coinfected patients. ( Funk, EK; Heytens, L; Kohli, A; Kottilil, S; Kwan, R; Masur, H; Nelson, A; Polis, MA; Shaffer, A; Shivakumar, B; Sneller, M, 2013)
"Occurrence of hypophosphatemic osteomalacia (HO) induced by administration of low-dose adefovir therapy is rare, and bone scintigraphy of the disease has rarely been reported."7.79Bone scintigraphic findings of hypophosphatemic osteomalacia associated with adefovir therapy: involvement of lower extremity skeletons. ( Ahn, BC; Kim, DH; Kweon, YO; Lee, J; Lee, SW, 2013)
"With the increasing use of tenofovir disoproxil in the management of HIV and hepatitis B, serious adverse effects, such as renal dysfunction, will inevitably increase in frequency."7.78Severe vitamin D deficiency in a patient treated for hepatitis B with tenofovir. ( Bower, M; Kumar, N; Nelson, M, 2012)
"Adefovir dipivoxil is commonly used for treatment of chronic hepatitis B."7.77[Adefovir dipivoxil-induced Fanconi syndrome and hypophosphatemic osteomalacia associated with muscular weakness in a patient with chronic hepatitis B]. ( Dong, GF; Li, L; Xie, YS; Zhang, X, 2011)
"The antiretroviral agent tenofovir can cause hypophosphatemic osteomalacia due to renal phosphate wasting."7.77Normal plasma FGF23 levels kinetic in tenofovir-related hypophosphatemic osteomalacia in an HIV-infected patient with von Recklinghausen disease. ( Boissier, MC; Prendki, V; Prie, D; Saidenberg-Kermanac'h, N; Souabni, L, 2011)
"We report two cases in which osteomalacia developed in patients on tenofovir-containing highly active antiretroviral therapy (HAART) in the context of Fanconi syndrome with hypophosphataemia."7.73The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy. ( Issa, BG; Parsonage, MJ; Savage, MW; Snowden, N; Wilkins, EG, 2005)
"Tenofovir disoproxil fumarate (TDF) has been anecdotally associated with isolated hypophosphatemia (HP) as well as proximal tubular toxicity and renal dysfunction in which HP has consistently been a feature."7.73Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice. ( Bannister, A; Day, SL; Fisher, M; Hankins, M; Leake Date, HA, 2005)
" Separate pharmacokinetic properties may be associated with distinct TDF toxicities: tenofovir with parathyroid hormone and altered calcium balance and tenofovir diphosphate with hypophosphatemia and FGF23 regulation."6.78Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency? ( Baker, A; Bethel, J; Flynn, PM; Gordon, CM; Havens, PL; Hazra, R; Kapogiannis, BG; Kiser, JJ; Liu, N; Lujan-Zilbermann, J; Mulligan, K; Pan, CG; Rutledge, B; Stephensen, CB; Van Loan, MD; Wilson, CM; Woodhouse, LR, 2013)
"Osteomalacia is a metabolic bone disease that leads to softening of the bones and can be caused by hypophosphatemia."6.49Hypophosphatemic osteomalacia induced by low-dose adefovir therapy: focus on manifestations in the skeletal system and literature review. ( Kim, du H; Min, YK; Sung, DH, 2013)
"Adefovir dipivoxil (ADV) is an acyclic nucleotide phosphate analogue, currently used for anti-HBV therapy."5.39[Hypophosphatemia and chest pain related to adefovir dipivoxil treatment for chronic hepatitis B: report of two cases]. ( Chen, Y; Liu, Z, 2013)
"Hypophosphatemic osteomalacia and renal Fanconi syndrome can be associated with low-dose ADV."5.39Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition. ( Dai, Z; Gu, X; Qian, Y; Wang, L; Wu, C; Zhang, H, 2013)
"Hypophosphatemia linked to a decreased proximal tubular reabsorption was frequently observed in HIV-positive adults independently of the use of tenofovir."5.12Is tenofovir involved in hypophosphatemia and decrease of tubular phosphate reabsorption in HIV-positive adults? ( Badiou, S; Baillat, V; Cristol, JP; De Boever, CM; Reynes, J; Terrier, N, 2006)
" He had been receiving low-dose adefovir dipivoxil (ADV) for the treatment of lamivudine-resistant chronic hepatitis B virus infection for eight years and subsequently developed severe hypophosphatemia and proximal renal tubule dysfunction."4.90Hypophosphatemic osteomalacia due to drug-induced Fanconi's syndrome associated with adefovir dipivoxil treatment for hepatitis B. ( Eguchi, H; Hiromatsu, Y; Kuwahara, R; Tani, J; Tsuruta, M, 2014)
"To investigate the clinical features and treatment protocol and prognosis for the hypophosphataemic osteomalacia related to adefovir dipivoxil."4.87[A case of adefovir dipivoxil induced hypophosphataemic osteomalacia and literature review]. ( Li, XP; Meng, XW; Sun, XF; Xia, WB; Xing, XP; Zhang, HB, 2011)
" He had been receiving adefovir dipivoxil (ADV) for the treatment of entecavir (ETV)-resistant chronic hepatitis B (CHB) for four years in his 8-year treatment of hepatocellular carcinoma (HCC), but was referred to our hospital after increased levels of bone pain in his ribs, knees, and ankles."3.91[Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B]. ( Ikeda, A; Ikeda, F; Kanzaki, H; Kitamura, Y; Makita, T; Murakawa, K; Nishihara, S; Okada, H; Onishi, H; Sendo, T; Shiraha, H; Takaki, A; Takeuchi, Y; Tanaka, Y; Wada, N; Yasunaka, T, 2019)
"Although denosumab is not generally an appropriate treatment for acquired Fanconi syndrome, it may be useful for patients who have hypophosphatemic osteomalacia due to adefovir dipivoxil-induced Fanconi syndrome associated with excessive bone resorption."3.91Denosumab improves clinical manifestations of hypophosphatemic osteomalacia by adefovir-induced Fanconi syndrome: a case report. ( Aso, Y; Iijima, T; Jojima, T; Kase, M; Kogai, T; Kunii, T; Sakurai, S; Shimizu, M; Usui, I, 2019)
"Adefovir dipivoxil (ADV) is one of the most important nucleostide analogues currently in use for the treatment of chronic hepatitis B virus (HBV) infection."3.91Low-dose adefovir dipivoxil-induced hypophosphatemia osteomalacia in five chronic hepatitis B virus-infected patients. Is low-dose adefovir dipivoxil-induced nephrotoxicity completely reversible? ( Dai, ZJ; Jin, J; Pan, YJ; Qian, YY; Ruan, LY; Shi, MT; Wu, CM; Zhu, YX, 2019)
" She had a 7-year history of taking adefovir at 10 mg/day for chronic hepatitis B."3.88Adefovir-induced Fanconi syndrome associated with osteomalacia. ( Cha, SK; Cho, DH; Kim, HS; Kim, JH; Kim, WI; Kim, YJ; Lee, EY; Lee, JH; Lee, SM; Park, KS; Park, S, 2018)
"To investigate the predictors of hypophosphatemic osteomalacia induced by adefovir dipivoxil (ADV) and to monitor for early detection."3.88Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil. ( Feng, L; Gao, RW; Li, R; Yang, YH; Zhang, B; Zhu, S; Zou, YZ, 2018)
"Retrieval of case reports was based on Pubmed, CNKI, Wan Fang and VIP databases using the key words adefovir dipivoxil, hypophosphatemia, osteomalacia and Fanconi syndrome."3.88Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series. ( Chen, N; Li, LY; Liu, LW; Peng, T; Tang, KX; Yu, F; Yu, X; Zhang, JB; Zhang, Q; Zhao, YP, 2018)
"Adefovir-induced hypophosphatemic osteomalacia in the context of hepatocarcinoma is rare and needs to be differentiated from metastatic hepatocarcinoma."3.85Adefovir-Induced Hypophosphatemic Osteomalacia Mimicking Bone Metastases From Primary Hepatocarcinoma. ( Luo, QY; Qiu, ZL; Shen, CT; Sun, ZK; Wei, WJ, 2017)
"In human immunodeficiency virus (HIV)-infected patients, tenofovir disoproxil fumarate (TDF) may cause hypophosphatemia leading to osteomalacia due to renal phosphate wasting."3.80Fibroblast growth factor 23 is elevated in tenofovir-related hypophosphatemia. ( Holmes, DT; Jiang, SY; Kendler, DL; Saeedi, R, 2014)
"Renal dysfunction and Fanconi's syndrome associated with hypophosphatemia caused by long-term administration of low-dose adefovir dipivoxil (ADV) has been reported in recent years."3.80Renal dysfunction and hypophosphatemia during long-term lamivudine plus adefovir dipivoxil therapy in patients with chronic hepatitis B. ( Akuta, N; Arase, Y; Hara, T; Hosaka, T; Ikeda, K; Kawamura, Y; Kobayashi, M; Kumada, H; Saitoh, S; Seko, Y; Sezaki, H; Suzuki, F; Suzuki, Y; Tanaka, M, 2014)
" Of all the patients, 15 were diagnosed as tumor-induced HO, 4 were long-term oral adefovir dipivoxil-related HO, 3 were associated with Fanconi syndrome, 2 were related to hyperparathyroidism, while 2 were Sjogren's syndrome complicated with renal tubular acidosis."3.80[The clinical characteristics of 26 cases of hypophosphatemia osteomalacia misdiagnosed as spondyloarthritis]. ( Feng, L; Huang, F; Jin, J; Luo, G; Ma, H; Sun, F; Wang, G; Wang, Y; Yang, J; Zhang, J; Zhao, W; Zhao, Z; Zhu, J, 2014)
" Treatment of chronic hepatitis C in patients coinfected with HIV is a complex problem associated with toxicities and drug interactions between HIV antiretrovirals and interferon and ribavirin."3.79Short communication: Interferon/ribavirin treatment for HCV is associated with the development of hypophosphatemia in HIV/hepatitis C virus-coinfected patients. ( Funk, EK; Heytens, L; Kohli, A; Kottilil, S; Kwan, R; Masur, H; Nelson, A; Polis, MA; Shaffer, A; Shivakumar, B; Sneller, M, 2013)
"Occurrence of hypophosphatemic osteomalacia (HO) induced by administration of low-dose adefovir therapy is rare, and bone scintigraphy of the disease has rarely been reported."3.79Bone scintigraphic findings of hypophosphatemic osteomalacia associated with adefovir therapy: involvement of lower extremity skeletons. ( Ahn, BC; Kim, DH; Kweon, YO; Lee, J; Lee, SW, 2013)
"With the increasing use of tenofovir disoproxil in the management of HIV and hepatitis B, serious adverse effects, such as renal dysfunction, will inevitably increase in frequency."3.78Severe vitamin D deficiency in a patient treated for hepatitis B with tenofovir. ( Bower, M; Kumar, N; Nelson, M, 2012)
"The antiretroviral agent tenofovir can cause hypophosphatemic osteomalacia due to renal phosphate wasting."3.77Normal plasma FGF23 levels kinetic in tenofovir-related hypophosphatemic osteomalacia in an HIV-infected patient with von Recklinghausen disease. ( Boissier, MC; Prendki, V; Prie, D; Saidenberg-Kermanac'h, N; Souabni, L, 2011)
"Adefovir dipivoxil is commonly used for treatment of chronic hepatitis B."3.77[Adefovir dipivoxil-induced Fanconi syndrome and hypophosphatemic osteomalacia associated with muscular weakness in a patient with chronic hepatitis B]. ( Dong, GF; Li, L; Xie, YS; Zhang, X, 2011)
"Adefovir dipivoxil, an acyclic nucleoside analogue, has been approved for the treatment of patients with chronic hepatitis B."3.76[A case of osteomalacia related to adefovir in a patient with chronic hepatitis B]. ( Ahn, SY; Choe, WH; Choi, YH; Jang, YM; Kim, BK; Ko, SY; Kwon, SY; Lee, CH, 2010)
"We report two cases in which osteomalacia developed in patients on tenofovir-containing highly active antiretroviral therapy (HAART) in the context of Fanconi syndrome with hypophosphataemia."3.73The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy. ( Issa, BG; Parsonage, MJ; Savage, MW; Snowden, N; Wilkins, EG, 2005)
"Tenofovir disoproxil fumarate (TDF) has been anecdotally associated with isolated hypophosphatemia (HP) as well as proximal tubular toxicity and renal dysfunction in which HP has consistently been a feature."3.73Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice. ( Bannister, A; Day, SL; Fisher, M; Hankins, M; Leake Date, HA, 2005)
" Separate pharmacokinetic properties may be associated with distinct TDF toxicities: tenofovir with parathyroid hormone and altered calcium balance and tenofovir diphosphate with hypophosphatemia and FGF23 regulation."2.78Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency? ( Baker, A; Bethel, J; Flynn, PM; Gordon, CM; Havens, PL; Hazra, R; Kapogiannis, BG; Kiser, JJ; Liu, N; Lujan-Zilbermann, J; Mulligan, K; Pan, CG; Rutledge, B; Stephensen, CB; Van Loan, MD; Wilson, CM; Woodhouse, LR, 2013)
" HIV serostatus, clinical and laboratory adverse events (AEs), adherence (pill count, Medication Event Monitoring System, and self-report), and sexual and other sociobehavioral data were assessed at 3-month intervals for 24 months."2.78Randomized trial of clinical safety of daily oral tenofovir disoproxil fumarate among HIV-uninfected men who have sex with men in the United States. ( Ackers, ML; Buchbinder, SP; Chillag, KL; Collins, BM; Grant, RM; Grohskopf, LA; Gvetadze, R; Liu, AY; Mayer, KH; Oʼhara, B; Pathak, SR; Paxton, LA; Rose, CE; Thompson, M, 2013)
"Osteomalacia is a metabolic bone disease that leads to softening of the bones and can be caused by hypophosphatemia."2.49Hypophosphatemic osteomalacia induced by low-dose adefovir therapy: focus on manifestations in the skeletal system and literature review. ( Kim, du H; Min, YK; Sung, DH, 2013)
"He had been diagnosed with diabetic kidney disease and osteomalacia due to vitamin D deficiency; thus, ADV was not discontinued until he was referred to us."1.51Hypophosphatemic Osteomalacia Associated with Adefovir-induced Fanconi Syndrome Initially Diagnosed as Diabetic Kidney Disease and Vitamin D Deficiency. ( Iino, N; Koda, R; Narita, I; Tsuchida, M, 2019)
"Acquired Fanconi syndrome has been associated with the long-term ingestion of several nucleoside analogs used to treat chronic hepatitis B virus infection."1.51A case of entecavir-induced Fanconi syndrome. ( Fujii, T; Kawasoe, K; Nitta, K; Ohta, A, 2019)
"Adefovir dipivoxil (ADV) is an acyclic nucleotide phosphate analogue, currently used for anti-HBV therapy."1.39[Hypophosphatemia and chest pain related to adefovir dipivoxil treatment for chronic hepatitis B: report of two cases]. ( Chen, Y; Liu, Z, 2013)
"Hypophosphatemic osteomalacia and renal Fanconi syndrome can be associated with low-dose ADV."1.39Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition. ( Dai, Z; Gu, X; Qian, Y; Wang, L; Wu, C; Zhang, H, 2013)
"Despite the recent publication of case reports describing various manifestations of tenofovir-related nephrotoxicity, data regarding the incidence of and risk factors for this adverse effect are currently lacking."1.33Incidence of and risk factors for tenofovir-induced nephrotoxicity: a retrospective cohort study. ( Antoniou, T; Chirhin, S; Gough, K; Govan, V; Loutfy, M; Raboud, J; Rachlis, A; Yoong, D, 2005)

Research

Studies (62)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.61)18.2507
2000's14 (22.58)29.6817
2010's42 (67.74)24.3611
2020's5 (8.06)2.80

Authors

AuthorsStudies
Alhamoudi, KM1
Alghamdi, B1
Alswailem, M1
Nasir, A1
Aljomaiah, A1
Al-Hindi, H1
Alzahrani, AS1
Leungsuwan, S1
Hooi, B1
Myint, KS1
Sun, L1
Yi, D1
Sun, W1
Wang, C1
Dong, X1
Chen, X1
Tian, Y1
Wang, J1
López Medina, JA1
Simón Frapolli, VJ1
Tinahones Madueño, FJ1
Wei, WJ1
Sun, ZK1
Shen, CT1
Qiu, ZL1
Luo, QY1
Park, S1
Kim, WI1
Cho, DH1
Kim, YJ1
Kim, HS1
Kim, JH1
Cha, SK1
Park, KS1
Lee, JH1
Lee, SM1
Lee, EY1
Zhu, S1
Yang, YH1
Gao, RW1
Li, R1
Zou, YZ1
Feng, L2
Zhang, B1
Chen, N1
Zhang, JB1
Zhang, Q1
Zhao, YP1
Li, LY1
Liu, LW1
Yu, F1
Yu, X1
Peng, T1
Tang, KX1
Koda, R1
Tsuchida, M1
Iino, N1
Narita, I1
Lv, Y1
Li, X1
Liang, S1
Liang, D1
Xu, F1
Zhu, X1
Zeng, C1
Makita, T1
Kanzaki, H1
Onishi, H1
Ikeda, A1
Takaki, A1
Wada, N1
Takeuchi, Y1
Yasunaka, T1
Ikeda, F1
Shiraha, H1
Tanaka, Y1
Nishihara, S1
Murakawa, K1
Kitamura, Y1
Okada, H1
Sendo, T1
Kunii, T1
Iijima, T1
Jojima, T1
Shimizu, M1
Kase, M1
Sakurai, S1
Kogai, T1
Usui, I1
Aso, Y1
Qian, YY1
Dai, ZJ1
Ruan, LY1
Pan, YJ1
Jin, J2
Shi, MT1
Zhu, YX1
Wu, CM1
Fujii, T1
Kawasoe, K1
Ohta, A1
Nitta, K1
Grohskopf, LA1
Chillag, KL1
Gvetadze, R1
Liu, AY1
Thompson, M1
Mayer, KH1
Collins, BM1
Pathak, SR1
Oʼhara, B1
Ackers, ML1
Rose, CE1
Grant, RM1
Paxton, LA1
Buchbinder, SP1
Kim, DH1
Lee, SW1
Kweon, YO1
Lee, J1
Ahn, BC1
Tanaka, M1
Suzuki, F1
Seko, Y1
Hara, T1
Kawamura, Y1
Sezaki, H1
Hosaka, T1
Akuta, N1
Kobayashi, M2
Suzuki, Y1
Saitoh, S1
Arase, Y1
Ikeda, K2
Kumada, H2
Ichchou, L1
Rist, S1
Lespessailles, E1
Prié, D3
Benhamou, CL1
Wu, C1
Zhang, H1
Qian, Y1
Wang, L1
Gu, X1
Dai, Z1
Funk, EK1
Shaffer, A1
Shivakumar, B1
Sneller, M1
Polis, MA1
Masur, H1
Heytens, L1
Nelson, A1
Kwan, R1
Kottilil, S1
Kohli, A1
Wainwright, E1
Sherrard, J1
Duncan, S1
Shine, B1
Dorrell, L1
Bickel, M1
Khaykin, P1
Stephan, C1
Schmidt, K1
Buettner, M1
Amann, K1
Lutz, T1
Gute, P1
Haberl, A1
Geiger, H1
Brodt, HR1
Jung, O1
Havens, PL1
Kiser, JJ1
Stephensen, CB1
Hazra, R1
Flynn, PM1
Wilson, CM1
Rutledge, B1
Bethel, J1
Pan, CG1
Woodhouse, LR1
Van Loan, MD1
Liu, N1
Lujan-Zilbermann, J1
Baker, A1
Kapogiannis, BG1
Gordon, CM1
Mulligan, K1
Liu, Z1
Chen, Y1
Eguchi, H1
Tsuruta, M1
Tani, J1
Kuwahara, R1
Hiromatsu, Y1
Hamnvik, OP1
Becker, CB1
Levy, BD1
Loscalzo, J1
Saeedi, R1
Jiang, SY1
Holmes, DT1
Kendler, DL1
Hirose, K1
Ubara, Y1
Hiramatsu, R1
Sawa, N1
Hasegawa, E1
Takaichi, K1
Murakami, M1
Maggi, P1
Montinaro, V1
Leone, A1
Fasano, M1
Volpe, A1
Bellacosa, C1
Grattagliano, V1
Coladonato, L1
Lapadula, G1
Santantonio, T1
Angarano, G1
Lin, Q1
Pan, F1
Hong, F1
Pan, C1
Sun, F1
Wang, G1
Yang, J1
Luo, G1
Ma, H1
Zhao, Z1
Wang, Y1
Zhao, W1
Zhang, J1
Zhu, J1
Huang, F1
Xu, LJ1
Jiang, Y1
Liao, RX1
Zhang, HB2
Mao, JF1
Chi, Y1
Li, M1
Wang, O1
Liu, XQ1
Liu, ZY1
Xing, XP2
Yu, W1
Xia, WB2
Oh, HM1
Oh, J1
Kim, KT1
Lee, JI1
Libório, AB1
Andrade, L1
Pereira, LV1
Sanches, TR1
Shimizu, MH1
Seguro, AC1
Lee, HJ1
Choi, JW1
Kim, TN1
Eun, JR1
Jaafar, A1
Séronie-Vivien, S1
Malard, L1
Massip, P1
Chatelut, E1
Tack, I1
Wood, SM1
Shah, SS1
Steenhoff, AP1
Meyers, KE1
Kaplan, BS1
Rutstein, RM1
Barril Cuadrado, G1
de Los Santos Gil, I1
Wong, T1
Girgis, CM1
Ngu, MC1
Chen, RC1
Emmett, L1
Archer, KA1
Seibel, MJ1
Judd, A1
Boyd, KL1
Stöhr, W1
Dunn, D1
Butler, K1
Lyall, H1
Sharland, M1
Shingadia, D1
Riordan, A1
Gibb, DM1
Kwon, SY1
Ahn, SY1
Ko, SY1
Jang, YM1
Choi, YH1
Kim, BK1
Choe, WH1
Lee, CH1
Saidenberg-Kermanac'h, N1
Souabni, L1
Prendki, V1
Boissier, MC1
Pérez-Rivera, AÁ1
Sáez, P1
León, E1
Lozano de León-Naranjo, F1
Kawate, H1
Taketomi, A1
Watanabe, T1
Nomura, M1
Kato, M1
Sakamoto, R1
Ikegami, T1
Soejima, Y1
Maehara, Y1
Takayanagi, R1
Fabbriciani, G1
de Socio, GV1
Massarotti, M1
Ceriani, R1
Marasini, B1
Li, L1
Dong, GF1
Zhang, X1
Xie, YS1
Sun, XF1
Li, XP1
Meng, XW1
Kumar, N1
Bower, M1
Nelson, M1
Bech, A1
Van Bentum, P1
Nabbe, K1
Gisolf, J1
Richter, C1
De Boer, H1
Schmid, H1
Tokarska-Schlattner, M1
Füeßl, B1
Röder, M1
Kay, L1
Attia, S1
Lederer, SR1
Goebel, FD1
Schlattner, U1
Bogner, JR1
Kim, du H1
Sung, DH1
Min, YK1
Peyrière, H1
Reynes, J2
Rouanet, I1
Daniel, N1
de Boever, CM2
Mauboussin, JM1
Leray, H1
Moachon, L1
Vincent, D1
Salmon-Céron, D1
Breton, G1
Alexandre, M1
Duval, X1
Peytavin, G1
Leport, C1
Vildei, JL1
Day, SL1
Leake Date, HA1
Bannister, A1
Hankins, M1
Fisher, M1
Antoniou, T1
Raboud, J1
Chirhin, S1
Yoong, D1
Govan, V1
Gough, K1
Rachlis, A1
Loutfy, M1
Fine, DM1
Parsonage, MJ1
Wilkins, EG1
Snowden, N1
Issa, BG1
Savage, MW1
Badiou, S1
Terrier, N1
Baillat, V1
Cristol, JP1
Buchacz, K1
Brooks, JT1
Tong, T1
Moorman, AC1
Baker, RK1
Holmberg, SD1
Greenberg, A1
Roselló, L1
Gort, A1
Planella, R1
Cabau, J1
Baker, R1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Sofosbuvir/Ledipasvir Treatment on the Pharmacokinetics and Renal Safety of Tenofovir[NCT02588287]14 participants (Actual)Interventional2015-11-30Completed
Effects of Ledipasvir/Sofosbuvir Treatment on the Pharmacokinetics and Renal Safety of Tenofovir Alafenamide (TAF) in Patients With HIV.[NCT03126370]Phase 410 participants (Actual)Interventional2018-01-08Completed
Randomized, Placebo-controlled Trial of the Safety and Effectiveness of Vitamin D Supplement to Improve Tubular Reabsorption of Phosphate and Decrease Bone Turnover in Adolescents and Young Adults With HIV Infection Being Treated With Antiretroviral Thera[NCT00490412]207 participants (Actual)Interventional2007-12-31Completed
The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With Tenofovir Disoproxil Fumarate[NCT05313477]Phase 464 participants (Anticipated)Interventional2022-05-01Recruiting
Impact of Drug Therapy and Co-Morbidities on the Development of Renal Impairment in HIV-Infected Patients[NCT00551655]684 participants (Actual)Observational2007-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Week 12 Plasma Tenofovir Area Under the Plasma Concentration vs. Time Curve From Time 0 to 24 Hours (AUC0-24) at 24 and 28 Weeks

Compare plasma tenofovir AUC0-24 between TAF with boosted PI vs. TDF with boosted PI (Phase 2 vs. 1), and between TAF with boosted PI and LDV/SOF vs. TDF with boosted PI (Phase 3 vs. 1) (NCT03126370)
Timeframe: 12 weeks and 24 weeks and 28 weeks

Interventionng*h/mL (Geometric Mean)
TDF With a Boosted PI3466
TAF With a Boosted PI743
TAF With a Boosted PI and LDV/SOF868

Change From Week 12 Tenofovir-diphosphate (TFV-DP) in Dried Blood Spots (DBS)

Compare tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) between TAF with a boosted PI vs. TDF with a boosted PI (Phase 2 vs. 1), and TAF with a boosted PI and LDV/SOF vs. TDF with a boosted PI (Phase 3 vs. 1) (NCT03126370)
Timeframe: 12 weeks and 24 and 28 weeks

Interventionfmol/2x7mm punches (Geometric Mean)
TDF With a Boosted PI36014
TAF With a Boosted PI6735
TAF With a Boosted PI and LDV/SOF6100

Change From Week 12 Tenofovir-diphosphate (TFV-DP) in Peripheral Blood Mononuclear Cells (PBMCs) at 24 and 28 Weeks

Compare tenofovir-diphosphate (TFV-DP) in peripheral blood mononuclear cells (PBMCs) between TAF with a boosted PI vs. TDF with a boosted PI (Phase 2 vs. 1), and TAF with a boosted PI and LDV/SOF vs. TDF with a boosted PI (Phase 3 vs. 1). (NCT03126370)
Timeframe: 12 weeks, and 24 weeks and 28 weeks

Interventionfmol/10^6 cells (Geometric Mean)
TDF With a Boosted PI83.0
TAF With a Boosted PI926
TAF With a Boosted PI and LDV/SOF1129

Change in Estimated Glomerular Filtration Rate (eGFR) and Renal Biomarkers: eGFR

Change in estimated glomerular filtration rate (eGFR) (NCT03126370)
Timeframe: 12 weeks, 24 weeks, and 28 weeks

InterventionmL/min/1.73 m^2 (Geometric Mean)
TDF With a Boosted PI86.7
TAF With a Boosted PI91.0
TAF With a Boosted PI and LDV/SOF88.1

Change in Estimated Glomerular Filtration Rate (eGFR) and Renal Biomarkers: UPCR

Change in estimated glomerular filtration rate (eGFR) and renal biomarkers: Urine protein to creatinine ratio (UPCR) (NCT03126370)
Timeframe: 12 weeks, 24 weeks, and 28 weeks

Interventionmg/g (Geometric Mean)
TDF With a Boosted PI134
TAF With a Boosted PI118
TAF With a Boosted PI and LDV/SOF97.3

Change in Estimated Glomerular Filtration Rate (eGFR) and Renal Biomarkers: B2M/Cr Ratio, and RBP/Cr Ratio

Change in renal biomarkers: urinary beta-2 microglobulin (B2M)/creatinine (Cr) ratio, and urinary retinol binding protein (RBP)/Cr ratio (NCT03126370)
Timeframe: 12 weeks, 24 weeks, and 28 weeks

,,
Interventionug/g (Geometric Mean)
β2M:Cr ratioRBP:Cr ratio
TAF With a Boosted PI224242
TAF With a Boosted PI and LDV/SOF178146
TDF With a Boosted PI419436

Reviews

6 reviews available for adenine and Hypophosphatemia

ArticleYear
Hypophosphatemic osteomalacia due to drug-induced Fanconi's syndrome associated with adefovir dipivoxil treatment for hepatitis B.
    Internal medicine (Tokyo, Japan), 2014, Volume: 53, Issue:3

    Topics: Adenine; Bone Diseases, Metabolic; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia;

2014
Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.
    AIDS patient care and STDs, 2009, Volume: 23, Issue:1

    Topics: Adenine; Adolescent; Age Factors; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Black or A

2009
[Management of renal toxicity in HIV-positive patients. What to measure, how to measure it and how frequently].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 8

    Topics: Adenine; Algorithms; Anti-HIV Agents; beta 2-Microglobulin; Clinical Trials as Topic; Cohort Studies

2008
[A case of adefovir dipivoxil induced hypophosphataemic osteomalacia and literature review].
    Zhonghua nei ke za zhi, 2011, Volume: 50, Issue:9

    Topics: Adenine; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia

2011
Hypophosphatemic osteomalacia induced by low-dose adefovir therapy: focus on manifestations in the skeletal system and literature review.
    Journal of bone and mineral metabolism, 2013, Volume: 31, Issue:2

    Topics: Adenine; Bone and Bones; Dose-Response Relationship, Drug; Humans; Hypophosphatemia; Male; Middle Ag

2013
Editorial comment: tenofovir nephrotoxicity--vigilance required.
    The AIDS reader, 2005, Volume: 15, Issue:7

    Topics: Adenine; Fanconi Syndrome; Glycosuria; HIV Infections; Humans; Hypokalemia; Hypophosphatemia; Organo

2005

Trials

3 trials available for adenine and Hypophosphatemia

ArticleYear
Randomized trial of clinical safety of daily oral tenofovir disoproxil fumarate among HIV-uninfected men who have sex with men in the United States.
    Journal of acquired immune deficiency syndromes (1999), 2013, Sep-01, Volume: 64, Issue:1

    Topics: Adenine; Adolescent; Anti-HIV Agents; Boston; CD4 Lymphocyte Count; Double-Blind Method; Follow-Up S

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibro

2013
Is tenofovir involved in hypophosphatemia and decrease of tubular phosphate reabsorption in HIV-positive adults?
    The Journal of infection, 2006, Volume: 52, Issue:5

    Topics: Adenine; Adult; Anti-HIV Agents; Cross-Sectional Studies; Female; HIV Infections; Humans; Hypophosph

2006

Other Studies

53 other studies available for adenine and Hypophosphatemia

ArticleYear
A Unique Mechanism of a Novel Synonymous PHEX Variant Causing X-Linked Hypophosphatemia.
    The Journal of clinical endocrinology and metabolism, 2022, 09-28, Volume: 107, Issue:10

    Topics: Adenine; Amino Acids; Codon, Terminator; Cytosine; DNA, Complementary; Familial Hypophosphatemic Ric

2022
Hypophosphatemic Osteomalacia Due to Adefovir-Induced Fanconi Syndrome.
    The American journal of medicine, 2020, Volume: 133, Issue:12

    Topics: Adenine; Aged; Alanine; Antiviral Agents; Fanconi Syndrome; Female; Hepatitis C, Chronic; Humans; Hy

2020
Retrospective analysis of the clinical characteristics of adefovir dipivoxil-induced Fanconi's syndrome in the Chinese population.
    Journal of clinical pharmacy and therapeutics, 2020, Volume: 45, Issue:4

    Topics: Adenine; Adult; Aged; Alkaline Phosphatase; Asian People; Bone Density; Fanconi Syndrome; Female; Gl

2020
Severe hypophosphataemic osteomalacia related to low-dose adefovir dipivoxil therapy in a hepatitis B virus patient.
    Endokrynologia Polska, 2021, Volume: 72, Issue:2

    Topics: Adenine; Antiviral Agents; Hepatitis B virus; Hepatitis B, Chronic; Humans; Hypophosphatemia; Organo

2021
[Adefovir-induced osteomalacia and hypophosphatemia].
    Medicina clinica, 2022, 03-11, Volume: 158, Issue:5

    Topics: Adenine; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia

2022
Adefovir-Induced Hypophosphatemic Osteomalacia Mimicking Bone Metastases From Primary Hepatocarcinoma.
    Clinical nuclear medicine, 2017, Volume: 42, Issue:9

    Topics: Adenine; Bone Neoplasms; Humans; Hypophosphatemia; Liver Neoplasms; Male; Middle Aged; Organophospho

2017
Adefovir-induced Fanconi syndrome associated with osteomalacia.
    Clinical and molecular hepatology, 2018, Volume: 24, Issue:3

    Topics: Adenine; Adult; Bone and Bones; Fanconi Syndrome; Female; Fibroblast Growth Factor-23; Fibroblast Gr

2018
Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil.
    Drug design, development and therapy, 2018, Volume: 12

    Topics: Adenine; Adult; Aged; Alkaline Phosphatase; Biomarkers; China; Cross-Sectional Studies; Drug Monitor

2018
Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series.
    BMC pharmacology & toxicology, 2018, 05-16, Volume: 19, Issue:1

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Asian People; Female; Hepatitis B, Chroni

2018
Hypophosphatemic Osteomalacia Associated with Adefovir-induced Fanconi Syndrome Initially Diagnosed as Diabetic Kidney Disease and Vitamin D Deficiency.
    Internal medicine (Tokyo, Japan), 2019, Mar-15, Volume: 58, Issue:6

    Topics: Adenine; Aged; Antiviral Agents; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diagnostic Error

2019
The clinical and pathological features of adefovir dipivoxil-related renal impairment
.
    Clinical nephrology, 2019, Volume: 91, Issue:3

    Topics: Adenine; Adult; Antiviral Agents; Creatinine; Female; Glycosuria; Hematuria; Hepatitis B, Chronic; H

2019
[Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019, Volume: 139, Issue:4

    Topics: Adenine; Aged; Carcinoma, Hepatocellular; Fanconi Syndrome; Fractures, Bone; Hepatitis B, Chronic; H

2019
Denosumab improves clinical manifestations of hypophosphatemic osteomalacia by adefovir-induced Fanconi syndrome: a case report.
    Journal of medical case reports, 2019, Apr-20, Volume: 13, Issue:1

    Topics: Adenine; Adult; Antiviral Agents; Bone Density Conservation Agents; Denosumab; Fanconi Syndrome; Hep

2019
Low-dose adefovir dipivoxil-induced hypophosphatemia osteomalacia in five chronic hepatitis B virus-infected patients. Is low-dose adefovir dipivoxil-induced nephrotoxicity completely reversible?
    Drug design, development and therapy, 2019, Volume: 13

    Topics: Adenine; Aged; Dose-Response Relationship, Drug; Fanconi Syndrome; Female; Hepatitis B, Chronic; Hum

2019
A case of entecavir-induced Fanconi syndrome.
    CEN case reports, 2019, Volume: 8, Issue:4

    Topics: Acidosis; Acute Kidney Injury; Adenine; Aged; Alanine; Antiviral Agents; Fanconi Syndrome; Guanine;

2019
Bone scintigraphic findings of hypophosphatemic osteomalacia associated with adefovir therapy: involvement of lower extremity skeletons.
    Clinical nuclear medicine, 2013, Volume: 38, Issue:5

    Topics: Adenine; Bone and Bones; Humans; Hypophosphatemia; Lower Extremity; Male; Middle Aged; Organophospho

2013
Renal dysfunction and hypophosphatemia during long-term lamivudine plus adefovir dipivoxil therapy in patients with chronic hepatitis B.
    Journal of gastroenterology, 2014, Volume: 49, Issue:3

    Topics: Adenine; Adult; Aged; Antiviral Agents; Creatinine; Drug Therapy, Combination; Female; Glomerular Fi

2014
Reversible increase in FGF23 in a hypophosphatemic renal and bone disease linked to antiviral therapy by adefovir.
    Joint bone spine, 2013, Volume: 80, Issue:6

    Topics: Adenine; Aged; Antiviral Agents; Bone Diseases; Female; Fibroblast Growth Factor-23; Fibroblast Grow

2013
Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition.
    Journal of clinical pharmacy and therapeutics, 2013, Volume: 38, Issue:4

    Topics: Adenine; Antiviral Agents; Dose-Response Relationship, Drug; Fanconi Syndrome; Humans; Hypophosphate

2013
Short communication: Interferon/ribavirin treatment for HCV is associated with the development of hypophosphatemia in HIV/hepatitis C virus-coinfected patients.
    AIDS research and human retroviruses, 2013, Volume: 29, Issue:9

    Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; Coinfection; Drug Interactions; Drug Therapy, Com

2013
Hypophosphataemia with non-tenofovir-containing antiretroviral therapy.
    International journal of STD & AIDS, 2013, Volume: 24, Issue:7

    Topics: Adenine; Adult; Anti-Retroviral Agents; Cross-Sectional Studies; Female; Glomerular Filtration Rate;

2013
Acute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administration.
    HIV medicine, 2013, Volume: 14, Issue:10

    Topics: Acute Kidney Injury; Adenine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Inter

2013
[Hypophosphatemia and chest pain related to adefovir dipivoxil treatment for chronic hepatitis B: report of two cases].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2013, Volume: 33, Issue:9

    Topics: Adenine; Chest Pain; Female; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Young

2013
Clinical problem-solving. Wasting away.
    The New England journal of medicine, 2014, Mar-06, Volume: 370, Issue:10

    Topics: Adenine; Adult; Bone Diseases, Metabolic; Cachexia; Diagnosis, Differential; Fanconi Syndrome; Femal

2014
Fibroblast growth factor 23 is elevated in tenofovir-related hypophosphatemia.
    Calcified tissue international, 2014, Volume: 94, Issue:6

    Topics: Adenine; Adult; Anti-HIV Agents; Bone Density; Fanconi Syndrome; Fibroblast Growth Factor-23; Fibrob

2014
[Case report; Fanconi's syndrome and hypophosphatemic osteomalacia associated with adefovir dipivoxil: a case report].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2014, Jun-10, Volume: 103, Issue:6

    Topics: Adenine; Aged; Antiviral Agents; Fanconi Anemia; Humans; Hypophosphatemia; Organophosphonates; Osteo

2014
Bone and kidney toxicity induced by nucleotide analogues in patients affected by HBV-related chronic hepatitis: a longitudinal study.
    The Journal of antimicrobial chemotherapy, 2015, Volume: 70, Issue:4

    Topics: Adenine; Adult; Aged; Antiviral Agents; Bone Diseases; Drug-Related Side Effects and Adverse Reactio

2015
[Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by adefovir in a patient with chronic hepatitis B].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2014, Volume: 22, Issue:10

    Topics: Adenine; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia; Organophosphonates; Osteo

2014
[The clinical characteristics of 26 cases of hypophosphatemia osteomalacia misdiagnosed as spondyloarthritis].
    Zhonghua nei ke za zhi, 2014, Volume: 53, Issue:11

    Topics: Adenine; Adult; Antirheumatic Agents; Biomarkers; C-Reactive Protein; Fanconi Syndrome; Female; Huma

2014
Low-dose adefovir dipivoxil may induce Fanconi syndrome: clinical characteristics and long-term follow-up for Chinese patients.
    Antiviral therapy, 2015, Volume: 20, Issue:6

    Topics: Adenine; Adult; Alkaline Phosphatase; Antiviral Agents; Asian People; Bone Density; Creatinine; Drug

2015
Osteomalacia as a Cause of Chronic Low Back and Buttock Pain.
    American journal of physical medicine & rehabilitation, 2015, Volume: 94, Issue:10

    Topics: Adenine; Adult; Antiviral Agents; Buttocks; Fractures, Spontaneous; Gait; Humans; Hypophosphatemia;

2015
Rosiglitazone reverses tenofovir-induced nephrotoxicity.
    Kidney international, 2008, Volume: 74, Issue:7

    Topics: Adenine; Animals; Drug-Related Side Effects and Adverse Reactions; Glomerular Filtration Rate; Hypog

2008
[A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus].
    The Korean journal of hepatology, 2008, Volume: 14, Issue:3

    Topics: Absorptiometry, Photon; Adenine; Adult; Antiviral Agents; Bone Density; DNA, Viral; Drug Resistance,

2008
Urinary cystatin C can improve the renal safety follow-up of tenofovir-treated patients.
    AIDS (London, England), 2009, Jan-14, Volume: 23, Issue:2

    Topics: Adenine; Anti-HIV Agents; Biomarkers; Creatinine; Cystatin C; Fanconi Syndrome; HIV Infections; Huma

2009
Hypophosphatemic osteomalacia after low-dose adefovir dipivoxil therapy for hepatitis B.
    The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:2

    Topics: Adenine; Adult; Antiviral Agents; Hepatitis B, Chronic; Humans; Hypophosphatemia; Magnetic Resonance

2010
Effect of tenofovir disoproxil fumarate on risk of renal abnormality in HIV-1-infected children on antiretroviral therapy: a nested case-control study.
    AIDS (London, England), 2010, Feb-20, Volume: 24, Issue:4

    Topics: Adenine; Adolescent; Anti-HIV Agents; Case-Control Studies; Child; Child, Preschool; England; Female

2010
[A case of osteomalacia related to adefovir in a patient with chronic hepatitis B].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2010, Volume: 56, Issue:2

    Topics: Adenine; Aged; Alkaline Phosphatase; Antiviral Agents; Dietary Supplements; DNA, Viral; Hepatitis B,

2010
Normal plasma FGF23 levels kinetic in tenofovir-related hypophosphatemic osteomalacia in an HIV-infected patient with von Recklinghausen disease.
    Joint bone spine, 2011, Volume: 78, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Drug Substitution; Fibroblast G

2011
[HIV infected women with intense bone and muscular pain and general weakness].
    Enfermedades infecciosas y microbiologia clinica, 2011, Volume: 29, Issue:4

    Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Therapy, Combina

2011
Hypophosphatemic osteomalacia as a long-term complication after liver transplantation.
    Transplantation, 2011, Jan-15, Volume: 91, Issue:1

    Topics: Adenine; Aged; Fanconi Syndrome; Female; Humans; Hypophosphatemia; Immunosuppressive Agents; Liver T

2011
Adefovir induced hypophosphatemic osteomalacia.
    Scandinavian journal of infectious diseases, 2011, Volume: 43, Issue:11-12

    Topics: Adenine; Aged; Humans; Hypophosphatemia; Male; Organophosphonates; Osteomalacia; Radionuclide Imagin

2011
[Adefovir dipivoxil-induced Fanconi syndrome and hypophosphatemic osteomalacia associated with muscular weakness in a patient with chronic hepatitis B].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011, Volume: 31, Issue:11

    Topics: Adenine; Antiviral Agents; Bone Diseases, Metabolic; Fanconi Syndrome; Hepatitis B, Chronic; Humans;

2011
Severe vitamin D deficiency in a patient treated for hepatitis B with tenofovir.
    International journal of STD & AIDS, 2012, Volume: 23, Issue:1

    Topics: Adenine; Hepatitis B; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Reverse Trans

2012
Fibroblast growth factor 23 in hypophosphataemic HIV-positive adults on tenofovir.
    HIV medicine, 2012, Volume: 13, Issue:9

    Topics: Adenine; Anti-HIV Agents; Calcium; Enzyme-Linked Immunosorbent Assay; Female; Fibroblast Growth Fact

2012
Macro CK2 accumulation in tenofovir-treated HIV patients is facilitated by CK oligomer stabilization but is not predictive for pathology.
    Antiviral therapy, 2013, Volume: 18, Issue:2

    Topics: Adenine; Anti-HIV Agents; Catalysis; Creatine Kinase, Mitochondrial Form; Enzyme Stability; Follow-U

2013
Renal tubular dysfunction associated with tenofovir therapy: report of 7 cases.
    Journal of acquired immune deficiency syndromes (1999), 2004, Mar-01, Volume: 35, Issue:3

    Topics: Adenine; Adult; Anti-HIV Agents; Body Weight; Drug Therapy, Combination; Female; Glycosuria; Humans;

2004
Tubulopathy consecutive to tenofovir-containing antiretroviral therapy in two patients infected with human immunodeficiency virus-1.
    Scandinavian journal of infectious diseases, 2004, Volume: 36, Issue:6-7

    Topics: Adenine; Anti-HIV Agents; Drug Therapy, Combination; Fanconi Syndrome; HIV Infections; HIV-1; Humans

2004
Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice.
    Journal of acquired immune deficiency syndromes (1999), 2005, Mar-01, Volume: 38, Issue:3

    Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blood Chemical Analysis; Creatinine

2005
Incidence of and risk factors for tenofovir-induced nephrotoxicity: a retrospective cohort study.
    HIV medicine, 2005, Volume: 6, Issue:4

    Topics: Adenine; Adult; Anti-HIV Agents; Creatinine; Female; HIV Infections; Humans; Hypophosphatemia; Kidne

2005
The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy.
    HIV medicine, 2005, Volume: 6, Issue:5

    Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Fanconi Syndrome; Female; HIV Infec

2005
Evaluation of hypophosphataemia in tenofovir disoproxil fumarate (TDF)-exposed and TDF-unexposed HIV-infected out-patients receiving highly active antiretroviral therapy.
    HIV medicine, 2006, Volume: 7, Issue:7

    Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Hypophosphate

2006
[Hypophosphatemia and multiple fractures in patient with human immunodeficiency virus infection treated with tenofovir].
    Medicina clinica, 2007, Jun-30, Volume: 129, Issue:5

    Topics: Adenine; Adult; Fractures, Bone; HIV Infections; Humans; Hypophosphatemia; Male; Organophosphonates;

2007
Kidney dysfunction: a safety update on adefovir (preveon).
    BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation, 1998

    Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Creatinine; Fanconi Syndrome; HIV Infections; Humans; Hy

1998