adenine has been researched along with Huntington Disease in 13 studies
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A hallmark of Huntington's disease (HD) is a prolonged polyglutamine sequence in the huntingtin protein and, correspondingly, an expanded cytosine, adenine, and guanine (CAG) triplet repeat region in the mRNA." | 1.91 | CAG-Repeat RNA Hairpin Folding and Recruitment to Nuclear Speckles with a Pivotal Role of ATP as a Cosolute. ( Appel, B; Ebbinghaus, S; Fatti, E; Hautke, A; Idiris, F; Lelièvre-Büttner, A; Lindner, F; Müller, S; Riel, A; Schug, A; Voronin, A; Weis, K; Zhu, J, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Di Tella, S | 1 |
| Lo Monaco, MR | 1 |
| Petracca, M | 1 |
| Zinzi, P | 1 |
| Solito, M | 1 |
| Piano, C | 1 |
| Calabresi, P | 1 |
| Silveri, MC | 1 |
| Bentivoglio, AR | 1 |
| Mantela, M | 1 |
| Lambropoulos, K | 1 |
| Simserides, C | 1 |
| Hautke, A | 1 |
| Voronin, A | 1 |
| Idiris, F | 1 |
| Riel, A | 1 |
| Lindner, F | 1 |
| Lelièvre-Büttner, A | 1 |
| Zhu, J | 1 |
| Appel, B | 1 |
| Fatti, E | 1 |
| Weis, K | 1 |
| Müller, S | 1 |
| Schug, A | 1 |
| Ebbinghaus, S | 1 |
| Tanner, C | 1 |
| Marder, K | 1 |
| Eberly, S | 1 |
| Biglan, K | 1 |
| Oakes, D | 1 |
| Shoulson, I | 1 |
| Bowie, LE | 1 |
| Maiuri, T | 1 |
| Alpaugh, M | 1 |
| Gabriel, M | 1 |
| Arbez, N | 1 |
| Galleguillos, D | 1 |
| Hung, CLK | 1 |
| Patel, S | 1 |
| Xia, J | 1 |
| Hertz, NT | 1 |
| Ross, CA | 1 |
| Litchfield, DW | 1 |
| Sipione, S | 1 |
| Truant, R | 1 |
| Pereira, GJ | 1 |
| Tressoldi, N | 1 |
| Hirata, H | 1 |
| Bincoletto, C | 1 |
| Smaili, SS | 1 |
| Ferrante, A | 1 |
| Martire, A | 1 |
| Pepponi, R | 1 |
| Varani, K | 1 |
| Vincenzi, F | 1 |
| Ferraro, L | 1 |
| Beggiato, S | 1 |
| Tebano, MT | 1 |
| Popoli, P | 1 |
| Kao, YH | 1 |
| Lin, MS | 1 |
| Chen, CM | 1 |
| Wu, YR | 1 |
| Chen, HM | 1 |
| Lai, HL | 1 |
| Chern, Y | 1 |
| Lin, CJ | 1 |
| Reis, SA | 1 |
| Thompson, MN | 1 |
| Lee, JM | 1 |
| Fossale, E | 1 |
| Kim, HH | 1 |
| Liao, JK | 1 |
| Moskowitz, MA | 1 |
| Shaw, SY | 1 |
| Dong, L | 1 |
| Haggarty, SJ | 1 |
| MacDonald, ME | 2 |
| Seong, IS | 1 |
| Ravikumar, B | 1 |
| Acevedo-Arozena, A | 1 |
| Imarisio, S | 1 |
| Berger, Z | 1 |
| Vacher, C | 1 |
| O'Kane, CJ | 1 |
| Brown, SD | 1 |
| Rubinsztein, DC | 2 |
| Zeng, W | 1 |
| Gillis, T | 1 |
| Hakky, M | 1 |
| Djoussé, L | 1 |
| Myers, RH | 1 |
| Gusella, JF | 1 |
| Vuillaume, I | 1 |
| Vermersch, P | 1 |
| Destée, A | 1 |
| Petit, H | 1 |
| Sablonnière, B | 1 |
| Berrios, GE | 1 |
| Wagle, AC | 1 |
| Marková, IS | 1 |
| Wagle, SA | 1 |
| Ho, LW | 1 |
| Whittaker, J | 1 |
| Ffrench-Constant, C | 1 |
| Kershaw, A | 1 |
| Rosser, A | 1 |
| Bak, T | 1 |
| Hodges, JR | 1 |
13 other studies available for adenine and Huntington Disease
| Article | Year |
|---|---|
Beyond the CAG triplet number: exploring potential predictors of delayed age of onset in Huntington's disease.
Topics: Adenine; Adult; Age of Onset; Child; Cytosine; Guanine; Humans; Huntington Disease; Neurodegenerativ | 2022 |
Charge transport properties of ideal and natural DNA segments, as mutation detectors.
Topics: Adenine; DNA; Guanine; Humans; Huntington Disease; Mutation | 2023 |
CAG-Repeat RNA Hairpin Folding and Recruitment to Nuclear Speckles with a Pivotal Role of ATP as a Cosolute.
Topics: Adenine; Adenosine Triphosphate; Humans; Huntingtin Protein; Huntington Disease; Nuclear Speckles; R | 2023 |
Selected health and lifestyle factors, cytosine-adenine-guanine status, and phenoconversion in Huntington's disease.
Topics: Adenine; Adult; Cytosine; Environment; Female; Follow-Up Studies; Guanine; Humans; Huntingtin Protei | 2018 |
N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation.
Topics: Adenine; Adenine Phosphoribosyltransferase; Animals; Casein Kinase II; Cell Line, Transformed; Disea | 2018 |
Autophagy as a neuroprotective mechanism against 3-nitropropionic acid-induced murine astrocyte cell death.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; bcl-2-Associated | 2013 |
Expression, pharmacology and functional activity of adenosine A1 receptors in genetic models of Huntington's disease.
Topics: Action Potentials; Adenine; Adenosine A1 Receptor Antagonists; Animals; Cerebral Cortex; Corpus Stri | 2014 |
Targeting ENT1 and adenosine tone for the treatment of Huntington's disease.
Topics: Adenine; Adenosine; Animals; Corpus Striatum; Disease Models, Animal; Equilibrative Nucleoside Trans | 2017 |
Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.
Topics: Adenine; Adenosine Triphosphate; Animals; Cadherins; Cell Adhesion; Cells, Cultured; Corpus Striatum | 2011 |
Dynein mutations impair autophagic clearance of aggregate-prone proteins.
Topics: Adenine; Adenylyl Imidodiphosphate; Animals; Autophagy; Behavior, Animal; Brain; Chlorocebus aethiop | 2005 |
Genetic analysis of the GRIK2 modifier effect in Huntington's disease.
Topics: 3' Untranslated Regions; Adenine; Age of Onset; Alleles; Cytosine; Exons; Genetic Variation; GluK2 K | 2006 |
Genetic polymorphisms adjacent to the CAG repeat influence clinical features at onset in Huntington's disease.
Topics: Adenine; Adult; Age of Onset; Aged; Alleles; Cytosine; Gene Deletion; Genotype; Guanine; Humans; Hun | 1998 |
Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers.
Topics: Adenine; Adult; Age of Onset; Cognition; Cytosine; Female; Genetic Predisposition to Disease; Guanin | 2001 |