adenine has been researched along with Hairy Cell Leukemia in 8 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " In vitro exposure of leukemia cells to CAde showed that it was eight times less toxic as compared to CdA." | 2.71 | Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia. ( Albertioni, F; Juliusson, G; Larsson, R; Liliemark, J; Lindemalm, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Visentin, A | 1 |
| Imbergamo, S | 1 |
| Trimarco, V | 1 |
| Pravato, S | 1 |
| Romano Gargarella, L | 1 |
| Frezzato, F | 1 |
| Scapinello, G | 1 |
| Bertorelle, R | 1 |
| Piva, E | 1 |
| Facco, M | 1 |
| Semenzato, G | 1 |
| Piazza, F | 1 |
| Trentin, L | 1 |
| Rogers, KA | 1 |
| Andritsos, LA | 1 |
| Wei, L | 1 |
| McLaughlin, EM | 1 |
| Ruppert, AS | 1 |
| Anghelina, M | 1 |
| Blachly, JS | 1 |
| Call, T | 1 |
| Chihara, D | 1 |
| Dauki, A | 1 |
| Guo, L | 1 |
| Ivy, SP | 1 |
| James, LR | 1 |
| Jones, D | 1 |
| Kreitman, RJ | 2 |
| Lozanski, G | 1 |
| Lucas, DM | 1 |
| Ngankeu, A | 1 |
| Phelps, M | 1 |
| Ravandi, F | 2 |
| Schiffer, CA | 1 |
| Carson, WE | 1 |
| Jones, JA | 1 |
| Grever, MR | 1 |
| Jain, P | 1 |
| Kanagal-Shamanna, R | 1 |
| Konoplev, S | 1 |
| Zuo, Z | 1 |
| Estrov, Z | 1 |
| Letendre, P | 1 |
| Doll, D | 1 |
| Sivina, M | 2 |
| Arons, E | 1 |
| Burger, JA | 2 |
| Bohn, JP | 1 |
| Wanner, D | 1 |
| Steurer, M | 1 |
| Lindemalm, S | 1 |
| Liliemark, J | 1 |
| Juliusson, G | 1 |
| Larsson, R | 1 |
| Albertioni, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter Phase 2 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 (Ibrutinib) for Treatment of Relapsed Hairy Cell Leukemia[NCT01841723] | Phase 2 | 44 participants (Anticipated) | Interventional | 2013-04-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for adenine and Hairy Cell Leukemia
| Article | Year |
|---|---|
Ibrutinib in relapsed hairy cell leukemia variant: A case report and review of the literature.
Topics: Adenine; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Biopsy; Fema | 2020 |
The importance of the tissue microenvironment in hairy cell leukemia.
Topics: Adenine; Antineoplastic Agents; B-Lymphocytes; Bone Marrow; CD40 Antigens; Gene Expression Regulatio | 2015 |
2 trials available for adenine and Hairy Cell Leukemia
| Article | Year |
|---|---|
Phase 2 study of ibrutinib in classic and variant hairy cell leukemia.
Topics: Adenine; Administration, Oral; Adult; Aged; Disease-Free Survival; Female; Follow-Up Studies; Humans | 2021 |
Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia.
Topics: Adenine; Administration, Oral; Area Under Curve; Humans; Infusions, Intravenous; Leukemia, Hairy Cel | 2004 |
4 other studies available for adenine and Hairy Cell Leukemia
| Article | Year |
|---|---|
Biclonal IGHV-4-34 hairy cell leukemia variant and CLL - successful treatment with ibrutinib and venetoclax.
Topics: Adenine; Bridged Bicyclo Compounds, Heterocyclic; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocyti | 2018 |
Novel therapeutics in the treatment of hairy cell leukemia variant.
Topics: Adenine; Aged; Aged, 80 and over; Antineoplastic Agents; Bendamustine Hydrochloride; Female; Humans; | 2018 |
The bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) blocks hairy cell leukaemia survival, proliferation and B cell receptor signalling: a new therapeutic approach.
Topics: Adenine; Adult; Agammaglobulinaemia Tyrosine Kinase; Aged; Antineoplastic Agents; Cell Proliferation | 2014 |
Ibrutinib for relapsed refractory hairy cell leukemia variant.
Topics: Adenine; Aged; Biopsy; Comorbidity; Drug Resistance, Neoplasm; Humans; Leukemia, Hairy Cell; Male; N | 2017 |