adenine and Experimental Leukemia studies

adenine and Experimental Leukemia

adenine has been researched along with Experimental Leukemia in 23 studies

Research Excerpts

Excerpt	Relevance	Reference
" Pharmacokinetic experiments with mice showed that the oral bioavailabilities of PMEA following oral gavage of bis(POM)-PMEA, diphenyl-PMEA, or PMEA (at a dose equivalent to 50 mg of PMEA per kg) were 53,3, and 16%, respectively."	1.29	Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine. ( Balzarini, J; Bischofberger, N; De Clercq, E; Naesens, L, 1996)

Research

Studies (23)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (78.26)	18.7374
1990's	4 (17.39)	18.2507
2000's	1 (4.35)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

18 (78.26)

18.7374

1990's

4 (17.39)

18.2507

2000's

1 (4.35)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
LAW, LW	1
RIMAN, J	1
SATO, K	1
LEPAGE, GA	2
Reem, GH	2
Friend, C	2
Müller, MM	1
Kraupp, M	1
Chiba, P	1
Rumpold, H	1
Yoshida, M	1
Hoshi, A	1
Kuretani, K	1
Avramis, VI	1
Plunkett, W	4
Otová, B	2
Sladká, M	2
Votruba, I	2
Holý, A	3
Kren, V	1
Blazek, K	1
Schramlová, J	1
Naesens, L	2
Neyts, J	1
Balzarini, J	2
Rosenberg, I	1
De Clercq, E	2
Bischofberger, N	1
Hakimelahi, GH	1
Ly, TW	1
Moosavi-Movahedi, AA	1
Jain, ML	1
Zakerinia, M	1
Davari, H	1
Mei, HC	1
Sambaiah, T	1
Moshfegh, AA	1
Hakimelahi, S	1
Vengris, VE	1
Pitha, PM	1
Sensenbrenner, LL	1
Alexander, L	2
Chubb, S	2
Loo, TL	2
Fathi-Afshar, R	1
Allen, TM	1
Krueger, CA	1
Cook, DA	1
Clanachan, AS	1
Vriend, R	1
Baer, HP	1
Cass, CE	1
Elton, TS	1
Nissen, MS	1
Reeves, R	1
Fuska, J	1
Fusková, A	1
Proksa, B	1
Bell, JP	1
Faures, ML	1
Kimball, AP	1
Kessel, D	1
Dodd, DC	1
Kreis, W	1
Piepho, SB	1
Bernhard, HV	1

Studies

LAW, LW

RIMAN, J

SATO, K

LEPAGE, GA

Reem, GH

Friend, C

Müller, MM

Kraupp, M

Chiba, P

Rumpold, H

Yoshida, M

Hoshi, A

Kuretani, K

Avramis, VI

Plunkett, W

Otová, B

Sladká, M

Votruba, I

Holý, A

Kren, V

Blazek, K

Schramlová, J

Naesens, L

Neyts, J

Balzarini, J

Rosenberg, I

De Clercq, E

Bischofberger, N

Hakimelahi, GH

Ly, TW

Moosavi-Movahedi, AA

Jain, ML

Zakerinia, M

Davari, H

Mei, HC

Sambaiah, T

Moshfegh, AA

Hakimelahi, S

Vengris, VE

Pitha, PM

Sensenbrenner, LL

Alexander, L

Chubb, S

Loo, TL

Fathi-Afshar, R

Allen, TM

Krueger, CA

Cook, DA

Clanachan, AS

Vriend, R

Baer, HP

Cass, CE

Elton, TS

Nissen, MS

Reeves, R

Fuska, J

Fusková, A

Proksa, B

Bell, JP

Faures, ML

Kimball, AP

Kessel, D

Dodd, DC

Kreis, W

Piepho, SB

Bernhard, HV

Trials

1 trial available for adenine and Experimental Leukemia

Article	Year
Inhibition of adenosine deaminase to increase the antitumor activity of adenine nucleoside analogues. Annals of the New York Academy of Sciences, 1985, Volume: 451 Topics: Adenine; Adenosine Deaminase Inhibitors; Adult; Animals; Carcinoma, Ehrlich Tumor; Clinical Trials a	1985

Article

Year

Inhibition of adenosine deaminase to increase the antitumor activity of adenine nucleoside analogues.

Annals of the New York Academy of Sciences, 1985, Volume: 451

Topics: Adenine; Adenosine Deaminase Inhibitors; Adult; Animals; Carcinoma, Ehrlich Tumor; Clinical Trials a

1985

Other Studies

22 other studies available for adenine and Experimental Leukemia

Article	Year
Resistance in leukemic cells to an adenine antagonist, 6-mercaptopurine. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1953, Volume: 84, Issue:2 Topics: Adenine; Animals; Humans; Leukemia, Experimental; Mercaptopurine; Purines	1953
EXPERIMENTAL VIRAL LEUKAEMIA AS A RHYTHMIC GROWTH PROCESS. II. SYSTEMATIC FLUCTUATION OF THE ADENOSINETRIPHOSPHATE (ATP) CONTENT AND CHANGES IN THE FREE ADENINE NUCLEOTIDE (ATP, ADP, AMP) POOL IN LEUKAEMIC CELLS DURING THE LEUKAEMIC PROCESS. Folia biologica, 1964, Volume: 10 Topics: Adenine; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate	1964
METABOLIC EFFECTS OF AN ANTIBIOTIC, NSC-51954, ON SUSCEPTIBLE AND RESISTANT TUMOR CELLS. Cancer research, 1965, Volume: 25 Topics: Adenine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA; DNA, Neopla	1965
Phosphoribosylamidotransferase: regulation of activity in virus-induced murine leukemia by purine nucleotides. Science (New York, N.Y.), 1967, Sep-08, Volume: 157, Issue:3793 Topics: Adenine; Adenine Nucleotides; Animals; Feedback; Friend murine leukemia virus; Glucosyltransferases;	1967
Regulation of purine uptake in normal and neoplastic cells. Advances in enzyme regulation, 1983, Volume: 21 Topics: 5'-Nucleotidase; Adenine; Adenosine Kinase; Cell Line; Erythrocytes; Granulocytes; Humans; Kinetics;	1983
Inhibition of phosphoribosylation of 5-fluorouracil by purines. Nucleic acids symposium series, 1980, Issue:8 Topics: Adenine; Animals; Fluorouracil; Inosine; Kinetics; Leukemia L5178; Leukemia, Experimental; Mice; Pen	1980
2-fluoro-ATP: a toxic metabolite of 9-beta-D-arabinosyl-2-fluoroadenine. Biochemical and biophysical research communications, 1983, May-31, Volume: 113, Issue:1 Topics: Adenine; Adenosine Triphosphate; Animals; Arabinonucleotides; Cell Line; Chromatography, High Pressu	1983
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats. Folia biologica, 1993, Volume: 39, Issue:3 Topics: Adenine; Animals; Antineoplastic Agents; Leukemia, Experimental; Leukemia, Lymphoid; Male; Organopho	1993
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats. Folia biologica, 1993, Volume: 39, Issue:3 Topics: Adenine; Animals; Antineoplastic Agents; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Experimental; Le	1993
Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice. Journal of medical virology, 1993, Volume: 39, Issue:2 Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cytomegalovirus Infections; Friend murine	1993
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:1 Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Female; Friend murine leukemia virus; Humans; I	1996
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses. Journal of medicinal chemistry, 2001, Oct-25, Volume: 44, Issue:22 Topics: Adenine; Adenine Nucleotides; Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Antivi	2001
Polymeric drugs: direct compared with indirect inhibition of leukemia virus replication in mice. Molecular pharmacology, 1978, Volume: 14, Issue:2 Topics: Adenine; Animals; Depression, Chemical; Female; Friend murine leukemia virus; Hematopoiesis; Immunit	1978
Comparison of the activity of 2'-deoxycoformycin and erythro-9-(2-hydroxy-3-nonyl)adenine in vivo. Biochemical pharmacology, 1979, Volume: 28, Issue:2 Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cells, Cultured; Coformycin; DNA, Neoplasm; Female	1979
Biochemical basis of the increased activity of 9-beta-D-arabinofuranosyladenine in the presence of inhibitors of adenosine deaminase. Cancer research, 1979, Volume: 39, Issue:9 Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Arabinonucleotides; Bone Marrow; Cell Line; Coform	1979
Purine metabolism in murine virus-induced erythroleukemic cells during differentiation in vitro. Proceedings of the National Academy of Sciences of the United States of America, 1975, Volume: 72, Issue:4 Topics: Adenine; Amidophosphoribosyltransferase; Ammonia; Animals; Cell Line; Cell Transformation, Neoplasti	1975
Some pharmacological activities of novel adenine-related compounds isolated from a marine sponge Agelas mauritiana. Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:4 Topics: Adenine; Adenosine; Animals; Aorta; Cell Cycle; Erythrocytes; In Vitro Techniques; Kinetics; Leukemi	1989
Specific A . T DNA sequence binding of RP-HPLC purified HMG-I. Biochemical and biophysical research communications, 1987, Feb-27, Volume: 143, Issue:1 Topics: Adenine; Animals; Base Sequence; Chromatography, High Pressure Liquid; Deoxyribonuclease I; DNA; Hig	1987
New cytotoxic and antitumor agents. VII. Derivatives of 1-benzylidenisoindolin-3-one and 5,6-dihydro-8H-isoquinolo(2,3-a)phthalasin-5-one. Neoplasma, 1985, Volume: 32, Issue:4 Topics: Adenine; Animals; Antineoplastic Agents; Benzylidene Compounds; Cell Division; Chemical Phenomena; C	1985
Immunosuppressive and antitumor activity of periodate oxidation product of beta-D-ribosyl-6-methylthiopurine. Cancer research, 1968, Volume: 28, Issue:4 Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Female; Glycine; Hemagglutination Tests; I	1968
Effects of persantin on several transport systems of murine leukemias. Biochimica et biophysica acta, 1972, Oct-23, Volume: 288, Issue:1 Topics: Adenine; Adenosine; Amino Acids; Animals; Biological Transport; Cell Line; Cyclopentanes; Cytidine;	1972
Studies on the metabolic fate of the C14 labeled methyl group of a methylhydrazine derivative in P815 mouse leukemia. Experientia, 1966, Jul-15, Volume: 22, Issue:7 Topics: Adenine; Alkylation; Animals; Carbon Isotopes; DNA; Formates; Guanine; Hydrazines; Hypoxanthines; Le	1966

Article

Year

Resistance in leukemic cells to an adenine antagonist, 6-mercaptopurine.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1953, Volume: 84, Issue:2

Topics: Adenine; Animals; Humans; Leukemia, Experimental; Mercaptopurine; Purines

1953

EXPERIMENTAL VIRAL LEUKAEMIA AS A RHYTHMIC GROWTH PROCESS. II. SYSTEMATIC FLUCTUATION OF THE ADENOSINETRIPHOSPHATE (ATP) CONTENT AND CHANGES IN THE FREE ADENINE NUCLEOTIDE (ATP, ADP, AMP) POOL IN LEUKAEMIC CELLS DURING THE LEUKAEMIC PROCESS.

Folia biologica, 1964, Volume: 10

Topics: Adenine; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate

1964

METABOLIC EFFECTS OF AN ANTIBIOTIC, NSC-51954, ON SUSCEPTIBLE AND RESISTANT TUMOR CELLS.

Cancer research, 1965, Volume: 25

Topics: Adenine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA; DNA, Neopla

1965

Phosphoribosylamidotransferase: regulation of activity in virus-induced murine leukemia by purine nucleotides.

Science (New York, N.Y.), 1967, Sep-08, Volume: 157, Issue:3793

Topics: Adenine; Adenine Nucleotides; Animals; Feedback; Friend murine leukemia virus; Glucosyltransferases;

1967

Regulation of purine uptake in normal and neoplastic cells.

Advances in enzyme regulation, 1983, Volume: 21

Topics: 5'-Nucleotidase; Adenine; Adenosine Kinase; Cell Line; Erythrocytes; Granulocytes; Humans; Kinetics;

1983

Inhibition of phosphoribosylation of 5-fluorouracil by purines.

Nucleic acids symposium series, 1980, Issue:8

Topics: Adenine; Animals; Fluorouracil; Inosine; Kinetics; Leukemia L5178; Leukemia, Experimental; Mice; Pen

1980

2-fluoro-ATP: a toxic metabolite of 9-beta-D-arabinosyl-2-fluoroadenine.

Biochemical and biophysical research communications, 1983, May-31, Volume: 113, Issue:1

Topics: Adenine; Adenosine Triphosphate; Animals; Arabinonucleotides; Cell Line; Chromatography, High Pressu

1983

Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats.

Folia biologica, 1993, Volume: 39, Issue:3

Topics: Adenine; Animals; Antineoplastic Agents; Leukemia, Experimental; Leukemia, Lymphoid; Male; Organopho

1993

Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats.

Folia biologica, 1993, Volume: 39, Issue:3

Topics: Adenine; Animals; Antineoplastic Agents; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Experimental; Le

1993

Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice.

Journal of medical virology, 1993, Volume: 39, Issue:2

Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cytomegalovirus Infections; Friend murine

1993

Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.

Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:1

Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Female; Friend murine leukemia virus; Humans; I

1996

Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.

Journal of medicinal chemistry, 2001, Oct-25, Volume: 44, Issue:22

Topics: Adenine; Adenine Nucleotides; Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Antivi

2001

Polymeric drugs: direct compared with indirect inhibition of leukemia virus replication in mice.

Molecular pharmacology, 1978, Volume: 14, Issue:2

Topics: Adenine; Animals; Depression, Chemical; Female; Friend murine leukemia virus; Hematopoiesis; Immunit

1978

Comparison of the activity of 2'-deoxycoformycin and erythro-9-(2-hydroxy-3-nonyl)adenine in vivo.

Biochemical pharmacology, 1979, Volume: 28, Issue:2

Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cells, Cultured; Coformycin; DNA, Neoplasm; Female

1979

Biochemical basis of the increased activity of 9-beta-D-arabinofuranosyladenine in the presence of inhibitors of adenosine deaminase.

Cancer research, 1979, Volume: 39, Issue:9

Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Arabinonucleotides; Bone Marrow; Cell Line; Coform

1979

Purine metabolism in murine virus-induced erythroleukemic cells during differentiation in vitro.

Proceedings of the National Academy of Sciences of the United States of America, 1975, Volume: 72, Issue:4

Topics: Adenine; Amidophosphoribosyltransferase; Ammonia; Animals; Cell Line; Cell Transformation, Neoplasti

1975

Some pharmacological activities of novel adenine-related compounds isolated from a marine sponge Agelas mauritiana.

Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:4

Topics: Adenine; Adenosine; Animals; Aorta; Cell Cycle; Erythrocytes; In Vitro Techniques; Kinetics; Leukemi

1989

Specific A . T DNA sequence binding of RP-HPLC purified HMG-I.

Biochemical and biophysical research communications, 1987, Feb-27, Volume: 143, Issue:1

Topics: Adenine; Animals; Base Sequence; Chromatography, High Pressure Liquid; Deoxyribonuclease I; DNA; Hig

1987

New cytotoxic and antitumor agents. VII. Derivatives of 1-benzylidenisoindolin-3-one and 5,6-dihydro-8H-isoquinolo(2,3-a)phthalasin-5-one.

Neoplasma, 1985, Volume: 32, Issue:4

Topics: Adenine; Animals; Antineoplastic Agents; Benzylidene Compounds; Cell Division; Chemical Phenomena; C

1985

Immunosuppressive and antitumor activity of periodate oxidation product of beta-D-ribosyl-6-methylthiopurine.

Cancer research, 1968, Volume: 28, Issue:4

Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Female; Glycine; Hemagglutination Tests; I

1968

Effects of persantin on several transport systems of murine leukemias.

Biochimica et biophysica acta, 1972, Oct-23, Volume: 288, Issue:1

Topics: Adenine; Adenosine; Amino Acids; Animals; Biological Transport; Cell Line; Cyclopentanes; Cytidine;

1972

Studies on the metabolic fate of the C14 labeled methyl group of a methylhydrazine derivative in P815 mouse leukemia.

Experientia, 1966, Jul-15, Volume: 22, Issue:7

Topics: Adenine; Alkylation; Animals; Carbon Isotopes; DNA; Formates; Guanine; Hydrazines; Hypoxanthines; Le

1966