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adenine and EHS Tumor

adenine has been researched along with EHS Tumor in 17 studies

Research Excerpts

ExcerptRelevanceReference
"9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a potent and selective inhibitor of the replication of human immunodeficiency virus (HIV) in vitro in human T-lymphocyte MT-4, H9, and ATH8 cells."3.67Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. ( Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Holy, A; Johns, DG; Naesens, L; Pauwels, R; Rosenberg, I, 1989)
" Pharmacokinetic studies with mice showed that the oral bioavailability of bis(POC)-PMPA (calculated from the curves of the concentration of free PMPA in plasma) was 20%."1.30Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice. ( Annaert, P; Arimilli, MN; Augustijns, P; Bischofberger, N; De Clercq, E; Kim, CU; Naesens, L; Van den Mooter, G, 1998)
" Pharmacokinetic experiments with mice showed that the oral bioavailabilities of PMEA following oral gavage of bis(POM)-PMEA, diphenyl-PMEA, or PMEA (at a dose equivalent to 50 mg of PMEA per kg) were 53,3, and 16%, respectively."1.29Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine. ( Balzarini, J; Bischofberger, N; De Clercq, E; Naesens, L, 1996)
" While the infrequent dosage regimen increased the anti-retrovirus activity of PMEA, it did not increase its toxicity for the host."1.28Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered. ( Balzarini, J; De Clercq, E; Naesens, L, 1990)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19907 (41.18)18.7374
1990's8 (47.06)18.2507
2000's2 (11.76)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
CERECEDO, LR1
SMITH, MJ1
VICENTE, J1
MANOILOV, SE1
KITAVIN, GS1
COMAR, VE1
ORLOVA, EU1
FURTH, JJ1
HO, P1
Balzarini, J8
Schols, D2
Van Laethem, K1
De Clercq, E9
Hocková, D1
Masojidkova, M1
Holý, A5
Zhu, H1
Huang, M1
Yang, F1
Chen, Y1
Miao, ZH1
Qian, XH1
Xu, YF1
Qin, YX1
Luo, HB1
Shen, X1
Geng, MY1
Cai, YJ1
Ding, J1
Otová, B1
Krenová, D1
Zídek, Z1
Votruba, I1
Kren, V1
Naesens, L8
Neyts, J1
Rosenberg, I2
Jindrich, J1
Snoeck, R1
Bischofberger, N2
Augustijns, P1
Annaert, P1
Van den Mooter, G1
Arimilli, MN1
Kim, CU1
Bańkowski, E1
Gindzieński, A1
Pawlicka, E1
Rzeczycki, W1
Sobis, H1
Vandeputte, M1
Herdewijn, P1
Pauwels, R1
Baba, M1
Johns, DG1
Dybing, E1
Fuska, J1
Ivanitskaya, L1
Horáková, K1
Kuhr, I1

Other Studies

17 other studies available for adenine and EHS Tumor

ArticleYear
TUMOR-HOST RELATIONSHIPS STUDIED IN VITRO: EXPERIMENTS WITH TISSUE SLICES.
    Archives of biochemistry and biophysics, 1964, Volume: 108

    Topics: Adenine; Carcinoma 256, Walker; DNA; In Vitro Techniques; Kidney; Liver; Lung; Lymphoma, Non-Hodgkin

1964
ON THE OXIDATIVE PHOSPHORYLATION AND NUCLEIC ACIDS METABOLISM IN SOME ORGANS OF ANIMALS WITH TRANSPLANTABLE TUMOURS.
    Acta - Unio Internationalis Contra Cancrum, 1964, Volume: 20

    Topics: Adenine; Carbohydrate Metabolism; Cytosine; DNA; DNA, Neoplasm; Glycolysis; Guanine; Intestines; Kid

1964
THE ENZYMATIC SYNTHESIS OF RIBONUCLEIC ACID IN ANIMAL TISSUE. I. THE DEOXYRIBONUCLEIC ACID-DIRECTED SYNTHESIS OF RIBONUCLEIC ACID AS CATALYZED BY AN ENZYME OBTAINED FROM BOVINE LYMPHOSARCOMA TISSUE.
    The Journal of biological chemistry, 1965, Volume: 240

    Topics: Adenine; Animals; Catalysis; Cattle; Cytosine; DNA; DNA Replication; DNA, Bacterial; Enzootic Bovine

1965
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.
    The Journal of antimicrobial chemotherapy, 2007, Volume: 59, Issue:1

    Topics: Adenine; Animals; Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV-1; HIV-2; Humans; Mice; Mo

2007
R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:2

    Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Division; Cell Proliferation; Cyt

2007
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). III. Rat and mouse carcinomas and sarcomas.
    Folia biologica, 1993, Volume: 39, Issue:6

    Topics: Adenine; Animals; Antiviral Agents; Carcinoma; Female; Mice; Mice, Inbred C57BL; Organophosphonates;

1993
Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice.
    Journal of medical virology, 1993, Volume: 39, Issue:2

    Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cytomegalovirus Infections; Friend murine

1993
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:2

    Topics: Adenine; Animals; Antimetabolites; Antineoplastic Agents; Antiviral Agents; Cytopathogenic Effect, V

1993
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:1

    Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Female; Friend murine leukemia virus; Humans; I

1996
Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:7

    Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Biological Transport; Caco-2 Cells; Female;

1998
Insoluble collagen of methylcholanthrene induced sarcoma.
    Molecular and cellular biochemistry, 1975, Jul-31, Volume: 8, Issue:1

    Topics: Adenine; Amino Acids; Animals; Carbohydrates; Collagen; Guanine; Methylcholanthrene; Rats; Sarcoma,

1975
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo.
    Antiviral research, 1991, Volume: 16, Issue:1

    Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Cell Transformation, Viral; Drug Ad

1991
Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus.
    International journal of cancer, 1990, Mar-15, Volume: 45, Issue:3

    Topics: Adenine; Animals; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; D

1990
Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered.
    International journal of cancer, 1990, Aug-15, Volume: 46, Issue:2

    Topics: Adenine; Animals; Antiviral Agents; Cell Transformation, Viral; Cytopathogenic Effect, Viral; Dose-R

1990
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:1

    Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; HIV

1989
Cycloheximide inhibition of hypoxanthine transport cultured cells.
    Biochimica et biophysica acta, 1974, Nov-27, Volume: 373, Issue:1

    Topics: Adenine; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Radioisotopes; Carcinoma, Hepa

1974
Letter: The cytotoxic effects of a new antibiotic vermicule.
    The Journal of antibiotics, 1974, Volume: 27, Issue:2

    Topics: Adenine; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Carbon Radioisotopes; Carcinom

1974