adenine has been researched along with EHS Tumor in 17 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a potent and selective inhibitor of the replication of human immunodeficiency virus (HIV) in vitro in human T-lymphocyte MT-4, H9, and ATH8 cells." | 3.67 | Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. ( Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Holy, A; Johns, DG; Naesens, L; Pauwels, R; Rosenberg, I, 1989) |
| " Pharmacokinetic studies with mice showed that the oral bioavailability of bis(POC)-PMPA (calculated from the curves of the concentration of free PMPA in plasma) was 20%." | 1.30 | Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice. ( Annaert, P; Arimilli, MN; Augustijns, P; Bischofberger, N; De Clercq, E; Kim, CU; Naesens, L; Van den Mooter, G, 1998) |
| " Pharmacokinetic experiments with mice showed that the oral bioavailabilities of PMEA following oral gavage of bis(POM)-PMEA, diphenyl-PMEA, or PMEA (at a dose equivalent to 50 mg of PMEA per kg) were 53,3, and 16%, respectively." | 1.29 | Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine. ( Balzarini, J; Bischofberger, N; De Clercq, E; Naesens, L, 1996) |
| " While the infrequent dosage regimen increased the anti-retrovirus activity of PMEA, it did not increase its toxicity for the host." | 1.28 | Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered. ( Balzarini, J; De Clercq, E; Naesens, L, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (41.18) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| CERECEDO, LR | 1 |
| SMITH, MJ | 1 |
| VICENTE, J | 1 |
| MANOILOV, SE | 1 |
| KITAVIN, GS | 1 |
| COMAR, VE | 1 |
| ORLOVA, EU | 1 |
| FURTH, JJ | 1 |
| HO, P | 1 |
| Balzarini, J | 8 |
| Schols, D | 2 |
| Van Laethem, K | 1 |
| De Clercq, E | 9 |
| Hocková, D | 1 |
| Masojidkova, M | 1 |
| Holý, A | 5 |
| Zhu, H | 1 |
| Huang, M | 1 |
| Yang, F | 1 |
| Chen, Y | 1 |
| Miao, ZH | 1 |
| Qian, XH | 1 |
| Xu, YF | 1 |
| Qin, YX | 1 |
| Luo, HB | 1 |
| Shen, X | 1 |
| Geng, MY | 1 |
| Cai, YJ | 1 |
| Ding, J | 1 |
| Otová, B | 1 |
| Krenová, D | 1 |
| Zídek, Z | 1 |
| Votruba, I | 1 |
| Kren, V | 1 |
| Naesens, L | 8 |
| Neyts, J | 1 |
| Rosenberg, I | 2 |
| Jindrich, J | 1 |
| Snoeck, R | 1 |
| Bischofberger, N | 2 |
| Augustijns, P | 1 |
| Annaert, P | 1 |
| Van den Mooter, G | 1 |
| Arimilli, MN | 1 |
| Kim, CU | 1 |
| Bańkowski, E | 1 |
| Gindzieński, A | 1 |
| Pawlicka, E | 1 |
| Rzeczycki, W | 1 |
| Sobis, H | 1 |
| Vandeputte, M | 1 |
| Herdewijn, P | 1 |
| Pauwels, R | 1 |
| Baba, M | 1 |
| Johns, DG | 1 |
| Dybing, E | 1 |
| Fuska, J | 1 |
| Ivanitskaya, L | 1 |
| Horáková, K | 1 |
| Kuhr, I | 1 |
17 other studies available for adenine and EHS Tumor
| Article | Year |
|---|---|
TUMOR-HOST RELATIONSHIPS STUDIED IN VITRO: EXPERIMENTS WITH TISSUE SLICES.
Topics: Adenine; Carcinoma 256, Walker; DNA; In Vitro Techniques; Kidney; Liver; Lung; Lymphoma, Non-Hodgkin | 1964 |
ON THE OXIDATIVE PHOSPHORYLATION AND NUCLEIC ACIDS METABOLISM IN SOME ORGANS OF ANIMALS WITH TRANSPLANTABLE TUMOURS.
Topics: Adenine; Carbohydrate Metabolism; Cytosine; DNA; DNA, Neoplasm; Glycolysis; Guanine; Intestines; Kid | 1964 |
THE ENZYMATIC SYNTHESIS OF RIBONUCLEIC ACID IN ANIMAL TISSUE. I. THE DEOXYRIBONUCLEIC ACID-DIRECTED SYNTHESIS OF RIBONUCLEIC ACID AS CATALYZED BY AN ENZYME OBTAINED FROM BOVINE LYMPHOSARCOMA TISSUE.
Topics: Adenine; Animals; Catalysis; Cattle; Cytosine; DNA; DNA Replication; DNA, Bacterial; Enzootic Bovine | 1965 |
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV-1; HIV-2; Humans; Mice; Mo | 2007 |
R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Division; Cell Proliferation; Cyt | 2007 |
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). III. Rat and mouse carcinomas and sarcomas.
Topics: Adenine; Animals; Antiviral Agents; Carcinoma; Female; Mice; Mice, Inbred C57BL; Organophosphonates; | 1993 |
Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cytomegalovirus Infections; Friend murine | 1993 |
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.
Topics: Adenine; Animals; Antimetabolites; Antineoplastic Agents; Antiviral Agents; Cytopathogenic Effect, V | 1993 |
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Female; Friend murine leukemia virus; Humans; I | 1996 |
Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice.
Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Biological Transport; Caco-2 Cells; Female; | 1998 |
Insoluble collagen of methylcholanthrene induced sarcoma.
Topics: Adenine; Amino Acids; Animals; Carbohydrates; Collagen; Guanine; Methylcholanthrene; Rats; Sarcoma, | 1975 |
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo.
Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Cell Transformation, Viral; Drug Ad | 1991 |
Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus.
Topics: Adenine; Animals; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; D | 1990 |
Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered.
Topics: Adenine; Animals; Antiviral Agents; Cell Transformation, Viral; Cytopathogenic Effect, Viral; Dose-R | 1990 |
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; HIV | 1989 |
Cycloheximide inhibition of hypoxanthine transport cultured cells.
Topics: Adenine; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Radioisotopes; Carcinoma, Hepa | 1974 |
Letter: The cytotoxic effects of a new antibiotic vermicule.
Topics: Adenine; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Carbon Radioisotopes; Carcinom | 1974 |