adenine has been researched along with Dysplastic Nevus Syndrome, Hereditary in 3 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " In search of such a drug, we examined the efficacy of graveoline, a bioactive compound isolated from Ruta graveolens on skin melanoma A375 cells through the use of specific signaling cascades and their inhibitors." | 7.80 | Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. ( Bishayee, K; Ghosh, S; Khuda-Bukhsh, AR, 2014) |
| " In search of such a drug, we examined the efficacy of graveoline, a bioactive compound isolated from Ruta graveolens on skin melanoma A375 cells through the use of specific signaling cascades and their inhibitors." | 3.80 | Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. ( Bishayee, K; Ghosh, S; Khuda-Bukhsh, AR, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, S | 1 |
| Wang, X | 1 |
| Song, J | 1 |
| Jin, G | 1 |
| Moschos, SJ | 1 |
| Eroglu, Z | 1 |
| Khushalani, NI | 1 |
| Kendra, KL | 1 |
| Ansstas, G | 1 |
| In, GK | 1 |
| Wang, P | 1 |
| Liu, G | 1 |
| Collichio, FA | 1 |
| Googe, PB | 1 |
| Carson, CC | 1 |
| McKinnon, K | 1 |
| Wang, HH | 1 |
| Nikolaishvilli-Feinberg, N | 1 |
| Ivanova, A | 1 |
| Arrowood, CC | 1 |
| Garrett-Mead, N | 1 |
| Conway, KC | 1 |
| Edmiston, SN | 1 |
| Ollila, DW | 1 |
| Serody, JS | 1 |
| Thomas, NE | 1 |
| Ivy, SP | 1 |
| Agrawal, L | 1 |
| Dees, EC | 1 |
| Abbruzzese, JL | 1 |
| Ghosh, S | 1 |
| Bishayee, K | 1 |
| Khuda-Bukhsh, AR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2 Study of Ibrutinib (PCI-32765) in Refractory Distant Metastatic Cutaneous Melanoma: Correlation of Biomarkers With Response and Resistance[NCT02581930] | Phase 2 | 18 participants (Actual) | Interventional | 2016-08-17 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Antitumor response defined as the sum of complete response (CR) and partial response (PR). CR is the disappearance of all target lesions. Any pathological lymph nodes (whether target or non-target) must have reduction in short axis to <10 mm (<1 cm). PR is at least a 30% decrease in the sum of the diameters of target lesions, taking as reference the baseline sum diameters. (NCT02581930)
Timeframe: 1 year
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment (Ibrutinib) | 0 |
Estimated using the Kaplan Meier method. (NCT02581930)
Timeframe: Duration of time from day 1 of treatment to death as a result of any cause, assessed up to 1 year
| Intervention | months (Median) |
|---|---|
| Treatment (Ibrutinib) | 6 |
Progression free survival (PFS) is defined as the duration of time from Day 1 of treatment to time of progression (based on clinical or radiographic grounds) or death as a result of any cause, whichever occurs first. (NCT02581930)
Timeframe: 1 year
| Intervention | months (Median) |
|---|---|
| Treatment (Ibrutinib) | 1.3 |
1 trial available for adenine and Dysplastic Nevus Syndrome, Hereditary
| Article | Year |
|---|---|
Targeting the IL-2 inducible kinase in melanoma; a phase 2 study of ibrutinib in systemic treatment-refractory distant metastatic cutaneous melanoma: preclinical rationale, biology, and clinical activity (NCI9922).
Topics: Adenine; Adult; Aged; Aged, 80 and over; Female; Humans; Interleukin-2; Male; Melanoma; Melanoma, Cu | 2021 |
2 other studies available for adenine and Dysplastic Nevus Syndrome, Hereditary
| Article | Year |
|---|---|
Discovery of novel ibrutinib analogues to treat malignant melanoma.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell P | 2021 |
Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Humans; Me | 2014 |