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adenine and Deficiency, Mental

adenine has been researched along with Deficiency, Mental in 18 studies

Research Excerpts

ExcerptRelevanceReference
"Activity of hypoxanthine-guanine and adenine phosphoribosyl transferase enzymes has been assayed in erythrocytes from 10 normal adults, 37 subjects with gout, and 21 mentally retarded children with high and normal urinary uric acid:creatinine ratios."3.65Phosphoribosyl transferase activity in normal subjects, gout patients, and children with mental retardation. ( Davison, AN; Eyre, C; Scott, JT, 1971)
"A sex-linked familial neurological disease consisting of cerebral palsy, mental retardation, choreoathetosis, and compulsive aggressive behavior is associated with a loss of an enzyme that participates in purine metabolism, namely, hypoxanthine-guanine phosphoribosyltransferase."3.64Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis. ( Kelley, WN; Rosenbloom, FM; Seegmiller, JE, 1967)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199017 (94.44)18.7374
1990's1 (5.56)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Seegmiller, JE4
Rosenbloom, FM2
Kelley, WN2
Micheli, V1
Pescaglini, M1
Rocchigiani, M1
Sestini, S1
Jacomelli, G1
Hayek, G1
Pompucci, G1
Fraser, JH1
Meyers, H1
Henderson, JF2
Brox, LW1
McCoy, EE1
van der Zee, SP3
Schretlen, ED3
Monnens, LA1
Boyle, JA2
Green, ML1
Wood, MH1
Fox, RM1
Vincent, L1
Reye, C1
O'Sullivan, WJ1
Sweetman, L3
Nyhan, WL4
Lommen, EJ2
Vogels, GD1
Trijbels, JM2
Dancis, J1
Cox, RP1
Berman, PH1
Jansen, V1
Balis, ME1
Raivio, KO1
Astrin, KH1
Schulman, JD1
Graf, ML1
Jacobsen, CB1
Frost, P1
Weinstein, GD1
Chow, DC1
Kawahara, FS1
Saunders, T1
Sorensen, LB1
Eyre, C1
Davison, AN1
Scott, JT1
Caldwell, IC1
James, JA1
Teberg, AJ1
Nelson, LG1
Watts, RW1

Other Studies

18 other studies available for adenine and Deficiency, Mental

ArticleYear
Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis.
    Science (New York, N.Y.), 1967, Mar-31, Volume: 155, Issue:3770

    Topics: Adenine; Adenine Nucleotides; Adolescent; Adult; Aggression; Athetosis; Azathioprine; Cerebral Palsy

1967
Altered pyridine metabolism in the erythrocytes of a mentally retarded infant with partial HPRT deficiency.
    Advances in experimental medicine and biology, 1994, Volume: 370

    Topics: Adenine; Carbon Radioisotopes; Child; Erythrocytes; Humans; Hypoxanthine; Hypoxanthine Phosphoribosy

1994
Individual variation in inosine triphosphate accumulation in human erythrocytes.
    Clinical biochemistry, 1975, Volume: 8, Issue:6

    Topics: Adenine; Adolescent; Adult; Child; Child, Preschool; Erythrocytes; Female; Guanine; Humans; Hypoxant

1975
Megaloblastic anaemia in the Lesch-Nyhan syndrome.
    Lancet (London, England), 1968, Jun-29, Volume: 1, Issue:7557

    Topics: Adenine; Anemia, Macrocytic; Cerebral Palsy; Child; Humans; Intellectual Disability; Male; Movement

1968
Substrate stabilization: genetically-controlled reciprocal relationship between two enzymes.
    Annals of the rheumatic diseases, 1971, Volume: 30, Issue:3

    Topics: Adenine; Athetosis; Diphosphates; Erythrocytes; Humans; Hypoxanthines; Intellectual Disability; Lesc

1971
The Lesch-Nyhan syndrome: report of three cases.
    Australian and New Zealand journal of medicine, 1972, Volume: 2, Issue:1

    Topics: Adenine; Adolescent; Adult; Allopurinol; Athetosis; Australia; Child; Humans; Hypoxanthines; Intelle

1972
Further studies of the enzyme composition of mutant cells in X-linked uric aciduria.
    Archives of internal medicine, 1972, Volume: 130, Issue:2

    Topics: Adenine; Athetosis; Erythrocytes; Fibroblasts; Guanine; Humans; Hypoxanthines; Inosine; Intellectual

1972
Concentration of purine nucleotides in erythrocytes of patients with the Lesch-Nyhan syndrome before and during oral administration of adenine.
    Acta paediatrica Scandinavica, 1971, Volume: 60, Issue:6

    Topics: Adenine; Athetosis; Chemical Precipitation; Child; Child, Preschool; Erythrocytes; Hematocrit; Human

1971
Detailed comparison of the urinary excretion of purines in a patient with the Lesch-Nyhan syndrome and a control subject.
    Biochemical medicine, 1970, Volume: 4, Issue:2

    Topics: Adenine; Adenosine; Athetosis; Child; Chromatography, Gel; Chromatography, Ion Exchange; Formamides;

1970
Cell population density and phenotypic expression of tissue culture fibroblasts from heterozygotes of Lesch-Nyhan's disease (inosinate pyrophosphorylase deficiency).
    Biochemical genetics, 1969, Volume: 3, Issue:6

    Topics: Adenine; Autoradiography; Cell Line; Culture Techniques; Female; Fibroblasts; Heterozygote; Humans;

1969
The influence of adenine on the clinical features and purine metabolism in the Lesch-Nyhan syndrome.
    Acta paediatrica Scandinavica, 1970, Volume: 59, Issue:3

    Topics: Adenine; Allopurinol; Athetosis; Bone Marrow; Carbon Isotopes; Child; Child, Preschool; Chorea; Comp

1970
Lesch-Nyhan syndrome: preventive control by prenatal diagnosis.
    Science (New York, N.Y.), 1970, Aug-14, Volume: 169, Issue:3946

    Topics: Adenine; Amniotic Fluid; Athetosis; Autoradiography; Basal Ganglia; Carbon Isotopes; Cerebellum; Cer

1970
Diagnosis of Lesch-Nyhan syndrome by direct study of skin specimens.
    JAMA, 1970, Apr-13, Volume: 212, Issue:2

    Topics: Adenine; Adolescent; Adult; Aged; Child; Clinical Enzyme Tests; Erythrocytes; Female; Fibroblasts; G

1970
A new assay method for hypoxanthine-guanine phosphoribosyltransferase.
    The Journal of laboratory and clinical medicine, 1970, Volume: 76, Issue:5

    Topics: Adenine; Adenine Nucleotides; Athetosis; Carbon Isotopes; Chorea; Chromatography; Compulsive Behavio

1970
Phosphoribosyl transferase activity in normal subjects, gout patients, and children with mental retardation.
    Journal of neurology, neurosurgery, and psychiatry, 1971, Volume: 34, Issue:1

    Topics: Adenine; Adolescent; Adult; Child; Child, Preschool; Creatinine; Erythrocytes; Female; Gout; Guanine

1971
Biochemical bases of accelerated purine biosynthesis de novo in human fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase.
    The Journal of biological chemistry, 1968, Mar-25, Volume: 243, Issue:6

    Topics: Adenine; Adenine Nucleotides; Adolescent; Adult; Athetosis; Biopsy; Carbon Isotopes; Child; Child, P

1968
A new disorder of purine metabolism with behavioral manifestations.
    The Journal of pediatrics, 1969, Volume: 74, Issue:1

    Topics: Adenine; Allopurinol; Autistic Disorder; Carbon Isotopes; Child Behavior Disorders; Child, Preschool

1969
Hyperuricaemia: some biochemical aspects.
    Proceedings of the Royal Society of Medicine, 1969, Volume: 62, Issue:8

    Topics: Adenine; Carbon Isotopes; Glycine; Humans; In Vitro Techniques; Intellectual Disability; Metabolic D

1969