Page last updated: 2024-10-16

adenine and Cytomegalovirus

adenine has been researched along with Cytomegalovirus in 43 studies

Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.

Research Excerpts

ExcerptRelevanceReference
"PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir] has shown anti-cytomegalovirus activity in animal models and in preliminary human trials."7.69In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir). ( Chen, MS; Cherrington, JM; Flores, C; Fuller, MD; Mendel, DB; Moon, K; Mulato, AS; Xiong, X, 1997)
" In this study, we evaluated the antiherpesvirus activity of oxetanocin A and its derivatives and found that 9-(2-deoxy-2-hydroxymethyl-beta-D-erythro-oxetanosyl)guanine (OXT-G) was very potent and selective in inhibiting the replication of human cytomegalovirus (HCMV) in vitro."7.67Selective inhibition of human cytomegalovirus replication by a novel nucleoside, oxetanocin G. ( Nishiyama, Y; Shimada, N; Takahash, K; Yamamoto, N, 1988)
" However, (S)-HPMPA is not orally bioavailable and has not been developed for clinical use."5.33Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses. ( Beadle, JR; Ciesla, SL; Hartline, C; Hostetler, KY; Keith, KA; Kern, ER; Wan, WB, 2006)
"A number of new nucleoside analogues with a Z- or E-methylenecyclopropane structure exhibited significant activity against human and murine cytomegaloviruses (HCMV, MCMV) in tissue culture that was generally comparable to, or greater than, 9-[(1-3-dihydroxy-2-propoxy)methyl]guanine (ganciclovir, GCV)."3.70Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides. ( Hartline, CB; Kern, ER; Qiu, YL; Rybak, RJ; Zemlicka, J, 1999)
"The Lesch-Nyhan syndrome is an X-linked disorder caused by a virtually complete absence of the key enzyme of purine recycling, hypoxanthine-guanine phosphoribosyltransferase (HPRT)."3.70Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium. ( Bain, D; Castro, MG; Fairbanks, LD; Larregina, AT; Löwenstein, PR; Morelli, AE; Simmonds, HA; Southgate, TD, 1999)
"Drug-resistant human cytomegalovirus (HCMV) strains were selected in human embryonic lung (HEL) fibroblasts under pressure of the (S)-3-hydroxy-2-phosphonylmethoxypropyl (HPMP) derivatives of cytosine (HPMPC) and adenine (HPMPA), the 2-phosphonylmethoxyethyl (PME) derivative of 2,6-diaminopurine (PMEDAP), ganciclovir (GCV), acyclovir (ACV), and foscarnet (PFA)."3.69Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro. ( Andrei, G; De Clercq, E; Snoeck, R, 1996)
"PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir] has shown anti-cytomegalovirus activity in animal models and in preliminary human trials."3.69In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir). ( Chen, MS; Cherrington, JM; Flores, C; Fuller, MD; Mendel, DB; Moon, K; Mulato, AS; Xiong, X, 1997)
"Phosphonylmethoxyalkylpurines and -pyrimidines, particularly (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and their cyclic forms (cHPMPC, cHPMPA) and the 3-deaza analogue of HPMPA (HPMPc3A) are selective and potent inhibitors of human cytomegalovirus (CMV) replication in vitro."3.68Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique. ( Andrei, G; De Clercq, E; Neyts, J; Schols, D; Snoeck, R, 1991)
" In this study, we evaluated the antiherpesvirus activity of oxetanocin A and its derivatives and found that 9-(2-deoxy-2-hydroxymethyl-beta-D-erythro-oxetanosyl)guanine (OXT-G) was very potent and selective in inhibiting the replication of human cytomegalovirus (HCMV) in vitro."3.67Selective inhibition of human cytomegalovirus replication by a novel nucleoside, oxetanocin G. ( Nishiyama, Y; Shimada, N; Takahash, K; Yamamoto, N, 1988)
"Adefovir dipivoxil is a novel nucleotide analogue with several promising in vitro anti-human immunodeficiency virus (HIV) characteristics."2.68The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial. ( Cherrington, JM; Collier, A; Deeks, SG; Drew, WL; Hellmann, N; Jaffe, HS; Kahn, J; Lalezari, J; Lamy, PD; Li, W; Mulato, AS; Pavia, A; Rodrigue, D; Toole, J, 1997)
" The most advantageous pharmacokinetic profile and the best oral bioavailability were found in tyrosinebased prodrugs."2.55Amino Acid Ester Prodrugs of Nucleoside and Nucleotide Antivirals. ( Krecmerova, M, 2017)
" (l)-Tyr-NH-i-Bu cHPMPA (11) was converted in rat or mouse plasma solely to two active metabolites and had significantly enhanced oral bioavailability vs parent drug 1 in a mouse model (39% vs <5%)."1.37Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies. ( Borysko, KZ; Breitenbach, JM; Collins, M; Drach, JC; Hilfinger, JM; Kashemirov, BA; Krylov, IS; McKenna, CE; Peterson, LW; Serpi, M; Zakharova, VM, 2011)
" However, (S)-HPMPA is not orally bioavailable and has not been developed for clinical use."1.33Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses. ( Beadle, JR; Ciesla, SL; Hartline, C; Hostetler, KY; Keith, KA; Kern, ER; Wan, WB, 2006)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19905 (11.63)18.7374
1990's19 (44.19)18.2507
2000's10 (23.26)29.6817
2010's7 (16.28)24.3611
2020's2 (4.65)2.80

Authors

AuthorsStudies
Zhang, ZJ1
Dong, SW1
Gao, DD1
Du, XY1
Xie, YQ1
Xia, XS1
Li, RT1
Solano de la Asunción, C1
Terol, MJ1
Saus, A1
Olea, B1
Giménez, E1
Albert, E1
López-Jiménez, J1
Andreu, R1
García, D1
Fox, L1
Remigia, MJ1
Amat, P1
Solano, C1
Navarro, D1
Luo, M1
Groaz, E1
Andrei, G7
Snoeck, R7
Kalkeri, R1
Ptak, RG2
Hartman, T1
Buckheit, RW1
Schols, D3
De Jonghe, S1
Herdewijn, P1
Kokosza, K1
Piotrowska, DG1
Liu, C1
Chen, Q1
Schneller, SW1
Krecmerova, M2
Tichý, T1
Dračínský, M1
Holý, A3
Balzarini, J3
Zakharova, VM1
Serpi, M1
Krylov, IS1
Peterson, LW1
Breitenbach, JM2
Borysko, KZ1
Drach, JC5
Collins, M1
Hilfinger, JM1
Kashemirov, BA1
McKenna, CE1
Ang, BC1
Teoh, SC1
Baldanti, F1
Sarasini, A1
Zemlicka, J5
Gerna, G1
Lee, JY1
Oh, CH1
Ko, OH1
Hong, JH2
HENSON, D1
PINKERTON, H1
Kwak, EY1
Park, Y1
Choi, BG1
Scott, GM1
Ng, HL1
Morton, CJ1
Parker, MW1
Rawlinson, WD1
De Clercq, E9
Beadle, JR3
Wan, WB2
Ciesla, SL1
Keith, KA1
Hartline, C1
Kern, ER5
Hostetler, KY3
Horejsí, K1
Pohl, R1
Zhou, S2
Gullen, E2
Cheng, YC2
Tamiya, S1
Mitsuya, H1
Tammewar, AM1
Cheng, L1
Falkenstein, I1
Barron, EC1
Kozak, I1
Freeman, WR1
Quenelle, DC1
Collins, DJ1
Pettway, LR1
Hartline, CB2
Neyts, J3
Sato, Y1
Maruyama, T2
Ma, TW1
Min, JM1
Zhang, LH1
Stals, F1
Bruggeman, C1
Dvoráková, H1
Jindrich, J1
Masojídková, M1
Budĕsínský, M1
Deeks, SG1
Collier, A1
Lalezari, J1
Pavia, A1
Rodrigue, D1
Drew, WL1
Toole, J1
Jaffe, HS1
Mulato, AS2
Lamy, PD1
Li, W1
Cherrington, JM2
Hellmann, N1
Kahn, J1
Xiong, X1
Flores, C1
Fuller, MD1
Mendel, DB1
Moon, K1
Chen, MS1
Qiu, YL2
Hempel, A1
Camerman, N1
Camerman, A1
Geiser, F1
Kira, T1
Li, L1
Gammon, RR1
Avery, N1
Mintz, PD1
Rybak, RJ1
Southgate, TD1
Bain, D1
Fairbanks, LD1
Morelli, AE1
Larregina, AT1
Simmonds, HA1
Castro, MG1
Löwenstein, PR1
Starrett, JE1
Tortolani, DR1
Hitchcock, MJ1
Martin, JC2
Mansuri, MM1
Shigeta, S1
Konno, K1
Baba, M1
Yokota, T1
Kim, CU1
Luh, BY1
Lagneaux, L1
Delforge, A1
Bron, D1
Van der Auwera, P1
Stryckmans, P1
Nishiyama, Y2
Yamamoto, N2
Yamada, Y1
Fujioka, H1
Shimada, N2
Takahashi, K1
Takahash, K1
Fiala, M1
Chow, AW1
Miyasaki, K1
Guze, LB1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Safety and Pharmacokinetics of Single Oral Doses of MBX-400 in Healthy Volunteers[NCT01433835]Phase 148 participants (Actual)Interventional2011-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for adenine and Cytomegalovirus

ArticleYear
Amino Acid Ester Prodrugs of Nucleoside and Nucleotide Antivirals.
    Mini reviews in medicinal chemistry, 2017, Volume: 17, Issue:10

    Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; Humans; Nucle

2017

Trials

1 trial available for adenine and Cytomegalovirus

ArticleYear
The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial.
    The Journal of infectious diseases, 1997, Volume: 176, Issue:6

    Topics: Adenine; Administration, Oral; Adult; Anti-HIV Agents; Carnitine; CD4 Lymphocyte Count; Cytomegalovi

1997

Other Studies

41 other studies available for adenine and Cytomegalovirus

ArticleYear
Unusual matrine-adenine hybrids isolated from Sophora davidii and their inhibitory effects on human cytomegalovirus.
    Phytochemistry, 2021, Volume: 190

    Topics: Adenine; Alkaloids; Cytomegalovirus; Humans; Matrines; Molecular Structure; Quinolizines; Sophora

2021
Cytomegalovirus-specific T-cell immunity and DNAemia in patients with chronic lymphocytic leukaemia undergoing treatment with ibrutinib.
    British journal of haematology, 2021, Volume: 195, Issue:4

    Topics: Adenine; Aged; Aged, 80 and over; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytomegalo

2021
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
    Journal of medicinal chemistry, 2017, 07-27, Volume: 60, Issue:14

    Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Aspartic Acid; Cell Line; Cytomegalovirus; Drug Resistan

2017
Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
    Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13

    Topics: Acrylamides; Adenine; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Cell Survival; Cycl

2015
Enantiomeric 3-deaza-1',6'-isoneplanocin and its 3-bromo analogue: Synthesis by the Ullmann reaction and their antiviral properties.
    Bioorganic & medicinal chemistry letters, 2016, Feb-01, Volume: 26, Issue:3

    Topics: Adenine; Adenosine; Adenosylhomocysteinase; Antiviral Agents; Cytomegalovirus; Ebolavirus; Humans; M

2016
New prodrugs of Adefovir and Cidofovir.
    Bioorganic & medicinal chemistry, 2011, Jun-01, Volume: 19, Issue:11

    Topics: Adenine; Animals; Antiviral Agents; Cell Line, Tumor; Cidofovir; Cytomegalovirus; Cytosine; Herpesvi

2011
Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
    Journal of medicinal chemistry, 2011, Aug-25, Volume: 54, Issue:16

    Topics: Adenine; Animals; Antiviral Agents; Area Under Curve; Biological Availability; Cell Line, Tumor; Cel

2011
Case report of cytomegalovirus retinitis in an HIV-positive patient with a CD4-count nadir of 254 cells per μl.
    Eye (London, England), 2012, Volume: 26, Issue:8

    Topics: Adenine; Administration, Oral; Adult; Alkynes; Anti-HIV Agents; Aqueous Humor; Benzoxazines; CD4 Lym

2012
Z-isomers of 2-hydroxymethylcyclopropylidenemethyl adenine (synadenol) and guanine (synguanol) are active against ganciclovir- and foscarnet-resistant human cytomegalovirus UL97 mutants.
    Antiviral research, 2002, Volume: 56, Issue:3

    Topics: Adenine; Antiviral Agents; Cyclopropanes; Cytomegalovirus; Cytomegalovirus Infections; Drug Resistan

2002
Synthesis and anti-HCMV activity of novel acyclic nucleosides.
    Nucleosides, nucleotides & nucleic acids, 2002, Volume: 21, Issue:10

    Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Cytosine; Humans; Lactose; Microbial Sensitiv

2002
EFFECT OF AMINOPTERIN ON THE REPLICATION OF THE MURINE SALIVARY GLAND VIRUS.
    Nature, 1964, Apr-25, Volume: 202

    Topics: Adenine; Aminopterin; Animals; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; DNA Re

1964
Synthesis and antiviral activity of novel C-methyl branched cyclopropyl nucleosides.
    Archives of pharmacal research, 2003, Volume: 26, Issue:9

    Topics: Adenine; Antiviral Agents; Crystallography, X-Ray; Cyclization; Cyclopropanes; Cytomegalovirus; Cyto

2003
Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus.
    The Journal of general virology, 2005, Volume: 86, Issue:Pt 8

    Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; DNA-Directed DN

2005
Inhibition of the replication of DNA viruses by phosphonylmethoxyalkyl-purines and -pyrimidines.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; DNA Viruses; Organophosphonates; Si

1989
Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.
    Journal of medicinal chemistry, 2006, Mar-23, Volume: 49, Issue:6

    Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Esters; Humans; Organophosphonates; Orthopoxv

2006
Tricyclic etheno analogs of PMEG and PMEDAP: synthesis and biological activity.
    Bioorganic & medicinal chemistry, 2006, Dec-01, Volume: 14, Issue:23

    Topics: Adenine; Antiviral Agents; Cell Proliferation; Cytomegalovirus; Guanine; Herpesvirus 3, Human; Human

2006
9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.
    Journal of medicinal chemistry, 2006, Oct-05, Volume: 49, Issue:20

    Topics: Adenine; Adenosine Deaminase; Antiviral Agents; Cyclopropanes; Cytomegalovirus; Cytopathogenic Effec

2006
Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines.
    Nucleosides, nucleotides & nucleic acids, 2007, Volume: 26, Issue:3

    Topics: Adenine; Antiviral Agents; Bromine; Chemistry, Pharmaceutical; Cyclopropanes; Cytomegalovirus; Cytom

2007
Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2007, Volume: 23, Issue:5

    Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cytomegalovirus; Cytomegalovirus Retinitis; Delayed-A

2007
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
    Antiviral research, 2008, Volume: 79, Issue:2

    Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegaloviru

2008
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity.
    Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1994, Volume: 56, Issue:6

    Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine

1994
Synthesis and antiviral activity of 3'-fluorocarbocyclic oxetanocin A.
    Chemical & pharmaceutical bulletin, 1995, Volume: 43, Issue:1

    Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cytomegalovirus; Herpesvirus 1, Human; Herpesvirus 2,

1995
Synthesis of galactosyl phosphate diester derivatives of nucleosides.
    Carbohydrate research, 1994, May-05, Volume: 257, Issue:2

    Topics: Adenine; Antiviral Agents; Cytomegalovirus; Cytosine; HIV; Humans; Indicators and Reagents; Magnetic

1994
Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1993, Volume: 12, Issue:6

    Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; DN

1993
Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity.
    Journal of medicinal chemistry, 1996, Sep-27, Volume: 39, Issue:20

    Topics: 3T3 Cells; Adenine; Animals; Antiviral Agents; Cell Transformation, Viral; Cytomegalovirus; Cytopath

1996
Synthesis of carbocyclic oxetanocin analogs bearing fluorine and their antiviral activities.
    Nucleic acids symposium series, 1995, Issue:34

    Topics: Adenine; Antiviral Agents; Cytomegalovirus; Fluorine; Herpesvirus 1, Human; Herpesvirus 2, Human; Hu

1995
Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1996, Volume: 15, Issue:7

    Topics: Acyclovir; Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytarabine; Cytomegalovirus; Cytom

1996
In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir).
    Antiviral research, 1997, Volume: 36, Issue:2

    Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; HeLa Cells; Humans; Organophosphonates

1997
(R)-(-)- and (S)-(+)-Synadenol: synthesis, absolute configuration, and enantioselectivity of antiviral effect.
    Journal of medicinal chemistry, 1998, Dec-17, Volume: 41, Issue:26

    Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Chlorocebus aethiops; Chromatography, High Pres

1998
Evaluation of CAPTURE CMV solid phase testing over the allowable shelf-life of red blood cells (adenine-saline added).
    Transfusion science, 1998, Volume: 19, Issue:3

    Topics: Adenine; Antibodies, Viral; Antibody Specificity; Anticoagulants; Antigen-Antibody Reactions; Blood

1998
Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides.
    Antiviral research, 1999, Volume: 43, Issue:3

    Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cells, Cultured; Cyclopropanes; Cytomegalo

1999
Adefovir dipivoxil. Bis-POM PMEA, GS 0840, GS 840, Piv2PMEA.
    Drugs in R&D, 1999, Volume: 2, Issue:5

    Topics: Adenine; Animals; Anti-HIV Agents; Biological Availability; Cytomegalovirus; Cytomegalovirus Infecti

1999
Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium.
    Metabolic brain disease, 1999, Volume: 14, Issue:4

    Topics: Adenine; Adenoviridae; Animals; Carbon Radioisotopes; Cell Survival; Cells, Cultured; Culture Media;

1999
Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.
    Antiviral research, 1992, Volume: 19, Issue:3

    Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Drug Evaluation, Preclinical; HIV; Humans; Or

1992
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique.
    Antiviral research, 1991, Volume: 16, Issue:1

    Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytomegalovirus; Cytosine; Flow Cytometry; Ganciclo

1991
Comparative inhibitory effects of nucleoside analogues on different clinical isolates of human cytomegalovirus in vitro.
    The Journal of infectious diseases, 1991, Volume: 163, Issue:2

    Topics: Adenine; Adenosine; Antiviral Agents; Cell Line; Cidofovir; Cytidine; Cytomegalovirus; Cytosine; Gan

1991
Synthesis and antiviral activity of (S)-9-[4-hydroxy-3-(phosphonomethoxy)butyl]guanine.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:6

    Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; Guanine; Organophosphonates; Organo

1990
Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1990, Volume: 9, Issue:8

    Topics: Adenine; Adult; Antiviral Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cidofovir; Cytome

1990
Efficacy of oxetanocin G against herpes simplex virus type 2 and murine cytomegalovirus infections in mice.
    The Journal of antibiotics, 1989, Volume: 42, Issue:8

    Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; Disease

1989
Selective inhibition of human cytomegalovirus replication by a novel nucleoside, oxetanocin G.
    Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:7

    Topics: Adenine; Antiviral Agents; Cell Cycle; Cytomegalovirus; DNA, Viral; Fibroblasts; Guanine; Humans; Si

1988
Susceptibility of herpesviruses to three nucleoside analogues and their combinations and enhancement of the antiviral effect of acid pH.
    The Journal of infectious diseases, 1974, Volume: 129, Issue:1

    Topics: Adenine; Antiviral Agents; Cell Migration Inhibition; Cells, Cultured; Cytarabine; Cytomegalovirus;

1974