adenine has been researched along with Cytomegalovirus in 43 studies
Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir] has shown anti-cytomegalovirus activity in animal models and in preliminary human trials." | 7.69 | In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir). ( Chen, MS; Cherrington, JM; Flores, C; Fuller, MD; Mendel, DB; Moon, K; Mulato, AS; Xiong, X, 1997) |
| " In this study, we evaluated the antiherpesvirus activity of oxetanocin A and its derivatives and found that 9-(2-deoxy-2-hydroxymethyl-beta-D-erythro-oxetanosyl)guanine (OXT-G) was very potent and selective in inhibiting the replication of human cytomegalovirus (HCMV) in vitro." | 7.67 | Selective inhibition of human cytomegalovirus replication by a novel nucleoside, oxetanocin G. ( Nishiyama, Y; Shimada, N; Takahash, K; Yamamoto, N, 1988) |
| " However, (S)-HPMPA is not orally bioavailable and has not been developed for clinical use." | 5.33 | Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses. ( Beadle, JR; Ciesla, SL; Hartline, C; Hostetler, KY; Keith, KA; Kern, ER; Wan, WB, 2006) |
| "A number of new nucleoside analogues with a Z- or E-methylenecyclopropane structure exhibited significant activity against human and murine cytomegaloviruses (HCMV, MCMV) in tissue culture that was generally comparable to, or greater than, 9-[(1-3-dihydroxy-2-propoxy)methyl]guanine (ganciclovir, GCV)." | 3.70 | Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides. ( Hartline, CB; Kern, ER; Qiu, YL; Rybak, RJ; Zemlicka, J, 1999) |
| "The Lesch-Nyhan syndrome is an X-linked disorder caused by a virtually complete absence of the key enzyme of purine recycling, hypoxanthine-guanine phosphoribosyltransferase (HPRT)." | 3.70 | Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium. ( Bain, D; Castro, MG; Fairbanks, LD; Larregina, AT; Löwenstein, PR; Morelli, AE; Simmonds, HA; Southgate, TD, 1999) |
| "Drug-resistant human cytomegalovirus (HCMV) strains were selected in human embryonic lung (HEL) fibroblasts under pressure of the (S)-3-hydroxy-2-phosphonylmethoxypropyl (HPMP) derivatives of cytosine (HPMPC) and adenine (HPMPA), the 2-phosphonylmethoxyethyl (PME) derivative of 2,6-diaminopurine (PMEDAP), ganciclovir (GCV), acyclovir (ACV), and foscarnet (PFA)." | 3.69 | Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro. ( Andrei, G; De Clercq, E; Snoeck, R, 1996) |
| "PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir] has shown anti-cytomegalovirus activity in animal models and in preliminary human trials." | 3.69 | In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir). ( Chen, MS; Cherrington, JM; Flores, C; Fuller, MD; Mendel, DB; Moon, K; Mulato, AS; Xiong, X, 1997) |
| "Phosphonylmethoxyalkylpurines and -pyrimidines, particularly (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and their cyclic forms (cHPMPC, cHPMPA) and the 3-deaza analogue of HPMPA (HPMPc3A) are selective and potent inhibitors of human cytomegalovirus (CMV) replication in vitro." | 3.68 | Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique. ( Andrei, G; De Clercq, E; Neyts, J; Schols, D; Snoeck, R, 1991) |
| " In this study, we evaluated the antiherpesvirus activity of oxetanocin A and its derivatives and found that 9-(2-deoxy-2-hydroxymethyl-beta-D-erythro-oxetanosyl)guanine (OXT-G) was very potent and selective in inhibiting the replication of human cytomegalovirus (HCMV) in vitro." | 3.67 | Selective inhibition of human cytomegalovirus replication by a novel nucleoside, oxetanocin G. ( Nishiyama, Y; Shimada, N; Takahash, K; Yamamoto, N, 1988) |
| "Adefovir dipivoxil is a novel nucleotide analogue with several promising in vitro anti-human immunodeficiency virus (HIV) characteristics." | 2.68 | The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial. ( Cherrington, JM; Collier, A; Deeks, SG; Drew, WL; Hellmann, N; Jaffe, HS; Kahn, J; Lalezari, J; Lamy, PD; Li, W; Mulato, AS; Pavia, A; Rodrigue, D; Toole, J, 1997) |
| " The most advantageous pharmacokinetic profile and the best oral bioavailability were found in tyrosinebased prodrugs." | 2.55 | Amino Acid Ester Prodrugs of Nucleoside and Nucleotide Antivirals. ( Krecmerova, M, 2017) |
| " (l)-Tyr-NH-i-Bu cHPMPA (11) was converted in rat or mouse plasma solely to two active metabolites and had significantly enhanced oral bioavailability vs parent drug 1 in a mouse model (39% vs <5%)." | 1.37 | Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies. ( Borysko, KZ; Breitenbach, JM; Collins, M; Drach, JC; Hilfinger, JM; Kashemirov, BA; Krylov, IS; McKenna, CE; Peterson, LW; Serpi, M; Zakharova, VM, 2011) |
| " However, (S)-HPMPA is not orally bioavailable and has not been developed for clinical use." | 1.33 | Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses. ( Beadle, JR; Ciesla, SL; Hartline, C; Hostetler, KY; Keith, KA; Kern, ER; Wan, WB, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (11.63) | 18.7374 |
| 1990's | 19 (44.19) | 18.2507 |
| 2000's | 10 (23.26) | 29.6817 |
| 2010's | 7 (16.28) | 24.3611 |
| 2020's | 2 (4.65) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, ZJ | 1 |
| Dong, SW | 1 |
| Gao, DD | 1 |
| Du, XY | 1 |
| Xie, YQ | 1 |
| Xia, XS | 1 |
| Li, RT | 1 |
| Solano de la Asunción, C | 1 |
| Terol, MJ | 1 |
| Saus, A | 1 |
| Olea, B | 1 |
| Giménez, E | 1 |
| Albert, E | 1 |
| López-Jiménez, J | 1 |
| Andreu, R | 1 |
| García, D | 1 |
| Fox, L | 1 |
| Remigia, MJ | 1 |
| Amat, P | 1 |
| Solano, C | 1 |
| Navarro, D | 1 |
| Luo, M | 1 |
| Groaz, E | 1 |
| Andrei, G | 7 |
| Snoeck, R | 7 |
| Kalkeri, R | 1 |
| Ptak, RG | 2 |
| Hartman, T | 1 |
| Buckheit, RW | 1 |
| Schols, D | 3 |
| De Jonghe, S | 1 |
| Herdewijn, P | 1 |
| Kokosza, K | 1 |
| Piotrowska, DG | 1 |
| Liu, C | 1 |
| Chen, Q | 1 |
| Schneller, SW | 1 |
| Krecmerova, M | 2 |
| Tichý, T | 1 |
| Dračínský, M | 1 |
| Holý, A | 3 |
| Balzarini, J | 3 |
| Zakharova, VM | 1 |
| Serpi, M | 1 |
| Krylov, IS | 1 |
| Peterson, LW | 1 |
| Breitenbach, JM | 2 |
| Borysko, KZ | 1 |
| Drach, JC | 5 |
| Collins, M | 1 |
| Hilfinger, JM | 1 |
| Kashemirov, BA | 1 |
| McKenna, CE | 1 |
| Ang, BC | 1 |
| Teoh, SC | 1 |
| Baldanti, F | 1 |
| Sarasini, A | 1 |
| Zemlicka, J | 5 |
| Gerna, G | 1 |
| Lee, JY | 1 |
| Oh, CH | 1 |
| Ko, OH | 1 |
| Hong, JH | 2 |
| HENSON, D | 1 |
| PINKERTON, H | 1 |
| Kwak, EY | 1 |
| Park, Y | 1 |
| Choi, BG | 1 |
| Scott, GM | 1 |
| Ng, HL | 1 |
| Morton, CJ | 1 |
| Parker, MW | 1 |
| Rawlinson, WD | 1 |
| De Clercq, E | 9 |
| Beadle, JR | 3 |
| Wan, WB | 2 |
| Ciesla, SL | 1 |
| Keith, KA | 1 |
| Hartline, C | 1 |
| Kern, ER | 5 |
| Hostetler, KY | 3 |
| Horejsí, K | 1 |
| Pohl, R | 1 |
| Zhou, S | 2 |
| Gullen, E | 2 |
| Cheng, YC | 2 |
| Tamiya, S | 1 |
| Mitsuya, H | 1 |
| Tammewar, AM | 1 |
| Cheng, L | 1 |
| Falkenstein, I | 1 |
| Barron, EC | 1 |
| Kozak, I | 1 |
| Freeman, WR | 1 |
| Quenelle, DC | 1 |
| Collins, DJ | 1 |
| Pettway, LR | 1 |
| Hartline, CB | 2 |
| Neyts, J | 3 |
| Sato, Y | 1 |
| Maruyama, T | 2 |
| Ma, TW | 1 |
| Min, JM | 1 |
| Zhang, LH | 1 |
| Stals, F | 1 |
| Bruggeman, C | 1 |
| Dvoráková, H | 1 |
| Jindrich, J | 1 |
| Masojídková, M | 1 |
| Budĕsínský, M | 1 |
| Deeks, SG | 1 |
| Collier, A | 1 |
| Lalezari, J | 1 |
| Pavia, A | 1 |
| Rodrigue, D | 1 |
| Drew, WL | 1 |
| Toole, J | 1 |
| Jaffe, HS | 1 |
| Mulato, AS | 2 |
| Lamy, PD | 1 |
| Li, W | 1 |
| Cherrington, JM | 2 |
| Hellmann, N | 1 |
| Kahn, J | 1 |
| Xiong, X | 1 |
| Flores, C | 1 |
| Fuller, MD | 1 |
| Mendel, DB | 1 |
| Moon, K | 1 |
| Chen, MS | 1 |
| Qiu, YL | 2 |
| Hempel, A | 1 |
| Camerman, N | 1 |
| Camerman, A | 1 |
| Geiser, F | 1 |
| Kira, T | 1 |
| Li, L | 1 |
| Gammon, RR | 1 |
| Avery, N | 1 |
| Mintz, PD | 1 |
| Rybak, RJ | 1 |
| Southgate, TD | 1 |
| Bain, D | 1 |
| Fairbanks, LD | 1 |
| Morelli, AE | 1 |
| Larregina, AT | 1 |
| Simmonds, HA | 1 |
| Castro, MG | 1 |
| Löwenstein, PR | 1 |
| Starrett, JE | 1 |
| Tortolani, DR | 1 |
| Hitchcock, MJ | 1 |
| Martin, JC | 2 |
| Mansuri, MM | 1 |
| Shigeta, S | 1 |
| Konno, K | 1 |
| Baba, M | 1 |
| Yokota, T | 1 |
| Kim, CU | 1 |
| Luh, BY | 1 |
| Lagneaux, L | 1 |
| Delforge, A | 1 |
| Bron, D | 1 |
| Van der Auwera, P | 1 |
| Stryckmans, P | 1 |
| Nishiyama, Y | 2 |
| Yamamoto, N | 2 |
| Yamada, Y | 1 |
| Fujioka, H | 1 |
| Shimada, N | 2 |
| Takahashi, K | 1 |
| Takahash, K | 1 |
| Fiala, M | 1 |
| Chow, AW | 1 |
| Miyasaki, K | 1 |
| Guze, LB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Pharmacokinetics of Single Oral Doses of MBX-400 in Healthy Volunteers[NCT01433835] | Phase 1 | 48 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for adenine and Cytomegalovirus
| Article | Year |
|---|---|
Amino Acid Ester Prodrugs of Nucleoside and Nucleotide Antivirals.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; Humans; Nucle | 2017 |
1 trial available for adenine and Cytomegalovirus
| Article | Year |
|---|---|
The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial.
Topics: Adenine; Administration, Oral; Adult; Anti-HIV Agents; Carnitine; CD4 Lymphocyte Count; Cytomegalovi | 1997 |
41 other studies available for adenine and Cytomegalovirus
| Article | Year |
|---|---|
Unusual matrine-adenine hybrids isolated from Sophora davidii and their inhibitory effects on human cytomegalovirus.
Topics: Adenine; Alkaloids; Cytomegalovirus; Humans; Matrines; Molecular Structure; Quinolizines; Sophora | 2021 |
Cytomegalovirus-specific T-cell immunity and DNAemia in patients with chronic lymphocytic leukaemia undergoing treatment with ibrutinib.
Topics: Adenine; Aged; Aged, 80 and over; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytomegalo | 2021 |
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Aspartic Acid; Cell Line; Cytomegalovirus; Drug Resistan | 2017 |
Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
Topics: Acrylamides; Adenine; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Cell Survival; Cycl | 2015 |
Enantiomeric 3-deaza-1',6'-isoneplanocin and its 3-bromo analogue: Synthesis by the Ullmann reaction and their antiviral properties.
Topics: Adenine; Adenosine; Adenosylhomocysteinase; Antiviral Agents; Cytomegalovirus; Ebolavirus; Humans; M | 2016 |
New prodrugs of Adefovir and Cidofovir.
Topics: Adenine; Animals; Antiviral Agents; Cell Line, Tumor; Cidofovir; Cytomegalovirus; Cytosine; Herpesvi | 2011 |
Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
Topics: Adenine; Animals; Antiviral Agents; Area Under Curve; Biological Availability; Cell Line, Tumor; Cel | 2011 |
Case report of cytomegalovirus retinitis in an HIV-positive patient with a CD4-count nadir of 254 cells per μl.
Topics: Adenine; Administration, Oral; Adult; Alkynes; Anti-HIV Agents; Aqueous Humor; Benzoxazines; CD4 Lym | 2012 |
Z-isomers of 2-hydroxymethylcyclopropylidenemethyl adenine (synadenol) and guanine (synguanol) are active against ganciclovir- and foscarnet-resistant human cytomegalovirus UL97 mutants.
Topics: Adenine; Antiviral Agents; Cyclopropanes; Cytomegalovirus; Cytomegalovirus Infections; Drug Resistan | 2002 |
Synthesis and anti-HCMV activity of novel acyclic nucleosides.
Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Cytosine; Humans; Lactose; Microbial Sensitiv | 2002 |
EFFECT OF AMINOPTERIN ON THE REPLICATION OF THE MURINE SALIVARY GLAND VIRUS.
Topics: Adenine; Aminopterin; Animals; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; DNA Re | 1964 |
Synthesis and antiviral activity of novel C-methyl branched cyclopropyl nucleosides.
Topics: Adenine; Antiviral Agents; Crystallography, X-Ray; Cyclization; Cyclopropanes; Cytomegalovirus; Cyto | 2003 |
Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; DNA-Directed DN | 2005 |
Inhibition of the replication of DNA viruses by phosphonylmethoxyalkyl-purines and -pyrimidines.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; DNA Viruses; Organophosphonates; Si | 1989 |
Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.
Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Esters; Humans; Organophosphonates; Orthopoxv | 2006 |
Tricyclic etheno analogs of PMEG and PMEDAP: synthesis and biological activity.
Topics: Adenine; Antiviral Agents; Cell Proliferation; Cytomegalovirus; Guanine; Herpesvirus 3, Human; Human | 2006 |
9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.
Topics: Adenine; Adenosine Deaminase; Antiviral Agents; Cyclopropanes; Cytomegalovirus; Cytopathogenic Effec | 2006 |
Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines.
Topics: Adenine; Antiviral Agents; Bromine; Chemistry, Pharmaceutical; Cyclopropanes; Cytomegalovirus; Cytom | 2007 |
Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cytomegalovirus; Cytomegalovirus Retinitis; Delayed-A | 2007 |
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegaloviru | 2008 |
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine | 1994 |
Synthesis and antiviral activity of 3'-fluorocarbocyclic oxetanocin A.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cytomegalovirus; Herpesvirus 1, Human; Herpesvirus 2, | 1995 |
Synthesis of galactosyl phosphate diester derivatives of nucleosides.
Topics: Adenine; Antiviral Agents; Cytomegalovirus; Cytosine; HIV; Humans; Indicators and Reagents; Magnetic | 1994 |
Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; DN | 1993 |
Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity.
Topics: 3T3 Cells; Adenine; Animals; Antiviral Agents; Cell Transformation, Viral; Cytomegalovirus; Cytopath | 1996 |
Synthesis of carbocyclic oxetanocin analogs bearing fluorine and their antiviral activities.
Topics: Adenine; Antiviral Agents; Cytomegalovirus; Fluorine; Herpesvirus 1, Human; Herpesvirus 2, Human; Hu | 1995 |
Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro.
Topics: Acyclovir; Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytarabine; Cytomegalovirus; Cytom | 1996 |
In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir).
Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; HeLa Cells; Humans; Organophosphonates | 1997 |
(R)-(-)- and (S)-(+)-Synadenol: synthesis, absolute configuration, and enantioselectivity of antiviral effect.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Chlorocebus aethiops; Chromatography, High Pres | 1998 |
Evaluation of CAPTURE CMV solid phase testing over the allowable shelf-life of red blood cells (adenine-saline added).
Topics: Adenine; Antibodies, Viral; Antibody Specificity; Anticoagulants; Antigen-Antibody Reactions; Blood | 1998 |
Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cells, Cultured; Cyclopropanes; Cytomegalo | 1999 |
Adefovir dipivoxil. Bis-POM PMEA, GS 0840, GS 840, Piv2PMEA.
Topics: Adenine; Animals; Anti-HIV Agents; Biological Availability; Cytomegalovirus; Cytomegalovirus Infecti | 1999 |
Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium.
Topics: Adenine; Adenoviridae; Animals; Carbon Radioisotopes; Cell Survival; Cells, Cultured; Culture Media; | 1999 |
Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Drug Evaluation, Preclinical; HIV; Humans; Or | 1992 |
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique.
Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytomegalovirus; Cytosine; Flow Cytometry; Ganciclo | 1991 |
Comparative inhibitory effects of nucleoside analogues on different clinical isolates of human cytomegalovirus in vitro.
Topics: Adenine; Adenosine; Antiviral Agents; Cell Line; Cidofovir; Cytidine; Cytomegalovirus; Cytosine; Gan | 1991 |
Synthesis and antiviral activity of (S)-9-[4-hydroxy-3-(phosphonomethoxy)butyl]guanine.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; Guanine; Organophosphonates; Organo | 1990 |
Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro.
Topics: Adenine; Adult; Antiviral Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cidofovir; Cytome | 1990 |
Efficacy of oxetanocin G against herpes simplex virus type 2 and murine cytomegalovirus infections in mice.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; Disease | 1989 |
Selective inhibition of human cytomegalovirus replication by a novel nucleoside, oxetanocin G.
Topics: Adenine; Antiviral Agents; Cell Cycle; Cytomegalovirus; DNA, Viral; Fibroblasts; Guanine; Humans; Si | 1988 |
Susceptibility of herpesviruses to three nucleoside analogues and their combinations and enhancement of the antiviral effect of acid pH.
Topics: Adenine; Antiviral Agents; Cell Migration Inhibition; Cells, Cultured; Cytarabine; Cytomegalovirus; | 1974 |