adenine has been researched along with Cytomegalovirus Infections in 21 studies
Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A number of new nucleoside analogues with a Z- or E-methylenecyclopropane structure exhibited significant activity against human and murine cytomegaloviruses (HCMV, MCMV) in tissue culture that was generally comparable to, or greater than, 9-[(1-3-dihydroxy-2-propoxy)methyl]guanine (ganciclovir, GCV)." | 3.70 | Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides. ( Hartline, CB; Kern, ER; Qiu, YL; Rybak, RJ; Zemlicka, J, 1999) |
| "Drug-resistant human cytomegalovirus (HCMV) strains were selected in human embryonic lung (HEL) fibroblasts under pressure of the (S)-3-hydroxy-2-phosphonylmethoxypropyl (HPMP) derivatives of cytosine (HPMPC) and adenine (HPMPA), the 2-phosphonylmethoxyethyl (PME) derivative of 2,6-diaminopurine (PMEDAP), ganciclovir (GCV), acyclovir (ACV), and foscarnet (PFA)." | 3.69 | Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro. ( Andrei, G; De Clercq, E; Snoeck, R, 1996) |
| "Adefovir dipivoxil is a novel nucleotide analogue with several promising in vitro anti-human immunodeficiency virus (HIV) characteristics." | 2.68 | The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial. ( Cherrington, JM; Collier, A; Deeks, SG; Drew, WL; Hellmann, N; Jaffe, HS; Kahn, J; Lalezari, J; Lamy, PD; Li, W; Mulato, AS; Pavia, A; Rodrigue, D; Toole, J, 1997) |
| "These results indicate that MAIDS can be used as a model for evaluating antivirals in an immunocompromised host, and suggest that both PMEA and HPMPC may be useful in the treatment of opportunistic CMV and HSV-1 infections." | 1.28 | Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS. ( De Castro, LM; De Clercq, E; Gangemi, JD; Ghaffar, A; Kern, ER; Mayer, EP; Vogt, PE, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Solano de la Asunción, C | 1 |
| Terol, MJ | 1 |
| Saus, A | 1 |
| Olea, B | 1 |
| Giménez, E | 1 |
| Albert, E | 1 |
| López-Jiménez, J | 1 |
| Andreu, R | 1 |
| García, D | 1 |
| Fox, L | 1 |
| Remigia, MJ | 1 |
| Amat, P | 1 |
| Solano, C | 1 |
| Navarro, D | 1 |
| Baldanti, F | 1 |
| Sarasini, A | 1 |
| Drach, JC | 2 |
| Zemlicka, J | 3 |
| Gerna, G | 1 |
| HENSON, D | 1 |
| PINKERTON, H | 1 |
| Ruiz, JC | 1 |
| Beadle, JR | 2 |
| Aldern, KA | 1 |
| Keith, KA | 1 |
| Hartline, CB | 3 |
| Kern, ER | 5 |
| Hostetler, KY | 2 |
| Zhou, S | 1 |
| Quenelle, DC | 1 |
| Collins, DJ | 1 |
| Pettway, LR | 1 |
| Wan, WB | 1 |
| Neyts, J | 3 |
| De Clercq, E | 5 |
| Naesens, L | 1 |
| Balzarini, J | 1 |
| Holy, A | 1 |
| Rosenberg, I | 1 |
| Stals, F | 1 |
| Bruggeman, C | 1 |
| Snoeck, R | 1 |
| Andrei, G | 1 |
| Deeks, SG | 1 |
| Collier, A | 1 |
| Lalezari, J | 1 |
| Pavia, A | 1 |
| Rodrigue, D | 1 |
| Drew, WL | 1 |
| Toole, J | 1 |
| Jaffe, HS | 1 |
| Mulato, AS | 1 |
| Lamy, PD | 1 |
| Li, W | 1 |
| Cherrington, JM | 1 |
| Hellmann, N | 1 |
| Kahn, J | 1 |
| Gammon, RR | 1 |
| Avery, N | 1 |
| Mintz, PD | 1 |
| Rybak, RJ | 1 |
| Qiu, YL | 1 |
| Cadman, J | 1 |
| Fisher, EJ | 1 |
| Chaloner, K | 1 |
| Cohn, DL | 1 |
| Grant, LB | 1 |
| Alston, B | 1 |
| Brosgart, CL | 1 |
| Schmetter, B | 1 |
| El-Sadr, WM | 1 |
| Sampson, J | 1 |
| Brunell, P | 1 |
| De Castro, LM | 1 |
| Ghaffar, A | 1 |
| Mayer, EP | 1 |
| Vogt, PE | 1 |
| Gangemi, JD | 1 |
| Sakuma, T | 1 |
| Azuma, M | 1 |
| Nishiyama, Y | 1 |
| Yamamoto, N | 1 |
| Yamada, Y | 1 |
| Fujioka, H | 1 |
| Shimada, N | 1 |
| Takahashi, K | 1 |
| Luby, JP | 1 |
| Johnson, MT | 1 |
| Jones, SR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Pharmacokinetics of Single Oral Doses of MBX-400 in Healthy Volunteers[NCT01433835] | Phase 1 | 48 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for adenine and Cytomegalovirus Infections
| Article | Year |
|---|---|
Antiviral chemotherapy.
Topics: Adenine; Amantadine; Antiviral Agents; Arabinose; Cytarabine; Cytomegalovirus Infections; Herpesviri | 1974 |
3 trials available for adenine and Cytomegalovirus Infections
| Article | Year |
|---|---|
The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial.
Topics: Adenine; Administration, Oral; Adult; Anti-HIV Agents; Carnitine; CD4 Lymphocyte Count; Cytomegalovi | 1997 |
The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Cytomegalovirus Infections; Double-Blind Method; Dru | 2001 |
Antiviral drugs for the neonate--the risk-benefit ledger.
Topics: Adenine; Animals; Antiviral Agents; Arabinose; Brain; Brain Diseases; Clinical Trials as Topic; Cyta | 1975 |
17 other studies available for adenine and Cytomegalovirus Infections
| Article | Year |
|---|---|
Cytomegalovirus-specific T-cell immunity and DNAemia in patients with chronic lymphocytic leukaemia undergoing treatment with ibrutinib.
Topics: Adenine; Aged; Aged, 80 and over; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytomegalo | 2021 |
Z-isomers of 2-hydroxymethylcyclopropylidenemethyl adenine (synadenol) and guanine (synguanol) are active against ganciclovir- and foscarnet-resistant human cytomegalovirus UL97 mutants.
Topics: Adenine; Antiviral Agents; Cyclopropanes; Cytomegalovirus; Cytomegalovirus Infections; Drug Resistan | 2002 |
EFFECT OF AMINOPTERIN ON THE REPLICATION OF THE MURINE SALIVARY GLAND VIRUS.
Topics: Adenine; Aminopterin; Animals; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; DNA Re | 1964 |
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.
Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cowpox; Cytomegalovirus Infections; Cytosine; Herpe | 2007 |
Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines.
Topics: Adenine; Antiviral Agents; Bromine; Chemistry, Pharmaceutical; Cyclopropanes; Cytomegalovirus; Cytom | 2007 |
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegaloviru | 2008 |
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine | 1994 |
Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cytomegalovirus Infections; Friend murine | 1993 |
Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; DN | 1993 |
Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro.
Topics: Acyclovir; Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytarabine; Cytomegalovirus; Cytom | 1996 |
Evaluation of CAPTURE CMV solid phase testing over the allowable shelf-life of red blood cells (adenine-saline added).
Topics: Adenine; Antibodies, Viral; Antibody Specificity; Anticoagulants; Antigen-Antibody Reactions; Blood | 1998 |
Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cells, Cultured; Cyclopropanes; Cytomegalo | 1999 |
Adefovir dipivoxil. Bis-POM PMEA, GS 0840, GS 840, Piv2PMEA.
Topics: Adenine; Animals; Anti-HIV Agents; Biological Availability; Cytomegalovirus; Cytomegalovirus Infecti | 1999 |
CMV trials struggle to enroll.
Topics: Adenine; AIDS-Related Opportunistic Infections; Antiviral Agents; CD4 Lymphocyte Count; Clinical Tri | 1997 |
Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus Infections; Cytosine; Ganciclovir; He | 1991 |
[Chemotherapy of cytomegalovirus infections].
Topics: Acyclovir; Adenine; Cytomegalovirus Infections; Foscarnet; Ganciclovir; Humans; Organophosphonates; | 1989 |
Efficacy of oxetanocin G against herpes simplex virus type 2 and murine cytomegalovirus infections in mice.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; Disease | 1989 |