adenine has been researched along with Cytomegalic Inclusion Disease in 21 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "A number of new nucleoside analogues with a Z- or E-methylenecyclopropane structure exhibited significant activity against human and murine cytomegaloviruses (HCMV, MCMV) in tissue culture that was generally comparable to, or greater than, 9-[(1-3-dihydroxy-2-propoxy)methyl]guanine (ganciclovir, GCV)." | 3.70 | Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides. ( Hartline, CB; Kern, ER; Qiu, YL; Rybak, RJ; Zemlicka, J, 1999) |
| "Drug-resistant human cytomegalovirus (HCMV) strains were selected in human embryonic lung (HEL) fibroblasts under pressure of the (S)-3-hydroxy-2-phosphonylmethoxypropyl (HPMP) derivatives of cytosine (HPMPC) and adenine (HPMPA), the 2-phosphonylmethoxyethyl (PME) derivative of 2,6-diaminopurine (PMEDAP), ganciclovir (GCV), acyclovir (ACV), and foscarnet (PFA)." | 3.69 | Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro. ( Andrei, G; De Clercq, E; Snoeck, R, 1996) |
| "Adefovir dipivoxil is a novel nucleotide analogue with several promising in vitro anti-human immunodeficiency virus (HIV) characteristics." | 2.68 | The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial. ( Cherrington, JM; Collier, A; Deeks, SG; Drew, WL; Hellmann, N; Jaffe, HS; Kahn, J; Lalezari, J; Lamy, PD; Li, W; Mulato, AS; Pavia, A; Rodrigue, D; Toole, J, 1997) |
| "These results indicate that MAIDS can be used as a model for evaluating antivirals in an immunocompromised host, and suggest that both PMEA and HPMPC may be useful in the treatment of opportunistic CMV and HSV-1 infections." | 1.28 | Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS. ( De Castro, LM; De Clercq, E; Gangemi, JD; Ghaffar, A; Kern, ER; Mayer, EP; Vogt, PE, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Solano de la Asunción, C | 1 |
| Terol, MJ | 1 |
| Saus, A | 1 |
| Olea, B | 1 |
| Giménez, E | 1 |
| Albert, E | 1 |
| López-Jiménez, J | 1 |
| Andreu, R | 1 |
| García, D | 1 |
| Fox, L | 1 |
| Remigia, MJ | 1 |
| Amat, P | 1 |
| Solano, C | 1 |
| Navarro, D | 1 |
| Baldanti, F | 1 |
| Sarasini, A | 1 |
| Drach, JC | 2 |
| Zemlicka, J | 3 |
| Gerna, G | 1 |
| HENSON, D | 1 |
| PINKERTON, H | 1 |
| Ruiz, JC | 1 |
| Beadle, JR | 2 |
| Aldern, KA | 1 |
| Keith, KA | 1 |
| Hartline, CB | 3 |
| Kern, ER | 5 |
| Hostetler, KY | 2 |
| Zhou, S | 1 |
| Quenelle, DC | 1 |
| Collins, DJ | 1 |
| Pettway, LR | 1 |
| Wan, WB | 1 |
| Neyts, J | 3 |
| De Clercq, E | 5 |
| Naesens, L | 1 |
| Balzarini, J | 1 |
| Holy, A | 1 |
| Rosenberg, I | 1 |
| Stals, F | 1 |
| Bruggeman, C | 1 |
| Snoeck, R | 1 |
| Andrei, G | 1 |
| Deeks, SG | 1 |
| Collier, A | 1 |
| Lalezari, J | 1 |
| Pavia, A | 1 |
| Rodrigue, D | 1 |
| Drew, WL | 1 |
| Toole, J | 1 |
| Jaffe, HS | 1 |
| Mulato, AS | 1 |
| Lamy, PD | 1 |
| Li, W | 1 |
| Cherrington, JM | 1 |
| Hellmann, N | 1 |
| Kahn, J | 1 |
| Gammon, RR | 1 |
| Avery, N | 1 |
| Mintz, PD | 1 |
| Rybak, RJ | 1 |
| Qiu, YL | 1 |
| Cadman, J | 1 |
| Fisher, EJ | 1 |
| Chaloner, K | 1 |
| Cohn, DL | 1 |
| Grant, LB | 1 |
| Alston, B | 1 |
| Brosgart, CL | 1 |
| Schmetter, B | 1 |
| El-Sadr, WM | 1 |
| Sampson, J | 1 |
| Brunell, P | 1 |
| De Castro, LM | 1 |
| Ghaffar, A | 1 |
| Mayer, EP | 1 |
| Vogt, PE | 1 |
| Gangemi, JD | 1 |
| Sakuma, T | 1 |
| Azuma, M | 1 |
| Nishiyama, Y | 1 |
| Yamamoto, N | 1 |
| Yamada, Y | 1 |
| Fujioka, H | 1 |
| Shimada, N | 1 |
| Takahashi, K | 1 |
| Luby, JP | 1 |
| Johnson, MT | 1 |
| Jones, SR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Pharmacokinetics of Single Oral Doses of MBX-400 in Healthy Volunteers[NCT01433835] | Phase 1 | 48 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for adenine and Cytomegalic Inclusion Disease
| Article | Year |
|---|---|
Antiviral chemotherapy.
Topics: Adenine; Amantadine; Antiviral Agents; Arabinose; Cytarabine; Cytomegalovirus Infections; Herpesviri | 1974 |
3 trials available for adenine and Cytomegalic Inclusion Disease
| Article | Year |
|---|---|
The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial.
Topics: Adenine; Administration, Oral; Adult; Anti-HIV Agents; Carnitine; CD4 Lymphocyte Count; Cytomegalovi | 1997 |
The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Cytomegalovirus Infections; Double-Blind Method; Dru | 2001 |
Antiviral drugs for the neonate--the risk-benefit ledger.
Topics: Adenine; Animals; Antiviral Agents; Arabinose; Brain; Brain Diseases; Clinical Trials as Topic; Cyta | 1975 |
17 other studies available for adenine and Cytomegalic Inclusion Disease
| Article | Year |
|---|---|
Cytomegalovirus-specific T-cell immunity and DNAemia in patients with chronic lymphocytic leukaemia undergoing treatment with ibrutinib.
Topics: Adenine; Aged; Aged, 80 and over; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytomegalo | 2021 |
Z-isomers of 2-hydroxymethylcyclopropylidenemethyl adenine (synadenol) and guanine (synguanol) are active against ganciclovir- and foscarnet-resistant human cytomegalovirus UL97 mutants.
Topics: Adenine; Antiviral Agents; Cyclopropanes; Cytomegalovirus; Cytomegalovirus Infections; Drug Resistan | 2002 |
EFFECT OF AMINOPTERIN ON THE REPLICATION OF THE MURINE SALIVARY GLAND VIRUS.
Topics: Adenine; Aminopterin; Animals; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; DNA Re | 1964 |
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.
Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cowpox; Cytomegalovirus Infections; Cytosine; Herpe | 2007 |
Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines.
Topics: Adenine; Antiviral Agents; Bromine; Chemistry, Pharmaceutical; Cyclopropanes; Cytomegalovirus; Cytom | 2007 |
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegaloviru | 2008 |
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine | 1994 |
Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cytomegalovirus Infections; Friend murine | 1993 |
Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; DN | 1993 |
Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro.
Topics: Acyclovir; Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytarabine; Cytomegalovirus; Cytom | 1996 |
Evaluation of CAPTURE CMV solid phase testing over the allowable shelf-life of red blood cells (adenine-saline added).
Topics: Adenine; Antibodies, Viral; Antibody Specificity; Anticoagulants; Antigen-Antibody Reactions; Blood | 1998 |
Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cells, Cultured; Cyclopropanes; Cytomegalo | 1999 |
Adefovir dipivoxil. Bis-POM PMEA, GS 0840, GS 840, Piv2PMEA.
Topics: Adenine; Animals; Anti-HIV Agents; Biological Availability; Cytomegalovirus; Cytomegalovirus Infecti | 1999 |
CMV trials struggle to enroll.
Topics: Adenine; AIDS-Related Opportunistic Infections; Antiviral Agents; CD4 Lymphocyte Count; Clinical Tri | 1997 |
Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus Infections; Cytosine; Ganciclovir; He | 1991 |
[Chemotherapy of cytomegalovirus infections].
Topics: Acyclovir; Adenine; Cytomegalovirus Infections; Foscarnet; Ganciclovir; Humans; Organophosphonates; | 1989 |
Efficacy of oxetanocin G against herpes simplex virus type 2 and murine cytomegalovirus infections in mice.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; Disease | 1989 |