adenine has been researched along with Cystic Fibrosis in 13 studies
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Extracellular adenine nucleotides also serve as precursors for adenosine, which promotes cyclic AMP-mediated activation of the cystic fibrosis transmembrane regulator chloride channel via A(2b) adenosine receptors." | 3.72 | Nucleotide release provides a mechanism for airway surface liquid homeostasis. ( Boucher, RC; Grubb, BR; Lazarowski, ER; Okada, S; Tarran, R; van Heusden, CA, 2004) |
| "Cystic fibrosis is caused by mutations of the Cystic Fibrosis Transmembrane conductance Regulator gene (CFTR)." | 1.37 | Splicing defects in the CFTR gene: minigene analysis of two mutations, 1811+1G>C and 1898+3A>G. ( Commandeur, D; Corcos, L; Dujardin, G; Ferec, C; Le Jossic-Corcos, C, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 4 (30.77) | 2.80 |
| Authors | Studies |
|---|---|
| Krishnamurthy, S | 1 |
| Traore, S | 1 |
| Cooney, AL | 1 |
| Brommel, CM | 1 |
| Kulhankova, K | 1 |
| Sinn, PL | 1 |
| Newby, GA | 2 |
| Liu, DR | 2 |
| McCray, PB | 1 |
| Amistadi, S | 1 |
| Maule, G | 1 |
| Ciciani, M | 1 |
| Ensinck, MM | 1 |
| De Keersmaecker, L | 1 |
| Ramalho, AS | 1 |
| Guidone, D | 1 |
| Buccirossi, M | 1 |
| Galietta, LJV | 1 |
| Carlon, MS | 1 |
| Cereseto, A | 1 |
| Geurts, MH | 1 |
| de Poel, E | 1 |
| Amatngalim, GD | 1 |
| Oka, R | 1 |
| Meijers, FM | 1 |
| Kruisselbrink, E | 1 |
| van Mourik, P | 1 |
| Berkers, G | 1 |
| de Winter-de Groot, KM | 1 |
| Michel, S | 1 |
| Muilwijk, D | 1 |
| Aalbers, BL | 1 |
| Mullenders, J | 1 |
| Boj, SF | 1 |
| Suen, SWF | 1 |
| Brunsveld, JE | 1 |
| Janssens, HM | 1 |
| Mall, MA | 1 |
| Graeber, SY | 1 |
| van Boxtel, R | 1 |
| van der Ent, CK | 1 |
| Beekman, JM | 1 |
| Clevers, H | 1 |
| Jiang, T | 1 |
| Henderson, JM | 1 |
| Coote, K | 1 |
| Cheng, Y | 1 |
| Valley, HC | 1 |
| Zhang, XO | 1 |
| Wang, Q | 1 |
| Rhym, LH | 1 |
| Cao, Y | 1 |
| Bihler, H | 1 |
| Mense, M | 1 |
| Weng, Z | 1 |
| Anderson, DG | 1 |
| McCaffrey, AP | 1 |
| Xue, W | 1 |
| Balakathiresan, NS | 1 |
| Bhattacharyya, S | 1 |
| Gutti, U | 1 |
| Long, RP | 1 |
| Jozwik, C | 1 |
| Huang, W | 1 |
| Srivastava, M | 1 |
| Pollard, HB | 1 |
| Biswas, R | 1 |
| Dujardin, G | 1 |
| Commandeur, D | 1 |
| Le Jossic-Corcos, C | 1 |
| Ferec, C | 1 |
| Corcos, L | 1 |
| Salvado, CS | 1 |
| Trounson, AO | 1 |
| Cram, DS | 1 |
| Lazarowski, ER | 1 |
| Tarran, R | 1 |
| Grubb, BR | 1 |
| van Heusden, CA | 1 |
| Okada, S | 1 |
| Boucher, RC | 1 |
| Dörk, T | 1 |
| Will, K | 1 |
| Demmer, A | 1 |
| Tümmler, B | 1 |
| Gelfi, C | 1 |
| Righetti, PG | 1 |
| Cremonesi, L | 1 |
| Ferrari, M | 1 |
| Onay, T | 1 |
| Topaloglu, O | 1 |
| Zielenski, J | 1 |
| Gokgoz, N | 1 |
| Kayserili, H | 1 |
| Camcioglu, Y | 1 |
| Cokugras, H | 1 |
| Akcakaya, N | 1 |
| Apak, M | 1 |
| Tsui, LC | 1 |
| Kirdar, B | 1 |
| Seia, M | 1 |
| Cantù-Rajnoldi, A | 1 |
| Ambrosioni, A | 1 |
| Fiori, S | 1 |
| Prandoni, S | 1 |
| Corbetta, C | 1 |
| Bassotti, A | 1 |
| Moretti, E | 1 |
| Giunta, A | 1 |
| Padoan, R | 1 |
| Miedzybrodzka, ZH | 1 |
| Kelly, KF | 1 |
| Davidson, M | 1 |
| Little, S | 1 |
| Shrimpton, AE | 1 |
| Dean, JC | 1 |
| Haites, NE | 1 |
13 other studies available for adenine and Cystic Fibrosis
| Article | Year |
|---|---|
Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors.
Topics: Adenine; Cell Line; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2021 |
Functional restoration of a CFTR splicing mutation through RNA delivery of CRISPR adenine base editor.
Topics: Adenine; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Editing; Humans; | 2023 |
CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank.
Topics: Adenine; Biological Specimen Banks; Clustered Regularly Interspaced Short Palindromic Repeats; Codon | 2020 |
Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope.
Topics: Adenine; Alleles; Animals; Cell Line; Codon; Codon, Nonsense; CRISPR-Cas Systems; Cystic Fibrosis; G | 2020 |
Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells.
Topics: Adenine; Cell Line; Cystic Fibrosis; Epithelial Cells; Gene Expression Regulation; Humans; Interleuk | 2009 |
Splicing defects in the CFTR gene: minigene analysis of two mutations, 1811+1G>C and 1898+3A>G.
Topics: Adenine; Alternative Splicing; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; | 2011 |
Towards preimplantation diagnosis of cystic fibrosis using microarrays.
Topics: Adenine; Alleles; Carbocyanines; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulato | 2004 |
Nucleotide release provides a mechanism for airway surface liquid homeostasis.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Cell Lin | 2004 |
A donor splice mutation (405 + 1 G-->A) in cystic fibrosis associated with exon skipping in epithelial CFTR mRNA.
Topics: Adenine; Adult; Alternative Splicing; Base Sequence; Cystic Fibrosis; Cystic Fibrosis Transmembrane | 1993 |
Detection of point mutations by capillary electrophoresis in liquid polymers in temporal thermal gradients.
Topics: Adenine; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cytosine; DNA; Electr | 1994 |
Analysis of the CFTR gene in Turkish cystic fibrosis patients: identification of three novel mutations (3172delAC, P1013L and M1028I).
Topics: Adenine; Amino Acid Substitution; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulat | 1998 |
A novel deletion in exon 12 (g1845delAG or g1846delGA) of the CFTR (ABCC7) gene in a CF infant presenting with meconium ileus.
Topics: Adenine; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Exons; Guanine; Human | 2000 |
Prenatal diagnosis for the cystic fibrosis mutation 1717-1, G-->A using arms.
Topics: Adenine; Base Sequence; Chorionic Villi Sampling; Cystic Fibrosis; DNA Mutational Analysis; Female; | 1992 |