adenine has been researched along with Choriocarcinoma in 6 studies
Choriocarcinoma: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, PMEA was found to have a strong differentiation-inducing effect on rat choriocarcinoma (RCHO) cells, comparable to that of methotrexate, which is the drug of choice for the chemotherapy of choriocarcinoma in humans." | 7.70 | Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model. ( Balzarini, J; De Clercq, E; Hatse, S; Naesens, L, 1998) |
| " Likewise, a clear dose-response relationship was established for the in vivo antitumor activity of PMEA in choriocarcinoma-bearing rats." | 5.30 | In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma. ( Balzarini, J; De Clercq, E; Degrève, B; Hatse, S; Naesens, L; Vandeputte, M; Waer, M, 1998) |
| " In the present study, PMEA was found to have a strong differentiation-inducing effect on rat choriocarcinoma (RCHO) cells, comparable to that of methotrexate, which is the drug of choice for the chemotherapy of choriocarcinoma in humans." | 3.70 | Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model. ( Balzarini, J; De Clercq, E; Hatse, S; Naesens, L, 1998) |
| " Likewise, a clear dose-response relationship was established for the in vivo antitumor activity of PMEA in choriocarcinoma-bearing rats." | 1.30 | In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma. ( Balzarini, J; De Clercq, E; Degrève, B; Hatse, S; Naesens, L; Vandeputte, M; Waer, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, L | 1 |
| Tan, Z | 1 |
| Zhang, Y | 2 |
| Kady Keita, N | 1 |
| Liu, H | 1 |
| Balzarini, J | 5 |
| Verstuyf, A | 1 |
| Hatse, S | 5 |
| Goebels, J | 1 |
| Sobis, H | 1 |
| Vandeputte, M | 3 |
| De Clercq, E | 5 |
| Naesens, L | 4 |
| Degrève, B | 2 |
| Segers, C | 2 |
| Waer, M | 3 |
| Verbeken, E | 1 |
6 other studies available for adenine and Choriocarcinoma
| Article | Year |
|---|---|
ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.
Topics: ADAM12 Protein; Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Cell P | 2020 |
The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines.
Topics: Adenine; Adenine Nucleotides; Animals; Antineoplastic Agents; Antiviral Agents; Cell Differentiation | 1995 |
Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats.
Topics: Adenine; Animals; Antiviral Agents; Choriocarcinoma; Drug Administration Schedule; Neoplasm Transpla | 1998 |
In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma.
Topics: Adenine; Alkaline Phosphatase; Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; | 1998 |
Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model.
Topics: Adenine; Alkaline Phosphatase; Animals; Antigens, Neoplasm; Antigens, Surface; Antiviral Agents; Cel | 1998 |
9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.
Topics: Adenine; Animals; Antineoplastic Agents; Choriocarcinoma; Female; Guanine; Male; Organophosphonates; | 1999 |