adenine and Cerebral Ischemia
adenine has been researched along with Cerebral Ischemia in 36 studies
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
" Importantly, the neuron-protective effect of MDL-28170 on ischemic insult was reversed by cotreatment with either class III-PI3K (phosphatidylinositol 3-kinase) inhibitor 3-methyladenine or lysosomal inhibitor chloroquine (chloroquine), suggesting that CAPN1 activation-mediated impairment of autophagic flux is crucial for cerebral ischemia-induced neuronal damage." | 8.02 | CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage. ( Cai, R; Che, X; Fu, X; Liu, Y; Luo, J; Yang, J; Yang, Y; Yao, Y; Yu, X; Zhang, H; Zhou, MS, 2021) |
"The elevated level of the amino acid metabolite homocysteine (Hcy) is known as a risk factor for ischemic stroke." | 7.91 | Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke. ( Cheng, M; Liang, X; Liu, H; Sai, N; Wang, M; Wang, X; Yang, L; Zhang, X, 2019) |
" The autophagy inhibitor, 3-methyladenine, inhibited inflammation and activation of nuclear factor kappa B pathway." | 7.78 | Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy. ( Dai, J; Jiang, Y; Liu, X; Wu, L; Xu, G; Zhu, J, 2012) |
" Importantly, the neuron-protective effect of MDL-28170 on ischemic insult was reversed by cotreatment with either class III-PI3K (phosphatidylinositol 3-kinase) inhibitor 3-methyladenine or lysosomal inhibitor chloroquine (chloroquine), suggesting that CAPN1 activation-mediated impairment of autophagic flux is crucial for cerebral ischemia-induced neuronal damage." | 4.02 | CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage. ( Cai, R; Che, X; Fu, X; Liu, Y; Luo, J; Yang, J; Yang, Y; Yao, Y; Yu, X; Zhang, H; Zhou, MS, 2021) |
"The elevated level of the amino acid metabolite homocysteine (Hcy) is known as a risk factor for ischemic stroke." | 3.91 | Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke. ( Cheng, M; Liang, X; Liu, H; Sai, N; Wang, M; Wang, X; Yang, L; Zhang, X, 2019) |
"It is established that the new compound, 9-[2-(4-isopropylphenoxy)ethyl]adenine (9-IPE-adenine) in a dose of 10 mg/kg per day produces neuroprotective effect in rats with brain ischemia model." | 3.80 | [Study of some pharmacological properties of a new adenine derivative]. ( Chel'naia, NA; Iasnetsov, VV; Ivanov, IuV; Karsanova, SK; Motin, VG; Ozerov, AA, 2014) |
" We evaluated the regulation of mRNAs containing adenine- and uridine-rich elements (ARE) by assessing HuR protein and hsp70 mRNA nuclear translocation, HuR polysome binding, and translation state analysis of CA1 and CA3 at 8 h of reperfusion after 10 min of global cerebral ischemia." | 3.79 | HuR function and translational state analysis following global brain ischemia and reperfusion. ( DeGracia, DJ; Jamison, JT; Szymanski, JJ; Wang, H, 2013) |
" The autophagy inhibitor, 3-methyladenine, inhibited inflammation and activation of nuclear factor kappa B pathway." | 3.78 | Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy. ( Dai, J; Jiang, Y; Liu, X; Wu, L; Xu, G; Zhu, J, 2012) |
"We used a cerebral ischemia mouse model (middle cerebral artery occlusion, MCAO) to evaluate the effects of inhibiting autophagy in ischemic brain pathology." | 1.62 | Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke. ( Doran, SJ; Li, J; McCullough, LD; Moruno-Manchon, JF; O'Keefe, LM; Patel, AR; Patrizz, AN; Tsvetkov, AS; Venna, VR, 2021) |
"Focal cerebral ischemia was induced in aged rats by middle cerebral artery occlusion (MCAO)." | 1.51 | Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion. ( Bi, J; Han, D; Liang, J; Lu, Y; Ren, L; Wang, P, 2019) |
"During cerebral ischemia/reperfusion (I/R) injury, DRAM1 protein expression is increased, and autophagy is activated." | 1.40 | DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy. ( Feng, Q; Gan, J; Jiang, Y; Ouyang, Y; Yu, M, 2014) |
"Focal cerebral ischemia was induced by permanent middle cerebral artery occlusion (pMCAO) in rats." | 1.36 | Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia. ( Hong, LZ; Liu, CF; Liu, J; Qin, AP; Qin, YY; Qin, ZH; Xu, M; Yang, L; Zhang, HL, 2010) |
"Focal cerebral ischemia was introduced by permanent middle cerebral artery occlusion (pMCAO)." | 1.35 | Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. ( Fukunaga, K; Han, F; Han, R; Qin, ZH; Sheng, R; Wen, YD; Zhang, LS; Zhang, X; Zhang, XD, 2008) |
"Rats were exposed to transient focal cerebral ischemia on postnatal day 12." | 1.35 | Postischemic treatment of neonatal cerebral ischemia should target autophagy. ( Clarke, PG; Mottier, V; Puyal, J; Vaslin, A, 2009) |
Research
Studies (36)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (2.78) | 18.7374 |
1990's | 3 (8.33) | 18.2507 |
2000's | 4 (11.11) | 29.6817 |
2010's | 24 (66.67) | 24.3611 |
2020's | 4 (11.11) | 2.80 |
Authors
Authors | Studies |
---|---|
Jin, L | 1 |
Mo, Y | 1 |
Yue, EL | 1 |
Liu, Y | 3 |
Liu, KY | 1 |
Madou, K | 1 |
Carrette, S | 1 |
Acou, M | 1 |
De Herdt, V | 1 |
Hemelsoet, D | 1 |
Wang, P | 3 |
Lu, Y | 1 |
Han, D | 1 |
Ren, L | 1 |
Bi, J | 1 |
Liang, J | 1 |
Che, X | 1 |
Zhang, H | 1 |
Fu, X | 1 |
Yao, Y | 1 |
Luo, J | 1 |
Yang, Y | 1 |
Cai, R | 1 |
Yu, X | 1 |
Yang, J | 1 |
Zhou, MS | 1 |
Patrizz, AN | 1 |
Moruno-Manchon, JF | 1 |
O'Keefe, LM | 1 |
Doran, SJ | 1 |
Patel, AR | 1 |
Venna, VR | 1 |
Tsvetkov, AS | 1 |
Li, J | 1 |
McCullough, LD | 1 |
Bao, L | 1 |
Li, RH | 1 |
Li, M | 2 |
Jin, MF | 1 |
Li, G | 1 |
Han, X | 1 |
Yang, YY | 1 |
Sun, B | 1 |
Xu, LX | 1 |
Feng, X | 1 |
Zhang, DM | 1 |
Zhang, T | 3 |
Wang, MM | 1 |
Wang, XX | 1 |
Qin, YY | 2 |
Wu, J | 1 |
Han, R | 4 |
Sheng, R | 4 |
Wang, Y | 1 |
Chen, Z | 2 |
Han, F | 2 |
Ding, Y | 1 |
Qin, ZH | 5 |
Wang, M | 1 |
Liang, X | 1 |
Cheng, M | 1 |
Yang, L | 2 |
Liu, H | 1 |
Wang, X | 2 |
Sai, N | 1 |
Zhang, X | 4 |
Yan, H | 1 |
Yuan, Y | 1 |
Gao, J | 1 |
Shen, Z | 1 |
Cheng, Y | 1 |
Shen, Y | 1 |
Wang, RR | 1 |
Hu, WW | 1 |
Wang, G | 1 |
Xia, DY | 1 |
Li, W | 1 |
Qian, HR | 1 |
Yao, S | 1 |
Liu, JG | 1 |
Qi, XK | 1 |
Szymanski, JJ | 1 |
Wang, H | 3 |
Jamison, JT | 1 |
DeGracia, DJ | 2 |
Li, Q | 1 |
Huang, J | 1 |
Sun, X | 1 |
Jiang, T | 2 |
Yu, JT | 1 |
Zhu, XC | 1 |
Wang, HF | 1 |
Tan, MS | 1 |
Cao, L | 1 |
Zhang, QQ | 1 |
Gao, L | 2 |
Shi, JQ | 1 |
Zhang, YD | 1 |
Tan, L | 1 |
Su, J | 1 |
Wang, K | 3 |
Zhu, T | 1 |
Li, X | 1 |
Yu, M | 1 |
Jiang, Y | 2 |
Feng, Q | 1 |
Ouyang, Y | 1 |
Gan, J | 1 |
Ozerov, AA | 1 |
Motin, VG | 1 |
Iasnetsov, VV | 1 |
Karsanova, SK | 1 |
Ivanov, IuV | 1 |
Chel'naia, NA | 1 |
He, G | 1 |
Xu, W | 1 |
Tong, L | 1 |
Li, S | 1 |
Su, S | 1 |
Tan, X | 1 |
Li, C | 1 |
Xu, Y | 1 |
Wang, J | 1 |
Song, X | 1 |
Qu, L | 1 |
Wei, R | 1 |
He, F | 1 |
Luo, B | 1 |
Tri Anggraini, F | 1 |
Chen, X | 1 |
Zhao, Y | 1 |
Huang, G | 1 |
Chen, S | 1 |
Gou, Y | 1 |
Dong, Z | 1 |
Wen, YD | 1 |
Zhang, LS | 3 |
Zhang, XD | 1 |
Fukunaga, K | 1 |
Puyal, J | 1 |
Vaslin, A | 1 |
Mottier, V | 1 |
Clarke, PG | 1 |
Liu, XQ | 2 |
Gao, B | 2 |
Qin, AP | 1 |
Liu, CF | 1 |
Hong, LZ | 1 |
Xu, M | 1 |
Liu, J | 1 |
Zhang, HL | 1 |
Wang, JY | 1 |
Xia, Q | 1 |
Chu, KT | 1 |
Pan, J | 2 |
Sun, LN | 1 |
Zeng, B | 1 |
Zhu, YJ | 1 |
Wang, Q | 1 |
Luo, BY | 1 |
Xin, XY | 1 |
Wang, XQ | 1 |
Ma, JF | 1 |
Ding, JQ | 1 |
Yang, GY | 1 |
Chen, SD | 1 |
Guan, YF | 1 |
Du, H | 1 |
Zhai, QW | 1 |
Su, DF | 1 |
Miao, CY | 1 |
Wu, YQ | 1 |
Zhang, XY | 1 |
Guo, J | 1 |
Cui, G | 1 |
Gu, L | 1 |
Su, L | 1 |
Zhang, Y | 1 |
Zhu, J | 1 |
Wu, L | 1 |
Xu, G | 1 |
Dai, J | 1 |
Liu, X | 1 |
Fowler, JC | 1 |
Barth, A | 1 |
Newell, DW | 1 |
Nguyen, LB | 1 |
Winn, HR | 1 |
Wender, R | 1 |
Meno, JR | 1 |
Janigro, D | 1 |
Kobayashi, T | 1 |
Yamada, T | 1 |
Okada, Y | 1 |
Nguyen, A | 1 |
Zhang, L | 1 |
Himi, T | 1 |
Murota, S | 1 |
Betz, AL | 1 |
Reviews
1 review available for adenine and Cerebral Ischemia
Article | Year |
---|---|
Review and management of patients with the prothrombin G20210A polymorphism.
Topics: 3' Untranslated Regions; Adenine; Brain Ischemia; Coronary Disease; Guanine; Humans; Ischemic Attack | 2000 |
Other Studies
35 other studies available for adenine and Cerebral Ischemia
Article | Year |
---|---|
Ibrutinib ameliorates cerebral ischemia/reperfusion injury through autophagy activation and PI3K/Akt/mTOR signaling pathway in diabetic mice.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbr | 2021 |
Ibrutinib-associated symptomatic intracerebral haemorrhage following IV thrombolysis for acute ischaemic stroke.
Topics: Adenine; Brain Ischemia; Cerebral Hemorrhage; Fibrinolytic Agents; Humans; Ischemic Stroke; Piperidi | 2022 |
Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Glucose; Infarction, Middle Cerebral Artery; Ischemic A | 2019 |
CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Beclin-1; Brain Ischemia; Calpain; Dipepti | 2021 |
Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Protein-1 Homolog; Becli | 2021 |
Autophagy-regulated AMPAR subunit upregulation in in vitro oxygen glucose deprivation/reoxygenation-induced hippocampal injury.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cell Hypoxia; Cell Survival; Cells, Cultured; Glucose; | 2017 |
TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Brain; Brain Ischemia; Cells, Cultured; | 2019 |
Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cell Death; Cell Survival; Cells, Cultured; Disease Mod | 2019 |
Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance.
Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Br | 2013 |
Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition.
Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 3; Cerebrum; Immunosuppressive Agent | 2013 |
HuR function and translational state analysis following global brain ischemia and reperfusion.
Topics: Adenine; Animals; Blotting, Western; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampa | 2013 |
Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model.
Topics: Adenine; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Autophagy; B | 2014 |
Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Brain; Brain Ischemia; Diseas | 2014 |
Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cerebral Infarction; Ischemic Postconditioning; Ischemi | 2014 |
DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Brain Ischemia; Cell Line, Tumor; Cell S | 2014 |
[Study of some pharmacological properties of a new adenine derivative].
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adenine; Animals; Brain Ischemia; CA1 Regio | 2014 |
Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury.
Topics: Adenine; Androstadienes; Animals; Antigens, Differentiation; Apoptosis; Autophagy; Brain Ischemia; C | 2016 |
RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF.
Topics: Adenine; Animals; Apoptosis Inducing Factor; Brain Ischemia; Cell Nucleus; Disease Models, Animal; D | 2016 |
Embryonic lethal abnormal vision proteins and adenine and uridine-rich element mRNAs after global cerebral ischemia and reperfusion in the rat.
Topics: Adenine; Animals; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Chromatography, | 2017 |
Folic acid deficiency increases brain cell injury via autophagy enhancement after focal cerebral ischemia.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Beclin-1; Biomarkers; Brain Ischemia; Cell Body; Cerebr | 2016 |
Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Autophagy; Biomarkers; Brain; Brain Ischemia; Cat | 2008 |
Postischemic treatment of neonatal cerebral ischemia should target autophagy.
Topics: Adenine; Animals; Animals, Newborn; Apoptosis; Autophagy; Brain; Brain Ischemia; Caspase Inhibitors; | 2009 |
Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Disease Models | 2010 |
Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; Beclin-1; Brain Ischemia; Ca | 2010 |
Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy.
Topics: Adenine; Animals; Autophagy; Blotting, Western; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; | 2011 |
2-methoxyestradiol attenuates autophagy activation after global ischemia.
Topics: 2-Methoxyestradiol; Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Isch | 2011 |
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Glucose; Infar | 2012 |
Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning.
Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 12; Caspase 3; Cells, Cultured; Cere | 2012 |
Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain; Brain Ischemia; Immunos | 2012 |
Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Inflammation; | 2012 |
Purine release and inhibition of synaptic transmission during hypoxia and hypoglycemia in rat hippocampal slices.
Topics: Adenine; Adenosine; Animals; Brain Ischemia; Electric Stimulation; Electrophysiology; Evoked Potenti | 1993 |
Neurotoxicity in organotypic hippocampal slices mediated by adenosine analogues and nitric oxide.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Br | 1997 |
The levels of adenosine and its metabolites in the guinea pig and rat brain during complete ischemia-in vivo study.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Br | 1998 |
Induction of hepatocyte growth factor (HGF) in rat microglial cells by prostaglandin E(2).
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Brain Ischemia; Bucladesine; Cells, Cultured; Cyclic | 2000 |
Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries.
Topics: Adenine; Allopurinol; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Ischemia; Cap | 1985 |