Page last updated: 2024-10-16

adenine and Cerebral Ischemia

adenine has been researched along with Cerebral Ischemia in 36 studies

Research Excerpts

ExcerptRelevanceReference
" Importantly, the neuron-protective effect of MDL-28170 on ischemic insult was reversed by cotreatment with either class III-PI3K (phosphatidylinositol 3-kinase) inhibitor 3-methyladenine or lysosomal inhibitor chloroquine (chloroquine), suggesting that CAPN1 activation-mediated impairment of autophagic flux is crucial for cerebral ischemia-induced neuronal damage."8.02CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage. ( Cai, R; Che, X; Fu, X; Liu, Y; Luo, J; Yang, J; Yang, Y; Yao, Y; Yu, X; Zhang, H; Zhou, MS, 2021)
"The elevated level of the amino acid metabolite homocysteine (Hcy) is known as a risk factor for ischemic stroke."7.91Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke. ( Cheng, M; Liang, X; Liu, H; Sai, N; Wang, M; Wang, X; Yang, L; Zhang, X, 2019)
" The autophagy inhibitor, 3-methyladenine, inhibited inflammation and activation of nuclear factor kappa B pathway."7.78Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy. ( Dai, J; Jiang, Y; Liu, X; Wu, L; Xu, G; Zhu, J, 2012)
" Importantly, the neuron-protective effect of MDL-28170 on ischemic insult was reversed by cotreatment with either class III-PI3K (phosphatidylinositol 3-kinase) inhibitor 3-methyladenine or lysosomal inhibitor chloroquine (chloroquine), suggesting that CAPN1 activation-mediated impairment of autophagic flux is crucial for cerebral ischemia-induced neuronal damage."4.02CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage. ( Cai, R; Che, X; Fu, X; Liu, Y; Luo, J; Yang, J; Yang, Y; Yao, Y; Yu, X; Zhang, H; Zhou, MS, 2021)
"The elevated level of the amino acid metabolite homocysteine (Hcy) is known as a risk factor for ischemic stroke."3.91Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke. ( Cheng, M; Liang, X; Liu, H; Sai, N; Wang, M; Wang, X; Yang, L; Zhang, X, 2019)
"It is established that the new compound, 9-[2-(4-isopropylphenoxy)ethyl]adenine (9-IPE-adenine) in a dose of 10 mg/kg per day produces neuroprotective effect in rats with brain ischemia model."3.80[Study of some pharmacological properties of a new adenine derivative]. ( Chel'naia, NA; Iasnetsov, VV; Ivanov, IuV; Karsanova, SK; Motin, VG; Ozerov, AA, 2014)
" We evaluated the regulation of mRNAs containing adenine- and uridine-rich elements (ARE) by assessing HuR protein and hsp70 mRNA nuclear translocation, HuR polysome binding, and translation state analysis of CA1 and CA3 at 8 h of reperfusion after 10 min of global cerebral ischemia."3.79HuR function and translational state analysis following global brain ischemia and reperfusion. ( DeGracia, DJ; Jamison, JT; Szymanski, JJ; Wang, H, 2013)
" The autophagy inhibitor, 3-methyladenine, inhibited inflammation and activation of nuclear factor kappa B pathway."3.78Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy. ( Dai, J; Jiang, Y; Liu, X; Wu, L; Xu, G; Zhu, J, 2012)
"We used a cerebral ischemia mouse model (middle cerebral artery occlusion, MCAO) to evaluate the effects of inhibiting autophagy in ischemic brain pathology."1.62Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke. ( Doran, SJ; Li, J; McCullough, LD; Moruno-Manchon, JF; O'Keefe, LM; Patel, AR; Patrizz, AN; Tsvetkov, AS; Venna, VR, 2021)
"Focal cerebral ischemia was induced in aged rats by middle cerebral artery occlusion (MCAO)."1.51Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion. ( Bi, J; Han, D; Liang, J; Lu, Y; Ren, L; Wang, P, 2019)
"During cerebral ischemia/reperfusion (I/R) injury, DRAM1 protein expression is increased, and autophagy is activated."1.40DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy. ( Feng, Q; Gan, J; Jiang, Y; Ouyang, Y; Yu, M, 2014)
"Focal cerebral ischemia was induced by permanent middle cerebral artery occlusion (pMCAO) in rats."1.36Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia. ( Hong, LZ; Liu, CF; Liu, J; Qin, AP; Qin, YY; Qin, ZH; Xu, M; Yang, L; Zhang, HL, 2010)
"Focal cerebral ischemia was introduced by permanent middle cerebral artery occlusion (pMCAO)."1.35Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. ( Fukunaga, K; Han, F; Han, R; Qin, ZH; Sheng, R; Wen, YD; Zhang, LS; Zhang, X; Zhang, XD, 2008)
"Rats were exposed to transient focal cerebral ischemia on postnatal day 12."1.35Postischemic treatment of neonatal cerebral ischemia should target autophagy. ( Clarke, PG; Mottier, V; Puyal, J; Vaslin, A, 2009)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.78)18.7374
1990's3 (8.33)18.2507
2000's4 (11.11)29.6817
2010's24 (66.67)24.3611
2020's4 (11.11)2.80

Authors

AuthorsStudies
Jin, L1
Mo, Y1
Yue, EL1
Liu, Y3
Liu, KY1
Madou, K1
Carrette, S1
Acou, M1
De Herdt, V1
Hemelsoet, D1
Wang, P3
Lu, Y1
Han, D1
Ren, L1
Bi, J1
Liang, J1
Che, X1
Zhang, H1
Fu, X1
Yao, Y1
Luo, J1
Yang, Y1
Cai, R1
Yu, X1
Yang, J1
Zhou, MS1
Patrizz, AN1
Moruno-Manchon, JF1
O'Keefe, LM1
Doran, SJ1
Patel, AR1
Venna, VR1
Tsvetkov, AS1
Li, J1
McCullough, LD1
Bao, L1
Li, RH1
Li, M2
Jin, MF1
Li, G1
Han, X1
Yang, YY1
Sun, B1
Xu, LX1
Feng, X1
Zhang, DM1
Zhang, T3
Wang, MM1
Wang, XX1
Qin, YY2
Wu, J1
Han, R4
Sheng, R4
Wang, Y1
Chen, Z2
Han, F2
Ding, Y1
Qin, ZH5
Wang, M1
Liang, X1
Cheng, M1
Yang, L2
Liu, H1
Wang, X2
Sai, N1
Zhang, X4
Yan, H1
Yuan, Y1
Gao, J1
Shen, Z1
Cheng, Y1
Shen, Y1
Wang, RR1
Hu, WW1
Wang, G1
Xia, DY1
Li, W1
Qian, HR1
Yao, S1
Liu, JG1
Qi, XK1
Szymanski, JJ1
Wang, H3
Jamison, JT1
DeGracia, DJ2
Li, Q1
Huang, J1
Sun, X1
Jiang, T2
Yu, JT1
Zhu, XC1
Wang, HF1
Tan, MS1
Cao, L1
Zhang, QQ1
Gao, L2
Shi, JQ1
Zhang, YD1
Tan, L1
Su, J1
Wang, K3
Zhu, T1
Li, X1
Yu, M1
Jiang, Y2
Feng, Q1
Ouyang, Y1
Gan, J1
Ozerov, AA1
Motin, VG1
Iasnetsov, VV1
Karsanova, SK1
Ivanov, IuV1
Chel'naia, NA1
He, G1
Xu, W1
Tong, L1
Li, S1
Su, S1
Tan, X1
Li, C1
Xu, Y1
Wang, J1
Song, X1
Qu, L1
Wei, R1
He, F1
Luo, B1
Tri Anggraini, F1
Chen, X1
Zhao, Y1
Huang, G1
Chen, S1
Gou, Y1
Dong, Z1
Wen, YD1
Zhang, LS3
Zhang, XD1
Fukunaga, K1
Puyal, J1
Vaslin, A1
Mottier, V1
Clarke, PG1
Liu, XQ2
Gao, B2
Qin, AP1
Liu, CF1
Hong, LZ1
Xu, M1
Liu, J1
Zhang, HL1
Wang, JY1
Xia, Q1
Chu, KT1
Pan, J2
Sun, LN1
Zeng, B1
Zhu, YJ1
Wang, Q1
Luo, BY1
Xin, XY1
Wang, XQ1
Ma, JF1
Ding, JQ1
Yang, GY1
Chen, SD1
Guan, YF1
Du, H1
Zhai, QW1
Su, DF1
Miao, CY1
Wu, YQ1
Zhang, XY1
Guo, J1
Cui, G1
Gu, L1
Su, L1
Zhang, Y1
Zhu, J1
Wu, L1
Xu, G1
Dai, J1
Liu, X1
Fowler, JC1
Barth, A1
Newell, DW1
Nguyen, LB1
Winn, HR1
Wender, R1
Meno, JR1
Janigro, D1
Kobayashi, T1
Yamada, T1
Okada, Y1
Nguyen, A1
Zhang, L1
Himi, T1
Murota, S1
Betz, AL1

Reviews

1 review available for adenine and Cerebral Ischemia

ArticleYear
Review and management of patients with the prothrombin G20210A polymorphism.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2000, Volume: 6, Issue:2

    Topics: 3' Untranslated Regions; Adenine; Brain Ischemia; Coronary Disease; Guanine; Humans; Ischemic Attack

2000

Other Studies

35 other studies available for adenine and Cerebral Ischemia

ArticleYear
Ibrutinib ameliorates cerebral ischemia/reperfusion injury through autophagy activation and PI3K/Akt/mTOR signaling pathway in diabetic mice.
    Bioengineered, 2021, Volume: 12, Issue:1

    Topics: Adenine; Animals; Autophagy; Brain Ischemia; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbr

2021
Ibrutinib-associated symptomatic intracerebral haemorrhage following IV thrombolysis for acute ischaemic stroke.
    Acta neurologica Belgica, 2022, Volume: 122, Issue:4

    Topics: Adenine; Brain Ischemia; Cerebral Hemorrhage; Fibrinolytic Agents; Humans; Ischemic Stroke; Piperidi

2022
Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion.
    Brain research, 2019, 11-15, Volume: 1723

    Topics: Adenine; Animals; Autophagy; Brain Ischemia; Glucose; Infarction, Middle Cerebral Artery; Ischemic A

2019
CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage.
    Stroke, 2021, Volume: 52, Issue:5

    Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Beclin-1; Brain Ischemia; Calpain; Dipepti

2021
Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke.
    Cells, 2021, 07-20, Volume: 10, Issue:7

    Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Protein-1 Homolog; Becli

2021
Autophagy-regulated AMPAR subunit upregulation in in vitro oxygen glucose deprivation/reoxygenation-induced hippocampal injury.
    Brain research, 2017, Aug-01, Volume: 1668

    Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cell Hypoxia; Cell Survival; Cells, Cultured; Glucose;

2017
TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury.
    Free radical biology & medicine, 2019, Volume: 137

    Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Brain; Brain Ischemia; Cells, Cultured;

2019
Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke.
    Cell death & disease, 2019, 07-22, Volume: 10, Issue:8

    Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cell Death; Cell Survival; Cells, Cultured; Disease Mod

2019
Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance.
    Autophagy, 2013, Volume: 9, Issue:9

    Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Br

2013
Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2013, Volume: 46, Issue:7

    Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 3; Cerebrum; Immunosuppressive Agent

2013
HuR function and translational state analysis following global brain ischemia and reperfusion.
    Translational stroke research, 2013, Volume: 4, Issue:6

    Topics: Adenine; Animals; Blotting, Western; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampa

2013
Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model.
    Neuroscience, 2014, Mar-28, Volume: 263

    Topics: Adenine; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Autophagy; B

2014
Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy.
    British journal of pharmacology, 2014, Volume: 171, Issue:13

    Topics: Adenine; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Brain; Brain Ischemia; Diseas

2014
Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats.
    Neurochemical research, 2014, Volume: 39, Issue:11

    Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cerebral Infarction; Ischemic Postconditioning; Ischemi

2014
DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.
    International journal of molecular sciences, 2014, Oct-23, Volume: 15, Issue:10

    Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Brain Ischemia; Cell Line, Tumor; Cell S

2014
[Study of some pharmacological properties of a new adenine derivative].
    Eksperimental'naia i klinicheskaia farmakologiia, 2014, Volume: 77, Issue:10

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adenine; Animals; Brain Ischemia; CA1 Regio

2014
Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury.
    Apoptosis : an international journal on programmed cell death, 2016, Volume: 21, Issue:4

    Topics: Adenine; Androstadienes; Animals; Antigens, Differentiation; Apoptosis; Autophagy; Brain Ischemia; C

2016
RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF.
    Scientific reports, 2016, 07-05, Volume: 6

    Topics: Adenine; Animals; Apoptosis Inducing Factor; Brain Ischemia; Cell Nucleus; Disease Models, Animal; D

2016
Embryonic lethal abnormal vision proteins and adenine and uridine-rich element mRNAs after global cerebral ischemia and reperfusion in the rat.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:4

    Topics: Adenine; Animals; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Chromatography,

2017
Folic acid deficiency increases brain cell injury via autophagy enhancement after focal cerebral ischemia.
    The Journal of nutritional biochemistry, 2016, Volume: 38

    Topics: Adenine; Animals; Autophagosomes; Autophagy; Beclin-1; Biomarkers; Brain Ischemia; Cell Body; Cerebr

2016
Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways.
    Autophagy, 2008, Volume: 4, Issue:6

    Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Autophagy; Biomarkers; Brain; Brain Ischemia; Cat

2008
Postischemic treatment of neonatal cerebral ischemia should target autophagy.
    Annals of neurology, 2009, Volume: 66, Issue:3

    Topics: Adenine; Animals; Animals, Newborn; Apoptosis; Autophagy; Brain; Brain Ischemia; Caspase Inhibitors;

2009
Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning.
    Autophagy, 2010, Volume: 6, Issue:4

    Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Disease Models

2010
Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia.
    Autophagy, 2010, Volume: 6, Issue:6

    Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; Beclin-1; Brain Ischemia; Ca

2010
Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy.
    Journal of neuropathology and experimental neurology, 2011, Volume: 70, Issue:4

    Topics: Adenine; Animals; Autophagy; Blotting, Western; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3;

2011
2-methoxyestradiol attenuates autophagy activation after global ischemia.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2011, Volume: 38, Issue:4

    Topics: 2-Methoxyestradiol; Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Isch

2011
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia.
    Autophagy, 2012, Volume: 8, Issue:1

    Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Glucose; Infar

2012
Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning.
    Autophagy, 2012, Volume: 8, Issue:3

    Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 12; Caspase 3; Cells, Cultured; Cere

2012
Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain; Brain Ischemia; Immunos

2012
Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Inflammation;

2012
Purine release and inhibition of synaptic transmission during hypoxia and hypoglycemia in rat hippocampal slices.
    Neuroscience letters, 1993, Jul-09, Volume: 157, Issue:1

    Topics: Adenine; Adenosine; Animals; Brain Ischemia; Electric Stimulation; Electrophysiology; Evoked Potenti

1993
Neurotoxicity in organotypic hippocampal slices mediated by adenosine analogues and nitric oxide.
    Brain research, 1997, Jul-11, Volume: 762, Issue:1-2

    Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Br

1997
The levels of adenosine and its metabolites in the guinea pig and rat brain during complete ischemia-in vivo study.
    Brain research, 1998, Mar-23, Volume: 787, Issue:2

    Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Br

1998
Induction of hepatocyte growth factor (HGF) in rat microglial cells by prostaglandin E(2).
    Journal of neuroscience research, 2000, Nov-01, Volume: 62, Issue:3

    Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Brain Ischemia; Bucladesine; Cells, Cultured; Cyclic

2000
Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries.
    Journal of neurochemistry, 1985, Volume: 44, Issue:2

    Topics: Adenine; Allopurinol; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Ischemia; Cap

1985
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