Page last updated: 2024-10-16

adenine and Carcinoma, Papillary

adenine has been researched along with Carcinoma, Papillary in 5 studies

Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, X1
Li, Z1
Song, Y1
Liu, W1
Liu, Z1
Lin, CI1
Whang, EE1
Abramson, MA1
Jiang, X1
Price, BD1
Donner, DB1
Moore, FD1
Ruan, DT1
Cohen, Y1
Xing, M2
Mambo, E1
Guo, Z1
Wu, G2
Trink, B2
Beller, U1
Westra, WH1
Ladenson, PW1
Sidransky, D1
Vasko, V1
Hu, S1
Xing, JC1
Larin, A1
Savchenko, V1
Karuzina, NP1
Shuvaeva, NI1
Klimanova, ZF1
Antoshechkina, ET1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I Trial of BAY 43-9006 (Sorafenib) and Bevacizumab in Refractory Solid Tumors With Biologic and Proteomic Analysis[NCT00095459]Phase 157 participants (Actual)Interventional2004-11-02Completed
A Phase II Study of Sorafenib and Bevacizumab in Epithelial Ovarian, Fallopian, and Peritoneal Cancer[NCT00436215]Phase 255 participants (Actual)Interventional2006-12-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Adverse Events

Here is the number of participants with adverse events. For a detailed list of adverse events, see the adverse event module. (NCT00436215)
Timeframe: up to 28 months

InterventionParticipants (Count of Participants)
BAY 43-9006 + Bevacizumab54

Progression-free Survival

Progression free survival is defined by the number of weeks between the first day of treatment and the date of cancer progression. (NCT00436215)
Timeframe: up to 28 months

InterventionWeeks (Mean)
BAY 43-9006 + Bevacizumab26

Clinical Response Rate.

Clinical response rate is defined as the percentage of participants with a complete response (CR) or partial response (PR) per the Response Evaluation Criteria in Solid Tumors (RECIST). CR is disappearance of all target lesions. PR is at least a 30% decrease in the sum of the longest diameter (LD) of target lesions, taking as reference the baseline sum LD. Progressive disease (PD) is a 20% increase in the sum of the LD of target lesions, taking as reference the smallest sum LD recorded since the treatment started or the appearance of one or more new lesions. Stable disease (SD) is neither sufficient increase to qualify for PD, taking as reference the smallest sum LD since the treatment started lasting at least 6 months. (NCT00436215)
Timeframe: patients were followed for a median of 18 weeks (range 1-116 weeks)

Interventionpercentage of participants (Number)
Complete ResponsePartial ResponseProgressive DiseaseStable Disease
BAY 43-9006 + Bevacizumab0192160

Other Studies

5 other studies available for adenine and Carcinoma, Papillary

ArticleYear
The mTOR Kinase Inhibitor CZ415 Inhibits Human Papillary Thyroid Carcinoma Cell Growth.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 46, Issue:2

    Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Carcinoma, Papillary; Cell Cycle Checkpoints; Cell

2018
Autophagy: a new target for advanced papillary thyroid cancer therapy.
    Surgery, 2009, Volume: 146, Issue:6

    Topics: Adenine; Antibiotics, Antineoplastic; Autophagy; Carcinoma, Papillary; Cell Line, Tumor; Doxorubicin

2009
BRAF mutation in papillary thyroid carcinoma.
    Journal of the National Cancer Institute, 2003, Apr-16, Volume: 95, Issue:8

    Topics: Adenine; Carcinoma, Papillary; Case-Control Studies; Head and Neck Neoplasms; Humans; Lung Neoplasms

2003
BRAF mutation in papillary thyroid carcinoma.
    Journal of the National Cancer Institute, 2003, Apr-16, Volume: 95, Issue:8

    Topics: Adenine; Carcinoma, Papillary; Case-Control Studies; Head and Neck Neoplasms; Humans; Lung Neoplasms

2003
BRAF mutation in papillary thyroid carcinoma.
    Journal of the National Cancer Institute, 2003, Apr-16, Volume: 95, Issue:8

    Topics: Adenine; Carcinoma, Papillary; Case-Control Studies; Head and Neck Neoplasms; Humans; Lung Neoplasms

2003
BRAF mutation in papillary thyroid carcinoma.
    Journal of the National Cancer Institute, 2003, Apr-16, Volume: 95, Issue:8

    Topics: Adenine; Carcinoma, Papillary; Case-Control Studies; Head and Neck Neoplasms; Humans; Lung Neoplasms

2003
High prevalence and possible de novo formation of BRAF mutation in metastasized papillary thyroid cancer in lymph nodes.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:9

    Topics: Adenine; Adolescent; Adult; Aged; Carcinoma, Papillary; Female; Gene Frequency; Humans; Lymphatic Me

2005
[Individual sensitivity of ovarian ascitic cancer to thiophosphamide].
    Voprosy onkologii, 1974, Volume: 20, Issue:8

    Topics: Adenine; Adenocarcinoma; Ascites; Ascitic Fluid; Carbon Radioisotopes; Carcinoma; Carcinoma, Papilla

1974