adenine has been researched along with Brain Ischemia in 36 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Importantly, the neuron-protective effect of MDL-28170 on ischemic insult was reversed by cotreatment with either class III-PI3K (phosphatidylinositol 3-kinase) inhibitor 3-methyladenine or lysosomal inhibitor chloroquine (chloroquine), suggesting that CAPN1 activation-mediated impairment of autophagic flux is crucial for cerebral ischemia-induced neuronal damage." | 8.02 | CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage. ( Cai, R; Che, X; Fu, X; Liu, Y; Luo, J; Yang, J; Yang, Y; Yao, Y; Yu, X; Zhang, H; Zhou, MS, 2021) |
| "The elevated level of the amino acid metabolite homocysteine (Hcy) is known as a risk factor for ischemic stroke." | 7.91 | Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke. ( Cheng, M; Liang, X; Liu, H; Sai, N; Wang, M; Wang, X; Yang, L; Zhang, X, 2019) |
| " The autophagy inhibitor, 3-methyladenine, inhibited inflammation and activation of nuclear factor kappa B pathway." | 7.78 | Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy. ( Dai, J; Jiang, Y; Liu, X; Wu, L; Xu, G; Zhu, J, 2012) |
| " Importantly, the neuron-protective effect of MDL-28170 on ischemic insult was reversed by cotreatment with either class III-PI3K (phosphatidylinositol 3-kinase) inhibitor 3-methyladenine or lysosomal inhibitor chloroquine (chloroquine), suggesting that CAPN1 activation-mediated impairment of autophagic flux is crucial for cerebral ischemia-induced neuronal damage." | 4.02 | CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage. ( Cai, R; Che, X; Fu, X; Liu, Y; Luo, J; Yang, J; Yang, Y; Yao, Y; Yu, X; Zhang, H; Zhou, MS, 2021) |
| "The elevated level of the amino acid metabolite homocysteine (Hcy) is known as a risk factor for ischemic stroke." | 3.91 | Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke. ( Cheng, M; Liang, X; Liu, H; Sai, N; Wang, M; Wang, X; Yang, L; Zhang, X, 2019) |
| "It is established that the new compound, 9-[2-(4-isopropylphenoxy)ethyl]adenine (9-IPE-adenine) in a dose of 10 mg/kg per day produces neuroprotective effect in rats with brain ischemia model." | 3.80 | [Study of some pharmacological properties of a new adenine derivative]. ( Chel'naia, NA; Iasnetsov, VV; Ivanov, IuV; Karsanova, SK; Motin, VG; Ozerov, AA, 2014) |
| " We evaluated the regulation of mRNAs containing adenine- and uridine-rich elements (ARE) by assessing HuR protein and hsp70 mRNA nuclear translocation, HuR polysome binding, and translation state analysis of CA1 and CA3 at 8 h of reperfusion after 10 min of global cerebral ischemia." | 3.79 | HuR function and translational state analysis following global brain ischemia and reperfusion. ( DeGracia, DJ; Jamison, JT; Szymanski, JJ; Wang, H, 2013) |
| " The autophagy inhibitor, 3-methyladenine, inhibited inflammation and activation of nuclear factor kappa B pathway." | 3.78 | Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy. ( Dai, J; Jiang, Y; Liu, X; Wu, L; Xu, G; Zhu, J, 2012) |
| "We used a cerebral ischemia mouse model (middle cerebral artery occlusion, MCAO) to evaluate the effects of inhibiting autophagy in ischemic brain pathology." | 1.62 | Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke. ( Doran, SJ; Li, J; McCullough, LD; Moruno-Manchon, JF; O'Keefe, LM; Patel, AR; Patrizz, AN; Tsvetkov, AS; Venna, VR, 2021) |
| "Focal cerebral ischemia was induced in aged rats by middle cerebral artery occlusion (MCAO)." | 1.51 | Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion. ( Bi, J; Han, D; Liang, J; Lu, Y; Ren, L; Wang, P, 2019) |
| "During cerebral ischemia/reperfusion (I/R) injury, DRAM1 protein expression is increased, and autophagy is activated." | 1.40 | DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy. ( Feng, Q; Gan, J; Jiang, Y; Ouyang, Y; Yu, M, 2014) |
| "Focal cerebral ischemia was induced by permanent middle cerebral artery occlusion (pMCAO) in rats." | 1.36 | Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia. ( Hong, LZ; Liu, CF; Liu, J; Qin, AP; Qin, YY; Qin, ZH; Xu, M; Yang, L; Zhang, HL, 2010) |
| "Focal cerebral ischemia was introduced by permanent middle cerebral artery occlusion (pMCAO)." | 1.35 | Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. ( Fukunaga, K; Han, F; Han, R; Qin, ZH; Sheng, R; Wen, YD; Zhang, LS; Zhang, X; Zhang, XD, 2008) |
| "Rats were exposed to transient focal cerebral ischemia on postnatal day 12." | 1.35 | Postischemic treatment of neonatal cerebral ischemia should target autophagy. ( Clarke, PG; Mottier, V; Puyal, J; Vaslin, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.78) | 18.7374 |
| 1990's | 3 (8.33) | 18.2507 |
| 2000's | 4 (11.11) | 29.6817 |
| 2010's | 24 (66.67) | 24.3611 |
| 2020's | 4 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, L | 1 |
| Mo, Y | 1 |
| Yue, EL | 1 |
| Liu, Y | 3 |
| Liu, KY | 1 |
| Madou, K | 1 |
| Carrette, S | 1 |
| Acou, M | 1 |
| De Herdt, V | 1 |
| Hemelsoet, D | 1 |
| Wang, P | 3 |
| Lu, Y | 1 |
| Han, D | 1 |
| Ren, L | 1 |
| Bi, J | 1 |
| Liang, J | 1 |
| Che, X | 1 |
| Zhang, H | 1 |
| Fu, X | 1 |
| Yao, Y | 1 |
| Luo, J | 1 |
| Yang, Y | 1 |
| Cai, R | 1 |
| Yu, X | 1 |
| Yang, J | 1 |
| Zhou, MS | 1 |
| Patrizz, AN | 1 |
| Moruno-Manchon, JF | 1 |
| O'Keefe, LM | 1 |
| Doran, SJ | 1 |
| Patel, AR | 1 |
| Venna, VR | 1 |
| Tsvetkov, AS | 1 |
| Li, J | 1 |
| McCullough, LD | 1 |
| Bao, L | 1 |
| Li, RH | 1 |
| Li, M | 2 |
| Jin, MF | 1 |
| Li, G | 1 |
| Han, X | 1 |
| Yang, YY | 1 |
| Sun, B | 1 |
| Xu, LX | 1 |
| Feng, X | 1 |
| Zhang, DM | 1 |
| Zhang, T | 3 |
| Wang, MM | 1 |
| Wang, XX | 1 |
| Qin, YY | 2 |
| Wu, J | 1 |
| Han, R | 4 |
| Sheng, R | 4 |
| Wang, Y | 1 |
| Chen, Z | 2 |
| Han, F | 2 |
| Ding, Y | 1 |
| Qin, ZH | 5 |
| Wang, M | 1 |
| Liang, X | 1 |
| Cheng, M | 1 |
| Yang, L | 2 |
| Liu, H | 1 |
| Wang, X | 2 |
| Sai, N | 1 |
| Zhang, X | 4 |
| Yan, H | 1 |
| Yuan, Y | 1 |
| Gao, J | 1 |
| Shen, Z | 1 |
| Cheng, Y | 1 |
| Shen, Y | 1 |
| Wang, RR | 1 |
| Hu, WW | 1 |
| Wang, G | 1 |
| Xia, DY | 1 |
| Li, W | 1 |
| Qian, HR | 1 |
| Yao, S | 1 |
| Liu, JG | 1 |
| Qi, XK | 1 |
| Szymanski, JJ | 1 |
| Wang, H | 3 |
| Jamison, JT | 1 |
| DeGracia, DJ | 2 |
| Li, Q | 1 |
| Huang, J | 1 |
| Sun, X | 1 |
| Jiang, T | 2 |
| Yu, JT | 1 |
| Zhu, XC | 1 |
| Wang, HF | 1 |
| Tan, MS | 1 |
| Cao, L | 1 |
| Zhang, QQ | 1 |
| Gao, L | 2 |
| Shi, JQ | 1 |
| Zhang, YD | 1 |
| Tan, L | 1 |
| Su, J | 1 |
| Wang, K | 3 |
| Zhu, T | 1 |
| Li, X | 1 |
| Yu, M | 1 |
| Jiang, Y | 2 |
| Feng, Q | 1 |
| Ouyang, Y | 1 |
| Gan, J | 1 |
| Ozerov, AA | 1 |
| Motin, VG | 1 |
| Iasnetsov, VV | 1 |
| Karsanova, SK | 1 |
| Ivanov, IuV | 1 |
| Chel'naia, NA | 1 |
| He, G | 1 |
| Xu, W | 1 |
| Tong, L | 1 |
| Li, S | 1 |
| Su, S | 1 |
| Tan, X | 1 |
| Li, C | 1 |
| Xu, Y | 1 |
| Wang, J | 1 |
| Song, X | 1 |
| Qu, L | 1 |
| Wei, R | 1 |
| He, F | 1 |
| Luo, B | 1 |
| Tri Anggraini, F | 1 |
| Chen, X | 1 |
| Zhao, Y | 1 |
| Huang, G | 1 |
| Chen, S | 1 |
| Gou, Y | 1 |
| Dong, Z | 1 |
| Wen, YD | 1 |
| Zhang, LS | 3 |
| Zhang, XD | 1 |
| Fukunaga, K | 1 |
| Puyal, J | 1 |
| Vaslin, A | 1 |
| Mottier, V | 1 |
| Clarke, PG | 1 |
| Liu, XQ | 2 |
| Gao, B | 2 |
| Qin, AP | 1 |
| Liu, CF | 1 |
| Hong, LZ | 1 |
| Xu, M | 1 |
| Liu, J | 1 |
| Zhang, HL | 1 |
| Wang, JY | 1 |
| Xia, Q | 1 |
| Chu, KT | 1 |
| Pan, J | 2 |
| Sun, LN | 1 |
| Zeng, B | 1 |
| Zhu, YJ | 1 |
| Wang, Q | 1 |
| Luo, BY | 1 |
| Xin, XY | 1 |
| Wang, XQ | 1 |
| Ma, JF | 1 |
| Ding, JQ | 1 |
| Yang, GY | 1 |
| Chen, SD | 1 |
| Guan, YF | 1 |
| Du, H | 1 |
| Zhai, QW | 1 |
| Su, DF | 1 |
| Miao, CY | 1 |
| Wu, YQ | 1 |
| Zhang, XY | 1 |
| Guo, J | 1 |
| Cui, G | 1 |
| Gu, L | 1 |
| Su, L | 1 |
| Zhang, Y | 1 |
| Zhu, J | 1 |
| Wu, L | 1 |
| Xu, G | 1 |
| Dai, J | 1 |
| Liu, X | 1 |
| Fowler, JC | 1 |
| Barth, A | 1 |
| Newell, DW | 1 |
| Nguyen, LB | 1 |
| Winn, HR | 1 |
| Wender, R | 1 |
| Meno, JR | 1 |
| Janigro, D | 1 |
| Kobayashi, T | 1 |
| Yamada, T | 1 |
| Okada, Y | 1 |
| Nguyen, A | 1 |
| Zhang, L | 1 |
| Himi, T | 1 |
| Murota, S | 1 |
| Betz, AL | 1 |
1 review available for adenine and Brain Ischemia
| Article | Year |
|---|---|
Review and management of patients with the prothrombin G20210A polymorphism.
Topics: 3' Untranslated Regions; Adenine; Brain Ischemia; Coronary Disease; Guanine; Humans; Ischemic Attack | 2000 |
35 other studies available for adenine and Brain Ischemia
| Article | Year |
|---|---|
Ibrutinib ameliorates cerebral ischemia/reperfusion injury through autophagy activation and PI3K/Akt/mTOR signaling pathway in diabetic mice.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbr | 2021 |
Ibrutinib-associated symptomatic intracerebral haemorrhage following IV thrombolysis for acute ischaemic stroke.
Topics: Adenine; Brain Ischemia; Cerebral Hemorrhage; Fibrinolytic Agents; Humans; Ischemic Stroke; Piperidi | 2022 |
Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Glucose; Infarction, Middle Cerebral Artery; Ischemic A | 2019 |
CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Beclin-1; Brain Ischemia; Calpain; Dipepti | 2021 |
Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Protein-1 Homolog; Becli | 2021 |
Autophagy-regulated AMPAR subunit upregulation in in vitro oxygen glucose deprivation/reoxygenation-induced hippocampal injury.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cell Hypoxia; Cell Survival; Cells, Cultured; Glucose; | 2017 |
TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Brain; Brain Ischemia; Cells, Cultured; | 2019 |
Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cell Death; Cell Survival; Cells, Cultured; Disease Mod | 2019 |
Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance.
Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Br | 2013 |
Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition.
Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 3; Cerebrum; Immunosuppressive Agent | 2013 |
HuR function and translational state analysis following global brain ischemia and reperfusion.
Topics: Adenine; Animals; Blotting, Western; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampa | 2013 |
Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model.
Topics: Adenine; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Autophagy; B | 2014 |
Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Brain; Brain Ischemia; Diseas | 2014 |
Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cerebral Infarction; Ischemic Postconditioning; Ischemi | 2014 |
DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Brain Ischemia; Cell Line, Tumor; Cell S | 2014 |
[Study of some pharmacological properties of a new adenine derivative].
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adenine; Animals; Brain Ischemia; CA1 Regio | 2014 |
Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury.
Topics: Adenine; Androstadienes; Animals; Antigens, Differentiation; Apoptosis; Autophagy; Brain Ischemia; C | 2016 |
RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF.
Topics: Adenine; Animals; Apoptosis Inducing Factor; Brain Ischemia; Cell Nucleus; Disease Models, Animal; D | 2016 |
Embryonic lethal abnormal vision proteins and adenine and uridine-rich element mRNAs after global cerebral ischemia and reperfusion in the rat.
Topics: Adenine; Animals; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Chromatography, | 2017 |
Folic acid deficiency increases brain cell injury via autophagy enhancement after focal cerebral ischemia.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Beclin-1; Biomarkers; Brain Ischemia; Cell Body; Cerebr | 2016 |
Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Autophagy; Biomarkers; Brain; Brain Ischemia; Cat | 2008 |
Postischemic treatment of neonatal cerebral ischemia should target autophagy.
Topics: Adenine; Animals; Animals, Newborn; Apoptosis; Autophagy; Brain; Brain Ischemia; Caspase Inhibitors; | 2009 |
Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Disease Models | 2010 |
Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; Beclin-1; Brain Ischemia; Ca | 2010 |
Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy.
Topics: Adenine; Animals; Autophagy; Blotting, Western; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; | 2011 |
2-methoxyestradiol attenuates autophagy activation after global ischemia.
Topics: 2-Methoxyestradiol; Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Isch | 2011 |
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Glucose; Infar | 2012 |
Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning.
Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 12; Caspase 3; Cells, Cultured; Cere | 2012 |
Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain; Brain Ischemia; Immunos | 2012 |
Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Inflammation; | 2012 |
Purine release and inhibition of synaptic transmission during hypoxia and hypoglycemia in rat hippocampal slices.
Topics: Adenine; Adenosine; Animals; Brain Ischemia; Electric Stimulation; Electrophysiology; Evoked Potenti | 1993 |
Neurotoxicity in organotypic hippocampal slices mediated by adenosine analogues and nitric oxide.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Br | 1997 |
The levels of adenosine and its metabolites in the guinea pig and rat brain during complete ischemia-in vivo study.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Br | 1998 |
Induction of hepatocyte growth factor (HGF) in rat microglial cells by prostaglandin E(2).
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Brain Ischemia; Bucladesine; Cells, Cultured; Cyclic | 2000 |
Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries.
Topics: Adenine; Allopurinol; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Ischemia; Cap | 1985 |