Page last updated: 2024-10-16

adenine and Autoimmune Disease

adenine has been researched along with Autoimmune Disease in 22 studies

Research Excerpts

ExcerptRelevanceReference
"While opportunistic infections and viral reactivations occur with both ibrutinib and idelalisib, these complications are less common and less severe with ibrutinib, especially when used as monotherapy without additional immunosuppressive agents."2.58Immunological changes with kinase inhibitor therapy for chronic lymphocytic leukemia. ( Pleyer, C; Sun, C; Wiestner, A, 2018)
"The clinical course of chronic lymphocytic leukemia (CLL) is often complicated by autoimmune cytopenia (AIC)."1.51[Improvement of autoimmune cytopenia with ibrutinib in a chronic lymphocytic leukemia patient complicated by monoclonal immunoglobulin deposition disease]. ( Hara, S; Ishikawa, T; Nakamura, M; Yamashita, D; Yoshioka, S, 2019)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.09)18.7374
1990's1 (4.55)18.2507
2000's2 (9.09)29.6817
2010's14 (63.64)24.3611
2020's3 (13.64)2.80

Authors

AuthorsStudies
Nakamura, M1
Yoshioka, S1
Yamashita, D1
Hara, S1
Ishikawa, T1
Vitale, C2
Salvetti, C1
Griggio, V1
Porrazzo, M1
Schiattone, L1
Zamprogna, G1
Visentin, A1
Vassallo, F1
Cassin, R1
Rigolin, GM1
Murru, R1
Laurenti, L1
Rivela, P1
Marchetti, M1
Pennese, E1
Gentile, M1
Boccellato, E1
Perutelli, F1
Montalbano, MC1
De Paoli, L1
Reda, G1
Orsucci, L1
Trentin, L1
Cuneo, A1
Tedeschi, A1
Scarfò, L1
Gaidano, G1
Mauro, FR1
Foà, R1
Boccadoro, M1
Coscia, M1
Tang, L1
Wei, X1
Li, T1
Chen, Y1
Dai, Z1
Lu, C1
Zheng, G1
Ma, WH1
Zhang, XG1
Guo, LL1
Zhang, JB1
Wei, FT1
Lu, QH1
Du, H1
Kong, YR1
Wang, X1
Xu, DL1
Zhang, Z1
Zhang, D1
Liu, Y1
Yang, D1
Ran, F1
Wang, ML1
Zhao, G1
Pleyer, C1
Wiestner, A2
Sun, C1
Wanner, D1
Bohn, JP1
Rudzki, J1
Stockhammer, G1
Steurer, M1
Hampel, PJ1
Larson, MC1
Kabat, B1
Call, TG1
Ding, W1
Kenderian, SS1
Bowen, D1
Boysen, J1
Schwager, SM1
Leis, JF1
Chanan-Khan, AA1
Muchtar, E1
Hanson, CA1
Slager, SL1
Kay, NE1
Chaffee, KG1
Shanafelt, TD1
Parikh, SA1
Quinquenel, A1
Godet, S1
Dartigeas, C1
Ysebaert, L1
Dupuis, J1
Ohanyan, H1
Collignon, A1
Gilardin, L1
Lepretre, S1
Dilhuydy, MS1
Vignon, M1
de Guibert, S1
Dmytruk, N1
Durot, E1
Ghez, D1
Roos Weil, D1
Béné, MC1
Toussaint, E1
Merabet, F1
Lévy, V1
Delmer, A1
Aurran, T1
Burger, JA2
Buggy, JJ2
Yuan, J1
Yu, M1
Li, HH1
Long, Q1
Liang, W1
Wen, S1
Wang, M1
Guo, HP1
Cheng, X1
Liao, YH1
Xing, L1
Huang, A1
Viganò, M1
Mangia, G1
Lampertico, P1
Kokhaei, P1
Jadidi-Niaragh, F1
Sotoodeh Jahromi, A1
Osterborg, A1
Mellstedt, H1
Hojjat-Farsangi, M1
Ahn, IE1
Sivina, M1
Ferrajoli, A1
Wierda, WG1
Estrov, Z1
Konoplev, SN1
Jain, N1
O'Brien, S1
Farooqui, M1
Keating, MJ1
Schliffke, S1
Akyüz, N1
Ford, CT1
Mährle, T1
Thenhausen, T1
Krohn-Grimberghe, A1
Knop, S1
Bokemeyer, C1
Binder, M1
Hayashi, T1
Gray, CS1
Chan, M1
Tawatao, RI1
Ronacher, L1
McGargill, MA1
Datta, SK1
Carson, DA1
Corr, M1
Honigberg, LA1
Smith, AM1
Sirisawad, M1
Verner, E1
Loury, D1
Chang, B1
Li, S1
Pan, Z1
Thamm, DH1
Miller, RA1
Lawson, BR1
Manenkova, Y1
Ahamed, J1
Chen, X1
Zou, JP1
Baccala, R1
Theofilopoulos, AN1
Yuan, C1
Ahmad, J1
Ashok, BT1
Ali, R1
Cowan, DH1
Graham, RC1
Lawley, PD1
Harris, G1
Phillips, E1
Irving, W1
Colaço, CB1
Lydyard, PM1
Roitt, IM1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of BCR Inhibitors in the Treatment of Autoimmune Cytopenias Associated With Chronic Lymphocytic Leukemia (CLL): A Retrospective Analysis of the French Innovative Leukemia Organization (FILO)[NCT03469895]40 participants (Actual)Observational2017-07-21Active, not recruiting
Phase III Randomized Study to Investigate the Use of Acalabrutinib in the Treatment of Patients With Early Stage CLL With High Risk of Early Disease Progression[NCT04178798]Phase 322 participants (Actual)Interventional2019-12-09Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for adenine and Autoimmune Disease

ArticleYear
Emerging Perspectives of RNA
    Frontiers in immunology, 2021, Volume: 12

    Topics: Adaptive Immunity; Adenine; Autoimmune Diseases; Dendritic Cells; Humans; Immunity, Innate; Methylat

2021
Targeting Bruton's tyrosine kinase for the treatment of B cell associated malignancies and autoimmune diseases: Preclinical and clinical developments of small molecule inhibitors.
    Archiv der Pharmazie, 2018, Volume: 351, Issue:7

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents; Autoimmune Diseases; B

2018
Immunological changes with kinase inhibitor therapy for chronic lymphocytic leukemia.
    Leukemia & lymphoma, 2018, Volume: 59, Issue:12

    Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Autoimmune Diseases; Autoimmunity; B-Lympho

2018
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765).
    Leukemia & lymphoma, 2013, Volume: 54, Issue:11

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Autoimmune Diseases; B-Lymphocytes; Drug Eval

2013
Bruton's TK inhibitors: structural insights and evolution of clinical candidates.
    Future medicinal chemistry, 2014, Volume: 6, Issue:6

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Autoimmune Diseases; Clinical Trials as Topic

2014
Management of patients with overt or resolved hepatitis B virus infection undergoing rituximab therapy.
    Expert opinion on biological therapy, 2014, Volume: 14, Issue:7

    Topics: Adenine; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Monoclonal, Murine-

2014
Ibrutinib-A double-edge sword in cancer and autoimmune disorders.
    Journal of drug targeting, 2016, Volume: 24, Issue:5

    Topics: Adenine; Animals; Autoimmune Diseases; Humans; Immunologic Factors; Neoplasms; Piperidines; Protein-

2016

Trials

3 trials available for adenine and Autoimmune Disease

ArticleYear
Preexisting and treatment-emergent autoimmune cytopenias in patients with CLL treated with targeted drugs.
    Blood, 2021, 06-24, Volume: 137, Issue:25

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Autoimmune

2021
Ibrutinib and idelalisib in the management of CLL-associated autoimmune cytopenias: a study from the FILO group.
    American journal of hematology, 2019, Volume: 94, Issue:7

    Topics: Adenine; Autoimmune Diseases; Disease-Free Survival; Female; Hematologic Diseases; Humans; Leukemia,

2019
Autoimmune cytopenias in patients with chronic lymphocytic leukemia treated with ibrutinib.
    Haematologica, 2016, Volume: 101, Issue:6

    Topics: Adenine; Aged; Anemia; Autoimmune Diseases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Mi

2016

Other Studies

12 other studies available for adenine and Autoimmune Disease

ArticleYear
[Improvement of autoimmune cytopenia with ibrutinib in a chronic lymphocytic leukemia patient complicated by monoclonal immunoglobulin deposition disease].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2019, Volume: 60, Issue:10

    Topics: Adenine; Aged; Antibodies, Monoclonal; Autoimmune Diseases; Female; Humans; Leukemia, Lymphocytic, C

2019
Androgen receptor inhibition alleviated inflammation in experimental autoimmune myocarditis by increasing autophagy in macrophages.
    European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:10

    Topics: Adenine; Androgen Receptor Antagonists; Animals; Anti-Inflammatory Agents; Apoptosis; Autoimmune Dis

2021
Autoimmune myelitis in a CLL patient undergoing treatment with ibrutinib.
    Annals of hematology, 2019, Volume: 98, Issue:1

    Topics: Adenine; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Aut

2019
Autoimmune cytopenias in patients with chronic lymphocytic leukaemia treated with ibrutinib in routine clinical practice at an academic medical centre.
    British journal of haematology, 2018, Volume: 183, Issue:3

    Topics: Academic Medical Centers; Adenine; Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Disease-Free

2018
Autophagy contributes to IL-17-induced plasma cell differentiation in experimental autoimmune myocarditis.
    International immunopharmacology, 2014, Volume: 18, Issue:1

    Topics: Adenine; ADP-ribosyl Cyclase 1; Animals; Apoptosis Regulatory Proteins; Autoimmune Diseases; Autopha

2014
Clinical response to ibrutinib is accompanied by normalization of the T-cell environment in CLL-related autoimmune cytopenia.
    Leukemia, 2016, Volume: 30, Issue:11

    Topics: Adenine; Aged; Autoimmune Diseases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Age

2016
Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Feb-24, Volume: 106, Issue:8

    Topics: Adenine; Animals; Autoimmune Diseases; Encephalomyelitis, Autoimmune, Experimental; Immune Tolerance

2009
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Jul-20, Volume: 107, Issue:29

    Topics: Adenine; Administration, Oral; Agammaglobulinaemia Tyrosine Kinase; Animals; Arthritis, Experimental

2010
Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Apr-15, Volume: 178, Issue:8

    Topics: Adenine; Adenosylhomocysteinase; Animals; Autoimmune Diseases; Butyrates; Calcium; CD4-Positive T-Ly

2007
Reactive oxygen species modified thymine and poly(dT) present unique epitope for human anti-DNA autoantibodies.
    Immunology letters, 1997, Volume: 58, Issue:2

    Topics: Adenine; Animals; Antibodies, Antinuclear; Antibody Specificity; Autoimmune Diseases; Cattle; Enzyme

1997
Studies on the platelet defect in alcoholism.
    Thrombosis et diathesis haemorrhagica, 1975, Apr-30, Volume: 33, Issue:2

    Topics: Adenine; Adenosine Diphosphate; Adenosine Triphosphate; Alcoholism; Autoimmune Diseases; Blood Plate

1975
Repair of chemical carcinogen-induced damage in DNA of human lymphocytes and lymphoid cell lines--studies of the kinetics of removal of O6-methylguanine and 3-methyladenine.
    Chemico-biological interactions, 1986, Volume: 57, Issue:1

    Topics: Adenine; Autoimmune Diseases; Carcinogens; Cell Line; DNA Repair; Guanine; Humans; Kinetics; Lymphoc

1986