adenine has been researched along with Astrocytoma, Grade IV in 14 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arsenic trioxide (arsenite) was the first chemotherapeutic drug to be described and is now being rediscovered in cancer treatment, including glioblastoma multiforme." | 7.76 | Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells. ( Castino, R; Falnoga, I; Isidoro, C; Lah, TT; Mirković, B; Pucer, A; Slejkovec, Z, 2010) |
| "Glioblastoma is the most aggressive cerebral gliomas." | 5.40 | Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells. ( Feng, J; Leng, X; Li, J; Li, W; Lian, S; Wang, C; Wang, H; Zhang, X, 2014) |
| "We have examined the capacity of structurally varied Des1 inhibitors to stimulate autophagy (LC3-II analysis), to increase dihydroceramides (mass spectrometry) and to reduce cell viability (SRB) in T98G and U87MG glioblastoma cells under different experimental conditions." | 3.85 | Dihydroceramide desaturase inhibitors induce autophagy via dihydroceramide-dependent and independent mechanisms. ( Casas, J; Casasampere, M; Fabrias, G; Ordóñez, YF, 2017) |
| "Novel ruthenium-letrozole complexes have been prepared, and cell viability of two human cancer cell types (breast and glioblastoma) was determined." | 3.78 | New ruthenium(II)-letrozole complexes as anticancer therapeutics. ( Castonguay, A; Doucet, C; Juhas, M; Maysinger, D, 2012) |
| "Arsenic trioxide (arsenite) was the first chemotherapeutic drug to be described and is now being rediscovered in cancer treatment, including glioblastoma multiforme." | 3.76 | Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells. ( Castino, R; Falnoga, I; Isidoro, C; Lah, TT; Mirković, B; Pucer, A; Slejkovec, Z, 2010) |
| "Glioblastoma is the most common malignant brain cancer in adults, with poor prognosis." | 2.58 | Targeting glioblastoma-derived pericytes improves chemotherapeutic outcome. ( Azevedo, PO; Birbrair, A; Guerra, DAP; Mintz, A; Paiva, AE; Sena, IFG; Silva, WN, 2018) |
| " The aim of the study was to define MerTK as a therapeutic target using an orally bioavailable inhibitor, UNC2025." | 1.48 | MerTK as a therapeutic target in glioblastoma. ( Bash, RE; Cohen, SM; Earp, HS; Ewend, MG; Frady, LN; Frye, SV; Gilbert, MR; Irvin, DM; Miller, CR; Schorzman, AN; Su, YT; Sulman, EP; Wang, X; Wu, J; Zamboni, WC, 2018) |
| "Polyploidy was detected by propidium iodide staining and metaphase spread." | 1.43 | MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme. ( DeRyckere, D; Dwivedi, B; Earp, HS; Frye, SV; Graham, DK; Keating, AK; Kowalski, J; Lee-Sherick, AB; Pierce, AM; Rupji, M; Sufit, A; Varella-Garcia, M; Wang, X, 2016) |
| "Inhibition of early steps of autophagy by 3-MA or Beclin 1 knockdown decreased the toxic effect of arsenic trioxide (ATO) in GBM cell lines." | 1.42 | Impact of autophagy inhibition at different stages on cytotoxic effect of autophagy inducer in glioblastoma cells. ( Bi, Y; Chen, X; Cho, K; Hou, X; Li, C; Liu, H; Liu, Y; Peng, F; Shen, C; Wang, K; Wang, X; Yang, Z; Zhang, J; Zhang, W; Zhang, X; Zhao, S; Zheng, Z; Zhong, C; Zou, H, 2015) |
| "Glioblastoma is the most aggressive cerebral gliomas." | 1.40 | Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells. ( Feng, J; Leng, X; Li, J; Li, W; Lian, S; Wang, C; Wang, H; Zhang, X, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 11 (78.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Guha, A | 1 |
| Waris, S | 1 |
| Nabors, LB | 1 |
| Filippova, N | 1 |
| Gorospe, M | 1 |
| Kwan, T | 1 |
| King, PH | 1 |
| Wu, J | 1 |
| Frady, LN | 1 |
| Bash, RE | 1 |
| Cohen, SM | 1 |
| Schorzman, AN | 1 |
| Su, YT | 1 |
| Irvin, DM | 1 |
| Zamboni, WC | 1 |
| Wang, X | 3 |
| Frye, SV | 2 |
| Ewend, MG | 1 |
| Sulman, EP | 1 |
| Gilbert, MR | 1 |
| Earp, HS | 2 |
| Miller, CR | 1 |
| Wang, J | 1 |
| Liu, X | 1 |
| Hong, Y | 1 |
| Wang, S | 1 |
| Chen, P | 1 |
| Gu, A | 1 |
| Guo, X | 1 |
| Zhao, P | 1 |
| Barrette, AM | 1 |
| Bouhaddou, M | 1 |
| Birtwistle, MR | 1 |
| Guerra, DAP | 1 |
| Paiva, AE | 1 |
| Sena, IFG | 1 |
| Azevedo, PO | 1 |
| Silva, WN | 1 |
| Mintz, A | 1 |
| Birbrair, A | 1 |
| Xie, Q | 1 |
| Wu, TP | 1 |
| Gimple, RC | 1 |
| Li, Z | 1 |
| Prager, BC | 1 |
| Wu, Q | 1 |
| Yu, Y | 1 |
| Wang, P | 1 |
| Wang, Y | 1 |
| Gorkin, DU | 1 |
| Zhang, C | 1 |
| Dowiak, AV | 1 |
| Lin, K | 1 |
| Zeng, C | 1 |
| Sui, Y | 1 |
| Kim, LJY | 1 |
| Miller, TE | 1 |
| Jiang, L | 1 |
| Lee-Poturalski, C | 1 |
| Huang, Z | 1 |
| Fang, X | 1 |
| Zhai, K | 1 |
| Mack, SC | 1 |
| Sander, M | 1 |
| Bao, S | 1 |
| Kerstetter-Fogle, AE | 1 |
| Sloan, AE | 1 |
| Xiao, AZ | 1 |
| Rich, JN | 1 |
| Zhang, X | 2 |
| Li, W | 1 |
| Wang, C | 1 |
| Leng, X | 1 |
| Lian, S | 1 |
| Feng, J | 1 |
| Li, J | 1 |
| Wang, H | 1 |
| Li, C | 1 |
| Liu, Y | 1 |
| Liu, H | 1 |
| Zhang, W | 1 |
| Shen, C | 1 |
| Cho, K | 1 |
| Chen, X | 1 |
| Peng, F | 1 |
| Bi, Y | 1 |
| Hou, X | 1 |
| Yang, Z | 1 |
| Zheng, Z | 1 |
| Wang, K | 1 |
| Zhang, J | 1 |
| Zhong, C | 1 |
| Zou, H | 1 |
| Zhao, S | 1 |
| Sufit, A | 1 |
| Lee-Sherick, AB | 1 |
| DeRyckere, D | 1 |
| Rupji, M | 1 |
| Dwivedi, B | 1 |
| Varella-Garcia, M | 1 |
| Pierce, AM | 1 |
| Kowalski, J | 1 |
| Keating, AK | 1 |
| Graham, DK | 1 |
| Casasampere, M | 1 |
| Ordóñez, YF | 1 |
| Casas, J | 1 |
| Fabrias, G | 1 |
| Pucer, A | 1 |
| Castino, R | 1 |
| Mirković, B | 1 |
| Falnoga, I | 1 |
| Slejkovec, Z | 1 |
| Isidoro, C | 1 |
| Lah, TT | 1 |
| Castonguay, A | 1 |
| Doucet, C | 1 |
| Juhas, M | 1 |
| Maysinger, D | 1 |
| Kondo, Y | 1 |
| Kondo, S | 1 |
| Komatsu, F | 1 |
| Masuda, T | 1 |
2 reviews available for adenine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
The versatile role of HuR in Glioblastoma and its potential as a therapeutic target for a multi-pronged attack.
Topics: Adenine; Brain Neoplasms; ELAV-Like Protein 1; Glioblastoma; Humans; Neovascularization, Pathologic; | 2022 |
Targeting glioblastoma-derived pericytes improves chemotherapeutic outcome.
Topics: Adenine; Animals; Blood-Brain Barrier; Brain Neoplasms; Drug Delivery Systems; Glioblastoma; Mice; P | 2018 |
12 other studies available for adenine and Astrocytoma, Grade IV
| Article | Year |
|---|---|
MerTK as a therapeutic target in glioblastoma.
Topics: Adenine; Animals; Brain Neoplasms; c-Mer Tyrosine Kinase; Cell Line, Tumor; Gene Expression Regulati | 2018 |
Ibrutinib, a Bruton's tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma.
Topics: Adenine; Animals; Autophagy; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Mice; Mice, | 2017 |
Integrating Transcriptomic Data with Mechanistic Systems Pharmacology Models for Virtual Drug Combination Trials.
Topics: Adenine; Anilides; Aniline Compounds; Antineoplastic Agents; Apoptosis; Blood-Brain Barrier; Cell Cy | 2018 |
N
Topics: Adenine; Adult; Aged; AlkB Homolog 1, Histone H2a Dioxygenase; Animals; Astrocytes; Brain Neoplasms; | 2018 |
Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; Boronic A | 2014 |
Impact of autophagy inhibition at different stages on cytotoxic effect of autophagy inducer in glioblastoma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenica | 2015 |
MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme.
Topics: Adenine; Antineoplastic Agents; c-Mer Tyrosine Kinase; Cell Death; Cell Line, Tumor; Cell Proliferat | 2016 |
Dihydroceramide desaturase inhibitors induce autophagy via dihydroceramide-dependent and independent mechanisms.
Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Survival; Ceramides; Enzyme Inhibitors; Fatty Acids, Mono | 2017 |
Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arseni | 2010 |
New ruthenium(II)-letrozole complexes as anticancer therapeutics.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Aromatase Inhibitors; Autophagy; Breast Neoplasms; C | 2012 |
American Association for Cancer Research--97th annual meeting.
Topics: Adenine; Animals; Antineoplastic Agents; Benzoquinones; Glioblastoma; HSP90 Heat-Shock Proteins; Hum | 2006 |
Cell-cell adhesion-independent killing due to lymphokine-activated killer cells against glioblastoma cell lines.
Topics: Acid Phosphatase; Adenine; Apoptosis; Cell Adhesion; Cell Membrane; Cells, Cultured; Dose-Response R | 2000 |