adenine has been researched along with Amyotrophic Lateral Sclerosis in 8 studies
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we aim to verify whether swim training can improve lactate metabolism, NAD+ and NADH levels, as well as modify the activity of glycolytic and NADH shuttle enzymes and monocarboxylate transporters (MCTs) in skeletal muscle of amyotrophic lateral sclerosis (ALS) mice." | 8.12 | Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis. ( Antosiewicz, J; Cieminski, K; Dzik, KP; Flis, DJ; Kaczor, JJ; Wieckowski, MR; Ziolkowski, W, 2022) |
| "In this study, we aim to verify whether swim training can improve lactate metabolism, NAD+ and NADH levels, as well as modify the activity of glycolytic and NADH shuttle enzymes and monocarboxylate transporters (MCTs) in skeletal muscle of amyotrophic lateral sclerosis (ALS) mice." | 4.12 | Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis. ( Antosiewicz, J; Cieminski, K; Dzik, KP; Flis, DJ; Kaczor, JJ; Wieckowski, MR; Ziolkowski, W, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Cieminski, K | 1 |
| Flis, DJ | 1 |
| Dzik, KP | 1 |
| Kaczor, JJ | 1 |
| Wieckowski, MR | 1 |
| Antosiewicz, J | 1 |
| Ziolkowski, W | 1 |
| Hans, F | 1 |
| Glasebach, H | 1 |
| Kahle, PJ | 1 |
| Bugallo, R | 1 |
| Marlin, E | 1 |
| Baltanás, A | 1 |
| Toledo, E | 1 |
| Ferrero, R | 1 |
| Vinueza-Gavilanes, R | 1 |
| Larrea, L | 1 |
| Arrasate, M | 1 |
| Aragón, T | 1 |
| Kim, HJ | 1 |
| Raphael, AR | 1 |
| LaDow, ES | 1 |
| McGurk, L | 1 |
| Weber, RA | 1 |
| Trojanowski, JQ | 1 |
| Lee, VM | 1 |
| Finkbeiner, S | 1 |
| Gitler, AD | 1 |
| Bonini, NM | 1 |
| Keskin, I | 1 |
| Forsgren, E | 1 |
| Lange, DJ | 1 |
| Weber, M | 1 |
| Birve, A | 1 |
| Synofzik, M | 1 |
| Gilthorpe, JD | 1 |
| Andersen, PM | 1 |
| Marklund, SL | 1 |
| Kira, Y | 1 |
| Nishikawa, M | 1 |
| Ochi, A | 1 |
| Sato, E | 1 |
| Inoue, M | 1 |
| Grunfeld, JF | 1 |
| Barhum, Y | 1 |
| Blondheim, N | 1 |
| Rabey, JM | 1 |
| Melamed, E | 1 |
| Offen, D | 1 |
| Yokoseki, A | 1 |
| Shiga, A | 1 |
| Tan, CF | 1 |
| Tagawa, A | 1 |
| Kaneko, H | 1 |
| Koyama, A | 1 |
| Eguchi, H | 1 |
| Tsujino, A | 1 |
| Ikeuchi, T | 1 |
| Kakita, A | 1 |
| Okamoto, K | 1 |
| Nishizawa, M | 1 |
| Takahashi, H | 1 |
| Onodera, O | 1 |
8 other studies available for adenine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis.
Topics: Adenine; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Lactic Acid; Malate Dehydro | 2022 |
Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules.
Topics: Acetylcysteine; Adenine; Amyotrophic Lateral Sclerosis; DNA-Binding Proteins; Frontotemporal Dementi | 2020 |
Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis.
Topics: Acetamides; Adenine; Amyotrophic Lateral Sclerosis; Animals; Cell Survival; Cells, Cultured; Cerebra | 2020 |
Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.
Topics: Adenine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Ataxins; DNA-Binding Proteins | 2014 |
Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients.
Topics: Adenine; Age of Onset; Aging; Amyotrophic Lateral Sclerosis; Autophagy; Bortezomib; C9orf72 Protein; | 2016 |
L-carnitine suppresses the onset of neuromuscular degeneration and increases the life span of mice with familial amyotrophic lateral sclerosis.
Topics: Adenine; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Carnitine; Disease Progression; Female; | 2006 |
Erythropoietin delays disease onset in an amyotrophic lateral sclerosis model.
Topics: Adenine; Amyotrophic Lateral Sclerosis; Animals; Disease Progression; Erythropoietin; Female; Guanin | 2007 |
TDP-43 mutation in familial amyotrophic lateral sclerosis.
Topics: Adenine; Aged; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Base Pairing; Cells, Cul | 2008 |