adenine and Adult Fanconi Syndrome studies

Research Excerpts

Excerpt	Relevance	Reference
" He had been receiving low-dose adefovir dipivoxil (ADV) for the treatment of lamivudine-resistant chronic hepatitis B virus infection for eight years and subsequently developed severe hypophosphatemia and proximal renal tubule dysfunction."	8.90	Hypophosphatemic osteomalacia due to drug-induced Fanconi's syndrome associated with adefovir dipivoxil treatment for hepatitis B. ( Eguchi, H; Hiromatsu, Y; Kuwahara, R; Tani, J; Tsuruta, M, 2014)
"This report suggests the possibility of severe tenofovir-induced nephrotoxicity with combined acute kidney injury, Fanconi syndrome, and nephrogenic diabetes insipidus in the absence of other provoking factors such as use with protease inhibitors or advanced HIV disease, chronic kidney disease, and age."	8.31	Fanconi syndrome, diabetes insipidus, and acute kidney injury due to tenofovir disoproxil fumarate: A case report. ( Gill, S; Kalinoski, T; Mehboob, G; Mpejane, O; Zilwa, N, 2023)
"Adefovir dipivoxil (ADV) is one of the most important nucleostide analogues currently in use for the treatment of chronic hepatitis B virus (HBV) infection."	7.91	Low-dose adefovir dipivoxil-induced hypophosphatemia osteomalacia in five chronic hepatitis B virus-infected patients. Is low-dose adefovir dipivoxil-induced nephrotoxicity completely reversible? ( Dai, ZJ; Jin, J; Pan, YJ; Qian, YY; Ruan, LY; Shi, MT; Wu, CM; Zhu, YX, 2019)
" He had been receiving adefovir dipivoxil (ADV) for the treatment of entecavir (ETV)-resistant chronic hepatitis B (CHB) for four years in his 8-year treatment of hepatocellular carcinoma (HCC), but was referred to our hospital after increased levels of bone pain in his ribs, knees, and ankles."	7.91	[Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B]. ( Ikeda, A; Ikeda, F; Kanzaki, H; Kitamura, Y; Makita, T; Murakawa, K; Nishihara, S; Okada, H; Onishi, H; Sendo, T; Shiraha, H; Takaki, A; Takeuchi, Y; Tanaka, Y; Wada, N; Yasunaka, T, 2019)
" She had a 7-year history of taking adefovir at 10 mg/day for chronic hepatitis B."	7.88	Adefovir-induced Fanconi syndrome associated with osteomalacia. ( Cha, SK; Cho, DH; Kim, HS; Kim, JH; Kim, WI; Kim, YJ; Lee, EY; Lee, JH; Lee, SM; Park, KS; Park, S, 2018)
"An increasing number of case reports suggest that acquired renal Fanconi syndrome may be associated with prolonged use of adefovir against hepatitis B virus."	7.85	Nephrolithiasis and Osteomalacia associated with adefovir-induced Fanconi syndrome in a patient with hepatitis B. ( Lin, J; Zhang, D; Zhuo, Y, 2017)
"In human immunodeficiency virus (HIV)-infected patients, tenofovir disoproxil fumarate (TDF) may cause hypophosphatemia leading to osteomalacia due to renal phosphate wasting."	7.80	Fibroblast growth factor 23 is elevated in tenofovir-related hypophosphatemia. ( Holmes, DT; Jiang, SY; Kendler, DL; Saeedi, R, 2014)
"A 64-year-old woman was prescribed lamivudine and adefovir (ADV) for chronic hepatitis B."	7.80	[A case of chronic hepatitis B managed with continued adefovir despite treatment-related Fanconi syndrome and osteomalacia]. ( Asahina, Y; Iizuka, K; Iizuka, Y; Ito, E; Kobayashi, K; Mochizuki, N; Sakai, H; Watanabe, M, 2014)
" Here, we describe two additional patients with chronic hepatitis B (CHB) who developed a TDF-induced Fanconi syndrome that reverted after TDF withdrawal and had viral replication fully suppressed upon switching to entecavir (ETV)."	7.80	Tenofovir-induced Fanconi syndrome in chronic hepatitis B monoinfected patients that reverted after tenofovir withdrawal. ( Brocchieri, A; Castelli, F; Colombo, M; Facchetti, F; Fugazza, A; Lampertico, P; Mangia, G; Spinetti, A; Viganò, M; Zaltron, S, 2014)
"Tenofovir disoproxil fumarate (TDF) is increasingly used in patients with chronic hepatitis B (CHB) infection."	7.79	Tenofovir-associated Fanconi syndrome in patients with chronic hepatitis B monoinfection. ( Gracey, DM; McKenzie, P; Snelling, P; Strasser, SI, 2013)
"We present a case of a 62-year-old man who underwent total hip arthroplasty for treatment of pathologic femoral neck fracture associated with adefovir dipivoxil-induced osteomalacia."	7.78	Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report. ( Arishima, Y; Hirotsu, M; Ishidou, Y; Kakoi, H; Kamizono, J; Komiya, S; Nagano, S; Nakamura, S; Saitoh, Y; Setoguchi, T; Tanaka, M; Yokouchi, M, 2012)
"Adefovir dipivoxil is commonly used for treatment of chronic hepatitis B."	7.77	[Adefovir dipivoxil-induced Fanconi syndrome and hypophosphatemic osteomalacia associated with muscular weakness in a patient with chronic hepatitis B]. ( Dong, GF; Li, L; Xie, YS; Zhang, X, 2011)
"We present 2 human immunodeficiency virus-infected patients with tenofovir disoproxil fumarate-induced Fanconi syndrome, leading to osteomalacia."	7.77	Tenofovir-induced Fanconi syndrome and osteomalacia in two HIV-infected patients: role of intracellular tenofovir diphosphate levels and review of the literature. ( Bronsveld, W; Haverkort, ME; Huitema, AD; Lips, P; Slieker, WA; ter Heine, R; van der Spek, BW, 2011)
"Combination therapy with adefovir dipivoxil (ADV) and lamivudine (LAM) is recommended for patients infected with LAM-refractory hepatitis B virus (HBV)."	7.76	Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus. ( Enomoto, M; Habu, D; Imanishi, Y; Iwai, S; Kawada, N; Kobayashi, S; Morikawa, H; Sakaguchi, H; Shiomi, S; Tamori, A, 2010)
"We report 3 cases of patients with HIV/AIDS in whom Fanconi syndrome and nephrogenic diabetes insipidus developed secondary to use of an antiretroviral regimen containing tenofovir disoproxil fumarate and didanosine."	7.75	Proximal tubular dysfunction associated with tenofovir and didanosine causing Fanconi syndrome and diabetes insipidus: a report of 3 cases. ( Alvarez, S; Brumble, LM; Dwyer, JP; Irizarry-Alvarado, JM; Mendez, JC, 2009)
"To determine the spectrum of clinical manifestations of hypokalemia associated with tenofovir, we reviewed all reports of grades 3/4 hypokalemia received by Gilead Sciences Department of Safety and Public Health."	7.74	Causes and consequences of hypokalemia in patients on tenofovir disoproxil fumarate. ( Curtis, S; Rooney, JF; Shepp, DH, 2007)
"Tenofovir-related tubule damage characterized by Fanconi syndrome, renal insufficiency and nephrogenic diabetes insipidus has been reported in the adult HIV-infected population."	7.73	Nephrotoxicity in a child with perinatal HIV on tenofovir, didanosine and lopinavir/ritonavir. ( Hussain, S; Khayat, A; Rathore, MH; Tolaymat, A, 2006)
"Tenofovir disoproxil fumarate (TDF) has been anecdotally associated with isolated hypophosphatemia (HP) as well as proximal tubular toxicity and renal dysfunction in which HP has consistently been a feature."	7.73	Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice. ( Bannister, A; Day, SL; Fisher, M; Hankins, M; Leake Date, HA, 2005)
"We report two cases in which osteomalacia developed in patients on tenofovir-containing highly active antiretroviral therapy (HAART) in the context of Fanconi syndrome with hypophosphataemia."	7.73	The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy. ( Issa, BG; Parsonage, MJ; Savage, MW; Snowden, N; Wilkins, EG, 2005)
"Fanconi syndrome with osteomalacia can develop in patients with chronic hepatitis B infection being treated with adefovir at a conventional low dosage of 10 mg/day."	5.56	Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report. ( Cen, X; Cui, Y; Liu, Z; Mu, G; Xiang, Q; Xie, Q; Yu, Y; Zhang, H; Zhang, J, 2020)
"This case indicates that Fanconi's syndrome with osteomalacia can be acquired by a chronic hepatitis B patient taking ADV at a conventional dosage of 10 mg/day."	5.42	Osteomalacia and Fanconi's syndrome caused by long-term low-dose adefovir dipivoxil. ( Chen, YS; Sun, FR; Wang, BF; Wang, BY; Wang, Y; Zhang, D, 2015)
"Hypophosphatemic osteomalacia and renal Fanconi syndrome can be associated with low-dose ADV."	5.39	Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition. ( Dai, Z; Gu, X; Qian, Y; Wang, L; Wu, C; Zhang, H, 2013)
"We present a case in wich acute renal failure and proximal tubular dysfunction developed after therapy with tenofovir in a patiente with HIV who had suffered from complications of didanosine treatment."	5.33	[Acute renal failure and proximal renal tubular dysfuntion in a patient with acquired immunodeficiency syndrome treated with tenofovir]. ( de la Prada, FJ; Morey, A; Prados, AM; Saus, C; Tugores, A; Uriol, M, 2006)
" He had been receiving low-dose adefovir dipivoxil (ADV) for the treatment of lamivudine-resistant chronic hepatitis B virus infection for eight years and subsequently developed severe hypophosphatemia and proximal renal tubule dysfunction."	4.90	Hypophosphatemic osteomalacia due to drug-induced Fanconi's syndrome associated with adefovir dipivoxil treatment for hepatitis B. ( Eguchi, H; Hiromatsu, Y; Kuwahara, R; Tani, J; Tsuruta, M, 2014)
"This report suggests the possibility of severe tenofovir-induced nephrotoxicity with combined acute kidney injury, Fanconi syndrome, and nephrogenic diabetes insipidus in the absence of other provoking factors such as use with protease inhibitors or advanced HIV disease, chronic kidney disease, and age."	4.31	Fanconi syndrome, diabetes insipidus, and acute kidney injury due to tenofovir disoproxil fumarate: A case report. ( Gill, S; Kalinoski, T; Mehboob, G; Mpejane, O; Zilwa, N, 2023)
" He had been receiving adefovir dipivoxil (ADV) for the treatment of entecavir (ETV)-resistant chronic hepatitis B (CHB) for four years in his 8-year treatment of hepatocellular carcinoma (HCC), but was referred to our hospital after increased levels of bone pain in his ribs, knees, and ankles."	3.91	[Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B]. ( Ikeda, A; Ikeda, F; Kanzaki, H; Kitamura, Y; Makita, T; Murakawa, K; Nishihara, S; Okada, H; Onishi, H; Sendo, T; Shiraha, H; Takaki, A; Takeuchi, Y; Tanaka, Y; Wada, N; Yasunaka, T, 2019)
"Adefovir dipivoxil (ADV) is one of the most important nucleostide analogues currently in use for the treatment of chronic hepatitis B virus (HBV) infection."	3.91	Low-dose adefovir dipivoxil-induced hypophosphatemia osteomalacia in five chronic hepatitis B virus-infected patients. Is low-dose adefovir dipivoxil-induced nephrotoxicity completely reversible? ( Dai, ZJ; Jin, J; Pan, YJ; Qian, YY; Ruan, LY; Shi, MT; Wu, CM; Zhu, YX, 2019)
"Adefovir dipivoxil is a nucleotide analogue that is approved for treatment of chronic hepatitis B."	3.91	Denosumab improves clinical manifestations of hypophosphatemic osteomalacia by adefovir-induced Fanconi syndrome: a case report. ( Aso, Y; Iijima, T; Jojima, T; Kase, M; Kogai, T; Kunii, T; Sakurai, S; Shimizu, M; Usui, I, 2019)
" The patient had been treated with lamivudine (LAM) in 2005, LAM+adefovir (ADV) in 2009, and ADV+entecavir in 2015 for chronic hepatitis B (CH-B)."	3.91	[Marked improvement in renal tubular markers after switching from adefovir to tenofovir alafenamide in a case of Fanconi syndrome diagnosed through high ALP levels]. ( Hiraoka, A; Izumoto, H; Kitahata, S; Kondoh, K; Michitaka, K; Ninomiya, T; Tsubouchi, E; Ueki, H; Yamago, H, 2019)
" She had a 7-year history of taking adefovir at 10 mg/day for chronic hepatitis B."	3.88	Adefovir-induced Fanconi syndrome associated with osteomalacia. ( Cha, SK; Cho, DH; Kim, HS; Kim, JH; Kim, WI; Kim, YJ; Lee, EY; Lee, JH; Lee, SM; Park, KS; Park, S, 2018)
"An increasing number of case reports suggest that acquired renal Fanconi syndrome may be associated with prolonged use of adefovir against hepatitis B virus."	3.85	Nephrolithiasis and Osteomalacia associated with adefovir-induced Fanconi syndrome in a patient with hepatitis B. ( Lin, J; Zhang, D; Zhuo, Y, 2017)
" He had been receiving low-dose adefovir dipivoxil (ADV, 10 mg/day) for the treatment of chronic hepatitis B virus infection for 7 years and he subsequently developed severe hypophosphatemia and proximal renal tubule dysfunction."	3.83	Pathologic Femoral Neck Fracture Due to Fanconi Syndrome Induced by Adefovir Dipivoxil Therapy for Hepatitis B. ( Dan, J; Kim, BK; Lee, HJ; Lee, YS, 2016)
" Of all the patients, 15 were diagnosed as tumor-induced HO, 4 were long-term oral adefovir dipivoxil-related HO, 3 were associated with Fanconi syndrome, 2 were related to hyperparathyroidism, while 2 were Sjogren's syndrome complicated with renal tubular acidosis."	3.80	[The clinical characteristics of 26 cases of hypophosphatemia osteomalacia misdiagnosed as spondyloarthritis]. ( Feng, L; Huang, F; Jin, J; Luo, G; Ma, H; Sun, F; Wang, G; Wang, Y; Yang, J; Zhang, J; Zhao, W; Zhao, Z; Zhu, J, 2014)
" Here, we describe two additional patients with chronic hepatitis B (CHB) who developed a TDF-induced Fanconi syndrome that reverted after TDF withdrawal and had viral replication fully suppressed upon switching to entecavir (ETV)."	3.80	Tenofovir-induced Fanconi syndrome in chronic hepatitis B monoinfected patients that reverted after tenofovir withdrawal. ( Brocchieri, A; Castelli, F; Colombo, M; Facchetti, F; Fugazza, A; Lampertico, P; Mangia, G; Spinetti, A; Viganò, M; Zaltron, S, 2014)
"A 64-year-old woman was prescribed lamivudine and adefovir (ADV) for chronic hepatitis B."	3.80	[A case of chronic hepatitis B managed with continued adefovir despite treatment-related Fanconi syndrome and osteomalacia]. ( Asahina, Y; Iizuka, K; Iizuka, Y; Ito, E; Kobayashi, K; Mochizuki, N; Sakai, H; Watanabe, M, 2014)
"In human immunodeficiency virus (HIV)-infected patients, tenofovir disoproxil fumarate (TDF) may cause hypophosphatemia leading to osteomalacia due to renal phosphate wasting."	3.80	Fibroblast growth factor 23 is elevated in tenofovir-related hypophosphatemia. ( Holmes, DT; Jiang, SY; Kendler, DL; Saeedi, R, 2014)
"Tenofovir disoproxil fumarate (TDF) is increasingly used in patients with chronic hepatitis B (CHB) infection."	3.79	Tenofovir-associated Fanconi syndrome in patients with chronic hepatitis B monoinfection. ( Gracey, DM; McKenzie, P; Snelling, P; Strasser, SI, 2013)
"We present a case of a 62-year-old man who underwent total hip arthroplasty for treatment of pathologic femoral neck fracture associated with adefovir dipivoxil-induced osteomalacia."	3.78	Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report. ( Arishima, Y; Hirotsu, M; Ishidou, Y; Kakoi, H; Kamizono, J; Komiya, S; Nagano, S; Nakamura, S; Saitoh, Y; Setoguchi, T; Tanaka, M; Yokouchi, M, 2012)
"We present 2 human immunodeficiency virus-infected patients with tenofovir disoproxil fumarate-induced Fanconi syndrome, leading to osteomalacia."	3.77	Tenofovir-induced Fanconi syndrome and osteomalacia in two HIV-infected patients: role of intracellular tenofovir diphosphate levels and review of the literature. ( Bronsveld, W; Haverkort, ME; Huitema, AD; Lips, P; Slieker, WA; ter Heine, R; van der Spek, BW, 2011)
"Adefovir dipivoxil is commonly used for treatment of chronic hepatitis B."	3.77	[Adefovir dipivoxil-induced Fanconi syndrome and hypophosphatemic osteomalacia associated with muscular weakness in a patient with chronic hepatitis B]. ( Dong, GF; Li, L; Xie, YS; Zhang, X, 2011)
"Combination therapy with adefovir dipivoxil (ADV) and lamivudine (LAM) is recommended for patients infected with LAM-refractory hepatitis B virus (HBV)."	3.76	Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus. ( Enomoto, M; Habu, D; Imanishi, Y; Iwai, S; Kawada, N; Kobayashi, S; Morikawa, H; Sakaguchi, H; Shiomi, S; Tamori, A, 2010)
"We report 3 cases of patients with HIV/AIDS in whom Fanconi syndrome and nephrogenic diabetes insipidus developed secondary to use of an antiretroviral regimen containing tenofovir disoproxil fumarate and didanosine."	3.75	Proximal tubular dysfunction associated with tenofovir and didanosine causing Fanconi syndrome and diabetes insipidus: a report of 3 cases. ( Alvarez, S; Brumble, LM; Dwyer, JP; Irizarry-Alvarado, JM; Mendez, JC, 2009)
"To determine the spectrum of clinical manifestations of hypokalemia associated with tenofovir, we reviewed all reports of grades 3/4 hypokalemia received by Gilead Sciences Department of Safety and Public Health."	3.74	Causes and consequences of hypokalemia in patients on tenofovir disoproxil fumarate. ( Curtis, S; Rooney, JF; Shepp, DH, 2007)
"Tenofovir disoproxil fumarate (TDF) has been anecdotally associated with isolated hypophosphatemia (HP) as well as proximal tubular toxicity and renal dysfunction in which HP has consistently been a feature."	3.73	Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice. ( Bannister, A; Day, SL; Fisher, M; Hankins, M; Leake Date, HA, 2005)
"We report two cases in which osteomalacia developed in patients on tenofovir-containing highly active antiretroviral therapy (HAART) in the context of Fanconi syndrome with hypophosphataemia."	3.73	The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy. ( Issa, BG; Parsonage, MJ; Savage, MW; Snowden, N; Wilkins, EG, 2005)
"Tenofovir-related tubule damage characterized by Fanconi syndrome, renal insufficiency and nephrogenic diabetes insipidus has been reported in the adult HIV-infected population."	3.73	Nephrotoxicity in a child with perinatal HIV on tenofovir, didanosine and lopinavir/ritonavir. ( Hussain, S; Khayat, A; Rathore, MH; Tolaymat, A, 2006)
"A total of 33 participants developed proximal renal tubular dysfunction during the trial, all but one in the ADV group."	2.70	A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial. ( , 2002)
"Fanconi syndrome with osteomalacia can develop in patients with chronic hepatitis B infection being treated with adefovir at a conventional low dosage of 10 mg/day."	1.56	Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report. ( Cen, X; Cui, Y; Liu, Z; Mu, G; Xiang, Q; Xie, Q; Yu, Y; Zhang, H; Zhang, J, 2020)
"He had been diagnosed with diabetic kidney disease and osteomalacia due to vitamin D deficiency; thus, ADV was not discontinued until he was referred to us."	1.51	Hypophosphatemic Osteomalacia Associated with Adefovir-induced Fanconi Syndrome Initially Diagnosed as Diabetic Kidney Disease and Vitamin D Deficiency. ( Iino, N; Koda, R; Narita, I; Tsuchida, M, 2019)
"Acquired Fanconi syndrome has been associated with the long-term ingestion of several nucleoside analogs used to treat chronic hepatitis B virus infection."	1.51	A case of entecavir-induced Fanconi syndrome. ( Fujii, T; Kawasoe, K; Nitta, K; Ohta, A, 2019)
"Fanconi syndrome is a rare adverse effect of tenofovir disoproxil fumarate (TDF)."	1.46	Short Communication: Resolution of Tenofovir Disoproxil Fumarate Induced Fanconi Syndrome with Switch to Tenofovir Alafenamide Fumarate in a HIV-1 and Hepatitis B Coinfected Patient. ( Karris, MY, 2017)
"This case indicates that Fanconi's syndrome with osteomalacia can be acquired by a chronic hepatitis B patient taking ADV at a conventional dosage of 10 mg/day."	1.42	Osteomalacia and Fanconi's syndrome caused by long-term low-dose adefovir dipivoxil. ( Chen, YS; Sun, FR; Wang, BF; Wang, BY; Wang, Y; Zhang, D, 2015)
"The long-term use of tenofovir, a commonly used anti-HIV drug, can result in renal damage."	1.40	Mitochondrial dysfunction and electron transport chain complex defect in a rat model of tenofovir disoproxil fumarate nephrotoxicity. ( Abraham, P; Isaac, B; Ramamoorthy, H, 2014)
"Hypophosphatemic osteomalacia and renal Fanconi syndrome can be associated with low-dose ADV."	1.39	Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition. ( Dai, Z; Gu, X; Qian, Y; Wang, L; Wu, C; Zhang, H, 2013)
"Adefovir dipivoxil (ADV) is an oral bioavailable prodrug of adefovir that possesses potent in vitro activity against hepadnaviruses, retroviruses and herpes viruses."	1.38	Nephrotoxicity, including acquired Fanconi's syndrome, caused by adefovir dipivoxil - is there a safe dose? ( Ho, YY; Law, ST; Li, KK, 2012)
"Fanconi syndrome is a side effect of tenofovir."	1.37	[Renal adverse reactions of antiretroviral medication: proximal tubular dysfunction associated with tenofovir]. ( Kuijper, A; Mudrikova, T; Rookmaker, MB, 2011)
" A relatively uncommon adverse effect of this drug is Fanconi syndrome."	1.35	Tenofovir-associated Fanconi syndrome: review of the FDA adverse event reporting system. ( Gupta, SK, 2008)
"We present a case in wich acute renal failure and proximal tubular dysfunction developed after therapy with tenofovir in a patiente with HIV who had suffered from complications of didanosine treatment."	1.33	[Acute renal failure and proximal renal tubular dysfuntion in a patient with acquired immunodeficiency syndrome treated with tenofovir]. ( de la Prada, FJ; Morey, A; Prados, AM; Saus, C; Tugores, A; Uriol, M, 2006)

Research

Studies (103)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Change From Week 12 Plasma Tenofovir Area Under the Plasma Concentration vs. Time Curve From Time 0 to 24 Hours (AUC0-24) at 24 and 28 Weeks

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (0.97)	18.2507
2000's	37 (35.92)	29.6817
2010's	60 (58.25)	24.3611
2020's	5 (4.85)	2.80

Authors	Studies
Zilwa, N	1
Mpejane, O	1
Mehboob, G	1
Gill, S	1
Kalinoski, T	1
Álvarez, H	1
Llibre, JM	1
Bahr, NC	2
Yarlagadda, SG	2
Leungsuwan, S	1
Hooi, B	1
Myint, KS	1
Sun, L	1
Yi, D	1
Sun, W	1
Wang, C	1
Xiang, Q	1
Liu, Z	1
Yu, Y	1
Zhang, H	2
Xie, Q	1
Mu, G	1
Zhang, J	2
Cen, X	1
Cui, Y	1
Song, K	1
Yan, Q	1
Yang, Y	1
Lv, M	1
Chen, Y	1
Dai, Y	1
Zhang, L	1
Huang, Y	1
Zhang, C	1
Gao, H	1
Karris, MY	1
Lin, J	1
Zhuo, Y	1
Zhang, D	2
Park, S	1
Kim, WI	1
Cho, DH	1
Kim, YJ	1
Kim, HS	1
Kim, JH	1
Cha, SK	1
Park, KS	1
Lee, JH	1
Lee, SM	1
Lee, EY	1
Cho, J	1
Cheung, PP	1
Watanabe, K	1
Hashimoto, S	1
Maoka, T	1
Yamamoto, R	1
Okamoto, N	1
Koike, T	1
Koda, R	1
Tsuchida, M	1
Iino, N	1
Narita, I	1
Makita, T	1
Kanzaki, H	1
Onishi, H	1
Ikeda, A	1
Takaki, A	2
Wada, N	1
Takeuchi, Y	1
Yasunaka, T	1
Ikeda, F	1
Shiraha, H	1
Tanaka, Y	1
Nishihara, S	1
Murakawa, K	1
Kitamura, Y	1
Okada, H	1
Sendo, T	1
Kondoh, K	1
Michitaka, K	1
Hiraoka, A	1
Izumoto, H	1
Ueki, H	1
Kitahata, S	1
Yamago, H	1
Tsubouchi, E	1
Ninomiya, T	1
Kunii, T	1
Iijima, T	1
Jojima, T	1
Shimizu, M	1
Kase, M	1
Sakurai, S	1
Kogai, T	1
Usui, I	1
Aso, Y	1
Qian, YY	1
Dai, ZJ	1
Ruan, LY	1
Pan, YJ	1
Jin, J	2
Shi, MT	1
Zhu, YX	1
Wu, CM	1
Fujii, T	1
Kawasoe, K	1
Ohta, A	1
Nitta, K	1
Wu, C	1
Qian, Y	1
Wang, L	1
Gu, X	1
Dai, Z	1
Gracey, DM	2
Snelling, P	1
McKenzie, P	1
Strasser, SI	1
Lucey, JM	1
Hsu, P	1
Ziegler, JB	1
Bickel, M	1
Khaykin, P	1
Stephan, C	1
Schmidt, K	1
Buettner, M	1
Amann, K	1
Lutz, T	1
Gute, P	1
Haberl, A	1
Geiger, H	1
Brodt, HR	1
Jung, O	1
Eguchi, H	1
Tsuruta, M	1
Tani, J	1
Kuwahara, R	1
Hiromatsu, Y	1
Hamnvik, OP	2
Vaidya, A	1
Becker, C	1
Terasaka, T	1
Ueta, E	1
Ebara, H	1
Waseda, K	1
Hanayama, Y	1
Kawabata, T	1
Sugiyama, H	1
Hidani, K	1
Otsuka, F	1
Becker, CB	1
Levy, BD	1
Loscalzo, J	1
Ramamoorthy, H	1
Abraham, P	2
Isaac, B	1
Zhu, LN	1
Mou, LJ	1
Hu, Y	1
Chen, JX	1
Gupta, SK	3
Anderson, AM	1
Ebrahimi, R	1
Fralich, T	1
Graham, H	1
Scharen-Guivel, V	2
Flaherty, JF	1
Fortin, C	1
Kalayjian, RC	1
Rachlis, A	1
Wyatt, CM	1
Saeedi, R	1
Jiang, SY	1
Holmes, DT	1
Kendler, DL	1
Iizuka, Y	1
Sakai, H	1
Kobayashi, K	1
Iizuka, K	1
Ito, E	1
Mochizuki, N	1
Asahina, Y	1
Watanabe, M	1
Samarkos, M	1
Theofanis, V	1
Eliadi, I	1
Vlachogiannakos, J	1
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Izzedine, H	3
Kheder-Elfekih, R	1
Housset, P	1
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Brocheriou, I	1
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Labarga, P	1
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Irizarry-Alvarado, JM	1
Dwyer, JP	1
Brumble, LM	1
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Fine, DM	3
Woodward, CL	1
Hall, AM	2
Williams, IG	1
Madge, S	1
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Nair, D	1
Edwards, SG	1
Johnson, MA	1
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Morelle, J	1
Labriola, L	1
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Tamori, A	1
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Kawada, N	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Severe Impairment of Solute-Free Water Clearance in Patients With HIV Infection[NCT01869010]		30 participants (Actual)	Observational	2010-01-31	Completed
Effects of Sofosbuvir/Ledipasvir Treatment on the Pharmacokinetics and Renal Safety of Tenofovir[NCT02588287]		14 participants (Actual)	Interventional	2015-11-30	Completed
Effects of Ledipasvir/Sofosbuvir Treatment on the Pharmacokinetics and Renal Safety of Tenofovir Alafenamide (TAF) in Patients With HIV.[NCT03126370]	Phase 4	10 participants (Actual)	Interventional	2018-01-08	Completed
Impact of Drug Therapy and Co-Morbidities on the Development of Renal Impairment in HIV-Infected Patients[NCT00551655]		684 participants (Actual)	Observational	2007-05-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Compare plasma tenofovir AUC0-24 between TAF with boosted PI vs. TDF with boosted PI (Phase 2 vs. 1), and between TAF with boosted PI and LDV/SOF vs. TDF with boosted PI (Phase 3 vs. 1) (NCT03126370)
Timeframe: 12 weeks and 24 weeks and 28 weeks

Change From Week 12 Tenofovir-diphosphate (TFV-DP) in Dried Blood Spots (DBS)

Intervention	ng*h/mL (Geometric Mean)
TDF With a Boosted PI	3466
TAF With a Boosted PI	743
TAF With a Boosted PI and LDV/SOF	868

Compare tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) between TAF with a boosted PI vs. TDF with a boosted PI (Phase 2 vs. 1), and TAF with a boosted PI and LDV/SOF vs. TDF with a boosted PI (Phase 3 vs. 1) (NCT03126370)
Timeframe: 12 weeks and 24 and 28 weeks

Change From Week 12 Tenofovir-diphosphate (TFV-DP) in Peripheral Blood Mononuclear Cells (PBMCs) at 24 and 28 Weeks

Intervention	fmol/2x7mm punches (Geometric Mean)
TDF With a Boosted PI	36014
TAF With a Boosted PI	6735
TAF With a Boosted PI and LDV/SOF	6100

Compare tenofovir-diphosphate (TFV-DP) in peripheral blood mononuclear cells (PBMCs) between TAF with a boosted PI vs. TDF with a boosted PI (Phase 2 vs. 1), and TAF with a boosted PI and LDV/SOF vs. TDF with a boosted PI (Phase 3 vs. 1). (NCT03126370)
Timeframe: 12 weeks, and 24 weeks and 28 weeks

Change in Estimated Glomerular Filtration Rate (eGFR) and Renal Biomarkers: eGFR

Intervention	fmol/10^6 cells (Geometric Mean)
TDF With a Boosted PI	83.0
TAF With a Boosted PI	926
TAF With a Boosted PI and LDV/SOF	1129

Change in estimated glomerular filtration rate (eGFR) (NCT03126370)
Timeframe: 12 weeks, 24 weeks, and 28 weeks

Change in Estimated Glomerular Filtration Rate (eGFR) and Renal Biomarkers: UPCR

Intervention	mL/min/1.73 m^2 (Geometric Mean)
TDF With a Boosted PI	86.7
TAF With a Boosted PI	91.0
TAF With a Boosted PI and LDV/SOF	88.1

Change in estimated glomerular filtration rate (eGFR) and renal biomarkers: Urine protein to creatinine ratio (UPCR) (NCT03126370)
Timeframe: 12 weeks, 24 weeks, and 28 weeks

Change in Estimated Glomerular Filtration Rate (eGFR) and Renal Biomarkers: B2M/Cr Ratio, and RBP/Cr Ratio

Intervention	mg/g (Geometric Mean)
TDF With a Boosted PI	134
TAF With a Boosted PI	118
TAF With a Boosted PI and LDV/SOF	97.3

Change in renal biomarkers: urinary beta-2 microglobulin (B2M)/creatinine (Cr) ratio, and urinary retinol binding protein (RBP)/Cr ratio (NCT03126370)
Timeframe: 12 weeks, 24 weeks, and 28 weeks

Intervention	ug/g (Geometric Mean)
	β2M:Cr ratio	RBP:Cr ratio
TAF With a Boosted PI	224	242
TAF With a Boosted PI and LDV/SOF	178	146
TDF With a Boosted PI	419	436

Article	Year
Fanconi syndrome induced by adefovir dipivoxil: a case report and clinical review. The Journal of international medical research, 2020, Volume: 48, Issue:10 Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organo	2020
Hypophosphatemic osteomalacia due to drug-induced Fanconi's syndrome associated with adefovir dipivoxil treatment for hepatitis B. Internal medicine (Tokyo, Japan), 2014, Volume: 53, Issue:3 Topics: Adenine; Bone Diseases, Metabolic; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia;	2014
Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus. Antiviral research, 2016, Volume: 125 Topics: Adenine; Alanine; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Density; Dru	2016
Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2011, Volume: 57, Issue:5 Topics: Adenine; Animals; Fanconi Syndrome; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Disea	2011
Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2011, Volume: 57, Issue:5 Topics: Adenine; Animals; Fanconi Syndrome; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Disea	2011
Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2011, Volume: 57, Issue:5 Topics: Adenine; Animals; Fanconi Syndrome; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Disea	2011
Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2011, Volume: 57, Issue:5 Topics: Adenine; Animals; Fanconi Syndrome; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Disea	2011
The use of biomarkers for assessing HAART-associated renal toxicity in HIV-infected patients. Current HIV research, 2012, Volume: 10, Issue:6 Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiretroviral Therapy, Highly Active; Biomarkers; Crea	2012
Tenofovir-related nephrotoxicity: case report and review of the literature. Pharmacotherapy, 2004, Volume: 24, Issue:3 Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adenine; Anti-HIV Agents; Clinical Chemistr	2004
Fanconi's syndrome in HIV+ adults: report of three cases and literature review. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2004, Volume: 19, Issue:5 Topics: Adenine; Adult; Anti-Retroviral Agents; Bone Density; Calcitriol; Calcium; Fanconi Syndrome; Female;	2004
Acute renal failure and Fanconi syndrome in an AIDS patient on tenofovir treatment--case report and review of literature. The Journal of infection, 2005, Volume: 51, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adenine; Anti-HIV Agents; Creatinine; Fanco	2005
Editorial comment: tenofovir nephrotoxicity--vigilance required. The AIDS reader, 2005, Volume: 15, Issue:7 Topics: Adenine; Fanconi Syndrome; Glycosuria; HIV Infections; Humans; Hypokalemia; Hypophosphatemia; Organo	2005
Fanconi syndrome associated with use of tenofovir in HIV-infected patients: a case report and review of the literature. The AIDS reader, 2005, Volume: 15, Issue:7 Topics: Adenine; Fanconi Syndrome; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Reverse Tr	2005

Article	Year
Fanconi syndrome, diabetes insipidus, and acute kidney injury due to tenofovir disoproxil fumarate: A case report. Antiviral therapy, 2023, Volume: 28, Issue:3 Topics: Acute Kidney Injury; Adenine; Anti-HIV Agents; Diabetes Insipidus; Diabetes Mellitus; Fanconi Syndro	2023
Fanconi Syndrome and Tenofovir Alafenamide. Annals of internal medicine, 2019, 10-15, Volume: 171, Issue:8 Topics: Adenine; Alanine; Anti-HIV Agents; Fanconi Syndrome; Humans; Tenofovir	2019
Fanconi Syndrome and Tenofovir Alafenamide. Annals of internal medicine, 2019, 10-15, Volume: 171, Issue:8 Topics: Adenine; Alanine; Anti-HIV Agents; Fanconi Syndrome; Humans; Tenofovir	2019
Hypophosphatemic Osteomalacia Due to Adefovir-Induced Fanconi Syndrome. The American journal of medicine, 2020, Volume: 133, Issue:12 Topics: Adenine; Aged; Alanine; Antiviral Agents; Fanconi Syndrome; Female; Hepatitis C, Chronic; Humans; Hy	2020
Retrospective analysis of the clinical characteristics of adefovir dipivoxil-induced Fanconi's syndrome in the Chinese population. Journal of clinical pharmacy and therapeutics, 2020, Volume: 45, Issue:4 Topics: Adenine; Adult; Aged; Alkaline Phosphatase; Asian People; Bone Density; Fanconi Syndrome; Female; Gl	2020
Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report. BMC pharmacology & toxicology, 2020, 06-05, Volume: 21, Issue:1 Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organo	2020
Short Communication: Resolution of Tenofovir Disoproxil Fumarate Induced Fanconi Syndrome with Switch to Tenofovir Alafenamide Fumarate in a HIV-1 and Hepatitis B Coinfected Patient. AIDS research and human retroviruses, 2017, Volume: 33, Issue:7 Topics: Adenine; Alanine; Anti-HIV Agents; Coinfection; Fanconi Syndrome; Hepatitis B, Chronic; HIV Infectio	2017
Nephrolithiasis and Osteomalacia associated with adefovir-induced Fanconi syndrome in a patient with hepatitis B. BMC nephrology, 2017, Aug-29, Volume: 18, Issue:1 Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B; Humans; Male; Middle Aged; Nephrolithiasis	2017
Adefovir-induced Fanconi syndrome associated with osteomalacia. Clinical and molecular hepatology, 2018, Volume: 24, Issue:3 Topics: Adenine; Adult; Bone and Bones; Fanconi Syndrome; Female; Fibroblast Growth Factor-23; Fibroblast Gr	2018
Osteomalacia Due to Drug-Induced Fanconi Syndrome. Arthritis & rheumatology (Hoboken, N.J.), 2018, Volume: 70, Issue:7 Topics: Adenine; Aged; Antiviral Agents; Fanconi Syndrome; Hepatitis B; Humans; Male; Organophosphonates; Os	2018
[A Case of Fanconi's Syndrome Induced by Adefovir in Hepatitis Type B Patient]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2016, Volume: 105, Issue:6 Topics: Adenine; Aged; Antiviral Agents; Fanconi Syndrome; Female; Guanine; Hepatitis B, Chronic; Humans; Or	2016
Hypophosphatemic Osteomalacia Associated with Adefovir-induced Fanconi Syndrome Initially Diagnosed as Diabetic Kidney Disease and Vitamin D Deficiency. Internal medicine (Tokyo, Japan), 2019, Mar-15, Volume: 58, Issue:6 Topics: Adenine; Aged; Antiviral Agents; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diagnostic Error	2019
Fanconi Syndrome and Tenofovir Alafenamide: A Case Report. Annals of internal medicine, 2019, 06-04, Volume: 170, Issue:11 Topics: Adenine; Alanine; Antiviral Agents; Fanconi Syndrome; HIV Infections; Humans; Male; Middle Aged; Ten	2019
[Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019, Volume: 139, Issue:4 Topics: Adenine; Aged; Carcinoma, Hepatocellular; Fanconi Syndrome; Fractures, Bone; Hepatitis B, Chronic; H	2019
[Marked improvement in renal tubular markers after switching from adefovir to tenofovir alafenamide in a case of Fanconi syndrome diagnosed through high ALP levels]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2019, Volume: 116, Issue:4 Topics: Adenine; Alanine; Alkaline Phosphatase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, V	2019
Denosumab improves clinical manifestations of hypophosphatemic osteomalacia by adefovir-induced Fanconi syndrome: a case report. Journal of medical case reports, 2019, Apr-20, Volume: 13, Issue:1 Topics: Adenine; Adult; Antiviral Agents; Bone Density Conservation Agents; Denosumab; Fanconi Syndrome; Hep	2019
Low-dose adefovir dipivoxil-induced hypophosphatemia osteomalacia in five chronic hepatitis B virus-infected patients. Is low-dose adefovir dipivoxil-induced nephrotoxicity completely reversible? Drug design, development and therapy, 2019, Volume: 13 Topics: Adenine; Aged; Dose-Response Relationship, Drug; Fanconi Syndrome; Female; Hepatitis B, Chronic; Hum	2019
A case of entecavir-induced Fanconi syndrome. CEN case reports, 2019, Volume: 8, Issue:4 Topics: Acidosis; Acute Kidney Injury; Adenine; Aged; Alanine; Antiviral Agents; Fanconi Syndrome; Guanine;	2019
Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition. Journal of clinical pharmacy and therapeutics, 2013, Volume: 38, Issue:4 Topics: Adenine; Antiviral Agents; Dose-Response Relationship, Drug; Fanconi Syndrome; Humans; Hypophosphate	2013
Tenofovir-associated Fanconi syndrome in patients with chronic hepatitis B monoinfection. Antiviral therapy, 2013, Volume: 18, Issue:7 Topics: Adenine; Adult; Antiviral Agents; Biopsy; Creatinine; Fanconi Syndrome; Hepatitis B, Chronic; Humans	2013
Tenofovir-related Fanconi's syndrome and osteomalacia in a teenager with HIV. BMJ case reports, 2013, Jul-09, Volume: 2013 Topics: Adenine; Adolescent; Anti-HIV Agents; Fanconi Syndrome; HIV Infections; Humans; Male; Organophosphon	2013
Acute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administration. HIV medicine, 2013, Volume: 14, Issue:10 Topics: Acute Kidney Injury; Adenine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Inter	2013
Interactive medical case: wasting away. The New England journal of medicine, 2014, Feb-13, Volume: 370, Issue:7 Topics: Adenine; Adult; Bone Density; Electrolytes; Fanconi Syndrome; Female; Hepatitis B, Chronic; Humans;	2014
Long-term observation of osteomalacia caused by adefovir-induced Fanconi's syndrome. Acta medica Okayama, 2014, Volume: 68, Issue:1 Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Humans; Male; Middle Aged; Organophosphonates; Osteomal	2014
Clinical problem-solving. Wasting away. The New England journal of medicine, 2014, Mar-06, Volume: 370, Issue:10 Topics: Adenine; Adult; Bone Diseases, Metabolic; Cachexia; Diagnosis, Differential; Fanconi Syndrome; Femal	2014
Mitochondrial dysfunction and electron transport chain complex defect in a rat model of tenofovir disoproxil fumarate nephrotoxicity. Journal of biochemical and molecular toxicology, 2014, Volume: 28, Issue:6 Topics: Adenine; Animals; Anti-HIV Agents; Electron Transport Chain Complex Proteins; Fanconi Syndrome; Kidn	2014
Fanconi syndrome caused by low-dose adefovir dipivoxil. Saudi medical journal, 2014, Volume: 35, Issue:3 Topics: Adenine; Dose-Response Relationship, Drug; Fanconi Syndrome; Female; Humans; Middle Aged; Organophos	2014
Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: a prospective, case-control study of predictors and resolution in HIV-infected patients. PloS one, 2014, Volume: 9, Issue:3 Topics: Adenine; Adult; Anti-HIV Agents; Case-Control Studies; Creatinine; Fanconi Syndrome; Female; Glomeru	2014
Fibroblast growth factor 23 is elevated in tenofovir-related hypophosphatemia. Calcified tissue international, 2014, Volume: 94, Issue:6 Topics: Adenine; Adult; Anti-HIV Agents; Bone Density; Fanconi Syndrome; Fibroblast Growth Factor-23; Fibrob	2014
[A case of chronic hepatitis B managed with continued adefovir despite treatment-related Fanconi syndrome and osteomalacia]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2014, Volume: 111, Issue:8 Topics: Adenine; Fanconi Syndrome; Female; Hepatitis B, Chronic; Humans; Middle Aged; Organophosphonates; Os	2014
Tenofovir-associated Fanconi syndrome in a patient with chronic hepatitis B. Journal of gastrointestinal and liver diseases : JGLD, 2014, Volume: 23, Issue:3 Topics: Adenine; Aged, 80 and over; Antiviral Agents; Fanconi Syndrome; Fatal Outcome; Hepatitis B, Chronic;	2014
Tenofovir-induced Fanconi syndrome in chronic hepatitis B monoinfected patients that reverted after tenofovir withdrawal. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2014, Volume: 61, Issue:4 Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Human	2014
A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome. Pharmacogenetics and genomics, 2015, Volume: 25, Issue:2 Topics: Adenine; Alleles; Anti-HIV Agents; Biomarkers, Pharmacological; Case-Control Studies; Fanconi Syndro	2015
[Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by adefovir in a patient with chronic hepatitis B]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2014, Volume: 22, Issue:10 Topics: Adenine; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia; Organophosphonates; Osteo	2014
[The clinical characteristics of 26 cases of hypophosphatemia osteomalacia misdiagnosed as spondyloarthritis]. Zhonghua nei ke za zhi, 2014, Volume: 53, Issue:11 Topics: Adenine; Adult; Antirheumatic Agents; Biomarkers; C-Reactive Protein; Fanconi Syndrome; Female; Huma	2014
[Case report; A case of Fanconi's syndrome with pathological ulnar fractures improved by dose reduction of adefovir and supplementation of oral phosphate]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2014, Aug-10, Volume: 103, Issue:8 Topics: Adenine; Administration, Oral; Aged; Antiviral Agents; Fanconi Syndrome; Female; Fractures, Spontane	2014
Osteomalacia and Fanconi's syndrome caused by long-term low-dose adefovir dipivoxil. Journal of clinical pharmacy and therapeutics, 2015, Volume: 40, Issue:3 Topics: Adenine; Antiviral Agents; Calcium; Dose-Response Relationship, Drug; Drug Monitoring; Fanconi Syndr	2015
Low-dose adefovir dipivoxil may induce Fanconi syndrome: clinical characteristics and long-term follow-up for Chinese patients. Antiviral therapy, 2015, Volume: 20, Issue:6 Topics: Adenine; Adult; Alkaline Phosphatase; Antiviral Agents; Asian People; Bone Density; Creatinine; Drug	2015
[Clinical analysis of Fanconi syndrome induced by adefovir dipivoxil]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2015, Volume: 23, Issue:4 Topics: Adenine; Fanconi Syndrome; Humans; Organophosphonates	2015
First case report of renal improvement on tenofovir alafenamide in an HIV/hepatitis B virus-coinfected patient with adefovir-induced Fanconi's syndrome. AIDS (London, England), 2016, 06-01, Volume: 30, Issue:9 Topics: Absorptiometry, Photon; Adenine; Alanine; Coinfection; Dose-Response Relationship, Drug; Fanconi Syn	2016
Pathologic Femoral Neck Fracture Due to Fanconi Syndrome Induced by Adefovir Dipivoxil Therapy for Hepatitis B. Clinics in orthopedic surgery, 2016, Volume: 8, Issue:2 Topics: Adenine; Adult; Antiviral Agents; Fanconi Syndrome; Femoral Neck Fractures; Fractures, Spontaneous;	2016
Urinary cystatin C can improve the renal safety follow-up of tenofovir-treated patients. AIDS (London, England), 2009, Jan-14, Volume: 23, Issue:2 Topics: Adenine; Anti-HIV Agents; Biomarkers; Creatinine; Cystatin C; Fanconi Syndrome; HIV Infections; Huma	2009
Adefovir dipivoxil-induced acute tubular necrosis and Fanconi syndrome in a renal transplant patient. AIDS (London, England), 2009, Feb-20, Volume: 23, Issue:4 Topics: Acute Kidney Injury; Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Kidn	2009
Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir. AIDS (London, England), 2009, Mar-27, Volume: 23, Issue:6 Topics: Adenine; Adult; Age Factors; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Creatinine; Epi	2009
Bone pain due to fractures revealing osteomalacia related to tenofovir-induced proximal renal tubular dysfunction in a human immunodeficiency virus-infected patient. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2009, Volume: 15, Issue:2 Topics: Adenine; Bone Density Conservation Agents; Fanconi Syndrome; Female; Fractures, Bone; HIV Infections	2009
Proximal tubular dysfunction associated with tenofovir and didanosine causing Fanconi syndrome and diabetes insipidus: a report of 3 cases. The AIDS reader, 2009, Volume: 19, Issue:3 Topics: Adenine; Adult; Anti-HIV Agents; Diabetes Insipidus; Didanosine; Drug Therapy, Combination; Fanconi	2009
Editorial comment: tenofovir nephrotoxicity--the disconnect between clinical trials and real-world practice. The AIDS reader, 2009, Volume: 19, Issue:3 Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Diabetes Insipidus; Didanosine; Drug Therapy, Co	2009
Tenofovir-associated renal and bone toxicity. HIV medicine, 2009, Volume: 10, Issue:8 Topics: Adenine; Adult; Anti-HIV Agents; Creatinine; Fanconi Syndrome; Female; Glycosuria; HIV Infections; H	2009
Tenofovir-related acute kidney injury and proximal tubule dysfunction precipitated by diclofenac: a case of drug-drug interaction. Clinical nephrology, 2009, Volume: 71, Issue:5 Topics: Acute Kidney Injury; Adenine; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Diag	2009
Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus. Journal of viral hepatitis, 2010, Feb-01, Volume: 17, Issue:2 Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Creatinine; DNA, Viral; Drug Resistanc	2010
Impact of tenofovir on renal function in HIV-infected, antiretroviral-naive patients. Journal of acquired immune deficiency syndromes (1999), 2010, Volume: 53, Issue:1 Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Creatinine; Fanconi Syndrome;	2010
Incidence of proximal renal tubular dysfunction in patients on tenofovir disoproxil fumarate. International journal of STD & AIDS, 2010, Volume: 21, Issue:2 Topics: Adenine; Anti-HIV Agents; Fanconi Syndrome; HIV Infections; Humans; Incidence; Organophosphonates; R	2010
[Fanconi syndrome associated with tenofovir treatment: a presentation of two cases]. Enfermedades infecciosas y microbiologia clinica, 2010, Volume: 28, Issue:9 Topics: Adenine; Adult; Fanconi Syndrome; Humans; Male; Middle Aged; Organophosphonates; Reverse Transcripta	2010
Tenofovir/probenecid combination in HIV/HBV-coinfected patients: how to escape Fanconi syndrome recurrence? AIDS (London, England), 2010, Apr-24, Volume: 24, Issue:7 Topics: Adenine; Fanconi Syndrome; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Male; Organophosphon	2010
[Two cases of Fanconi's syndrome induced by tenofovir in the Ivory Coast]. Medecine et maladies infectieuses, 2011, Volume: 41, Issue:2 Topics: Adenine; Aged; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cote d	2011
[HIV infected women with intense bone and muscular pain and general weakness]. Enfermedades infecciosas y microbiologia clinica, 2011, Volume: 29, Issue:4 Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Therapy, Combina	2011
[Renal adverse reactions of antiretroviral medication: proximal tubular dysfunction associated with tenofovir]. Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155 Topics: Adenine; Anti-HIV Agents; Fanconi Syndrome; HIV Infections; Humans; Male; Middle Aged; Organophospho	2011
Hypophosphatemic osteomalacia as a long-term complication after liver transplantation. Transplantation, 2011, Jan-15, Volume: 91, Issue:1 Topics: Adenine; Aged; Fanconi Syndrome; Female; Humans; Hypophosphatemia; Immunosuppressive Agents; Liver T	2011
Increased risk of abnormal proximal renal tubular function with HIV infection and antiretroviral therapy. Kidney international, 2011, Volume: 80, Issue:3 Topics: Adenine; Adult; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; C	2011
Tenofovir-induced Fanconi syndrome and osteomalacia in two HIV-infected patients: role of intracellular tenofovir diphosphate levels and review of the literature. Scandinavian journal of infectious diseases, 2011, Volume: 43, Issue:10 Topics: Adenine; Adult; Anti-HIV Agents; Diphosphates; Fanconi Syndrome; HIV Infections; Humans; Male; Middl	2011
Nephrotoxicity, including acquired Fanconi's syndrome, caused by adefovir dipivoxil - is there a safe dose? Journal of clinical pharmacy and therapeutics, 2012, Volume: 37, Issue:2 Topics: Adenine; Aged; Antiviral Agents; Dose-Response Relationship, Drug; Fanconi Syndrome; Female; Hepatit	2012
Bilateral pathologic hip fractures associated with antiretroviral therapy: a case report. The Journal of bone and joint surgery. American volume, 2011, Jul-20, Volume: 93, Issue:14 Topics: Accidental Falls; Adenine; Alendronate; Anti-HIV Agents; Bone Density Conservation Agents; Comorbidi	2011
Fanconi syndrome-like tubular acidosis associated with a tenofovir-containing antiretroviral regimen in a human immunodeficiency virus-1-infected Asian woman. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2012, Volume: 18, Issue:2 Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Drug Therapy, Combin	2012
[Adefovir dipivoxil-induced Fanconi syndrome and hypophosphatemic osteomalacia associated with muscular weakness in a patient with chronic hepatitis B]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011, Volume: 31, Issue:11 Topics: Adenine; Antiviral Agents; Bone Diseases, Metabolic; Fanconi Syndrome; Hepatitis B, Chronic; Humans;	2011
An unrecognised case of tenofovir-associated Fanconi syndrome. The Medical journal of Australia, 2012, Feb-06, Volume: 196 Topics: Adenine; Adolescent; Anti-HIV Agents; Fanconi Syndrome; HIV Infections; Humans; Male; Organophosphon	2012
Prolonged adefovir therapy associated Fanconi syndrome and interstitial nephritis in hepatitis B. Internal medicine journal, 2012, Volume: 42, Issue:8 Topics: Adenine; Drug Administration Schedule; Fanconi Syndrome; Hepatitis B; Humans; Male; Middle Aged; Nep	2012
Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report. Diagnostic pathology, 2012, Aug-20, Volume: 7 Topics: Adenine; Antiviral Agents; Arthroplasty, Replacement, Hip; Fanconi Syndrome; Femoral Neck Fractures;	2012
Osteomalacia due to Fanconi's syndrome and renal failure caused by long-term low-dose adefovir dipivoxil. Clinical and experimental nephrology, 2013, Volume: 17, Issue:1 Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organo	2013
Fanconi syndrome and renal failure induced by tenofovir: a first case report. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 40, Issue:6 Topics: Adenine; Anti-HIV Agents; Fanconi Syndrome; Female; HIV Seropositivity; Humans; Middle Aged; Organop	2002
Renal lesions in HIV-1-positive patient treated with tenofovir. AIDS (London, England), 2003, Apr-11, Volume: 17, Issue:6 Topics: Acute Kidney Injury; Adenine; Anti-HIV Agents; Fanconi Syndrome; HIV Infections; HIV-1; Humans; Male	2003
Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Apr-15, Volume: 36, Issue:8 Topics: Acidosis; Adenine; Adult; Anti-HIV Agents; Creatinine; Diabetes Insipidus, Nephrogenic; Drug Monitor	2003
Fanconi-like syndrome and rhabdomyolysis in a person with HIV infection on highly active antiretroviral treatment including tenofovir. The Journal of infection, 2003, Volume: 47, Issue:3 Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Fanconi Syndrome; Female; HIV Serop	2003
Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosine. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Dec-15, Volume: 37, Issue:12 Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Diabetes Insipidus, Nephrogenic	2003
Fanconi syndrome and acute renal failure in a patient treated with tenofovir: a call for caution. AIDS (London, England), 2004, Jan-23, Volume: 18, Issue:2 Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Fanconi Syndrome; HIV Seropositivity; HIV-1; H	2004
Biological effects of short-term or prolonged administration of 9-[2-(phosphonomethoxy)propyl]adenine (tenofovir) to newborn and infant rhesus macaques. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:5 Topics: Absorptiometry, Photon; Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Area Under Curve; Blood	2004
Tubulopathy consecutive to tenofovir-containing antiretroviral therapy in two patients infected with human immunodeficiency virus-1. Scandinavian journal of infectious diseases, 2004, Volume: 36, Issue:6-7 Topics: Adenine; Anti-HIV Agents; Drug Therapy, Combination; Fanconi Syndrome; HIV Infections; HIV-1; Humans	2004
Tenofovir-associated nephrotoxicity: Fanconi syndrome and renal failure. The American journal of medicine, 2004, Aug-15, Volume: 117, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Fanconi Syndrome; Humans; Kidne	2004
Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice. Journal of acquired immune deficiency syndromes (1999), 2005, Mar-01, Volume: 38, Issue:3 Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blood Chemical Analysis; Creatinine	2005
[Acute renal failure, Fanconi syndrome and insipidus diabetes in a HIV-infected patient treated with Tenofovir]. La Revue de medecine interne, 2005, Volume: 26, Issue:6 Topics: Acute Kidney Injury; Adenine; Adult; Diabetes Insipidus; Fanconi Syndrome; HIV Infections; Humans; M	2005
Tenofovir-induced renal tubular dysfunction presenting with hypocalcaemia. The Journal of infection, 2006, Volume: 52, Issue:4 Topics: Adenine; Anti-HIV Agents; Bone Density Conservation Agents; Fanconi Syndrome; HIV Infections; Humans	2006
The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy. HIV medicine, 2005, Volume: 6, Issue:5 Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Fanconi Syndrome; Female; HIV Infec	2005
Nephrotoxicity in a child with perinatal HIV on tenofovir, didanosine and lopinavir/ritonavir. Pediatric nephrology (Berlin, Germany), 2006, Volume: 21, Issue:7 Topics: Adenine; Anti-HIV Agents; Child; Diabetes Insipidus, Nephrogenic; Didanosine; Drug Therapy, Combinat	2006
Estimating renal function in patients on tenofovir disoproxil fumarate: suggestions for safer use. HIV medicine, 2006, Volume: 7, Issue:7 Topics: Adenine; Creatinine; Dose-Response Relationship, Drug; Fanconi Syndrome; Glomerular Filtration Rate;	2006
Acquired Fanconi's syndrome associated with tenofovir therapy. Journal of general internal medicine, 2006, Volume: 21, Issue:11 Topics: Adenine; Adult; Fanconi Syndrome; Humans; Male; Organophosphonates; Tenofovir	2006
Toward a pharmacogenetic understanding of nucleotide and nucleoside analogue toxicity. The Journal of infectious diseases, 2006, Dec-01, Volume: 194, Issue:11 Topics: Adenine; Anti-HIV Agents; Fanconi Syndrome; Haplotypes; HIV Infections; Humans; Membrane Transport P	2006
Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. The Journal of infectious diseases, 2006, Dec-01, Volume: 194, Issue:11 Topics: Adenine; Adult; Aged; Anti-HIV Agents; Case-Control Studies; Fanconi Syndrome; Female; Gene Frequenc	2006
[Acute renal failure and proximal renal tubular dysfuntion in a patient with acquired immunodeficiency syndrome treated with tenofovir]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2006, Volume: 26, Issue:5 Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adenine; Aged; Anti-HIV Agents; Fanconi Syn	2006
Causes and consequences of hypokalemia in patients on tenofovir disoproxil fumarate. AIDS (London, England), 2007, Jul-11, Volume: 21, Issue:11 Topics: Adenine; Adult; Cause of Death; Drug Monitoring; Drug Synergism; Fanconi Syndrome; Female; Guideline	2007
Bone disease and pathologic fractures in a patient with tenofovir-induced Fanconi syndrome. The AIDS reader, 2007, Volume: 17, Issue:6 Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Diseases; Fanconi Syndrome; Fe	2007
Editorial comment: Fanconi syndrome and tenofovir--understanding proximal tubular function. The AIDS reader, 2007, Volume: 17, Issue:6 Topics: Adenine; Adult; Anti-HIV Agents; Child; Fanconi Syndrome; Humans; Kidney Tubules, Proximal; Organoph	2007
Tenofovir-associated Fanconi syndrome: review of the FDA adverse event reporting system. AIDS patient care and STDs, 2008, Volume: 22, Issue:2 Topics: Adenine; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Anti-HIV Agents; Child; F	2008
Kidney dysfunction: a safety update on adefovir (preveon). BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation, 1998 Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Creatinine; Fanconi Syndrome; HIV Infections; Humans; Hy	1998

adenine and Adult Fanconi Syndrome