adenine has been researched along with Adjuvant Arthritis in 10 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objectives were: (1) to test the association of methotrexate (MTX) efficacy in rat adjuvant arthritis (rat AA) with interference of purine biosynthesis and adenosine metabolism and (2) to test the efficacy of erythro-9-(2-hydroxynon-3-yl) adenine (EHNA), an inhibitor of adenosine deaminase, and the efficacy of aminoimidazolecarboxamide (AICA) riboside plus MTX in rat AA." | 7.74 | Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism. ( Baggott, JE; Morgan, SL, 2007) |
| "The objectives were: (1) to test the association of methotrexate (MTX) efficacy in rat adjuvant arthritis (rat AA) with interference of purine biosynthesis and adenosine metabolism and (2) to test the efficacy of erythro-9-(2-hydroxynon-3-yl) adenine (EHNA), an inhibitor of adenosine deaminase, and the efficacy of aminoimidazolecarboxamide (AICA) riboside plus MTX in rat AA." | 3.74 | Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism. ( Baggott, JE; Morgan, SL, 2007) |
| " Chronic dosing may exacerbate the emergence of drug resistance, with resistant mutations already observed in ibrutinib-treated patients." | 2.53 | Investigational Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis. ( Norman, P, 2016) |
| " Both prophylactic and therapeutic dosing regimens were effective." | 1.30 | Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). ( Franková, D; Holý, A; Zídek, Z, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, R | 1 |
| Zhu, F | 1 |
| Wu, X | 1 |
| Song, S | 1 |
| Chen, Y | 1 |
| Zhu, C | 1 |
| Dai, B | 1 |
| Qian, X | 1 |
| Wang, K | 1 |
| Hu, W | 1 |
| Chen, F | 1 |
| Cheng, NT | 1 |
| Guo, A | 1 |
| Meng, H | 1 |
| Norman, P | 1 |
| Honigberg, LA | 1 |
| Smith, AM | 1 |
| Sirisawad, M | 1 |
| Verner, E | 1 |
| Loury, D | 1 |
| Chang, B | 1 |
| Li, S | 1 |
| Pan, Z | 1 |
| Thamm, DH | 1 |
| Miller, RA | 1 |
| Buggy, JJ | 2 |
| Chang, BY | 1 |
| Huang, MM | 1 |
| Francesco, M | 1 |
| Chen, J | 1 |
| Sokolove, J | 1 |
| Magadala, P | 1 |
| Robinson, WH | 1 |
| Ruderman, EM | 1 |
| Pope, RM | 1 |
| Baggott, JE | 1 |
| Morgan, SL | 1 |
| Randis, TM | 1 |
| Puri, KD | 1 |
| Zhou, H | 1 |
| Diacovo, TG | 1 |
| Zídek, A | 1 |
| Holý, A | 2 |
| Franková, D | 2 |
| Otová, B | 1 |
| Zídek, Z | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Randomized Study to Investigate the Use of Acalabrutinib in the Treatment of Patients With Early Stage CLL With High Risk of Early Disease Progression[NCT04178798] | Phase 3 | 22 participants (Actual) | Interventional | 2019-12-09 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for adenine and Adjuvant Arthritis
| Article | Year |
|---|---|
Investigational Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Arthritis, Experimental; Arthritis, Rheumatoi | 2016 |
9 other studies available for adenine and Adjuvant Arthritis
| Article | Year |
|---|---|
Effects of autophagy on apoptosis of articular chondrocytes in adjuvant arthritis rats.
Topics: Adenine; Animals; Apoptosis; Arthritis, Experimental; Autophagy; Cartilage, Articular; Cells, Cultur | 2019 |
The protective role of autophagy in experimental osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by activating autophagy.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Arthritis, Experimental; Autophagy; Beclin-1; Carti | 2016 |
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy.
Topics: Adenine; Administration, Oral; Agammaglobulinaemia Tyrosine Kinase; Animals; Arthritis, Experimental | 2010 |
The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Arthritis, Experimental; Arthritis, Rheumatoi | 2011 |
More than just B-cell inhibition.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Arthritis, Experimental; Arthritis, Rheumatoi | 2011 |
Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; | 2007 |
Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils.
Topics: Adenine; Animals; Arthritis, Experimental; Chemotaxis, Leukocyte; Class I Phosphatidylinositol 3-Kin | 2008 |
Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs.
Topics: Adenine; Animals; Arthritis, Experimental; Cidofovir; Cytosine; Female; Organophosphonates; Organoph | 1995 |
Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemokine CCL5; | 1999 |