adenine has been researched along with Adenocarcinoma, Basal Cell in 48 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twelve patients with recurrent, metastatic, or inoperable gastric adenocarcinoma were enrolled in an Illinois Cancer Center phase II trial of amonafide (nafidimide), a novel compound that acts as a DNA intercalator." | 9.07 | Phase II study of amonafide in gastric adenocarcinoma. An Illinois Cancer Center trial. ( Bauman, A; Benson, AB; Blough, RR; Carroll, RB; French, SL; Kilton, LJ; Mullane, MR; Schilsky, RL; Wade, JL, 1994) |
| "To determine the efficacy of amonafide in patients with advanced, measurable pancreatic adenocarcinoma, 15 patients previously untreated with chemotherapy were entered on a phase II trial." | 9.07 | Phase II study of amonafide in advanced pancreatic adenocarcinoma. ( Abbruzzese, JL; Ajani, JA; Bradof, JE; Daugherty, K; Levin, B; Linke, K; Pazdur, R; Winn, R, 1991) |
| "Amonafide, a benzisoquinoline-1,3-dione with anti-tumor activity in preclinical screens, was administered to patients with recurrent or metastatic bidimensionally measurable colorectal cancer." | 9.07 | Phase II study of amonafide (nafidamide, NSC 308847) in advanced colorectal cancer. ( Comis, RL; Hudes, GR; O'Dwyer, PJ; Ozols, RF; Paul, AR; Walczak, J, 1991) |
| "Altered cyclin D1 (CD1), a cell cycle regulator, may play an important role in imparting aggressive nature to esophageal adenocarcinoma (EAC)." | 7.74 | Cyclin D1 guanine/adenine 870 polymorphism with altered protein expression is associated with genomic instability and aggressive clinical biology of esophageal adenocarcinoma. ( Ajani, JA; Chao, CK; Correa, A; Ensor, J; Hittelman, WN; Izzo, JG; Luthra, R; Pan, J; Swisher, SG; Wu, TT; Wu, X, 2007) |
| "Amonafide, 300 mg/m2, was administered intravenously over 1 hour daily for 5 consecutive days." | 6.67 | Phase II trial of amonafide in patients with advanced metastatic or recurrent endometrial adenocarcinoma. A Southwest Oncology Group study. ( Alberts, DS; Craig, JB; Liu, PY; Malviya, VK; O'Sullivan, J; O'Toole, R; Rosenoff, S; Surwit, E; Ward, JH; Yu, A, 1994) |
| "Amonafide is a substituted benzisoquinolinedione that exerts its cytotoxicity through effects on macromolecular synthesis and intercalation of DNA." | 6.67 | Phase II trial of amonafide in advanced colorectal cancer: a SouthWest Oncology Group study. ( Brown, TD; Craig, JB; Einstein, AB; Fleming, T; Goodman, PJ; Macdonald, JS, 1993) |
| "Twelve patients with recurrent, metastatic, or inoperable gastric adenocarcinoma were enrolled in an Illinois Cancer Center phase II trial of amonafide (nafidimide), a novel compound that acts as a DNA intercalator." | 5.07 | Phase II study of amonafide in gastric adenocarcinoma. An Illinois Cancer Center trial. ( Bauman, A; Benson, AB; Blough, RR; Carroll, RB; French, SL; Kilton, LJ; Mullane, MR; Schilsky, RL; Wade, JL, 1994) |
| "To determine the efficacy of amonafide in patients with advanced, measurable pancreatic adenocarcinoma, 15 patients previously untreated with chemotherapy were entered on a phase II trial." | 5.07 | Phase II study of amonafide in advanced pancreatic adenocarcinoma. ( Abbruzzese, JL; Ajani, JA; Bradof, JE; Daugherty, K; Levin, B; Linke, K; Pazdur, R; Winn, R, 1991) |
| "Amonafide, a benzisoquinoline-1,3-dione with anti-tumor activity in preclinical screens, was administered to patients with recurrent or metastatic bidimensionally measurable colorectal cancer." | 5.07 | Phase II study of amonafide (nafidamide, NSC 308847) in advanced colorectal cancer. ( Comis, RL; Hudes, GR; O'Dwyer, PJ; Ozols, RF; Paul, AR; Walczak, J, 1991) |
| " We found that in a gastric adenocarcinoma cell line GTL-16, where MET activity is deregulated due to receptor overexpression, two different MET inhibitors PHA665752 and EMD1214063 lead to cell death paralleled by the induction of autophagy." | 3.79 | Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells. ( Aebersold, DM; Bladt, F; Blaukat, A; Fey, MF; Humbert, M; Medová, M; Tschan, MP; Zimmer, Y, 2013) |
| "Novel ruthenium-letrozole complexes have been prepared, and cell viability of two human cancer cell types (breast and glioblastoma) was determined." | 3.78 | New ruthenium(II)-letrozole complexes as anticancer therapeutics. ( Castonguay, A; Doucet, C; Juhas, M; Maysinger, D, 2012) |
| " The aim of this study is to investigate the effects of combined autophagy inhibitor 3-methyladenine (3-MA) on the radiosensitivity of human adenocarcinoma A549 cells in hypoxia condition." | 3.78 | [The effect of autophagy on the radioresistance of human adenocarcinoma A549 cell in hypoxia condition]. ( Cai, A; Li, L; Li, Y; Xu, L; Zhong, X, 2012) |
| "Altered cyclin D1 (CD1), a cell cycle regulator, may play an important role in imparting aggressive nature to esophageal adenocarcinoma (EAC)." | 3.74 | Cyclin D1 guanine/adenine 870 polymorphism with altered protein expression is associated with genomic instability and aggressive clinical biology of esophageal adenocarcinoma. ( Ajani, JA; Chao, CK; Correa, A; Ensor, J; Hittelman, WN; Izzo, JG; Luthra, R; Pan, J; Swisher, SG; Wu, TT; Wu, X, 2007) |
| " The highest tested dose of ibrutinib, 560 mg once daily, was combined with a fixed dose of pembrolizumab 200 mg every 3 weeks for the phase 2 portion." | 3.01 | A phase 1/2 trial of ibrutinib in combination with pembrolizumab in patients with mismatch repair proficient metastatic colorectal cancer. ( Carballido, E; Imanirad, I; Kim, DW; Kim, RD; Martinez, M; Mehta, R; Schell, MJ; Strosberg, J; Tan, E; Yu, J; Zhou, JM, 2021) |
| "Amonafide was given at a dose of 225 mg/m2 intravenously daily for 5 days." | 2.67 | Phase II trial of amonafide for the treatment of advanced, hormonally refractory carcinoma of the prostate. A Southwest Oncology Group study. ( Ahmann, F; Blumenstein, B; Craig, JB; Crawford, ED; Eisenberger, M; Marshall, ME; Thompson, IM, 1994) |
| "Amonafide, 300 mg/m2, was administered intravenously over 1 hour daily for 5 consecutive days." | 2.67 | Phase II trial of amonafide in patients with advanced metastatic or recurrent endometrial adenocarcinoma. A Southwest Oncology Group study. ( Alberts, DS; Craig, JB; Liu, PY; Malviya, VK; O'Sullivan, J; O'Toole, R; Rosenoff, S; Surwit, E; Ward, JH; Yu, A, 1994) |
| "Amonafide is a substituted benzisoquinolinedione that exerts its cytotoxicity through effects on macromolecular synthesis and intercalation of DNA." | 2.67 | Phase II trial of amonafide in advanced colorectal cancer: a SouthWest Oncology Group study. ( Brown, TD; Craig, JB; Einstein, AB; Fleming, T; Goodman, PJ; Macdonald, JS, 1993) |
| "Oesophageal cancer is the fifth most frequent cause of cancer death world wide and most of these cancers occur in developing countries." | 2.40 | Molecular precursor lesions in oesophageal cancer. ( Hainaut, P; Montesano, R, 1998) |
| "Upon metabolic perturbation, prostate cancer cell lines upregulate MTAP and this correlates with recovery of SAM levels." | 1.43 | The essential role of methylthioadenosine phosphorylase in prostate cancer. ( Affronti, HC; Bistulfi, G; Foster, BA; Gillard, B; Karasik, E; Mohler, J; Morrison, C; Phillips, JG; Smiraglia, DJ, 2016) |
| "The bleak prognosis associated with pancreatic cancer (PDAC) drives the need for the development of novel treatment methodologies." | 1.42 | Annexin V-Directed Enzyme Prodrug Therapy Plus Docetaxel for the Targeted Treatment of Pancreatic Cancer. ( Guillen, KP; Harrison, RG; Kurkjian, C; Restuccia, A, 2015) |
| "In contrast, colorectal cancers with codon 12 aspartic acid substitutions accounted for most of the distant hematogenous deposits (P < 0." | 1.29 | Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type. ( Christensen, S; Finkelstein, SD; Sayegh, R; Swalsky, PA, 1993) |
| " With the low response rate and the toxicity observed, amonafide at this dosage and schedule has limited use in the treatment of non-small-cell lung cancer." | 1.28 | Phase II trial of amonafide in patients with stage III and IV non-small-cell lung cancer. ( Berger, MZ; Dimaggio, JJ; Gralla, RJ; Heelan, RT; Kris, MG; Marks, LD; Potanovich, LM, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (27.08) | 18.7374 |
| 1990's | 13 (27.08) | 18.2507 |
| 2000's | 5 (10.42) | 29.6817 |
| 2010's | 13 (27.08) | 24.3611 |
| 2020's | 4 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 3 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 6 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 3 |
| Chen, L | 2 |
| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
| Schneider, MP | 1 |
| Meiselbach, H | 1 |
| Nadal, J | 1 |
| Schmid, MC | 1 |
| Saritas, T | 1 |
| Krane, V | 1 |
| Sommerer, C | 1 |
| Baid-Agrawal, S | 1 |
| Voelkl, J | 1 |
| Kotsis, F | 1 |
| Köttgen, A | 1 |
| Eckardt, KU | 1 |
| Scherberich, JE | 1 |
| Li, H | 4 |
| Yao, L | 2 |
| Sun, L | 3 |
| Zhu, Z | 1 |
| Naren, N | 1 |
| Zhang, XX | 2 |
| Gentile, GL | 1 |
| Rupert, AS | 1 |
| Carrasco, LI | 1 |
| Garcia, EM | 1 |
| Kumar, NG | 1 |
| Walsh, SW | 1 |
| Jefferson, KK | 1 |
| Guest, RL | 1 |
| Samé Guerra, D | 1 |
| Wissler, M | 1 |
| Grimm, J | 1 |
| Silhavy, TJ | 1 |
| Lee, JH | 2 |
| Yoo, JS | 1 |
| Kim, Y | 1 |
| Kim, JS | 2 |
| Lee, EJ | 1 |
| Roe, JH | 1 |
| Delorme, M | 1 |
| Bouchard, PA | 1 |
| Simon, M | 1 |
| Simard, S | 1 |
| Lellouche, F | 1 |
| D'Urzo, KA | 1 |
| Mok, F | 1 |
| D'Urzo, AD | 1 |
| Koneru, B | 1 |
| Lopez, G | 1 |
| Farooqi, A | 1 |
| Conkrite, KL | 1 |
| Nguyen, TH | 1 |
| Macha, SJ | 1 |
| Modi, A | 1 |
| Rokita, JL | 1 |
| Urias, E | 1 |
| Hindle, A | 1 |
| Davidson, H | 1 |
| Mccoy, K | 1 |
| Nance, J | 1 |
| Yazdani, V | 1 |
| Irwin, MS | 1 |
| Yang, S | 1 |
| Wheeler, DA | 1 |
| Maris, JM | 1 |
| Diskin, SJ | 1 |
| Reynolds, CP | 1 |
| Abhilash, L | 1 |
| Kalliyil, A | 1 |
| Sheeba, V | 1 |
| Hartley, AM | 2 |
| Meunier, B | 2 |
| Pinotsis, N | 1 |
| Maréchal, A | 2 |
| Xu, JY | 1 |
| Genko, N | 1 |
| Haraux, F | 1 |
| Rich, PR | 1 |
| Kamalanathan, M | 1 |
| Doyle, SM | 1 |
| Xu, C | 1 |
| Achberger, AM | 1 |
| Wade, TL | 1 |
| Schwehr, K | 1 |
| Santschi, PH | 1 |
| Sylvan, JB | 1 |
| Quigg, A | 1 |
| Leong, W | 1 |
| Xu, W | 2 |
| Gao, S | 1 |
| Zhai, X | 1 |
| Wang, C | 2 |
| Gilson, E | 1 |
| Ye, J | 1 |
| Lu, Y | 1 |
| Yan, R | 1 |
| Zhang, Y | 6 |
| Hu, Z | 1 |
| You, Q | 1 |
| Cai, Q | 1 |
| Yang, D | 1 |
| Gu, S | 1 |
| Dai, H | 1 |
| Zhao, X | 1 |
| Gui, C | 1 |
| Gui, J | 1 |
| Wu, PK | 1 |
| Hong, SK | 1 |
| Starenki, D | 1 |
| Oshima, K | 1 |
| Shao, H | 1 |
| Gestwicki, JE | 1 |
| Tsai, S | 1 |
| Park, JI | 1 |
| Wang, Y | 7 |
| Zhao, R | 1 |
| Gu, Z | 1 |
| Dong, C | 2 |
| Guo, G | 1 |
| Li, L | 5 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
| de Blois, E | 1 |
| de Swart, J | 1 |
| Verhagen, HJ | 1 |
| Maina, T | 1 |
| Nock, BA | 1 |
| Norenberg, JP | 1 |
| de Jong, M | 1 |
| Gijsen, FJH | 1 |
| Bernsen, MR | 1 |
| Martínez-Milla, J | 1 |
| Galán-Arriola, C | 1 |
| Carnero, M | 1 |
| Cobiella, J | 1 |
| Pérez-Camargo, D | 1 |
| Bautista-Hernández, V | 1 |
| Rigol, M | 1 |
| Solanes, N | 1 |
| Villena-Gutierrez, R | 1 |
| Lobo, M | 1 |
| Mateo, J | 1 |
| Vilchez-Tschischke, JP | 1 |
| Salinas, B | 1 |
| Cussó, L | 1 |
| López, GJ | 1 |
| Fuster, V | 1 |
| Desco, M | 1 |
| Sanchez-González, J | 1 |
| Ibanez, B | 1 |
| van den Berg, P | 1 |
| Schweitzer, DH | 1 |
| van Haard, PMM | 1 |
| Geusens, PP | 1 |
| van den Bergh, JP | 1 |
| Zhu, X | 1 |
| Huang, X | 2 |
| Xu, H | 2 |
| Yang, G | 2 |
| Lin, Z | 1 |
| Salem, HF | 1 |
| Nafady, MM | 1 |
| Kharshoum, RM | 1 |
| Abd El-Ghafar, OA | 1 |
| Farouk, HO | 1 |
| Domiciano, D | 1 |
| Nery, FC | 1 |
| de Carvalho, PA | 1 |
| Prudente, DO | 1 |
| de Souza, LB | 1 |
| Chalfun-Júnior, A | 1 |
| Paiva, R | 1 |
| Marchiori, PER | 1 |
| Lu, M | 2 |
| An, Z | 1 |
| Jiang, J | 2 |
| Li, J | 7 |
| Du, S | 1 |
| Zhou, H | 1 |
| Cui, J | 1 |
| Wu, W | 1 |
| Liu, Y | 7 |
| Song, J | 1 |
| Lian, Q | 1 |
| Uddin Ahmad, Z | 1 |
| Gang, DD | 1 |
| Konggidinata, MI | 1 |
| Gallo, AA | 1 |
| Zappi, ME | 1 |
| Yang, TWW | 1 |
| Johari, Y | 1 |
| Burton, PR | 1 |
| Earnest, A | 1 |
| Shaw, K | 1 |
| Hare, JL | 1 |
| Brown, WA | 1 |
| Kim, GA | 1 |
| Han, S | 1 |
| Choi, GH | 1 |
| Choi, J | 1 |
| Lim, YS | 1 |
| Gallo, A | 1 |
| Cancelli, C | 1 |
| Ceron, E | 1 |
| Covino, M | 1 |
| Capoluongo, E | 1 |
| Pocino, K | 1 |
| Ianiro, G | 1 |
| Cammarota, G | 1 |
| Gasbarrini, A | 1 |
| Montalto, M | 1 |
| Somasundar, Y | 1 |
| Lu, IC | 1 |
| Mills, MR | 1 |
| Qian, LY | 1 |
| Olivares, X | 1 |
| Ryabov, AD | 1 |
| Collins, TJ | 1 |
| Zhao, L | 1 |
| Doddipatla, S | 1 |
| Thomas, AM | 1 |
| Nikolayev, AA | 1 |
| Galimova, GR | 1 |
| Azyazov, VN | 1 |
| Mebel, AM | 1 |
| Kaiser, RI | 1 |
| Guo, S | 1 |
| Yang, P | 1 |
| Yu, X | 2 |
| Wu, Y | 2 |
| Zhang, H | 1 |
| Yu, B | 2 |
| Han, B | 1 |
| George, MW | 1 |
| Moor, MB | 1 |
| Bonny, O | 1 |
| Langenberg, E | 1 |
| Paik, H | 1 |
| Smith, EH | 1 |
| Nair, HP | 1 |
| Hanke, I | 1 |
| Ganschow, S | 1 |
| Catalan, G | 1 |
| Domingo, N | 1 |
| Schlom, DG | 1 |
| Assefa, MK | 1 |
| Wu, G | 2 |
| Hayton, TW | 1 |
| Becker, B | 1 |
| Enikeev, D | 1 |
| Netsch, C | 1 |
| Gross, AJ | 1 |
| Laukhtina, E | 1 |
| Glybochko, P | 1 |
| Rapoport, L | 1 |
| Herrmann, TRW | 1 |
| Taratkin, M | 1 |
| Dai, W | 1 |
| Shi, J | 2 |
| Carreno, J | 1 |
| Kloner, RA | 1 |
| Pickersgill, NA | 1 |
| Vetter, JM | 1 |
| Kim, EH | 1 |
| Cope, SJ | 1 |
| Du, K | 1 |
| Venkatesh, R | 1 |
| Giardina, JD | 1 |
| Saad, NES | 1 |
| Bhayani, SB | 1 |
| Figenshau, RS | 1 |
| Eriksson, J | 1 |
| Landfeldt, E | 1 |
| Ireland, S | 1 |
| Jackson, C | 1 |
| Wyatt, E | 1 |
| Gaudig, M | 1 |
| Stancill, JS | 1 |
| Happ, JT | 1 |
| Broniowska, KA | 1 |
| Hogg, N | 1 |
| Corbett, JA | 1 |
| Tang, LF | 1 |
| Bi, YL | 1 |
| Fan, Y | 2 |
| Sun, YB | 1 |
| Wang, AL | 1 |
| Xiao, BH | 1 |
| Wang, LF | 1 |
| Qiu, SW | 1 |
| Guo, SW | 1 |
| Wáng, YXJ | 1 |
| Sun, J | 2 |
| Chu, S | 1 |
| Pan, Q | 1 |
| Li, D | 2 |
| Zheng, S | 2 |
| Ma, L | 1 |
| Wang, L | 3 |
| Hu, T | 1 |
| Wang, F | 1 |
| Han, Z | 1 |
| Yin, Z | 1 |
| Ge, X | 1 |
| Xie, K | 1 |
| Lei, P | 1 |
| Dias-Santagata, D | 1 |
| Lennerz, JK | 1 |
| Sadow, PM | 1 |
| Frazier, RP | 1 |
| Govinda Raju, S | 1 |
| Henry, D | 1 |
| Chung, T | 1 |
| Kherani, J | 1 |
| Rothenberg, SM | 1 |
| Wirth, LJ | 1 |
| Marti, CN | 1 |
| Choi, NG | 1 |
| Bae, SJ | 1 |
| Ni, L | 1 |
| Luo, X | 1 |
| Dai, T | 1 |
| Yang, Y | 3 |
| Lee, R | 1 |
| Fleischer, AS | 1 |
| Wemhoff, AP | 1 |
| Ford, CR | 1 |
| Kleppinger, EL | 1 |
| Helms, K | 1 |
| Bush, AA | 1 |
| Luna-Abanto, J | 1 |
| García Ruiz, L | 1 |
| Laura Martinez, J | 1 |
| Álvarez Larraondo, M | 1 |
| Villoslada Terrones, V | 1 |
| Dukic, L | 1 |
| Maric, N | 1 |
| Simundic, AM | 1 |
| Chogtu, B | 1 |
| Ommurugan, B | 1 |
| Thomson, SR | 1 |
| Kalthur, SG | 1 |
| Benidir, M | 1 |
| El Massoudi, S | 1 |
| El Ghadraoui, L | 1 |
| Lazraq, A | 1 |
| Benjelloun, M | 1 |
| Errachidi, F | 1 |
| Cassar, M | 1 |
| Law, AD | 1 |
| Chow, ES | 1 |
| Giebultowicz, JM | 1 |
| Kretzschmar, D | 1 |
| Salonurmi, T | 1 |
| Nabil, H | 1 |
| Ronkainen, J | 1 |
| Hyötyläinen, T | 1 |
| Hautajärvi, H | 1 |
| Savolainen, MJ | 1 |
| Tolonen, A | 1 |
| Orešič, M | 1 |
| Känsäkoski, P | 1 |
| Rysä, J | 1 |
| Hakkola, J | 1 |
| Hukkanen, J | 1 |
| Zhu, N | 1 |
| Li, Y | 5 |
| Du, Q | 1 |
| Hao, P | 1 |
| Cao, X | 1 |
| Li, CX | 1 |
| Zhao, S | 1 |
| Luo, XM | 1 |
| Feng, JX | 1 |
| Gonzalez-Cotto, M | 1 |
| Guo, L | 1 |
| Karwan, M | 1 |
| Sen, SK | 1 |
| Barb, J | 1 |
| Collado, CJ | 1 |
| Elloumi, F | 1 |
| Palmieri, EM | 1 |
| Boelte, K | 1 |
| Kolodgie, FD | 1 |
| Finn, AV | 1 |
| Biesecker, LG | 1 |
| McVicar, DW | 1 |
| Qu, F | 1 |
| Deng, Z | 1 |
| Xie, Y | 2 |
| Tang, J | 3 |
| Chen, Z | 2 |
| Luo, W | 1 |
| Xiong, D | 1 |
| Zhao, D | 1 |
| Fang, J | 1 |
| Zhou, Z | 1 |
| Niu, PP | 1 |
| Song, B | 1 |
| Xu, YM | 1 |
| Zhang, Z | 2 |
| Qiu, N | 1 |
| Yin, J | 1 |
| Zhang, J | 3 |
| Guo, W | 1 |
| Liu, M | 2 |
| Liu, T | 2 |
| Chen, D | 5 |
| Luo, K | 1 |
| He, Z | 2 |
| Zheng, G | 1 |
| Xu, F | 1 |
| Sun, W | 1 |
| Yin, F | 1 |
| van Hest, JCM | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I/II Study of Pembrolizumab in Combination With Ibrutinib for Advanced, Refractory Colorectal Cancers[NCT03332498] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2018-01-24 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Standard 3+3 Design: The first cohort will enroll a minimum of 3 participants, according to a standard 3+3 design. If 0 out of the first 3 participants in the first cohort experience a dose-limiting toxicity (DLT), then dose escalation will continue as planned. If 1 out of the first 3 participants experience a DLT, then the cohort will be expanded to a total of 6 participants, and if no more than 1 out of 6 participants experiences a DLT in a given dose cohort, dose escalation will continue as planned. If ≥ 2 DLTs are observed in the first dose cohort, the principle investigator will discuss with Janssen on how to proceed. The DLT evaluation period will be defined as the time from the first dose of pembrolizumab and ibrutinib to 42 days after the first dose or if a participant experiences a DLT within this time period. (NCT03332498)
Timeframe: 42 days post first dose
| Intervention | mg (Number) |
|---|---|
| Pembrolizumab and Ibrutinib | 560 |
Percentage of participants who achieved disease control at 4 months. Disease control rate = Complete Response (CR) + Partial Response (PR) + Stable Disease (SD). Tumor response by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and RECIST based immune-related response criteria (irRC). (NCT03332498)
Timeframe: 4 months
| Intervention | percentage of participants (Number) |
|---|---|
| Phase 2: Treatment at RP2D | 13 |
2 reviews available for adenine and Adenocarcinoma, Basal Cell
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Molecular precursor lesions in oesophageal cancer.
Topics: Adenine; Adenocarcinoma; Base Pairing; Carcinoma, Squamous Cell; Clone Cells; Disease Progression; E | 1998 |
9 trials available for adenine and Adenocarcinoma, Basal Cell
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
A phase 1/2 trial of ibrutinib in combination with pembrolizumab in patients with mismatch repair proficient metastatic colorectal cancer.
Topics: Adenine; Adenocarcinoma; Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Che | 2021 |
Phase II study of amonafide in gastric adenocarcinoma. An Illinois Cancer Center trial.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Female; Hematologic Diseases; Humans; Imides; Isoqui | 1994 |
Phase II trial of amonafide for the treatment of advanced, hormonally refractory carcinoma of the prostate. A Southwest Oncology Group study.
Topics: Adenine; Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Administration Schedul | 1994 |
Phase II trial of amonafide in patients with advanced metastatic or recurrent endometrial adenocarcinoma. A Southwest Oncology Group study.
Topics: Adenine; Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Endometrial Neoplasms; Female; Humans; | 1994 |
Phase II trial of amonafide in advanced colorectal cancer: a SouthWest Oncology Group study.
Topics: Adenine; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms | 1993 |
An ECOG phase II study of amonafide in unresectable or recurrent carcinoma of the head and neck (PB390). Eastern Cooperative Oncology Group.
Topics: Adenine; Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Female; Head | 1997 |
Phase II study of amonafide in advanced pancreatic adenocarcinoma.
Topics: Adenine; Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Humans; Imides | 1991 |
Phase II study of amonafide (nafidamide, NSC 308847) in advanced colorectal cancer.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Colorectal Neoplasms; Drug Evaluation; Humans; Imide | 1991 |
38 other studies available for adenine and Adenocarcinoma, Basal Cell
| Article | Year |
|---|---|
Modulation of protein S and growth arrest specific 6 protein signaling inhibits pancreatic cancer cell survival and proliferation.
Topics: Adenine; Adenocarcinoma; Apoptosis; Axl Receptor Tyrosine Kinase; c-Mer Tyrosine Kinase; Carcinoma, | 2020 |
Targeting B cells in pancreatic adenocarcinoma: does RESOLVE resolve the question?
Topics: Adenine; Adenocarcinoma; Albumins; B-Lymphocytes; Deoxycytidine; Gemcitabine; Humans; Paclitaxel; Pa | 2021 |
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
Topics: Adenine; Adenocarcinoma; Animals; Carcinogenesis; Cell Line, Tumor; Dual Specificity Phosphatase 6; | 2021 |
Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells.
Topics: Adenine; Adenocarcinoma; Adenocarcinoma of Lung; Anoikis; Antigens, CD; Antigens, Neoplasm; Autophag | 2013 |
Optimization of global DNA methylation measurement by LC-MS/MS and its application in lung cancer patients.
Topics: Adenine; Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Chromatography, Liquid; Deoxycytidine; DNA | 2013 |
The role of autophagy induced by pemetrexed in lung adenocarcinoma cells.
Topics: Adenine; Adenocarcinoma; Adenocarcinoma of Lung; Annexin A5; Antimetabolites, Antineoplastic; Apopto | 2014 |
Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 12; Autophagy-R | 2014 |
Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma.
Topics: Adenine; Adenocarcinoma; Animals; Antineoplastic Agents; Female; Fibrosis; Male; Mice; Mice, Inbred | 2015 |
Annexin V-Directed Enzyme Prodrug Therapy Plus Docetaxel for the Targeted Treatment of Pancreatic Cancer.
Topics: Adenine; Adenocarcinoma; Annexin A5; Antineoplastic Combined Chemotherapy Protocols; Carbon-Sulfur L | 2015 |
The essential role of methylthioadenosine phosphorylase in prostate cancer.
Topics: Adenine; Adenocarcinoma; Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Humans; Male; Me | 2016 |
Resolution of lung adenocarcinoma after discontinuation of ibrutinib.
Topics: Adenine; Adenocarcinoma; Adenocarcinoma of Lung; Aged; Humans; Lung; Lung Neoplasms; Male; Piperidin | 2016 |
Polymorphisms of XRCC1 gene and risk of gastric cardiac adenocarcinoma.
Topics: Adenine; Adenocarcinoma; Adult; Aged; Arginine; Cardia; Case-Control Studies; Codon; Cytosine; DNA R | 2009 |
Chromium (VI) induces both bulky DNA adducts and oxidative DNA damage at adenines and guanines in the p53 gene of human lung cells.
Topics: Adenine; Adenocarcinoma; Carcinogens, Environmental; Cell Line, Tumor; Chromium; DNA Adducts; DNA Da | 2012 |
New ruthenium(II)-letrozole complexes as anticancer therapeutics.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Aromatase Inhibitors; Autophagy; Breast Neoplasms; C | 2012 |
[The effect of autophagy on the radioresistance of human adenocarcinoma A549 cell in hypoxia condition].
Topics: Adenine; Adenocarcinoma; Adenocarcinoma of Lung; Autophagy; Cell Hypoxia; Cell Line, Tumor; Gamma Ra | 2012 |
Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells.
Topics: Adenine; Adenocarcinoma; Autophagy; Autophagy-Related Protein 7; Cell Line, Tumor; Cell Survival; Dr | 2013 |
Decreased repair activities of 1,N(6)-ethenoadenine and 3,N(4)-ethenocytosine in lung adenocarcinoma patients.
Topics: Adenine; Adenocarcinoma; Adult; Age Factors; Aged; Cytosine; DNA Adducts; DNA Repair; DNA, Neoplasm; | 2003 |
POTENTIAL PURINE ANTAGONISTS. 32. THE SYNTHESIS AND ANTITUMOR ACTIVITY OF CERTAIN COMPOUNDS RELATED TO 4-AMINOPYRAZOLO(3,4-D)PYRIMIDINE.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Chemical Phenomena; Chemistry; Pharmacology; Purines | 1962 |
Cyclin D1 guanine/adenine 870 polymorphism with altered protein expression is associated with genomic instability and aggressive clinical biology of esophageal adenocarcinoma.
Topics: Adenine; Adenocarcinoma; Adult; Aged; Biomarkers, Tumor; Biopsy, Needle; Cohort Studies; Cyclin D1; | 2007 |
Some effects of inhibitors of polyamine synthesis on experimental prostatic cancer.
Topics: Adenine; Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Gu | 1984 |
Autophagic degradation of N-linked glycoproteins is downregulated in differentiated human colon adenocarcinoma cells.
Topics: Adenine; Adenocarcinoma; Asparagine; Autophagy; Carbon Radioisotopes; Carcinogens; Cell Differentiat | 1993 |
Mutational heterogeneity among individual tumors in a case of multiple primary malignancy of the colon.
Topics: Adenine; Adenocarcinoma; Adenoma; Aged; Alleles; Base Sequence; Carcinoma; Codon; Colonic Neoplasms; | 1993 |
High rate of multilocus deletion in a human tumor cell line.
Topics: Adenine; Adenine Phosphoribosyltransferase; Adenocarcinoma; Alleles; Base Sequence; Cell Transformat | 1993 |
Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type.
Topics: Adenine; Adenocarcinoma; Aspartic Acid; Biology; Codon; Colonic Neoplasms; Gene Frequency; Genes, ra | 1993 |
A novel activating mutation of the K-ras gene in human primary colon adenocarcinoma.
Topics: 3T3 Cells; Adenine; Adenocarcinoma; Animals; Base Sequence; Cell Transformation, Neoplastic; Colonic | 2000 |
Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer.
Topics: Adenine; Adenocarcinoma; Adult; Age Factors; Aged; Aged, 80 and over; Alleles; Amino Acid Sequence; | 2001 |
Phase II trial of amonafide in patients with stage III and IV non-small-cell lung cancer.
Topics: Adenine; Adenocarcinoma; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Evaluatio | 1991 |
Alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP production.
Topics: Adenine; Adenocarcinoma; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Cell Line; Colforsin; C | 1987 |
[Individual sensitivity of ovarian ascitic cancer to thiophosphamide].
Topics: Adenine; Adenocarcinoma; Ascites; Ascitic Fluid; Carbon Radioisotopes; Carcinoma; Carcinoma, Papilla | 1974 |
In vitro demonstration of iodide-trapping defect but normal thyrotropin (TSH) responsiveness in benign and malignant "cold" thyroid nodules.
Topics: Adenine; Adenocarcinoma; Adenoma; Adenylyl Cyclases; Carbon Dioxide; Carbon Isotopes; Colloids; Cycl | 1972 |
Studies on the nucleic acid metabolism of renal tumour cells in vitro.
Topics: Adenine; Adenocarcinoma; Carbon Radioisotopes; Carcinoma, Transitional Cell; Cells, Cultured; DNA, N | 1974 |
Nonspecific inhibition of precursor uptake by alkyl-substituted purines and prednisolone.
Topics: Acetates; Adenine; Adenocarcinoma; Animals; Carbon Radioisotopes; Cell Division; Cell Line; Choline; | 1974 |
Inhibition of guanine metabolism of mammalian tumor cells by the carbocyclic analogue of adenosine.
Topics: Adenine; Adenocarcinoma; Adenosine; Carbon Isotopes; Cells, Cultured; Chromatography, Paper; Cyclope | 1971 |
Determination of individual human tumour sensitivity to antitumour agents by tissue-slice incubation.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Carbon Isotopes; Carcinoma; Colonic Neoplasms; Cultu | 1971 |
Hypoxanthine phosphoribosyltransferase and guanine metabolism of adenocarcinoma 755 cells.
Topics: Adenine; Adenocarcinoma; Buffers; Carbon Isotopes; Guanine; Hydrogen-Ion Concentration; Hypoxanthine | 1970 |
Feedback inhibition of purine biosynthesis in adenocarcinoma 755 and sarcoma 180 cells in culture.
Topics: Adenine; Adenocarcinoma; Animals; Azaserine; Carbon Isotopes; Cell Line; Feedback; Hypoxanthines; Me | 1970 |
Reversal of the growth inhibitory effects of 6-methylthiopurine ribonucleoside.
Topics: Adenine; Adenocarcinoma; Animals; Cell Division; Cell Line; Guanine; Hypoxanthines; Imidazoles; Mice | 1970 |
Purine N-oxides. XVI. Oncogenic derivatives of xanthine and guanine.
Topics: Adenine; Adenocarcinoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Female; Fibroblasts; Fibros | 1965 |