Page last updated: 2024-10-16

adenine and Acute Liver Injury, Drug-Induced

adenine has been researched along with Acute Liver Injury, Drug-Induced in 23 studies

Research Excerpts

ExcerptRelevanceReference
"Renal toxicity is a concern in patients with chronic hepatitis B taking nucleotide analogues, such as adefovir (ADV) and tenofovir disoproxil fumarate (TDF)."7.96Long-term Nucleotide Analogue Treatment Has Higher Levels of Renal Toxicities than Does Entecavir in Patients with Chronic Hepatitis B. ( Chang, Y; Cho, EJ; Cho, H; Cho, YY; Kim, YJ; Lee, JH; Nam, JY; Yoon, JH; Yu, SJ, 2020)
"Renal toxicity is a concern in patients with chronic hepatitis B taking nucleotide analogues, such as adefovir (ADV) and tenofovir disoproxil fumarate (TDF)."3.96Long-term Nucleotide Analogue Treatment Has Higher Levels of Renal Toxicities than Does Entecavir in Patients with Chronic Hepatitis B. ( Chang, Y; Cho, EJ; Cho, H; Cho, YY; Kim, YJ; Lee, JH; Nam, JY; Yoon, JH; Yu, SJ, 2020)
" Twelve subjects in the QD Group (14%) discontinued treatment due to adverse events, mainly nevirapine-related hepatitis (6%)."2.71Safety and efficacy of once-daily didanosine, tenofovir and nevirapine as a simplification antiretroviral approach. ( Burger, D; Clotet, B; Galindos, MJ; Gel, S; Miralles, C; Moltó, J; Muñoz-Moreno, JA; Negredo, E; Pedrol, E; Puig, J; Ribera, E; Rodriguez Fumaz, C; Rodríguez, E; Ruiz, L; Viciana, P; Videla, S, 2004)
"Limited published real-world data describe adverse events (AEs) among patients treated for mantle-cell lymphoma (MCL)."1.62Adverse Events and Economic Burden Among Patients Receiving Systemic Treatment for Mantle Cell Lymphoma: A Real-World Retrospective Cohort Study. ( Byfield, SD; Kabadi, SM; LE, L; Olufade, T, 2021)
" Its poor oral bioavailability leads to frequent administration causing severe adverse effects."1.56Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting: Estimation of liver function panel and uptake following intravenous injection of radioiodinated indicator. ( Abd El-Halim, SM; Abdelbary, GA; Amin, MM; Ibrahim, AB; Shamsel-Din, HA; Zakaria, MY, 2020)
"Chloroform is a common contaminant in the drinking water."1.483-methyadenine attenuates chloroform-induced hepatotoxicity via autophagy activation. ( Chen, C; Li, X; Wang, L, 2018)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19906 (26.09)18.7374
1990's0 (0.00)18.2507
2000's5 (21.74)29.6817
2010's9 (39.13)24.3611
2020's3 (13.04)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Warner, DJ1
Chen, H1
Cantin, LD1
Kenna, JG1
Stahl, S1
Walker, CL1
Noeske, T1
Abd El-Halim, SM1
Abdelbary, GA1
Amin, MM1
Zakaria, MY1
Shamsel-Din, HA1
Ibrahim, AB1
Kabadi, SM1
Byfield, SD1
LE, L1
Olufade, T1
Wang, L1
Li, X1
Chen, C1
Tan, R1
Tian, H1
Yang, B1
Zhang, B1
Dai, C1
Han, Z1
Wang, M2
Li, Y1
Wei, L1
Chen, D1
Wang, G1
Yang, H1
He, F1
Chen, Z1
Cho, YY1
Chang, Y1
Nam, JY1
Cho, H1
Cho, EJ1
Lee, JH1
Yu, SJ1
Yoon, JH1
Kim, YJ1
Echenique, IA1
Rich, JD1
Mandala, J1
Nanda, K1
De Baetselier, I1
Deese, J1
Lombaard, J1
Owino, F1
Malahleha, M1
Manongi, R1
Taylor, D1
Van Damme, L1
Tuma, P1
Vispo, E1
Barreiro, P1
Soriano, V1
Ribera Pascuet, E1
Curran, A1
Ortu, F1
Weimer, LE1
Floridia, M1
Manconi, PE1
Ni, HM1
Bockus, A1
Boggess, N1
Jaeschke, H1
Ding, WX1
Schouten, JN1
Van der Ende, ME1
Koëter, T1
Rossing, HH1
Komuta, M1
Verheij, J1
van der Valk, M1
Hansen, BE1
Janssen, HL1
Negredo, E1
Moltó, J1
Muñoz-Moreno, JA1
Pedrol, E1
Ribera, E1
Viciana, P1
Galindos, MJ1
Miralles, C1
Burger, D1
Rodriguez Fumaz, C1
Puig, J1
Gel, S1
Rodríguez, E1
Videla, S1
Ruiz, L1
Clotet, B1
Girault, V1
Lattuada, E1
Lanzafame, M1
Carolo, G1
Gottardi, M1
Concia, E1
Vento, S1
Tuchweber, B2
Salas, M2
Kovacs, K2
Garg, BD2
Belloni, AS1
Rebuffat, P1
Neri, G1
Mazzocchi, G1
Meneghelli, V1
Nussdorfer, GG1
Molnar, JJ1
Riede, UN2
Widmer, A1
Rohr, HP2
Widmer, AE1
Bianchi, L1
Molnar, J1
Khandekar, JD1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase 3, Multi-center, Double-blind, Randomized, Placebo-controlled Effectiveness and Safety Study to Assess the Role of Truvada® in Preventing HIV Acquisition in Women[NCT00625404]Phase 32,120 participants (Actual)Interventional2009-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

CD4+ T-cell Count

CD4+ T-cell Count at the Time of HIV Seroconversion through 16 weeks (NCT00625404)
Timeframe: Up to 16 weeks

Interventioncells/mL (Mean)
Truvada Arm579.3
Placebo Arm601.4

Confirmed Grade 2 or Higher Serum Creatinine Toxicity

Repeat specimens were collected to confirm chemistry toxicities. Grade 2 or higher serum creatinine toxicity was defined as ≥1.4 times the upper limit of normal (NCT00625404)
Timeframe: cumulative toxicity through 52 weeks of product use and 4 weeks post product

Interventionparticipants (Number)
Truvada Arm4
Placebo Arm2

Confirmed Grade 3 or Higher ALT Elevation

Grade 3 or higher ALT elevation was defined as ≥ 2.6 times the upper limit of normal (NCT00625404)
Timeframe: Through 52 weeks on product and 4 weeks post-product

Interventionparticipants (Number)
Truvada Arm6
Placebo Arm8

Confirmed Grade 3 or Higher AST Elevation

Grade 3 or higher AST elevation was defined as ≥ 2.6 times the upper limit of normal (NCT00625404)
Timeframe: Through 52 weeks on product and 4 weeks post-product

Interventionparticipants (Number)
Truvada Arm3
Placebo Arm1

Confirmed Grade 3 or Higher Reduction in Phosphorus

Repeat specimens were collected to confirm chemistry toxicities. Grade 3 phosphorus reduction was defined as ≤2.4mg/dL (NCT00625404)
Timeframe: Through 52 weeks on product and 4 weeks post-product

Interventionparticipants (Number)
Truvada Arm45
Placebo Arm40

Frequency of Adverse Events (AEs) During and Within 4 Weeks After Study Product Administration

The total number of adverse events in the placebo and Truvada arms during and within 4 weeks after study product administration. (NCT00625404)
Timeframe: 10-26 months per site

InterventionNumber of adverse events (Number)
Truvada Arm2257
Placebo Arm2384

FTC and/or Tenofovir Resistance

"Genotypic resistance to FTC and/or tenofovir at the time of HIV diagnosis and 4 weeks later. If resistance was present, testing was repeated at weeks 12, 24, 36 and 52 as necessary (resistance testing will stop if no resistance is detected).~participants were classified as having resistance if they had one or more visits in which resistance was detected, even if the resistance became undetectable over time." (NCT00625404)
Timeframe: up to 52 weeks

Interventionparticipants (Number)
Truvada Arm3
Placebo Arm1

HIV Infection

HIV Seroconversion, with time to infection refined based on PCR results obtained from stored specimens. (NCT00625404)
Timeframe: Cumulative HIV infection between enrollment and 52 weeks

Interventionparticipants (Number)
Truvada Arm33
Placebo Arm35

Participant Report of Change in Number of Sexual Partners

Difference in mean number of reported sexual partners between final study visit and enrollment visit (NCT00625404)
Timeframe: Up to 52 weeks

Interventionmean number of sexual partners (Mean)
Truvada Arm-0.14
Placebo Arm-0.13

Pill Counts and Participant Report of Adherence to Once-daily Pill Taking

Pill counts and participant report of adherence to once-daily pill taking reported as mean days study product could have been used according to pill counts (NCT00625404)
Timeframe: Up to 52 weeks

Interventionpercentage of days (Mean)
Truvada Arm87
Placebo Arm89

Plasma HIV RNA Level (HIV-1 Viral Load)

Viral load at the time of HIV detection, HIV conversion and through 16 weeks (NCT00625404)
Timeframe: up to 16 weeks

Interventionlog copies/mL (Log Mean)
Truvada Arm4.40
Placebo Arm4.37

Pregnancy Complications

Reported complications during pregnancy, including spontaneous abortion, vaginal or uterine bleeding, emergency c-section and other complications (NCT00625404)
Timeframe: up to 60 weeks

Interventionparticipants (Number)
Truvada Arm20
Placebo Arm10

Reviews

4 reviews available for adenine and Acute Liver Injury, Drug-Induced

ArticleYear
EFV/FTC/TDF-associated hepatotoxicity: a case report and review.
    AIDS patient care and STDs, 2013, Volume: 27, Issue:9

    Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 L

2013
[Role of tenofovir in HIV and hepatitis C virus coinfection].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 8

    Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; Chemical and Drug

2008
[Current role of tenofovir in clinical medicine].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 8

    Topics: Adenine; Anti-HIV Agents; Antimetabolites; Antiretroviral Therapy, Highly Active; Chemical and Drug

2008
[The treatment of HIV infection].
    Presse medicale (Paris, France : 1983), 2005, Nov-19, Volume: 34, Issue:20 Pt 2

    Topics: Adenine; Anti-Retroviral Agents; Carbamates; Chemical and Drug Induced Liver Injury; Clinical Trials

2005

Trials

2 trials available for adenine and Acute Liver Injury, Drug-Induced

ArticleYear
Liver and renal safety of tenofovir disoproxil fumarate in combination with emtricitabine among African women in a pre-exposure prophylaxis trial.
    BMC pharmacology & toxicology, 2014, Dec-24, Volume: 15

    Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Anti-HIV Agents; Aspartate Aminotransferases; Blac

2014
Safety and efficacy of once-daily didanosine, tenofovir and nevirapine as a simplification antiretroviral approach.
    Antiviral therapy, 2004, Volume: 9, Issue:3

    Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-CD8 Ratio; Chemical and Drug Induced Live

2004

Other Studies

17 other studies available for adenine and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting: Estimation of liver function panel and uptake following intravenous injection of radioiodinated indicator.
    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2020, Volume: 28, Issue:2

    Topics: Adenine; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Drug Stability; Inje

2020
Adverse Events and Economic Burden Among Patients Receiving Systemic Treatment for Mantle Cell Lymphoma: A Real-World Retrospective Cohort Study.
    Anticancer research, 2021, Volume: 41, Issue:2

    Topics: Adenine; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydro

2021
3-methyadenine attenuates chloroform-induced hepatotoxicity via autophagy activation.
    Biomedical research (Tokyo, Japan), 2018, Volume: 39, Issue:2

    Topics: Adenine; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Chloroform; Cytokines; Disease

2018
Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice.
    Scientific reports, 2018, 10-02, Volume: 8, Issue:1

    Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Chro

2018
Long-term Nucleotide Analogue Treatment Has Higher Levels of Renal Toxicities than Does Entecavir in Patients with Chronic Hepatitis B.
    Gut and liver, 2020, 03-15, Volume: 14, Issue:2

    Topics: Adenine; Adult; Aged; Antiviral Agents; Chemical and Drug Induced Liver Injury; Female; Glomerular F

2020
Raltegravir, tenofovir, and emtricitabine in an HIV-infected patient with HCV chronic hepatitis, NNRTI intolerance and protease inhibitors-induced severe liver toxicity.
    European journal of medical research, 2010, Feb-26, Volume: 15, Issue:2

    Topics: Adenine; Adult; Antiviral Agents; CD4-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury

2010
Activation of autophagy protects against acetaminophen-induced hepatotoxicity.
    Hepatology (Baltimore, Md.), 2012, Volume: 55, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Adenine; Analgesics, Non-Narcotic; Animals; Autophagy; Chemical and D

2012
Risk factors and outcome of HIV-associated idiopathic noncirrhotic portal hypertension.
    Alimentary pharmacology & therapeutics, 2012, Volume: 36, Issue:9

    Topics: Adenine; Adult; Anti-HIV Agents; Case-Control Studies; Chemical and Drug Induced Liver Injury; Didan

2012
Does tenofovir increase efavirenz hepatotoxicity?
    AIDS (London, England), 2008, May-11, Volume: 22, Issue:8

    Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Chemi

2008
Prevention of CeCl3-induced hepatotoxicity by hypolipidemic compounds.
    Archives of toxicology, 1978, Dec-28, Volume: 41, Issue:3

    Topics: Adenine; Animals; Cesium; Chemical and Drug Induced Liver Injury; Cholesterol; Clofibrate; Female; H

1978
Effect of cerium on the rat liver: an ultrastructural and biochemical study.
    Beitrage zur Pathologie, 1976, Volume: 157, Issue:1

    Topics: Adenine; Adenosine Triphosphate; Alanine Transaminase; Animals; Bilirubin; Cell Nucleus; Cerium; Che

1976
Effects of 4-aminopyrazolo (3,4-d) pyrimidine on rat hepatocytes: an ultrastructural morphometric study.
    Histology and histopathology, 1989, Volume: 4, Issue:1

    Topics: Adenine; Animals; Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Cholesterol; End

1989
[Adenine induced liver parenchymal cell injury].
    Verhandlungen der Deutschen Gesellschaft fur Pathologie, 1970, Volume: 54

    Topics: Adenine; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Male; Microscopy, E

1970
[Ultrastructural-morphometric study on rat liver parenchymal cells in acute adenine poisoning].
    Pathologia Europaea, 1971, Volume: 6, Issue:1

    Topics: Adenine; Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Golgi Apparatus; In

1971
Beloxamide effects on the liver ultrastructure in rats.
    Archives of pathology, 1971, Volume: 92, Issue:4

    Topics: Acetamides; Adenine; Animals; Benzyl Compounds; Chemical and Drug Induced Liver Injury; Cytoplasm; E

1971