adefovir and HIV
adefovir has been researched along with HIV in 25 studies
*HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2. [MeSH]
Research
Studies (25)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 10 (40.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Alam, M; Brankovan, V; Bronson, JJ; Datema, R; Hitchcock, MJ; Martin, JC; Patick, A; Yang, H; Yu, KL | 1 |
| Andrei, G; Balzarini, J; Dračínský, M; Holý, A; Krečmerová, M; Snoeck, R; Tichý, T | 1 |
| Andrei, G; Balzarini, J; Hocková, D; Holý, A; Snoeck, R | 1 |
| Balzarini, J; Flynn, ÁS; Hinsinger, K; McGuigan, C; Pertusati, F; Powell, N; Tristram, A | 1 |
| Camarasa, MJ; de Castro, S | 1 |
| Kaltashov, IA; Xu, S | 1 |
| Naing, C; Poovorawan, Y; Tong, KS | 1 |
| Bakshi, KK; Chen, J; Condra, JH; Danovich, RM; DiNubile, MJ; Graham, DJ; Haas, DW; Holder, DJ; Rhodes, RR; Saah, AJ; Shivaprakash, M | 1 |
| Camino, N; Núñez, M; Puoti, M; Soriano, V | 1 |
| Benhamou, Y | 1 |
| Acosta, EP; Brundage, RC; Fletcher, CV; Gulick, RM; Haubrich, R; Jiang, H; Katzenstein, D | 1 |
| Claas, EC; Gelinck, LB; Kroon, FP | 1 |
| De Clercq, E | 2 |
| Balzarini, J; De Clercq, E; Goebels, J; Hatse, S; Sobis, H; Vandeputte, M; Verstuyf, A | 1 |
| Aquaro, S; Balestra, E; Balzarini, J; Calio, R; Cenci, A; Di Pierro, D; Lazzarino, G; Panti, S; Perno, CF; Tavazzi, B | 1 |
| Collier, AC; Schwartz, MA | 1 |
| Delaney, WE; Locarnini, S; Shaw, T | 1 |
| Balzarini, J; Bergamini, A; Calio, R; De Clercq, E; Milanese, G; Pauwels, R; Perno, CF; Rocchi, G; Yarchoan, R | 1 |
| Hitchcock, MJ; Mansuri, MM; Martin, JC; Starrett, JE; Tortolani, DR | 1 |
| Balzarini, J; De Clercq, E; Hao, Z; Herdewijn, P; Johns, DG | 1 |
| Broder, S; Kageyama, S; Mitsuya, H; Yarchoan, R | 1 |
| Bronson, JJ; De Boeck, H; Ghazzouli, I; Hitchcock, MJ; Ho, HT; Martin, JC; Woods, K | 1 |
| Balzarini, J; Borst, M; De Clercq, E; Egberink, H; Horzinek, M; Koolen, M; Neu, H; Niphuis, H; Schellekens, H | 1 |
| Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Holy, A; Johns, DG; Naesens, L; Pauwels, R; Rosenberg, I | 1 |
Reviews
7 review(s) available for adefovir and HIV
| Article | Year |
|---|---|
Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Therapy, Combination; HIV; Humans; Microbial Sensitivity Tests; Molecular Structure; Polypharmacology | 2018 |
Comparative effectiveness of anti-viral drugs with dual activity for treating hepatitis B and HIV co-infected patients: a network meta-analysis.
Topics: Adenine; Adult; Aged; Antiviral Agents; Coinfection; Emtricitabine; Female; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Network Meta-Analysis; Organophosphonates; Tenofovir; Treatment Outcome; Young Adult | 2018 |
Strategies for second-line antiretroviral therapy in adults with HIV infection.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Drug Therapy, Combination; HIV; HIV Infections; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; Virus Latency; Virus Replication | 1999 |
Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation.
Topics: 2-Aminopurine; Adenine; Amino Acid Sequence; Animals; Anti-HIV Agents; Antimetabolites; Antiviral Agents; Biological Availability; Cell Line; Clinical Trials as Topic; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Viral; Drug Therapy, Combination; Enzyme Inhibitors; Famciclovir; Gene Products, pol; Hepatitis B; Hepatitis B virus; Hepatitis Viruses; Hepatitis, Animal; HIV; Humans; Lamivudine; Models, Animal; Molecular Sequence Data; Molecular Structure; Nucleosides; Organophosphonates; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Virus Replication | 2001 |
Targeted therapy of human immunodeficiency virus-related disease.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; CD4 Antigens; Didanosine; Dideoxynucleosides; Dipyridamole; Drug Synergism; Gene Expression Regulation, Viral; Genes, nef; Genes, rev; Genes, tat; HIV; HIV Protease; Interferon Type I; Organophosphonates; RNA-Directed DNA Polymerase; Stavudine; Transcription, Genetic; Zalcitabine; Zidovudine | 1991 |
Biochemical pharmacology of acyclic nucleotide analogues.
Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; HIV; Humans; Nucleotides; Organophosphonates; Organophosphorus Compounds | 1990 |
New acquisitions in the development of anti-HIV agents.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Antiviral Agents; Dideoxynucleosides; Drug Design; HIV; Molecular Structure; Organophosphonates; Polysaccharides; Purines | 1989 |
Trials
2 trial(s) available for adefovir and HIV
| Article | Year |
|---|---|
Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Resistance, Viral; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Middle Aged; Nelfinavir; Organophosphonates; Oxazines; Treatment Failure | 2003 |
Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359.
Topics: Adenine; Adult; Anti-HIV Agents; Delavirdine; Double-Blind Method; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Male; Middle Aged; Nelfinavir; Organophosphonates; Ritonavir; RNA, Viral; Saquinavir; Sex Factors | 2004 |
Other Studies
16 other study(ies) available for adefovir and HIV
| Article | Year |
|---|---|
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
Topics: Antiviral Agents; Cell Line; Guanine; HIV; Microbial Sensitivity Tests; Organophosphorus Compounds; Simplexvirus; Stereoisomerism; Structure-Activity Relationship | 1992 |
New prodrugs of Adefovir and Cidofovir.
Topics: Adenine; Animals; Antiviral Agents; Cell Line, Tumor; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; HIV; Humans; Organophosphonates; Prodrugs; Simplexvirus | 2011 |
Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity.
Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Herpes Simplex; HIV; HIV Infections; Humans; Mice; Nucleosides; Organophosphonates; Simplexvirus; Structure-Activity Relationship; Vaccinia; Vaccinia virus; Virus Diseases; Viruses | 2011 |
PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer.
Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; HIV; HIV Infections; Humans; Microbial Sensitivity Tests; Molecular Structure; Organophosphonates; Papillomavirus Infections; Prodrugs; Structure-Activity Relationship; Tenofovir; Tumor Cells, Cultured | 2014 |
Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein.
Topics: Adenine; Chromatography, Ion Exchange; Chromatography, Liquid; Cidofovir; Cytosine; HIV; Nucleosides; Organophosphonates; Pharmaceutical Preparations; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tenofovir | 2017 |
Treatment of chronic hepatitis B in the human immunodeficiency virus-infected patient: present and future.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Forecasting; Hepatitis B, Chronic; HIV; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
Antiretroviral therapy and HIV/hepatitis B virus coinfection.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
The risk of adefovir monotherapy in human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infected patients.
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Organophosphonates; Treatment Outcome | 2005 |
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Hepacivirus; Hepatitis B virus; HIV; Humans; Organophosphonates; Papillomaviridae; Poxviridae; Tenofovir; Virus Diseases; Viruses | 2007 |
The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines.
Topics: Adenine; Adenine Nucleotides; Animals; Antineoplastic Agents; Antiviral Agents; Cell Differentiation; Cell Division; Choriocarcinoma; HIV; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Promyelocytic, Acute; Organophosphonates; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tumor Cells, Cultured | 1995 |
Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines.
Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Deoxyadenine Nucleotides; Granulocyte-Macrophage Colony-Stimulating Factor; Herpesvirus 1, Human; HIV; Humans; Macrophage Colony-Stimulating Factor; Macrophages; Organophosphonates; Vero Cells | 1996 |
Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages.
Topics: Adenine; Antibodies, Viral; Antiviral Agents; Benzodiazepines; CD4 Antigens; Cytokines; Didanosine; Doxorubicin; Drug Interactions; HIV; HIV Infections; Humans; Imidazoles; Leukocytes, Mononuclear; Lymphocytes; Macrophages; Monocytes; Organ Specificity; Organophosphonates; Zalcitabine; Zidovudine | 1992 |
Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Drug Evaluation, Preclinical; HIV; Humans; Organophosphonates; Prodrugs; Simplexvirus | 1992 |
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.
Topics: Adenine; Animals; Antiviral Agents; Biotransformation; Cattle; Cell Line; DNA Polymerase II; HIV; Humans; Kinetics; Organophosphonates; Phosphorylation; Reverse Transcriptase Inhibitors; Ribose-Phosphate Pyrophosphokinase; Thymus Gland; Tritium | 1991 |
Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine.
Topics: Adenine; Animals; Antiviral Agents; Cats; Cell Line; HIV; Immunologic Deficiency Syndromes; Opportunistic Infections; Organophosphonates; Retroviridae; Retroviridae Infections; T-Lymphocytes; Virus Replication; Zidovudine | 1990 |
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; HIV; Mice; Mice, Inbred Strains; Moloney murine sarcoma virus; Organophosphonates; Sarcoma, Experimental | 1989 |