Page last updated: 2024-08-24

adefovir and HIV

adefovir has been researched along with HIV in 25 studies

*HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2. [MeSH]

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.00)18.7374
1990's10 (40.00)18.2507
2000's7 (28.00)29.6817
2010's6 (24.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alam, M; Brankovan, V; Bronson, JJ; Datema, R; Hitchcock, MJ; Martin, JC; Patick, A; Yang, H; Yu, KL1
Andrei, G; Balzarini, J; Dračínský, M; Holý, A; Krečmerová, M; Snoeck, R; Tichý, T1
Andrei, G; Balzarini, J; Hocková, D; Holý, A; Snoeck, R1
Balzarini, J; Flynn, ÁS; Hinsinger, K; McGuigan, C; Pertusati, F; Powell, N; Tristram, A1
Camarasa, MJ; de Castro, S1
Kaltashov, IA; Xu, S1
Naing, C; Poovorawan, Y; Tong, KS1
Bakshi, KK; Chen, J; Condra, JH; Danovich, RM; DiNubile, MJ; Graham, DJ; Haas, DW; Holder, DJ; Rhodes, RR; Saah, AJ; Shivaprakash, M1
Camino, N; Núñez, M; Puoti, M; Soriano, V1
Benhamou, Y1
Acosta, EP; Brundage, RC; Fletcher, CV; Gulick, RM; Haubrich, R; Jiang, H; Katzenstein, D1
Claas, EC; Gelinck, LB; Kroon, FP1
De Clercq, E2
Balzarini, J; De Clercq, E; Goebels, J; Hatse, S; Sobis, H; Vandeputte, M; Verstuyf, A1
Aquaro, S; Balestra, E; Balzarini, J; Calio, R; Cenci, A; Di Pierro, D; Lazzarino, G; Panti, S; Perno, CF; Tavazzi, B1
Collier, AC; Schwartz, MA1
Delaney, WE; Locarnini, S; Shaw, T1
Balzarini, J; Bergamini, A; Calio, R; De Clercq, E; Milanese, G; Pauwels, R; Perno, CF; Rocchi, G; Yarchoan, R1
Hitchcock, MJ; Mansuri, MM; Martin, JC; Starrett, JE; Tortolani, DR1
Balzarini, J; De Clercq, E; Hao, Z; Herdewijn, P; Johns, DG1
Broder, S; Kageyama, S; Mitsuya, H; Yarchoan, R1
Bronson, JJ; De Boeck, H; Ghazzouli, I; Hitchcock, MJ; Ho, HT; Martin, JC; Woods, K1
Balzarini, J; Borst, M; De Clercq, E; Egberink, H; Horzinek, M; Koolen, M; Neu, H; Niphuis, H; Schellekens, H1
Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Holy, A; Johns, DG; Naesens, L; Pauwels, R; Rosenberg, I1

Reviews

7 review(s) available for adefovir and HIV

ArticleYear
Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
    European journal of medicinal chemistry, 2018, Apr-25, Volume: 150

    Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Therapy, Combination; HIV; Humans; Microbial Sensitivity Tests; Molecular Structure; Polypharmacology

2018
Comparative effectiveness of anti-viral drugs with dual activity for treating hepatitis B and HIV co-infected patients: a network meta-analysis.
    BMC infectious diseases, 2018, Nov-14, Volume: 18, Issue:1

    Topics: Adenine; Adult; Aged; Antiviral Agents; Coinfection; Emtricitabine; Female; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Network Meta-Analysis; Organophosphonates; Tenofovir; Treatment Outcome; Young Adult

2018
Strategies for second-line antiretroviral therapy in adults with HIV infection.
    Advances in experimental medicine and biology, 1999, Volume: 458

    Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Drug Therapy, Combination; HIV; HIV Infections; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; Virus Latency; Virus Replication

1999
Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation.
    Antiviral chemistry & chemotherapy, 2001, Volume: 12, Issue:1

    Topics: 2-Aminopurine; Adenine; Amino Acid Sequence; Animals; Anti-HIV Agents; Antimetabolites; Antiviral Agents; Biological Availability; Cell Line; Clinical Trials as Topic; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Viral; Drug Therapy, Combination; Enzyme Inhibitors; Famciclovir; Gene Products, pol; Hepatitis B; Hepatitis B virus; Hepatitis Viruses; Hepatitis, Animal; HIV; Humans; Lamivudine; Models, Animal; Molecular Sequence Data; Molecular Structure; Nucleosides; Organophosphonates; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Virus Replication

2001
Targeted therapy of human immunodeficiency virus-related disease.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1991, Volume: 5, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; CD4 Antigens; Didanosine; Dideoxynucleosides; Dipyridamole; Drug Synergism; Gene Expression Regulation, Viral; Genes, nef; Genes, rev; Genes, tat; HIV; HIV Protease; Interferon Type I; Organophosphonates; RNA-Directed DNA Polymerase; Stavudine; Transcription, Genetic; Zalcitabine; Zidovudine

1991
Biochemical pharmacology of acyclic nucleotide analogues.
    Annals of the New York Academy of Sciences, 1990, Volume: 616

    Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; HIV; Humans; Nucleotides; Organophosphonates; Organophosphorus Compounds

1990
New acquisitions in the development of anti-HIV agents.
    Antiviral research, 1989, Volume: 12, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Antiviral Agents; Dideoxynucleosides; Drug Design; HIV; Molecular Structure; Organophosphonates; Polysaccharides; Purines

1989

Trials

2 trial(s) available for adefovir and HIV

ArticleYear
Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy.
    The Journal of infectious diseases, 2003, Apr-01, Volume: 187, Issue:7

    Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Resistance, Viral; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Middle Aged; Nelfinavir; Organophosphonates; Oxazines; Treatment Failure

2003
Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359.
    The Journal of infectious diseases, 2004, Apr-01, Volume: 189, Issue:7

    Topics: Adenine; Adult; Anti-HIV Agents; Delavirdine; Double-Blind Method; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Male; Middle Aged; Nelfinavir; Organophosphonates; Ritonavir; RNA, Viral; Saquinavir; Sex Factors

2004

Other Studies

16 other study(ies) available for adefovir and HIV

ArticleYear
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
    Journal of medicinal chemistry, 1992, Aug-07, Volume: 35, Issue:16

    Topics: Antiviral Agents; Cell Line; Guanine; HIV; Microbial Sensitivity Tests; Organophosphorus Compounds; Simplexvirus; Stereoisomerism; Structure-Activity Relationship

1992
New prodrugs of Adefovir and Cidofovir.
    Bioorganic & medicinal chemistry, 2011, Jun-01, Volume: 19, Issue:11

    Topics: Adenine; Animals; Antiviral Agents; Cell Line, Tumor; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; HIV; Humans; Organophosphonates; Prodrugs; Simplexvirus

2011
Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity.
    Bioorganic & medicinal chemistry, 2011, Aug-01, Volume: 19, Issue:15

    Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Herpes Simplex; HIV; HIV Infections; Humans; Mice; Nucleosides; Organophosphonates; Simplexvirus; Structure-Activity Relationship; Vaccinia; Vaccinia virus; Virus Diseases; Viruses

2011
PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer.
    European journal of medicinal chemistry, 2014, May-06, Volume: 78

    Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; HIV; HIV Infections; Humans; Microbial Sensitivity Tests; Molecular Structure; Organophosphonates; Papillomavirus Infections; Prodrugs; Structure-Activity Relationship; Tenofovir; Tumor Cells, Cultured

2014
Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein.
    Molecular pharmaceutics, 2017, 08-07, Volume: 14, Issue:8

    Topics: Adenine; Chromatography, Ion Exchange; Chromatography, Liquid; Cidofovir; Cytosine; HIV; Nucleosides; Organophosphonates; Pharmaceutical Preparations; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tenofovir

2017
Treatment of chronic hepatitis B in the human immunodeficiency virus-infected patient: present and future.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Dec-15, Volume: 37, Issue:12

    Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Forecasting; Hepatitis B, Chronic; HIV; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir

2003
Antiretroviral therapy and HIV/hepatitis B virus coinfection.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004, Mar-01, Volume: 38 Suppl 2

    Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Tenofovir

2004
The risk of adefovir monotherapy in human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infected patients.
    Journal of hepatology, 2005, Volume: 43, Issue:2

    Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Organophosphonates; Treatment Outcome

2005
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge.
    Biochemical pharmacology, 2007, Apr-01, Volume: 73, Issue:7

    Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Hepacivirus; Hepatitis B virus; HIV; Humans; Organophosphonates; Papillomaviridae; Poxviridae; Tenofovir; Virus Diseases; Viruses

2007
The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines.
    International journal of cancer, 1995, Mar-29, Volume: 61, Issue:1

    Topics: Adenine; Adenine Nucleotides; Animals; Antineoplastic Agents; Antiviral Agents; Cell Differentiation; Cell Division; Choriocarcinoma; HIV; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Promyelocytic, Acute; Organophosphonates; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tumor Cells, Cultured

1995
Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines.
    Molecular pharmacology, 1996, Volume: 50, Issue:2

    Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Deoxyadenine Nucleotides; Granulocyte-Macrophage Colony-Stimulating Factor; Herpesvirus 1, Human; HIV; Humans; Macrophage Colony-Stimulating Factor; Macrophages; Organophosphonates; Vero Cells

1996
Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages.
    Antiviral research, 1992, Volume: 17, Issue:4

    Topics: Adenine; Antibodies, Viral; Antiviral Agents; Benzodiazepines; CD4 Antigens; Cytokines; Didanosine; Doxorubicin; Drug Interactions; HIV; HIV Infections; Humans; Imidazoles; Leukocytes, Mononuclear; Lymphocytes; Macrophages; Monocytes; Organ Specificity; Organophosphonates; Zalcitabine; Zidovudine

1992
Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.
    Antiviral research, 1992, Volume: 19, Issue:3

    Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Drug Evaluation, Preclinical; HIV; Humans; Organophosphonates; Prodrugs; Simplexvirus

1992
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.
    Proceedings of the National Academy of Sciences of the United States of America, 1991, Feb-15, Volume: 88, Issue:4

    Topics: Adenine; Animals; Antiviral Agents; Biotransformation; Cattle; Cell Line; DNA Polymerase II; HIV; Humans; Kinetics; Organophosphonates; Phosphorylation; Reverse Transcriptase Inhibitors; Ribose-Phosphate Pyrophosphokinase; Thymus Gland; Tritium

1991
Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:8

    Topics: Adenine; Animals; Antiviral Agents; Cats; Cell Line; HIV; Immunologic Deficiency Syndromes; Opportunistic Infections; Organophosphonates; Retroviridae; Retroviridae Infections; T-Lymphocytes; Virus Replication; Zidovudine

1990
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:1

    Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; HIV; Mice; Mice, Inbred Strains; Moloney murine sarcoma virus; Organophosphonates; Sarcoma, Experimental

1989