adamantane has been researched along with Malaria, Falciparum in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ballard, E; Chalon, S; Collins, KA; Elliott, SL; Griffin, P; Marquart, L; McCarthy, JS; Möhrle, JJ; Rückle, T | 1 |
| Andenmatten, N; Leroy, D; Mäser, P; Walz, A; Wittlin, S | 1 |
| Akakpo, S; Chalon, S; Chughlay, MF; Csermak-Renner, K; Djeriou, E; Gaur, AH; Leboulleux, D; McCarthy, J; Odedra, A; Shanks, GD; Winnips, C | 1 |
| Abd-Rahman, AN; Ballard, E; Chalon, S; Collins, KA; Gobeau, N; Griffin, P; Marquart, L; McCarthy, JS; Möhrle, JJ | 1 |
| Adoke, Y; Bejuit, R; Bohissou, F; Bonzela, JE; Bouyou-Akotet, M; Cantalloube, C; Cherkaoui-Rbati, MH; Duong, TT; Jessel, A; Kaguthi, G; Kibuuka, A; Laurijssens, B; Leroy, D; Macintyre, F; Marrast, AC; Mawili-Mboumba, DP; Mombo-Ngoma, G; Mugenya, I; Nahum, A; Ogutu, B; Olewe, F; Ouattara, D; Ouedraogo, A; Ouoba, S; Phuc, BQ; Soulama, I; Tinto, H; Tiono, AB; Wartha, F; Wells, TNC; White, D; Zoleko-Manego, R | 1 |
| Adams, M; Bousema, T; Chalon, S; Collins, KA; Elliott, S; McCarthy, JS; Mitchell, H; Möhrle, JJ; Rampton, M; Reuling, IJ; Sauerwein, R; Wang, CY | 1 |
| Adoke, Y; Barry, A; Dossou, Y; Duong, TT; Khim, N; Klopper, R; Laurijssens, B; Legrand, E; Leroy, D; Macintyre, F; Ménard, D; Mombo-Ngoma, G; Ndong Ngomo, JM; Ouoba, S; Phuc, BQ; Tshefu, AK; Varo, R | 1 |
| Rosenthal, PJ | 1 |
| Baker, M; Duparc, S; Imwong, M; Jittamala, P; Macintyre, F; Möhrle, JJ; Nosten, FH; Phyo, AP; Pukrittayakamee, S; White, NJ | 1 |
| Baker, M; Griffin, P; Hooft van Huijsduijnen, R; Marquart, L; McCarthy, JS; Möhrle, JJ; O'Rourke, P | 1 |
| Amante, F; Cooper, MA; Dwyer, PJ; Faleiro, R; Horne-Debets, JM; Huang, JX; Karunarathne, DS; Lee, JS; Leow, CY; McCarthy, JS; Miles, JJ; Poh, CM; Rénia, L; Richard, D; Sharpe, AH; Stacey, KJ; Watkins, TS; Wykes, MN; Yarski, M | 1 |
| Brun, R; Charman, SA; Charman, WN; Chiu, FC; Chollet, J; Dong, Y; Dorn, A; Karle, JM; Matile, H; Santo Tomas, J; Scheurer, C; Scorneaux, B; Snyder, C; Tang, Y; Urwyler, H; Vennerstrom, JL; Wang, X; Wittlin, S | 1 |
5 trial(s) available for adamantane and Malaria, Falciparum
| Article | Year |
|---|---|
A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum in Healthy Volunteers.
Topics: Adamantane; Administration, Oral; Adult; Antimalarials; Drug Combinations; Female; Healthy Volunteers; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Peroxides; Plasmodium falciparum; Pyrimidines; Triazoles; Young Adult | 2019 |
A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria.
Topics: Adamantane; Adolescent; Adult; Aged; Aminoquinolines; Antimalarials; Benin; Burkina Faso; Child; Child, Preschool; Double-Blind Method; Drug Combinations; Female; Ferrous Compounds; Gabon; Humans; Infant; Kenya; Malaria, Falciparum; Male; Metallocenes; Middle Aged; Mozambique; Peroxides; Plasmodium falciparum; Uganda; Vietnam; Young Adult | 2021 |
A controlled human malaria infection model enabling evaluation of transmission-blocking interventions.
Topics: Adamantane; Adolescent; Adult; Animals; Antimalarials; Culicidae; Erythrocytes; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Models, Biological; Peroxides; Plasmodium falciparum; Primaquine; Quinolines | 2018 |
African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker.
Topics: Adamantane; Adolescent; Adult; Africa; Aged; Antimalarials; Aspartic Acid Endopeptidases; Biomarkers; Child; Child, Preschool; DNA Copy Number Variations; Drug Combinations; Drug Resistance; Female; Genotype; Humans; Infant; Malaria, Falciparum; Male; Middle Aged; Peroxides; Plasmodium falciparum; Protozoan Proteins; Quinolines; Vietnam; Young Adult | 2019 |
Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial.
Topics: Adamantane; Adolescent; Adult; Antimalarials; Cohort Studies; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Middle Aged; Peroxides; Thailand; Young Adult | 2016 |
7 other study(ies) available for adamantane and Malaria, Falciparum
| Article | Year |
|---|---|
Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay.
Topics: Adamantane; Antimalarials; Dose-Response Relationship, Drug; Humans; Malaria, Falciparum; Peroxides; Plasmodium falciparum | 2019 |
Liver Enzyme Elevations in
Topics: Acrylamides; Adamantane; Adult; Alanine Transaminase; Aminopyridines; Aminoquinolines; Antimalarials; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Erythrocyte Transfusion; Erythrocytes; Female; Ferrous Compounds; Healthy Volunteers; Heterocyclic Compounds, 4 or More Rings; Humans; Indoles; Isoquinolines; Malaria, Falciparum; Male; Metallocenes; Parasitemia; Peroxides; Piperazines; Plasmodium falciparum; Primaquine; Pyrimidines; Quinolines; Spiro Compounds; Sulfones; Triazoles; Young Adult | 2020 |
Antimalarial Activity of Artefenomel Against Asexual Parasites and Transmissible Gametocytes During Experimental Blood-Stage Plasmodium vivax Infection.
Topics: Adamantane; Animals; Antimalarials; Culicidae; Folic Acid Antagonists; Humans; Malaria, Falciparum; Malaria, Vivax; Parasites; Peroxides; Plasmodium falciparum; Plasmodium vivax | 2022 |
Artefenomel: a promising new antimalarial drug.
Topics: Adamantane; Antimalarials; Female; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Peroxides | 2016 |
Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers.
Topics: Adamantane; Administration, Oral; Adolescent; Adult; Antimalarials; Cohort Studies; Female; Healthy Volunteers; Humans; Malaria, Falciparum; Male; Microbial Sensitivity Tests; Parasite Load; Peroxides; Plasmodium falciparum; Real-Time Polymerase Chain Reaction; Treatment Outcome; Young Adult | 2016 |
Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity.
Topics: Adamantane; Adult; Animals; Antimalarials; B7-H1 Antigen; CD4-Positive T-Lymphocytes; Cells, Cultured; Clinical Trials as Topic; Dendritic Cells; Female; Humans; Immunity, Cellular; Lymphocyte Activation; Malaria, Falciparum; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Parasitemia; Peroxides; Plasmodium falciparum; Programmed Cell Death 1 Ligand 2 Protein; Programmed Cell Death 1 Receptor; Pyrimidines; Triazoles; Young Adult | 2016 |
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Topics: Adamantane; Animals; Antimalarials; Cell Line, Tumor; Drug Resistance; Half-Life; Malaria; Malaria, Falciparum; Mice; Micronucleus Tests; Ozone; Peroxides; Plasmodium berghei; Rats; Spiro Compounds; Structure-Activity Relationship | 2005 |