adamantane and Disease Models, Animal

Topics: Adamantane; Animals; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Humans; Hypoglycemic Agents; Incretins; Nitriles; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Vildagliptin

Topics: 1-Deoxynojirimycin; Adamantane; Animals; Cardiovascular Diseases; Ceramides; Diabetes Mellitus, Type 2; Dioxanes; Disease Models, Animal; Fatty Acids; Fatty Liver; Gaucher Disease; Glucosyltransferases; Glycosphingolipids; Humans; Insulin Resistance; Metabolic Syndrome; Mice; Mice, Obese; Non-alcoholic Fatty Liver Disease; Obesity; Pyrrolidines; Receptor, Insulin; Signal Transduction

Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Cinnamates; Disease Models, Animal; Humans; Leukemia, Myeloid, Acute; Mice; Neoplasms; Sensitivity and Specificity; Treatment Outcome; Tumor Cells, Cultured

Topics: Adamantane; Aminobenzoates; Anilides; Animals; Biofilms; Delayed-Action Preparations; Disease Models, Animal; Drug Liberation; Humans; Hydrogels; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Nanoparticle Drug Delivery System; Polyamines; Staphylococcal Skin Infections; Wound Healing; Wound Infection

Topics: Adamantane; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain; Brain-Derived Neurotrophic Factor; Caspase 3; Depression; Dipeptides; Disease Models, Animal; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Incretins; Inflammation; Male; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Stress, Psychological

Topics: Adamantane; Animals; Arthritis, Rheumatoid; Bone and Bones; Bone Density; Bone Remodeling; Bone Resorption; Disease Models, Animal; Janus Kinase Inhibitors; Male; Mice, Inbred DBA; Niacinamide; Osteoblasts; Osteoporosis; RANK Ligand

Topics: Adamantane; Animals; Atrial Natriuretic Factor; Cell Adhesion Molecules; Chemokine CXCL12; Cyclic AMP; Dipeptides; Disease Models, Animal; Glucagon-Like Peptide 1; Glutathione; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Male; Malondialdehyde; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Receptors, CXCR4; Reperfusion Injury; Signal Transduction; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A

Topics: Adamantane; Animals; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Gentamicins; Kidney; Kidney Diseases; Linagliptin; Male; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate

Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Disease Models, Animal; Epoxide Hydrolases; Female; Humans; Lauric Acids; Lung; MAP Kinase Signaling System; Mice; Ovalbumin; Signal Transduction; STAT3 Transcription Factor

Topics: Adamantane; Animals; Anticonvulsants; CA1 Region, Hippocampal; Calcium; Dibenzazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Feedback, Physiological; Hippocampus; Inhibitory Postsynaptic Potentials; Interneurons; Long-Term Potentiation; Muscarinic Agonists; Neural Inhibition; Neuronal Plasticity; Neurons; Pilocarpine; Pyramidal Cells; Rats; Receptors, AMPA

Topics: Adamantane; Amygdala; Animals; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Electroshock; Kindling, Neurologic; Male; Mice; Neuroprotective Agents; Neurotoxins; Pentylenetetrazole; Rats, Wistar; Receptors, GABA-A; Seizures; Time Factors

Topics: Adamantane; Alzheimer Disease; Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Early Medical Intervention; Maze Learning; Mice; Mice, Transgenic; Nerve Growth Factors; Neuronal Plasticity; Oligopeptides; Postpartum Period; Signal Transduction; Treatment Outcome

Topics: Adamantane; Animals; Antidepressive Agents; Basolateral Nuclear Complex; Cyclic AMP-Dependent Protein Kinases; Depression; Disease Models, Animal; Disks Large Homolog 4 Protein; Fluoxetine; Gene Expression Regulation; Guanylate Kinases; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Neurons; Phosphorylation; Post-Synaptic Density; Receptors, AMPA; Signal Transduction; Stress, Psychological; Synapses; Synaptophysin; Synaptosomes

Topics: Adamantane; Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Cognition Disorders; Disease Models, Animal; Drug Administration Schedule; Female; Mice; Mice, Transgenic; Mutation; Neurodegenerative Diseases; Neuroprotective Agents; Oligopeptides; Presenilin-1; Recognition, Psychology; tau Proteins; Tauopathies

Topics: Adamantane; AMP-Activated Protein Kinases; Animals; Apoptosis; Benzhydryl Compounds; CARD Signaling Adaptor Proteins; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fibroblasts; Fibrosis; Glucosides; Hypoglycemic Agents; Inflammasomes; Inflammation Mediators; Kidney Tubules, Proximal; Male; Mice, Inbred C57BL; Mice, Obese; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Stroke Volume; Time Factors; Ventricular Function, Left

Topics: Adamantane; Alcoholism; Animals; Animals, Outbred Strains; Choice Behavior; Disease Models, Animal; Male; Mice; Mice, Inbred DBA; Motivation; Rats; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome

Topics: Adamantane; Alzheimer Disease; Amyloid beta-Peptides; Animals; bcl-2-Associated X Protein; Caspase 3; Cognitive Dysfunction; Disease Models, Animal; Disks Large Homolog 4 Protein; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Hippocampus; Injections, Intraventricular; Male; Maze Learning; Neurons; Neuroprotective Agents; Nitriles; Nootropic Agents; Peptide Fragments; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrrolidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Synaptophysin; tau Proteins; Vildagliptin

Topics: Adamantane; Animals; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Glucosides; Inflammasomes; Inflammation Mediators; Kidney; Male; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors

Topics: Adamantane; Animals; Behavior, Animal; Dipeptides; Disease Models, Animal; Dopaminergic Neurons; Male; Memory; Motor Activity; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Rats, Wistar; Treatment Outcome

Topics: Adamantane; Animals; Aorta, Thoracic; Coronary Vessels; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Heart Failure; Ligation; Male; Stroke Volume; Swine; Swine, Miniature; Vascular Stiffness; Ventricular Remodeling

Topics: A549 Cells; Adamantane; Administration, Oral; Amino Alcohols; Aminophenols; Animals; Cell Line; Disease Models, Animal; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Influenza A virus; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Isoforms; Pyridines; RNA, Small Interfering; Sphingosine; Thiazoles; Virus Replication

Topics: Adamantane; Adaptor Proteins, Signal Transducing; Animals; Cell Line; Crystallography, X-Ray; Disease Models, Animal; Female; Gene Knock-In Techniques; HEK293 Cells; Humans; Male; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 14; Mutation; Myocardial Infarction; Myocardium; Phosphorylation; Protein Binding; Protein Interaction Domains and Motifs; Reperfusion Injury

Topics: Adamantane; Adenosine Triphosphate; Animals; Cardiotonic Agents; Disease Models, Animal; Endothelium; Fibrosis; Heme Oxygenase-1; Hemodynamics; Hypertrophy; Inflammation Mediators; Lauric Acids; Male; Metabolic Syndrome; Mitochondria; Myocardium; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats, Wistar; Up-Regulation

Topics: Adamantane; Animals; Antitubercular Agents; Clofazimine; Diarylquinolines; Disease Models, Animal; Drug Combinations; Ethylenediamines; Humans; Lung; Mice; Mycobacterium tuberculosis; Pyrazinamide; Tuberculosis

Topics: A549 Cells; Acute Lung Injury; Adamantane; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Humans; Inflammation; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Oxidative Stress; RAW 264.7 Cells; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tight Junctions; Tumor Necrosis Factor-alpha

Topics: Adamantane; Aminobenzoates; Anilides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Docking Simulation; Peritonitis; Staphylococcal Infections

Topics: Adamantane; Animals; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Isolated Heart Preparation; Lauric Acids; Linoleic Acid; Male; Mice, Inbred C57BL; Myocardial Reperfusion Injury; Myocardium; Oleic Acids; Recovery of Function; Signal Transduction; Ventricular Function, Left; Ventricular Pressure

Topics: Adamantane; Animals; Brain Ischemia; Cell Polarity; Disease Models, Animal; Encephalitis; Epoxide Hydrolases; Lauric Acids; Macrophages; Male; Monocytes; Rats, Inbred WKY; Rotarod Performance Test; Stroke

Topics: Adamantane; Aminobenzoates; Anilides; Animals; Anti-Bacterial Agents; Biofilms; Burns; Disease Models, Animal; Drug Resistance, Bacterial; Drug Stability; Fatty Acid Synthase, Type II; Fatty Acid Synthesis Inhibitors; Female; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microsomes; Peritonitis; Prodrugs; Staphylococcal Skin Infections; Sulfides; Treatment Outcome

Topics: Adamantane; Animals; beta-Cyclodextrins; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelial Progenitor Cells; Extracellular Vesicles; Fibrosis; Gels; Hemodynamics; Human Umbilical Vein Endothelial Cells; Humans; Hyaluronic Acid; Inflammation Mediators; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; Rats, Wistar; Time Factors; Time-to-Treatment

Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Structure-Activity Relationship

Topics: Adamantane; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibiotics, Antineoplastic; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Exploratory Behavior; Gene Expression Regulation; Glucagon-Like Peptide 1; Hippocampus; Interleukin-1beta; Male; Maze Learning; Rats; Rats, Wistar; Streptozocin; tau Proteins; Tumor Necrosis Factor-alpha

Topics: Adamantane; Animals; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Female; In Vitro Techniques; Kainic Acid; Nerve Degeneration; Neurons; Ouabain; Patch-Clamp Techniques; Piperidines; Pregnancy; Rats; Rats, Wistar; Receptors, AMPA

Topics: Acidosis, Lactic; Adamantane; Adenosine Triphosphate; Alkynes; Animals; Cytokines; Disease Models, Animal; Gasotransmitters; Glycine; Hemodynamics; Hydrogen Sulfide; KATP Channels; Male; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Morpholines; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats, Wistar; Reperfusion Injury; Shock, Hemorrhagic; Sulfides; Up-Regulation; Vasoconstrictor Agents

Topics: Adamantane; Alternative Splicing; Animals; Apolipoproteins E; Atherosclerosis; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Foam Cells; Gene Expression Profiling; Gene Expression Regulation; Gene Order; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Incretins; Macrophages; Male; Mice; Mice, Inbred NOD; Mice, Knockout; Nitriles; Pyrrolidines; Receptors, Glucagon; Vildagliptin

Topics: Adamantane; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fatty Liver; Homeodomain Proteins; Inflammation; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Nitriles; Phlorhizin; Pyrrolidines; Tetrazoles; Trans-Activators; Valine; Valsartan; Vildagliptin

Topics: Adamantane; Animals; Anti-Inflammatory Agents; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 1; Kidney Diseases; Kidney Glomerulus; Male; Nitriles; Protective Agents; Pyrrolidines; Rats; Rats, Sprague-Dawley

Topics: Adamantane; Animals; Apoptosis; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Male; Mitochondria; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitriles; Pyrrolidines; Rats; Rats, Wistar; Vildagliptin

Topics: Adamantane; Amidohydrolases; Animals; Anti-Inflammatory Agents; Body Weight; Cannabinoids; Colitis; Disease Models, Animal; Enzyme Inhibitors; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Protein Binding; Receptor, Cannabinoid, CB2; Structure-Activity Relationship

Topics: Adamantane; Analgesics; Animals; Calcium Channels, N-Type; Disease Models, Animal; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Structure; Neuralgia; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship

Topics: Adamantane; Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

Topics: Adamantane; Animals; bcl-2-Associated X Protein; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Disease Models, Animal; Hepatocytes; Insulin Resistance; Lipids; Liver; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley

Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cinnamates; Disease Models, Animal; DNA Damage; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Gene Products, tax; Humans; Leukemia-Lymphoma, Adult T-Cell; Leukemic Infiltration; Mice; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

Topics: Adamantane; Animals; Animals, Genetically Modified; Calcium; Cardiomegaly; Diabetes Mellitus, Type 2; Disease Models, Animal; Eicosanoids; Epoxide Hydrolases; Heart; Humans; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Myocardium; Myocytes, Cardiac; Obesity; Oxidative Stress; Pancreas; Prediabetic State; Rats; Sarcolemma; Urea

Topics: Adamantane; Allyl Compounds; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Freund's Adjuvant; Isothiocyanates; Male; Mice; Nitriles; Pyrrolidines; Sitagliptin Phosphate; Temperature; Urinary Bladder; Vildagliptin

Topics: Adamantane; Animals; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 1; Mitochondria, Muscle; Mitochondrial Proteins; Motor Activity; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type III; Organelle Biogenesis; Physical Conditioning, Animal; Rats; Treatment Outcome

Topics: Adamantane; Animals; Antiparkinson Agents; Body Weight; Brain; Cathepsin C; Cyclic AMP; Dipeptides; Disease Models, Animal; Dopamine; Drug Evaluation, Preclinical; Gene Expression Regulation; Insecticides; Lipid Peroxidation; Male; Nerve Tissue Proteins; NF-E2-Related Factor 2; Parkinson Disease; Rats; Rats, Wistar; Rotenone; Tyrosine 3-Monooxygenase

Topics: Adamantane; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Male; Pentylenetetrazole; Rats, Wistar; Receptors, AMPA; Seizures

Topics: Adamantane; Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cinnamates; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Enzyme Activation; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Potential, Mitochondrial; Mice; Reactive Oxygen Species; Retinoids; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Adamantane; Animals; Autoradiography; Carbon Radioisotopes; Disease Models, Animal; Humans; Inflammation; Male; Mice; Molecular Imaging; Molecular Structure; Nervous System Diseases; Positron-Emission Tomography; Quinolones; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Tissue Distribution

Topics: Adamantane; Administration, Oral; Animals; Autografts; Calcium; Calcium Signaling; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Glucagon-Like Peptide 1; Hyperplasia; Jugular Veins; Male; Neointima; Nitric Oxide; Nitric Oxide Synthase; Nitriles; Pyrrolidines; Time Factors; Vasodilation; Vasodilator Agents; Vildagliptin

Topics: Adamantane; Angiotensin-Converting Enzyme Inhibitors; Animals; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Enalapril; Fibrosis; Heart Rate; Hypoglycemic Agents; Male; Metformin; Myocardial Infarction; Myocardium; Nitriles; Oxidative Stress; Pyrrolidines; Rats, Wistar; Recovery of Function; Signal Transduction; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling; Vildagliptin

Topics: Adamantane; Albuminuria; Animals; Blood Glucose; Blood Pressure; Cytoprotection; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Kidney Diseases; Kidney Glomerulus; Male; Rats, Inbred Dahl; Sitagliptin Phosphate

Topics: Adamantane; Animals; Anticonvulsants; Arginine; CHO Cells; Cricetulus; Dipeptides; Disease Models, Animal; HEK293 Cells; Humans; Limbic System; Male; Pilocarpine; Rats, Wistar; Receptors, Neuropeptide; Receptors, Neuropeptide Y; Seizures

Topics: Adamantane; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Chloroquine; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Administration Schedule; Injections, Subcutaneous; Male; Microtubule-Associated Proteins; Myocardial Infarction; Myocardium; Nitriles; Proto-Oncogene Proteins c-bcl-2; Pyrrolidines; Rats, Inbred OLETF; Signal Transduction; Time Factors; Ventricular Function, Left; Vildagliptin

Topics: Adamantane; Animals; Attention; Blood-Brain Barrier; Brain; Capillary Permeability; Dementia, Vascular; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Executive Function; Male; Maze Learning; Neuroprotective Agents; Nitriles; Pancreatectomy; Pyrrolidines; Rats, Wistar; Treatment Outcome; Vildagliptin

Topics: Adamantane; Administration, Oral; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Blotting, Western; Cerebral Cortex; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Hippocampus; Humans; Immunoblotting; Nootropic Agents; Oligopeptides; Rats, Inbred F344; Recombinant Proteins; tau Proteins; Treatment Outcome

Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cinnamates; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Heterografts; Humans; Mice; Oncogene Proteins, Fusion; Rhabdomyosarcoma; S Phase Cell Cycle Checkpoints; Signal Transduction; Tumor Suppressor Protein p53

Topics: Adamantane; Animals; Biomarkers, Tumor; Ceramides; Disease Models, Animal; Humans; Kidney Neoplasms; Lysophospholipids; Mice; Pancreatic Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingosine; Transplantation, Heterologous

Topics: Adamantane; Adenylyl Cyclases; Animals; Behavior, Animal; Calcium; Cell Membrane; Chronic Pain; Disease Models, Animal; Excitatory Postsynaptic Potentials; Gene Deletion; Glutamates; Gyrus Cinguli; Injections; Irritable Bowel Syndrome; Mice; Models, Biological; Phosphorylation; Phosphoserine; Protein Transport; Receptors, AMPA; Synaptic Transmission; Time Factors; Up-Regulation; Visceral Pain; Zymosan

Topics: Adamantane; Analysis of Variance; Animals; Anti-Inflammatory Agents; Brain; Brain-Derived Neurotrophic Factor; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Encephalitis; Female; Gene Expression Regulation; Interleukin-1beta; Lipopolysaccharides; Malondialdehyde; Membrane Proteins; Mice; Mice, Inbred C57BL; Nitric Oxide; Prostaglandins E; Superoxide Dismutase; Thiazoles; Tumor Necrosis Factor-alpha

Topics: Adamantane; Allografts; Animals; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; DNA; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation; Graft Rejection; Immunohistochemistry; Interleukin-10; Lung Transplantation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitriles; Pyrrolidines; Vildagliptin

Topics: Adamantane; Animals; Atrial Natriuretic Factor; Cyclic GMP; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Echocardiography; Hypertrophy, Left Ventricular; Male; Natriuretic Peptide, Brain; Neuropeptide Y; Phosphodiesterase 5 Inhibitors; Signal Transduction; Swine; Swine, Miniature; Tadalafil; Ventricular Function, Left

Topics: Adamantane; Adenosine Triphosphate; Aminoquinolines; Animals; Disease Models, Animal; Excitatory Amino Acid Agents; Female; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; Male; Membrane Potentials; Mice; Mice, Transgenic; Muscarinic Agonists; Neural Stem Cells; Nucleotides; Pilocarpine; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; Receptors, Purinergic P2Y1; Status Epilepticus

Topics: Adamantane; Amnesia; Animals; Animals, Outbred Strains; Anticonvulsants; Benzimidazoles; Brain Ischemia; Disease Models, Animal; Exercise Test; Gluconeogenesis; Male; Mice; Neuroprotective Agents; Nootropic Agents; Physical Conditioning, Animal; Picolines; Piracetam; Rats; Swimming; Tryptophan

Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Cells, Cultured; Disease Models, Animal; Down-Regulation; Endothelial Cells; Epoxy Compounds; Fatty Acids, Unsaturated; Humans; Intercellular Adhesion Molecule-1; Lauric Acids; Male; Mice; Retinal Vasculitis; Retinal Vessels; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

Topics: Adamantane; Animals; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Down-Regulation; Immunohistochemistry; Kininogens; Lung; Lung Transplantation; Male; Mice; Nitriles; Peroxidase; Pyrrolidines; Up-Regulation; Vildagliptin

Topics: Adamantane; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzamides; Benzoxazoles; Calcium; Disease Models, Animal; Humans; Inflammation; Inhibitory Concentration 50; Pain; Purinergic P2 Receptor Antagonists; Quinolinium Compounds; Rats; Receptors, Purinergic P2X7

Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Female; Gene Deletion; Heart Ventricles; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Time Factors; Urea

Topics: Acoustic Stimulation; Adamantane; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Benzopyrans; Cognition; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Male; Memory; Motor Activity; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Sensory Gating; Stereotyped Behavior; Time Factors

Topics: 1-Deoxynojirimycin; Adamantane; Animals; Disease Models, Animal; Fatty Liver; Glucose; Glycosphingolipids; Homeostasis; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Triglycerides

Topics: Adamantane; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gerbillinae; Glucagon-Like Peptide 1; Immunohistochemistry; Insulin; Liraglutide; Male; Nitriles; Pancreas; Pyrrolidines; Reference Standards; Vildagliptin

Topics: Adamantane; Aminosalicylic Acids; Animals; Body Weight; Colon; Crohn Disease; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Epithelial Cells; Female; Gastrointestinal Agents; Humans; Interleukin-1beta; Leukocytes; Male; Mice; Mice, Inbred C57BL; Neutrophils; Peroxidase; Phosphotransferases (Alcohol Group Acceptor); Prednisolone; Pyridines; Rats; Rats, Sprague-Dawley; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha

Topics: 1-Deoxynojirimycin; Adamantane; Animals; Apolipoproteins E; Atherosclerosis; Bile; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Feces; Female; Glucosyltransferases; Glycosphingolipids; Hyperlipidemias; Kinetics; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mutation; Receptors, LDL

Topics: Adamantane; Animals; Apolipoproteins E; Arachidonic Acids; Atherosclerosis; Carotid Artery Diseases; Carotid Artery, Common; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Femoral Artery; Hyperlipidemias; Hyperplasia; Inflammation Mediators; Lauric Acids; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Tunica Intima

Topics: Adamantane; Animals; Cells, Cultured; Cellular Senescence; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Exenatide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Heme Oxygenase-1; Humans; Hydrogen Peroxide; Hypoglycemic Agents; Male; NAD(P)H Dehydrogenase (Quinone); Nitriles; Oxidants; Oxidative Stress; Peptides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrrolidines; Rats; Rats, Zucker; Reactive Oxygen Species; Receptors, Glucagon; Signal Transduction; Venoms; Vildagliptin

Topics: Adamantane; Administration, Oral; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelium, Vascular; Epoxide Hydrolases; Hypertension; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Niacinamide; Obesity; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Urea; Vasodilation

Topics: Adamantane; Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Blood Glucose; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Hypertension; Insulin Resistance; Mice; Obesity; Rats; Urea

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adamantane; Animals; Corpus Striatum; Disease Models, Animal; Hippocampus; Male; MPTP Poisoning; Neurotoxins; Parkinson Disease; Parkinson Disease, Secondary; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D1

Topics: Adamantane; Animals; Apoptosis; Chondrocytes; Disease Models, Animal; Iodoacetates; Male; Osteoarthritis; Pain; Pain Measurement; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Rats, Wistar

Topics: Adamantane; Aminobenzoates; Anilides; Animals; Anti-Infective Agents; Diabetes Mellitus; Disease Models, Animal; Fatty Acid Synthases; Fatty Acids; Fatty Liver; Glucose; Humans; Hypoglycemic Agents; Liver; Mice; Mice, Mutant Strains; Oxidation-Reduction; Sterols

Topics: Adamantane; Animals; Antitubercular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Macrophages; Mice; Mice, Inbred C3H; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Piperidines; Small Molecule Libraries; Structure-Activity Relationship; Weight Loss

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adamantane; Animals; Antiparkinson Agents; Disease Models, Animal; Doxycycline; Drug Combinations; Drug Synergism; Male; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; Neurotoxins; Parkinson Disease, Secondary

Topics: Adamantane; Amantadine; Animals; Behavior, Animal; Benserazide; Disease Models, Animal; Dyskinesia, Drug-Induced; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Rats; Substantia Nigra

Topics: Adamantane; Animals; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Administration Schedule; Heart Failure; Male; Myocardial Infarction; Nitriles; Pyrrolidines; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors; Vildagliptin

Topics: Action Potentials; Adamantane; Analysis of Variance; Animals; Area Under Curve; Cholinergic Antagonists; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesias; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Functional Laterality; Green Fluorescent Proteins; Interneurons; LIM-Homeodomain Proteins; Male; Mecamylamine; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Scopolamine; Transcription Factors

Topics: Adamantane; Animals; Coronary Circulation; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Heart Failure; Hemodynamics; Lauric Acids; Male; Myocardial Infarction; Myocardium; Nitric Oxide; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Ventricular Function, Left; Ventricular Remodeling

Topics: Adamantane; Administration, Oral; Animal Structures; Animals; Anthelmintics; Disease Models, Animal; Female; Liver; Male; Mesenteric Veins; Mice; Rabbits; Schistosoma japonicum; Schistosomiasis japonica; Survival Analysis; Treatment Outcome

Topics: Adamantane; Animals; Atherosclerosis; Cell Adhesion Molecules; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Cytokines; Dendritic Cells; Disease Models, Animal; Disease Progression; Endothelium, Vascular; Enzyme Inhibitors; Humans; Inflammation Mediators; Mice; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Proprotein Convertases; Pyridines; Receptors, LDL; Serine Endopeptidases; T-Lymphocytes

Topics: Adamantane; Animals; Antidepressive Agents; Anxiety Disorders; Behavior, Animal; Depression; Disease Models, Animal; Imipramine; Inflammation; Injections, Intraperitoneal; Interleukin-17; Interleukin-4; Interleukin-6; Male; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; Organ Size; Spleen; Stress, Psychological; Thymus Gland

Topics: Adamantane; Adjuvants, Immunologic; Animals; Disease Models, Animal; Glycosylation; Immunization; Mannose; Mice; Molecular Structure; Oligopeptides; Ovalbumin

Topics: Adamantane; Animals; Blood Glucose; Blotting, Western; Calcium Signaling; Crosses, Genetic; Diabetes Complications; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Heart Diseases; Hypoglycemic Agents; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Mitochondria, Heart; Myocytes, Cardiac; Myofibrils; Rats; Rats, Sprague-Dawley; Rats, Zucker; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Time Factors; Urea

Topics: Adamantane; Amantadine; Animals; Antiparkinson Agents; Cerebral Hemorrhage, Traumatic; Disease Models, Animal; Exploratory Behavior; Male; Memory; Muscle Tonus; Rats

Topics: Adamantane; Albumins; Animals; Cell Separation; Disease Models, Animal; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation, Enzymologic; Inflammation; Isoenzymes; Kidney Glomerulus; Lupus Nephritis; Mice; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Sphingolipids; Spleen; Thromboxane B2

Topics: Adamantane; Alternative Splicing; Animals; Antiparkinson Agents; Cocaine; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Iodine Isotopes; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Messenger; Sympatholytics

Topics: Adamantane; Animals; Binding, Competitive; Blood Flow Velocity; Brain; Cell Line; Cell Survival; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Estradiol; Estradiol Congeners; Estrogen Receptor alpha; Estrogen Receptor beta; Estrone; Female; Glutamic Acid; Humans; Infarction, Middle Cerebral Artery; Ligands; Mice; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Estrogen

Topics: Adamantane; Animals; Anticonvulsants; Brain; Cations; Convulsants; Diamines; Disease Models, Animal; In Vitro Techniques; Male; Mice; Neurons; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures

Topics: 1-Deoxynojirimycin; Adamantane; Animals; Anti-Inflammatory Agents; Antibodies; Body Weight; Colitis; Colon; Disease Models, Animal; Enzyme Inhibitors; Glycolipids; Haptens; Immunoglobulin G; Immunosuppressive Agents; Interferon-gamma; Interleukin-18; Male; Mice; Mice, Inbred C57BL; Oxazolone; Peroxidase; Trinitrobenzenesulfonic Acid

Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Animals; Aorta; Arteriosclerosis; Azepines; Blood Glucose; Cortisone; Diet, Atherogenic; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Fatty Acids; Hydrocortisone; Insulin; Insulin Resistance; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Syndrome; Triazoles; Triglycerides

Topics: Adamantane; Animals; Antidepressive Agents; Autoradiography; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Expression Regulation; Immobility Response, Tonic; In Situ Hybridization; Male; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; RNA, Messenger; Swimming; Tetrahydroisoquinolines

Topics: Adamantane; Animals; Antineoplastic Agents; Calcium; Cell Death; Cell Differentiation; Cells, Cultured; Chlorocebus aethiops; Cinnamates; COS Cells; Cytosol; Disease Models, Animal; G2 Phase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Mitosis; Receptors, Retinoic Acid; Retinoic Acid Receptor gamma; Retinoids; RNA, Messenger; Teratocarcinoma; Tretinoin

Topics: Adamantane; Animals; Antiplatyhelmintic Agents; Bile Ducts; Disease Models, Animal; Echinostoma; Echinostomiasis; Fasciola hepatica; Fascioliasis; Female; Mice; Microscopy, Electron, Scanning; Rats; Rats, Wistar

Topics: Adamantane; Administration, Oral; Animals; Antiplatyhelmintic Agents; Artemether; Artemisinins; Benzimidazoles; Bile Ducts; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance; Fasciola hepatica; Fascioliasis; Female; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Triclabendazole

Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Blood Pressure; Cardiovascular Agents; Coronary Circulation; Diazoxide; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epoxide Hydrolases; Female; Heart Rate; Lauric Acids; Male; Mitochondria, Heart; Myocardial Infarction; Myocardium; Potassium Channels

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adamantane; Animals; Benzopyrans; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Locomotion; Macaca; Parkinson Disease; Receptors, Dopamine D1

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adamantane; Animals; Benzopyrans; Callithrix; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Female; Levodopa; Locomotion; Male; Quinolones; Receptors, Dopamine D1; Thiophenes

Topics: Acoustic Stimulation; Adamantane; Animals; Antipsychotic Agents; Behavior, Animal; Brain; Conditioning, Classical; Dibenzothiazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Female; Haloperidol; Imidazoles; Inhibition, Psychological; Neurotensin; Photic Stimulation; Psychomotor Performance; Quetiapine Fumarate; Rats; Rats, Long-Evans; Reaction Time; Receptors, Neurotensin; Reflex, Startle; RNA, Messenger; Schizophrenia; Social Isolation; Synaptic Transmission

Topics: Adamantane; Animals; Cyclohexylamines; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Mice; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis

Topics: Adamantane; Aniline Compounds; Animals; Arteriosclerosis; Clofibrate; Coturnix; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Haplorhini; Humans; Hypolipidemic Agents; Macaca fascicularis; Male; Mitotane; Piperidines; Rats; Terminology as Topic

Topics: Adamantane; Administration, Oral; Animals; Disease Models, Animal; Influenza A virus; Injections, Intraperitoneal; Lung; Male; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Rimantadine

Topics: Adamantane; Animals; Cricetinae; Disease Models, Animal; Leukocyte Elastase; Lung; Lung Compliance; Male; Mesocricetus; Oligopeptides; Pancreatic Elastase; Pulmonary Emphysema; Respiratory Function Tests