adamantane has been researched along with Alloxan Diabetes in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.82) | 18.2507 |
| 2000's | 3 (5.45) | 29.6817 |
| 2010's | 46 (83.64) | 24.3611 |
| 2020's | 5 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CT; Chen, CY; Chiu, TY; Huang, YW; Juang, JH; Kao, CW | 1 |
| Chen, W; Li, W; Ni, W; Pan, Y; Sun, Y; Xu, Y; Yang, H | 1 |
| Hu, W; Hu, Y; Lv, L; Xing, Y; Ye, S; Zhou, W | 1 |
| Abdel-Aal, RA; Abdel-Rahman, MS; Al Bayoumi, S; Ali, LA | 1 |
| Arya, DS; Bhargava, P; Bhatia, J; Kumar, R; Suchal, K | 1 |
| Abo-Kamar, AM; Al-Wahaibi, LH; El-Emam, AA; Ghabbour, HA; Hassan, HM | 1 |
| Bogdanov, P; García-Ramírez, M; Genís, X; Hernández, C; Sampedro, J; Simó, R; Simó-Servat, O; Solà-Adell, C; Valeri, M | 1 |
| Li, M; Ping, F; Wang, T; Wang, X; Xiao, X; Yu, M; Zhang, Q; Zheng, J | 2 |
| Ansari, MT; Baig, MMFA; Khan, GJ; Khan, S; Naeem, MA | 1 |
| Abdelaziz, RR; Abdelhamid, AM; Salem, HAA | 1 |
| Liu, L; Wang, DW; Wang, K; Wang, P; Wang, W; Wen, Z; Wu, L | 1 |
| Elgheznawy, A; Fleming, I; Loot, AE; Pierson, I; Randriamboavonjy, V; Stark, H; Syzonenko, T; Zivković, A | 1 |
| Ben-Hassine, M; Boutarfa, A; Braun, A; Castro, A; Coutant, AL; Crespin, O; Dadji-Faïhun, R; de Miguel, B; Engel, C; Farjot, G; Guillot, E; Güssregen, S; Leger, C; Maniani, K; Monseau, C; Mougenot, C; Mougenot, P; Namane, C; Nicolaï, E; Noah, L; Onofri, B; Pacquet, F; Pascal, C; Philippo, C; Pruniaux, MP; Ragot, JL; Van-Pham, T; Venier, O | 1 |
| Araújo, GR; Ávila, Dde L; Costa, DC; de Lima, WG; Diniz, MF; Miranda, PH; Pedrosa, ML; Silva, M; Silva, ME | 1 |
| Ishibashi, Y; Maeda, S; Matsui, T; Nakashima, S; Nishino, Y; Ojima, A; Yamagishi, S; Yamakawa, R; Yoshida, Y | 1 |
| Abe, H; Fujitani, Y; Hara, A; Ishibashi, K; Kanazawa, A; Kawamori, R; Komiya, K; Ogihara, T; Tamaki, M; Uchida, T; Watada, H | 1 |
| Araki, E; Goto, R; Igata, M; Kawasaki, S; Kawashima, J; Kitano, S; Kondo, T; Matsumura, T; Matsuyama, R; Miyagawa, K; Motoshima, H; Ono, K | 1 |
| Hirota, D; Kajitani, N; Kodera, R; Makino, H; Miyamoto, S; Oda, K; Ono, T; Shikata, K; Takatsuka, T; Usui, HK | 1 |
| Bergholm, AM; Brodie, T; Chadwick, KD; Graziano, MJ; LaCerte, C; Mangipudy, RS; Parkes, D; Reilly, TP; Roy, D; Tatarkiewicz, K | 1 |
| Costa, TD; de Andrade, C; de Araújo Lock, G; de Araújo, BV; Haas, SE; Pigatto, MC | 1 |
| Cho, SW; Dal Nam, K; Hahn, HG; Je Lee, W; Kim, EA; Yang, SJ; Young Choi, S | 1 |
| Iwamura, T; Kainoh, M; Kawai, K; Kumagai, H; Nakaki, J; Nitta, A; Okazaki, S; Sakami, S; Sato, M; Sekiya, Y; Takahashi, T; Yagi, M | 1 |
| Costa, DC; de Amorim Miranda, PH; de Lima, WG; Monteiro, OM; Rossoni, JV; Silva, ME | 1 |
| Ahn, SK; Byun, SY; Hong, SP; Nam, KY; Shin, YJ | 1 |
| Abadeh, A; Advani, A; Advani, SL; Connelly, KA; Desjardins, JF; Gilbert, RE; Kabir, G; Mitchell, M; Thai, K; Zhang, Y | 1 |
| Ambrósio, AF; Castilho, Á; Hartveit, E; Veruki, ML | 1 |
| Al-Abdullah, ES; Al-Alshaikh, MA; Al-Tuwaijri, HM; El-Emam, AA; Habib, EE; Hassan, HM | 1 |
| Ahn, JH; Bae, MA; Han, SJ; Kim, D; Kim, JY; Kim, KY; Kwak, HJ; Lee, DH; Lee, GB; Pagire, HS; Pagire, SH; Park, MJ; Rhee, SD; Ryu, JI; Song, JS | 1 |
| Akhtar, M; Khan, S; Najmi, AK; Panda, BP | 1 |
| Gangadharan Komala, M; Gross, S; Panchapakesan, U; Pollock, C; Zaky, A | 1 |
| Duranti, E; Natali, A; Rossi, C; Solini, A; Taddei, S; Virdis, A | 1 |
| Choi, CS; Han, HY; Jeong, KH; Jun, HS; Kim, S; Kim, SS; Lee, HJ; Oh, H; Ryu, JH; Sa, JH; Son, HJ | 1 |
| El Batch, MM; El Batsh, MM; Shafik, NM; Younos, IH | 1 |
| Hayami, N; Iwasaki, YK; Murakawa, Y; Sekiguchi, A; Yamashita, T | 1 |
| El Sarha, A; Refaat, R; Sakr, A; Salama, M | 1 |
| Feng, B; Li, P; Tang, Z; Wang, L; Yan, X | 1 |
| Asakura, M; Atsuda, K; Fujii, H; Fujiwara, R; Fukami, T; Itoh, T; Nakajima, M | 1 |
| Eom, YS; Gwon, AR; Kim, BJ; Kim, JY; Kim, KW; Kim, YS; Kwak, KM; Lee, K; Lee, S; Park, IB; Yu, SH | 1 |
| Abdallah, DM; Al-Shorbagy, MY; Aldakinah, AA; El-Abhar, HS | 1 |
| Baek, HS; Jin, HY; Liu, WJ; Park, JH; Park, TS | 1 |
| Anandan, SK; Chen, D; Gless, RD; MacIntyre, DE; Rubanyi, GM; Vincelette, J; Wang, YX; Webb, HK; Zhang, LN | 1 |
| Bianchi, R; Burkey, B; Cavaletti, G; Cervellini, I; Ghezzi, P; Lauria, G; Oggioni, N; Porretta-Serapiglia, C | 1 |
| Akarte, AS; Gandhi, S; Srinivasan, BP | 2 |
| Jin, HY; Kim, W; Liu, WJ; Liu, YN; Park, SK; Park, TS; Shao, YM; Xie, SH | 1 |
| Maeda, S; Matsui, T; Yamagishi, S | 1 |
| Cheetham, S; Francis, J; Kirby, M; Poucher, SM; Vickers, SP; Zinker, B | 1 |
| Akarte, AS; Gandhi, S; Sole, S; Srinivasan, BP | 1 |
| Hamamoto, S; Hashiramoto, M; Kaku, K; Kanda, Y; Kohara, K; Shimoda, M; Tatsumi, F; Tawaramoto, K | 1 |
| de Beer, D; Fey, SJ; Joubert, E; Louw, J; Malherbe, CJ; Muller, CJ; Sanderson, M | 1 |
| Dhakad, PK; Joshi, M; Joshi, S; Kanawat, DS; Kurmi, MK; Mishra, A; Raikwar, SK; Sharma, AK; Sharma, P; Srinivasan, BP; Srivastava, V | 1 |
| Bansal, VS; Davis, JA; Dhar, A; Khanna, V; Mahajan, DC; Mittra, S; Priyadarsiny, P; Roy, S; Saini, KS; Sattigeri, J; Singh, S | 1 |
| Hammock, BD; Imig, JD; Kim, IH; Luria, A; Mitchell, BC; Newman, JW; Olearczyk, JJ; Quigley, JE; Yamamoto, T | 1 |
| Albinus, M; Blach, D; Vallon, V | 1 |
55 other study(ies) available for adamantane and Alloxan Diabetes
| Article | Year |
|---|---|
Implanted islet mass influences the effects of dipeptidyl peptidase-IV inhibitor LAF237 on transplantation outcomes in diabetic mice.
Topics: Adamantane; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Humans; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Pyrrolidines | 2021 |
[Saxagliptin alleviates kidney injury in diabetic rats by down-regulating the expression of mammalian target of rapamycin (mTOR)].
Topics: Adamantane; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptides; Interleukin-1; Interleukin-6; Kidney; Male; Mammals; Rats; Sirolimus; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2022 |
Saxagliptin attenuates glomerular podocyte injury by increasing the expression of renal nephrin and podocin in type 2 diabetic rats.
Topics: Adamantane; Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dipeptides; Glycated Hemoglobin; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Male; Membrane Proteins; p38 Mitogen-Activated Protein Kinases; Podocytes; Rats; Rats, Sprague-Dawley | 2020 |
Effect of stevia aqueous extract on the antidiabetic activity of saxagliptin in diabetic rats.
Topics: Adamantane; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptides; Herb-Drug Interactions; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Male; Niacinamide; Plant Extracts; Rats; Rats, Wistar; Stevia; Streptozocin | 2021 |
Targeting AGE-RAGE signaling pathway by Saxagliptin prevents myocardial injury in isoproterenol challenged diabetic rats.
Topics: Adamantane; Animals; Apoptosis; Diabetes Complications; Diabetes Mellitus, Experimental; Dipeptides; Heart Diseases; Isoproterenol; Male; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Signal Transduction | 2021 |
Adamantane-Isothiourea Hybrid Derivatives: Synthesis, Characterization, In Vitro Antimicrobial, and In Vivo Hypoglycemic Activities.
Topics: Adamantane; Animals; Anti-Bacterial Agents; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Disk Diffusion Antimicrobial Tests; Gram-Positive Bacteria; Hydrogen Bonding; Hypoglycemic Agents; Models, Molecular; Rats, Sprague-Dawley; Thiourea | 2017 |
Topical administration of DPP-IV inhibitors prevents retinal neurodegeneration in experimental diabetes.
Topics: Adamantane; Animals; Diabetes Mellitus, Experimental; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Electroretinography; Glucagon-Like Peptide 1; Humans; Immunohistochemistry; Male; Mice; Retina; Sitagliptin Phosphate | 2017 |
Vildagliptin increases butyrate-producing bacteria in the gut of diabetic rats.
Topics: Adamantane; Administration, Oral; Animals; Blood Glucose; Butyrates; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Gastrointestinal Microbiome; Glucagon-Like Peptide 1; Insulin Resistance; Interleukin-6; Male; Nitriles; Pyrrolidines; Random Allocation; Rats, Sprague-Dawley; RNA, Ribosomal, 16S; Vildagliptin | 2017 |
Vildagliptin loaded triangular DNA nanospheres coated with eudragit for oral delivery and better glycemic control in type 2 diabetes mellitus.
Topics: Adamantane; Administration, Oral; Animals; Blood Glucose; Crystallization; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; DNA; Drug Carriers; Drug Delivery Systems; Drug Liberation; Hypoglycemic Agents; Male; Mice; Nanospheres; Nanotechnology; Nitriles; Particle Size; Polymethacrylic Acids; Pyrrolidines; Vildagliptin | 2018 |
Vildagliptin/pioglitazone combination improved the overall glycemic control in type I diabetic rats.
Topics: Adamantane; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Glucagon; Glutathione; Glycated Hemoglobin; Insulin; Male; Malondialdehyde; Nitric Oxide; Nitriles; Pancreas; Pioglitazone; Pyrrolidines; Rats, Sprague-Dawley; Streptozocin; Superoxide Dismutase; Thiazolidinediones; Vildagliptin | 2018 |
Glucagon-like peptide-1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPARα pathway.
Topics: Adamantane; Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Dipeptides; Exenatide; Glucagon-Like Peptide 1; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; PPAR alpha | 2018 |
A Possible Mechanism: Vildagliptin Prevents Aortic Dysfunction through Paraoxonase and Angiopoietin-Like 3.
Topics: Adamantane; Angiopoietin-like Proteins; Angiopoietins; Animals; Aryldialkylphosphatase; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Male; Nitriles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Vildagliptin | 2018 |
Ca2+-sensing receptor cleavage by calpain partially accounts for altered vascular reactivity in mice fed a high-fat diet.
Topics: Adamantane; Animals; Aorta; Calpain; Cells, Cultured; Diabetes Mellitus, Experimental; Diet, High-Fat; DNA Primers; Endothelium, Vascular; Immunoblotting; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Quinoxalines; Receptors, Calcium-Sensing; Reverse Transcriptase Polymerase Chain Reaction; Vasoconstrictor Agents | 2013 |
Discovery of SAR184841, a potent and long-lasting inhibitor of 11β-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Structure-Activity Relationship | 2013 |
Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats.
Topics: Adamantane; Animals; Antioxidants; Biomarkers; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Female; Incretins; Insulin; Insulin-Secreting Cells; Nitriles; Oxidation-Reduction; Oxidative Stress; Pyrrolidines; Rats; Streptozocin; Superoxide Dismutase; Vildagliptin | 2013 |
Beneficial effects of vildagliptin on retinal injury in obese type 2 diabetic rats.
Topics: Adamantane; Administration, Oral; Analysis of Variance; Animals; Biomarkers; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Dipeptidyl-Peptidase IV Inhibitors; Gene Expression Profiling; Male; Nitriles; Obesity; Pyrrolidines; Rats; Real-Time Polymerase Chain Reaction; Retina; Vildagliptin | 2013 |
Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlled db/db mice.
Topics: 1-Deoxynojirimycin; Adamantane; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Glucose Tolerance Test; Hypoglycemic Agents; Islets of Langerhans; Male; Mice; Mice, Inbred Strains; Nitriles; Pyrrolidines; Vildagliptin | 2013 |
Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.
Topics: Adamantane; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fatty Liver; Homeodomain Proteins; Inflammation; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Nitriles; Phlorhizin; Pyrrolidines; Tetrazoles; Trans-Activators; Valine; Valsartan; Vildagliptin | 2013 |
Dipeptidyl peptidase-4 inhibitor ameliorates early renal injury through its anti-inflammatory action in a rat model of type 1 diabetes.
Topics: Adamantane; Animals; Anti-Inflammatory Agents; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 1; Kidney Diseases; Kidney Glomerulus; Male; Nitriles; Protective Agents; Pyrrolidines; Rats; Rats, Sprague-Dawley | 2014 |
The glucagon-like peptide-1-based therapeutics exenatide and saxagliptin did not cause detrimental effects on the pancreas in mice, rats, dogs and monkeys.
Topics: Adamantane; Animals; Diabetes Mellitus, Experimental; Dipeptides; Dogs; Exenatide; Glucagon-Like Peptide 1; Haplorhini; Injections, Subcutaneous; Maximum Tolerated Dose; Mice; Organ Size; Pancreas; Peptides; Rats; Venoms | 2014 |
Validation of LC-MS/MS method applied to evaluation of free tissue concentrations of vildagliptin in diabetic rats by microdialysis.
Topics: Adamantane; Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Drug Stability; Liver; Male; Microdialysis; Muscles; Nitriles; Pyrrolidines; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tissue Distribution; Vildagliptin | 2014 |
Effects of N-adamantyl-4-methylthiazol-2-amine on hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats.
Topics: Adamantane; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Glutathione; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Interleukin-1beta; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Malondialdehyde; NF-kappa B; Nitric Oxide; Oxidative Stress; Rats, Sprague-Dawley; Superoxide Dismutase; Thiazoles; Tumor Necrosis Factor-alpha; Vitamin E | 2014 |
HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Administration, Oral; Animals; Azepines; Carbenoxolone; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Obesity; Pioglitazone; Thiazolidinediones; Triazoles | 2014 |
Vildagliptin induces β-cell neogenesis and improves the lipid profile in a later phase of type 1 diabetes.
Topics: Adamantane; Animals; Blood Glucose; Cell Proliferation; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Lipid Metabolism; Nitriles; Pyrrolidines; Rats, Inbred F344; Triglycerides; Vildagliptin | 2015 |
A novel highly potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, UI-1499.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 3T3 Cells; Adamantane; Adipocytes; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Design; Enzyme Inhibitors; Glucocorticoids; Haplorhini; Humans; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Sulfonamides; Treatment Outcome | 2015 |
Dipeptidyl peptidase-4 inhibition improves cardiac function in experimental myocardial infarction: Role of stromal cell-derived factor-1α.
Topics: Adamantane; Animals; Benzylamines; Cardiac Catheterization; Chemokine CXCL12; Cyclams; Diabetes Mellitus, Experimental; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Echocardiography; Glucagon-Like Peptide-1 Receptor; Heterocyclic Compounds; Hypoglycemic Agents; Liraglutide; Male; Myocardial Infarction; Rats; Rats, Inbred F344 | 2016 |
Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus.
Topics: Adamantane; Amacrine Cells; Animals; Calcium; Diabetes Mellitus, Experimental; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; Neural Pathways; Rats; Receptors, AMPA; Retinal Bipolar Cells; Retinal Rod Photoreceptor Cells; Up-Regulation | 2015 |
Synthesis, Antimicrobial and Hypoglycemic Activities of Novel N-(1-Adamantyl)carbothioamide Derivatives.
Topics: Adamantane; Animals; Anti-Bacterial Agents; Candida albicans; Diabetes Mellitus, Experimental; Gram-Negative Bacteria; Gram-Positive Bacteria; Hydrazines; Hypoglycemic Agents; Isothiocyanates; Male; Microbial Sensitivity Tests; Rats; Rats, Sprague-Dawley; Triazoles | 2015 |
Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes.
Topics: Adamantane; Animals; Diabetes Mellitus, Experimental; Diacylglycerol O-Acyltransferase; Diet, High-Fat; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Obesity; Structure-Activity Relationship; Zebrafish | 2015 |
Potential effects of vildagliptin on biomarkers associated with prothrombosis in diabetes mellitus.
Topics: Adamantane; Administration, Oral; Animals; Biomarkers; Diabetes Mellitus, Experimental; Disease Progression; Drug Therapy, Combination; Fibrinogen; Hypoglycemic Agents; Male; Nitriles; Pioglitazone; Platelet Count; Pyrrolidines; Rats; Rats, Sprague-Dawley; Streptozocin; Thiazolidinediones; Thrombosis; Vildagliptin | 2015 |
Saxagliptin reduces renal tubulointerstitial inflammation, hypertrophy and fibrosis in diabetes.
Topics: Adamantane; Albuminuria; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Fibronectins; Fibrosis; Glomerulonephritis; Hypertrophy; Insulin; Kidney; Male; Mice, Knockout; Nephritis, Interstitial; Nitric Oxide Synthase Type III; Phosphorylation; Signal Transduction; Smad2 Protein; Smad3 Protein; Streptozocin; Transcription Factor RelA; Transforming Growth Factor beta | 2016 |
Saxagliptin prevents vascular remodeling and oxidative stress in db/db mice. Role of endothelial nitric oxide synthase uncoupling and cyclooxygenase.
Topics: Adamantane; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptides; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pyrazoles; Vascular Remodeling; Vasodilation | 2016 |
A potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, SKI2852, ameliorates metabolic syndrome in diabetic mice models.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Adipose Tissue; Animals; Body Weight; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glycated Hemoglobin; Insulin Resistance; Lipids; Liver; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Pyrimidines | 2015 |
Favorable effects of vildagliptin on metabolic and cognitive dysfunctions in streptozotocin-induced diabetic rats.
Topics: Adamantane; Animals; Behavior, Animal; Body Weight; Brain; Brain-Derived Neurotrophic Factor; Cognition; Diabetes Mellitus, Experimental; Male; Neuroprotective Agents; Nitriles; Oxidative Stress; Pyrrolidines; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Vildagliptin | 2015 |
No Additional Effect of DPP-4 Inhibitor on Preventing Atrial Fibrosis in Streptozotocin-Induced Diabetic Rat as Compared With Sulfonylurea.
Topics: Adamantane; Animals; Anti-Inflammatory Agents; Atrial Fibrillation; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Endomyocardial Fibrosis; Female; Glyburide; Heart Atria; Hypoglycemic Agents; Immunohistochemistry; Inflammation; Nitriles; Pyrrolidines; Rats; Rats, Wistar; Statistics as Topic | 2016 |
Combination of Vildagliptin and Pioglitazone in Experimental Type 2 Diabetes in Male Rats.
Topics: Adamantane; Animals; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Hypoglycemic Agents; Inflammation; Insulin; Kidney; Liver; Male; Nitriles; Oxidative Stress; Pancreas; Pioglitazone; Pyrrolidines; Rats; Rats, Wistar; Thiazolidinediones; Urea; Vildagliptin | 2016 |
Structural modulation of the gut microbiota and the relationship with body weight: compared evaluation of liraglutide and saxagliptin treatment.
Topics: Adamantane; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dipeptides; DNA, Bacterial; Eating; Feces; Gastrointestinal Microbiome; Gene Expression; Glucagon-Like Peptide-1 Receptor; Hyperglycemia; Hypoglycemic Agents; Liraglutide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Ribosomal, 16S; Streptozocin | 2016 |
Hepatic Dipeptidyl Peptidase-4 Controls Pharmacokinetics of Vildagliptin In Vivo.
Topics: Adamantane; Animals; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Hydrolysis; Liver; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Nitriles; Pyrrolidines; Tissue Distribution; Vildagliptin | 2017 |
Protective Effects of Vildagliptin against Pioglitazone-Induced Bone Loss in Type 2 Diabetic Rats.
Topics: Adamantane; Animals; Biomarkers; Bone Density; Bone Resorption; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Male; Nitriles; Pioglitazone; Pyrrolidines; Rats; Rats, Zucker; Tartrate-Resistant Acid Phosphatase; Thiazolidinediones; Vildagliptin | 2016 |
Trigonelline and vildagliptin antidiabetic effect: improvement of insulin signalling pathway.
Topics: Adamantane; Alkaloids; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Insulin Resistance; Lipids; Male; Nitriles; Pyrrolidines; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction; Vildagliptin | 2017 |
Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats.
Topics: Adamantane; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Eating; Electric Stimulation; Epidermis; Glucagon-Like Peptide 1; Humans; Insulin; Male; Nerve Degeneration; Nitriles; Peripheral Nerves; Pyrrolidines; Random Allocation; Rats; Rats, Sprague-Dawley; Ubiquitin Thiolesterase; Vildagliptin | 2009 |
Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension.
Topics: Adamantane; Administration, Oral; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelium, Vascular; Epoxide Hydrolases; Hypertension; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Niacinamide; Obesity; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Urea; Vasodilation | 2011 |
Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy.
Topics: Adamantane; Animals; Behavior, Animal; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dipeptidyl-Peptidase IV Inhibitors; Disease Progression; Dose-Response Relationship, Drug; Drinking; Eating; Glucagon-Like Peptide 1; Glucose Tolerance Test; Male; Neural Conduction; Nitriles; Pain Threshold; Peripheral Nervous System Diseases; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Vildagliptin | 2012 |
A novel long acting DPP-IV inhibitor PKF-275-055 stimulates β-cell proliferation resulting in improved glucose homeostasis in diabetic rats.
Topics: Adamantane; Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Homeostasis; Hypoglycemic Agents; Insulin-Secreting Cells; Nitriles; Pyrrolidines; Rats; Rats, Wistar | 2012 |
Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adamantane; Animals; Blood Glucose; Body Weight; Caspase 3; Cyclic AMP; Deoxyguanosine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Eating; Gene Expression; Glomerular Basement Membrane; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Insulin; Kidney; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Transforming Growth Factor beta1 | 2012 |
Relationships between the islets blood flow, nitric oxide, insulin, and cytosolic calcium in rat pancreatic islets: effects of DPP-IV inhibitor vildagliptin.
Topics: Adamantane; Animals; Blood Glucose; Calcium; Cardiac Output; Cytokines; Cytosol; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Glucose; Hemodynamics; Insulin; Insulin-Secreting Cells; Nitric Oxide; Nitriles; Peroxynitrous Acid; Pyrrolidines; Rats; Rats, Wistar; Regional Blood Flow; Vildagliptin | 2012 |
Vildagliptin inhibits oxidative stress and vascular damage in streptozotocin-induced diabetic rats.
Topics: Adamantane; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dipeptidyl-Peptidase IV Inhibitors; Male; Nitriles; Oxidative Stress; Pyrrolidines; Rats; Rats, Sprague-Dawley; Vildagliptin | 2012 |
Effects of saxagliptin and sitagliptin on glycaemic control and pancreatic β-cell mass in a streptozotocin-induced mouse model of type 2 diabetes.
Topics: Adamantane; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Dipeptides; Drinking; Eating; Glucose Tolerance Test; Glycated Hemoglobin; Hypoglycemic Agents; Immunohistochemistry; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Pyrazines; Sitagliptin Phosphate; Triazoles | 2012 |
Chronic DPP-IV inhibition with PKF-275-055 attenuates inflammation and improves gene expressions responsible for insulin secretion in streptozotocin induced diabetic rats.
Topics: Adamantane; Animals; Blood Glucose; Blood Proteins; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Gene Expression Regulation; Glucagon-Like Peptide 1; Glucose Transporter Type 2; Glucose Transporter Type 4; Glycogen; Hypoglycemic Agents; Inflammation; Insulin; Insulin Secretion; Liver; Muscle, Skeletal; Nitrates; Nitriles; Nitrites; Pancreas; Pyrrolidines; Rats; Rats, Wistar; RNA, Messenger; Tumor Necrosis Factor-alpha | 2012 |
Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes.
Topics: Adamantane; Animals; Apoptosis; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Stress; Gene Expression Regulation, Developmental; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Nitriles; Oxidative Stress; Pyrrolidines; Real-Time Polymerase Chain Reaction; Triglycerides; Up-Regulation; Vildagliptin | 2013 |
Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential.
Topics: Adamantane; Animals; Aspalathus; Blood Glucose; Cell Line; Chalcones; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Glucose Tolerance Test; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Male; Nitriles; Phytotherapy; Plant Extracts; Pyrrolidines; Rats; Rats, Wistar; Rutin; Vildagliptin | 2012 |
Dual therapy of vildagliptin and telmisartan on diabetic nephropathy in experimentally induced type 2 diabetes mellitus rats.
Topics: Adamantane; Albuminuria; Animals; Benzimidazoles; Benzoates; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Body Weight; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diastole; Drug Therapy, Combination; Fasting; Hypoglycemic Agents; Male; Nitriles; Pyrrolidines; Rats, Wistar; Systole; Telmisartan; Vildagliptin | 2014 |
Combination of dipeptidylpeptidase IV inhibitor and low dose thiazolidinedione: preclinical efficacy and safety in db/db mice.
Topics: Adamantane; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Glucose Tolerance Test; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Pyrrolidines; Rosiglitazone; Thiazolidinediones; Triglycerides | 2007 |
Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats.
Topics: Adamantane; Animals; Antihypertensive Agents; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Hypertension; Insulin; Lauric Acids; Lipids; Male; NF-kappa B; Rats; Rats, Inbred Strains | 2009 |
Effect of KATP channel blocker U37883A on renal function in experimental diabetes mellitus in rats.
Topics: Adamantane; Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Kidney; Male; Morpholines; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Streptozocin | 1998 |