acyclovir-monophosphate and HIV-Infections

acyclovir-monophosphate has been researched along with HIV-Infections* in 1 studies

Other Studies

1 other study(ies) available for acyclovir-monophosphate and HIV-Infections

Article	Year
Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro. Bioorganic & medicinal chemistry, 2012, Oct-01, Volume: 20, Issue:19 The antiviral activity against HIV and HSV and the chemical stability of ACV phosphoramidate derivatives were studied. The phosphoramidates of ACV demonstrated moderate activity. The best compound appeared to be 9-(2-hydroxymethyl)guanine phosphoromonomorpholidate (7), which inhibited virus replication in pseudo-HIV-1 particles by 50% at 50 μM. It also inhibited replication of wild-type HSV-1 (9.7 μM) as well as an acyclovir-resistant strain (25 μM). None of the synthesised compounds showed any cytotoxicity. Topics: Acyclovir; Animals; Antiviral Agents; Chlorocebus aethiops; HEK293 Cells; Herpes Simplex; Herpesvirus 1, Human; HIV Infections; HIV-1; Humans; Vero Cells; Virus Replication	2012

Article

Year

Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.

Bioorganic & medicinal chemistry, 2012, Oct-01, Volume: 20, Issue:19

The antiviral activity against HIV and HSV and the chemical stability of ACV phosphoramidate derivatives were studied. The phosphoramidates of ACV demonstrated moderate activity. The best compound appeared to be 9-(2-hydroxymethyl)guanine phosphoromonomorpholidate (7), which inhibited virus replication in pseudo-HIV-1 particles by 50% at 50 μM. It also inhibited replication of wild-type HSV-1 (9.7 μM) as well as an acyclovir-resistant strain (25 μM). None of the synthesised compounds showed any cytotoxicity.

Topics: Acyclovir; Animals; Antiviral Agents; Chlorocebus aethiops; HEK293 Cells; Herpes Simplex; Herpesvirus 1, Human; HIV Infections; HIV-1; Humans; Vero Cells; Virus Replication

2012