acyclovir and Uterine-Cervical-Neoplasms

Sexually transmitted diseases (STDs) continue to be a global epidemic with significant risk of morbidity/mortality for the fetus. STDs with prominent cutaneous findings including condylomata acuminata, genital herpes infections, and syphilis are reviewed. Important clinical cutaneous findings help aid early diagnosis and facilitate treatment. Condylomata acuminata have the potential of causing cervical cancer, anogenital cancer, and oropharyngeal cancer. Significant advances have been made in human papilloma virus vaccinations and treatment. Genital herpes infection can produce significant physical and emotional distress to the patient and significant potential harm to the fetus. Early clinical recognition of STDs and their appropriate management is critical.

Topics: Acyclovir; Aminoquinolines; Anti-Bacterial Agents; Antineoplastic Agents; Antiviral Agents; Chancre; Condylomata Acuminata; Female; Herpes Genitalis; Humans; Imiquimod; Papillomavirus Infections; Papillomavirus Vaccines; Penicillins; Podophyllotoxin; Sexually Transmitted Diseases; Syphilis, Cutaneous; Uterine Cervical Neoplasms; Valacyclovir; Valine

Topics: Acyclovir; Condylomata Acuminata; Female; Herpes Genitalis; Humans; Interferons; Recurrence; Uterine Cervical Neoplasms; Vulvar Neoplasms

Topics: Acyclovir; Female; Herpes Genitalis; Humans; Male; Pregnancy; Pregnancy Complications, Infectious; Uterine Cervical Neoplasms

Fourteen semisynthetic compounds derived from the natural scopadulane-type diterpenes thyrsiflorin A (4), B (5), and C (6), including several precursors, have been examined in vitro for their antiherpetic activity against Herpes simplex virus type II (HSV-2) and cytotoxicity against two human tumor cell lines. Four of these compounds showed moderate antiherpetic activity, but none of them exhibited a significant cytotoxicity against the cell lines used. Some structure-activity relationships have been identified for the antiviral activity in these scopadulane derivatives as well as important structural features for the cytotoxic activity.

Topics: Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Cattle; Cell Survival; Cells, Cultured; Chlorocebus aethiops; CHO Cells; Cricetinae; Diterpenes; Ear; Female; HeLa Cells; Herpesvirus 2, Human; Humans; Inhibitory Concentration 50; Kidney; Laryngeal Neoplasms; Ovary; Plants, Medicinal; Skin; Structure-Activity Relationship; Tumor Cells, Cultured; Uterine Cervical Neoplasms; Vero Cells

Topics: Acyclovir; Antigens, Viral; Female; Herpes Genitalis; Humans; Immunoglobulin A; Immunoglobulins; Injections, Intravenous; Reference Values; Simplexvirus; Uterine Cervical Neoplasms

The inhibition of herpes simplex virus type 1 (HSV-1) plaque formation by acycloguanosine (ACG) was assayed in human fetal lung fibroblasts (HL), cell lines from human cervical carcinoma, rabbit cornea, and human rhabdomyosarcoma, and three green monkey kidney cell lines. The ACG concentration giving 50% plaque reduction (PR50) of HSV-1 was lowest in HL. In two green monkey kidney cell lines, HSV-1 plaque formation was relatively insensitive to ACG, with PR50 of 25 and 60 muM, respectively. In the other cells, HSV-1 showed an intermediate sensitivity to ACG. Also, HSV-2 was more sensitive to ACG in HL than in monkey kidney cells. HSV-1 plaque reduction on HL cells was studied as a function of increasing virus MOI with a constant concentration of ACG. An increased MOI decreased the sensitivity to ACG. The sensitivity of cytomegalovirus (CMV), strain Ad. 169, and four fresh CMV isolates to ACG was studied in HL cells. At low MOIs, three of the five CMV strains were somewhat sensitive to ACG, PR50 values ranging from 60 to 450 muM ACG. At high MOIs none of the virus strains were sensitive. ACG at concentrations of 200 muM or less did not significantly affect host cell DNA synthesis, as measured by 3H-thymidine incorporation. In cell culture, the inhibition of herpesviruses by ACG appears to be complex, depending on the type of virus, virus concentration, type of host cells, and condition of the cells.

Topics: Acyclovir; Animals; Cell Line; Chlorocebus aethiops; Cornea; Cytomegalovirus; DNA; Female; Fibroblasts; Guanine; Humans; Lung; Rhabdomyosarcoma; Simplexvirus; Uterine Cervical Neoplasms; Viral Plaque Assay