acyclovir and Stevens-Johnson-Syndrome

Topics: Acyclovir; Administration, Oral; Adult; Antiviral Agents; Diagnosis, Differential; Fatal Outcome; Herpes Labialis; Humans; Male; Stevens-Johnson Syndrome

A 14-month-old boy presented with generalised vesicular eruption involving the face, trunk and extremities accompanied by high grade fever. He had associated redness and purulent discharge from both eyes. Examination revealed erosions on the tongue, soft palate and genitalia with haemorrhagic crusts on the lips and nasal orifices. All laboratory investigations were within normal limits except leucocytosis. Chest x-ray showed left middle zone pneumonitis. Treatment was by paracetamol, antibiotics and oral acyclovir. Desquamation started from the eighth day. Our purpose in reporting this case is to highlight the fact that varicella can be atypical with distal involvement and can present as SJS-TEN overlap syndrome.

Topics: Acyclovir; Chickenpox; Comorbidity; Diagnosis, Differential; Foot; Hand; Herpesvirus 3, Human; Humans; Infant; Male; Stevens-Johnson Syndrome

Topics: Acyclovir; Adult; Antiviral Agents; HIV Infections; Humans; Male; Stevens-Johnson Syndrome

We describe a 36-year-old man with recurrent Stevens-Johnson syndrome, which became progressively more severe over a 13-year period. His episodes were apparently preceded by herpes simplex virus oral mucosal infections. A management protocol, including immediate therapy with acyclovir and prednisone at the onset of herpes simplex virus oropharyngitis, is outlined. This management strategy has successfully prevented four subsequent episodes of progression to Stevens-Johnson syndrome. Thus, Stevens-Johnson syndrome associated with herpes simplex virus may be prevented by early use of acyclovir and prednisone.

Topics: Acyclovir; Adult; Humans; Male; Prednisone; Recurrence; Stevens-Johnson Syndrome; Stomatitis, Herpetic

Topics: Acute Disease; Acyclovir; Humans; Joint Diseases; Pain; Recurrence; Stevens-Johnson Syndrome