acyclovir and Penile-Diseases

Neurotoxicity associated with acyclovir use is infrequently encountered. However, the half-life of acyclovir is greatly prolonged in patients with end-stage renal disease, predisposing these patients to neurological side effects that are generally reversible but occasionally severe. In general, renal dialysis effectively decreases the serum level of acyclovir, which correlates with toxicity. We report an unusual case of delirium and coma in a patient undergoing hemodialysis who was receiving what appeared to be an appropriately adjusted dose of acyclovir.

Topics: Acyclovir; Aged; Coma; Delirium; Herpes Simplex; Humans; Kidney Failure, Chronic; Male; Penile Diseases; Renal Dialysis; Ulcer

We have described a case of herpes genitalis in a patient with Evans's syndrome who had violaceous macules leading to deep ulcerations. This case serves as a reminder that HSV infection may be atypical and have an unusual course in immunocompromised patients. With the availability of specific therapy for this infection, it is important to consider HSV in the differential diagnosis of all ulcerative skin lesions.

Topics: Acyclovir; Anemia, Hemolytic, Autoimmune; Herpes Genitalis; Humans; Immunosuppression Therapy; Male; Middle Aged; Penile Diseases; Recurrence; Skin Ulcer; Syndrome; Thrombocytopenia

Topics: Acyclovir; Anti-HIV Agents; Antiviral Agents; Chronic Disease; HIV Infections; HIV-1; Humans; Male; Penile Diseases; Skin Ulcer; Valacyclovir; Valine; Young Adult

Topics: Acyclovir; Adult; Antigens, Viral; Antiviral Agents; Biomarkers; Diagnosis, Differential; Herpes Simplex; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunohistochemistry; Male; Penile Diseases; Polymerase Chain Reaction; Treatment Outcome; Valacyclovir; Valine

Topics: Acyclovir; Adult; Antiviral Agents; Diagnosis, Differential; Herpes Genitalis; Herpesvirus 2, Human; Humans; Male; Penile Diseases; Skin Diseases, Viral

Erythema multiforme is an acute mucocutaneous disorder, characterized by varying degrees of blistering and ulceration. We report a case of recurrent herpes-associated erythema multiforme managed with prophylactic acyclovir. An 11-year-old boy had lesions in the oral cavity and lips, which had been diagnosed as erythema multiforme minor. Four months later, the patient had desquamative gingivitis with erythematous lesions and necrotic areas in the skin. This episode was not related to drug intake, which suggests that the erythema multiforme was a result of herpetic infection. This hypothesis was supported by positive serology for herpes simplex virus. Five months later, the patient returned with new oral, skin and penis mucosal lesions. The diagnosis was confirmed as herpes simplex virus-associated erythema multiforme major. The episode was treated with acyclovir, and acyclovir was used prophylactically for 7 months to control the disease.

Topics: Acyclovir; Antiviral Agents; Child; Erythema Multiforme; Follow-Up Studies; Gingivitis; Herpes Genitalis; Herpes Labialis; Humans; Lip Diseases; Male; Mouth Diseases; Penile Diseases; Recurrence; Simplexvirus; Stomatitis, Herpetic

Topics: Acyclovir; Adult; Antiviral Agents; Diagnosis, Differential; Herpes Genitalis; Humans; Male; Penile Diseases; Ulcer; Valacyclovir; Valine

Topics: Acyclovir; Adult; Antiviral Agents; Dermatitis, Atopic; Hand Dermatoses; Humans; Kaposi Varicelliform Eruption; Male; Penile Diseases; Recurrence

Topics: Acyclovir; Adult; Drug Resistance, Microbial; Herpes Genitalis; Herpesvirus 2, Human; Humans; Immunocompetence; Male; Microbial Sensitivity Tests; Penile Diseases; Recurrence

We present a patient with chronic lymphocytic leukemia who developed a painful penile ulcer that was initially diagnosed as leukemia cutis, as evidenced by an atypical leukemic infiltrate on biopsy. A Tzanck preparation was positive for multinucleated giant cells, and the diagnosis of herpes genitalis was confirmed by viral culture. In patients with hematologic malignancies, herpes simplex virus must be included in the differential diagnosis of ulcerative lesions. The histopathologic findings of inflammatory dermatoses in these patients may include an atypical infiltrate, because of the predominance of atypical inflammatory cells in the peripheral circulation.

Topics: Acyclovir; Biopsy; Cells, Cultured; Diagnosis, Differential; Herpes Genitalis; Humans; Immunoenzyme Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Penile Diseases; Ulcer