acyclovir and Orchitis

acyclovir has been researched along with Orchitis* in 3 studies

Other Studies

3 other study(ies) available for acyclovir and Orchitis

ArticleYear
Neonatal testicular cell transplantation restores murine spermatogenesis damaged in the course of herpes simplex virus-induced orchitis.
    Reproduction, fertility, and development, 2016, Volume: 28, Issue:6

    Genital tract infection and inflammation may affect male fertility, causing germ and Sertoli cell loss. We determined if testicular cell transplantation is effective at repairing testicular injury induced by herpes simplex virus (HSV) orchitis. ROSA26 mice were used as donors and the recipients were C57BL/6 mice after HSV testicular inoculation; some of the recipients were treated with the antiviral drug acyclovir (ACV). ACV reduced the amount of HSV antigen in testes on Day 3 after transplantation and enhanced the efficacy of transplantation at Day 30. In recipient testes, donor Sertoli cells formed new seminiferous tubules; significantly more new tubules were observed in the testes of ACV-treated mice compared with mice not treated with ACV (17.8% vs 3.6%). Over half (50.4%) of new tubules in ACV-treated testes contained germ cells and round spermatids were detected in 14.2% of new tubules compared with 15.9% and 5.3% in testes not treated with ACV, respectively. At Day 150 the seminiferous epithelium was completely recovered in some donor tubules and elongated spermatids were observed inside it. Thus, our findings reveal the effectiveness of the combination of antiviral therapy with neonatal testis-cell transplantation for the restoration of spermatogenesis damaged by viral infection.

    Topics: Acyclovir; Animals; Animals, Newborn; Antiviral Agents; Cell Transplantation; Combined Modality Therapy; Herpes Genitalis; Immunohistochemistry; Infertility, Male; Kinetics; Male; Mice, Inbred C57BL; Mice, Transgenic; Orchitis; Seminiferous Tubules; Sertoli Cells; Simplexvirus; Spermatids; Spermatogenesis; Testis

2016
Testicular involvement during Toscana virus infection: an unusual manifestation?
    Infection, 2013, Volume: 41, Issue:3

    Topics: Acyclovir; Adult; Anti-Bacterial Agents; Antibodies, Viral; Antiviral Agents; Bunyaviridae Infections; Ceftriaxone; Cerebrospinal Fluid; Humans; Immunoglobulin G; Immunoglobulin M; Male; Orchitis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Sandfly fever Naples virus

2013
Infection of the male reproductive tract.
    Current therapy in endocrinology and metabolism, 1994, Volume: 5

    Topics: Acyclovir; Anti-Bacterial Agents; Bacterial Infections; Chancroid; Chlamydia Infections; Epididymitis; Escherichia coli Infections; Female; Genital Diseases, Male; Herpes Simplex; Humans; Infertility, Male; Male; Mumps; Orchitis; Prostatitis; Syphilis; Urethritis

1994