acyclovir and Macular-Edema

A 55 year-old female patient with unilateral Acute Retinal Necrosis (ARN) developed macular oedema (MO) after the resolution of her necrosis. The macular oedema (MO) was managed and controlled for four years with intravitreal anti-VEGF injections. Anti-VEGF therapy could be useful for the treatment of MO secondary to ARN, the same as for treating MO resulting from panuveitis, where its efficacy has been already demonstrated.

Topics: Acyclovir; Angiogenesis Inhibitors; Antiviral Agents; Female; Humans; Macular Edema; Middle Aged; Ranibizumab; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Retinal Necrosis Syndrome, Acute; Vascular Endothelial Growth Factor A

Topics: Acyclovir; Administration, Oral; Antiviral Agents; Aqueous Humor; DNA, Viral; Drug Therapy, Combination; Eye Infections, Viral; Female; Fluorescein Angiography; Ganciclovir; Herpes Simplex; Herpesvirus 1, Human; Humans; Infusions, Intravenous; Intravitreal Injections; Macular Edema; Middle Aged; Polymerase Chain Reaction; Prednisolone; Retinal Detachment; Retinal Necrosis Syndrome, Acute; Tomography, Optical Coherence

We report a case of herpes simplex virus (HSV) epithelial keratitis that developed after a subtenon triamcinolone acetonide (TA) injection.. A 78-year-old woman with a branch retinal vein occlusion and diffuse macular edema in her left eye received a subtenon injection of 20 mg of TA.. Six days after the injection, the patient presented with a foreign body sensation, tearing, redness, and photophobia in the same eye. Slit-lamp examination revealed multiple corneal dendriform ulcers. She was diagnosed with HSV epithelial keratitis and treated with topical acyclovir ointment. The epithelial lesions healed after 1 week of therapy.. HSV epithelial keratitis can be a possible complication of a TA subtenon injection.

Topics: Acyclovir; Aged; Antiviral Agents; Epithelium, Corneal; Fascia; Female; Glucocorticoids; Herpesvirus 1, Human; Humans; Injections; Keratitis, Herpetic; Macular Edema; Retinal Vein Occlusion; Triamcinolone Acetonide; Virus Activation

To report a case of recurrent herpes simplex virus (HSV) epithelial keratitis after intravitreal triamcinolone acetonide injection for the treatment of diabetic macular edema.. Case report.. We describe a case of a 59-year-old woman with a history of ocular HSV disease and severe proliferative diabetic retinopathy. She received an intravitreal injection of triamcinolone acetonide for macular edema in the right eye. One week later, she developed foreign body sensation, redness, and photophobia in the same eye. Slit-lamp examination revealed a corneal epithelial dendritic lesion. She was diagnosed with a recurrence of HSV epithelial keratitis and was treated with oral acyclovir 400 mg, 5 times a day, with good resolution of HSV signs and symptoms.. Intravitreal triamcinolone acetonide injection may result in reactivation of HSV keratitis.

Topics: Acyclovir; Antiviral Agents; Diabetic Retinopathy; Female; Glucocorticoids; Herpesvirus 1, Human; Humans; Injections; Keratitis, Herpetic; Macular Edema; Middle Aged; Recurrence; Triamcinolone Acetonide; Virus Activation; Vitreous Body

We report a case of herpetic epithelial keratitis that developed after intravitreal triamcinolone acetonide injection.. An 81-year-old man with diabetes with severe nonproliferative diabetic retinopathy and diffuse macular edema in both eyes received bilateral intravitreal injections of 0.4 mg/0.1 mL of triamcinolone acetonide.. Eighteen days after the injections, the patient presented with redness, tearing, foreign body sensation, and decreased visual acuity in the right eye. The cornea showed dendriform ulcers that exhibited positive fluorescein staining. Diagnosis for herpes simplex epithelial keratitis was made, and topical acyclovir ointment therapy was initiated. The epithelial lesions healed after 7 days of therapy.. Herpes simplex epithelial keratitis can be a possible complication of intravitreal triamcinolone acetonide injection. The course and response to conventional therapy was no different from that of the classical course of the disease.

Topics: Acyclovir; Aged, 80 and over; Antiviral Agents; Epithelium, Corneal; Glucocorticoids; Herpesvirus 1, Human; Humans; Injections; Keratitis, Herpetic; Macular Edema; Male; Triamcinolone Acetonide; Virus Activation; Vitreous Body