acyclovir and Latent-Infection

Topics: Acyclovir; Adult; Aged; Antiviral Agents; Female; France; Herpes Simplex; Humans; Latent Infection; Male; Middle Aged; Oropharynx; Respiration, Artificial; Retrospective Studies; Virus Shedding

Understanding the molecular mechanisms of herpes simplex virus 1 (HSV-1) latent infection and reactivation in neurons requires the use of

Topics: Acyclovir; Antiviral Agents; DNA Replication; DNA, Viral; Herpes Simplex; Herpesvirus 1, Human; Histone Demethylases; Humans; Latent Infection; MAP Kinase Kinase Kinases; Virus Activation; Virus Latency; Virus Replication

To report two cases of herpes simplex virus keratitis reactivation following Pfizer-BioNTech COVID-19 (BNT162b2) mRNA vaccination.. Two patients (one male, age 42 years, and one female, age 29 years) who are known to have herpetic keratitis presented to our emergency room in a time frame between 4 days and 4 weeks of receiving the vaccine. One patient presented with necrotizing stromal keratitis; the other presented with endotheliitis and epithelial keratitis. PCR for herpes simplex virus (HSV) was obtained from the two patients, and all cases received systemic acyclovir.. PCR for HSV came positive in both cases. Patients responded well to the provided treatment.. Ocular herpetic infection may be activated by COVID-19 (BNT162b2) mRNA vaccine. Treating physician should be alert to such associations, and patients should be followed closely. No direct causality has been proven, but further reporting and investigating similar conditions is recommended.

Topics: Acyclovir; Adult; Antiviral Agents; BNT162 Vaccine; COVID-19; Female; Herpesvirus 1, Human; Humans; Keratitis, Herpetic; Latent Infection; Male; Polymerase Chain Reaction; SARS-CoV-2; Vaccination

To describe the reactivation of Varicella-Zoster Virus Anterior Uveitis after YAG laser peripheral iridotomy.. A 69-year-old woman referred with unilateral, anterior uveitis associated with decreased corneal sensation and increased intraocular pressure 5 days after YAG laser peripheral iridotomy. The impression of herpetic anterior uveitis reactivation followed by YAG PI confirmed by polymerase chain reaction of aqueous humor by detecting varicella zoster virus. Treatment with oral acyclovir and topical corticosteroid and cycloplegic resulted control of both the intraocular inflammation and pressure.. YAG PI may be a risk factor for reactivation of herpetic anterior uveitis. Prophylaxis with acyclovir may be necessary after YAG PI to prevent reactivation of herpetic anterior uveitis.

Topics: Acyclovir; Aged; Antiviral Agents; Aqueous Humor; Eye Infections, Viral; Female; Herpesvirus 3, Human; Humans; Iris; Lasers, Solid-State; Latent Infection; Polymerase Chain Reaction; Uveitis, Anterior; Varicella Zoster Virus Infection