acyclovir and Hypesthesia

Ramsay Hunt syndrome (RHS) complicated with encephalitis is rare, and the appearance of hemi-motosensory deficit in RHS is even rarer. We reported two such cases. Both patients had a peripheral type facial palsy, facial numbness and zoster in the ipsilateral ear canal. The consciousness was clear and cognitive function was normal. The functional deficits of extremities were ipsilateral to the facial palsy in one case, but contralateral in the other. Magnetic resonance imaging of the brain in both cases showed no abnormality. The manifestations were compared with two more cases from the literature.

Topics: Acyclovir; Adult; Female; Herpes Zoster Oticus; Humans; Hypesthesia; Male; Middle Aged; Paresis

We report a case of indolent herpetic whitlow of the toe occurring in an elderly male patient with poorly controlled diabetes mellitus. In this case, the mechanism of transmission was not clear, although he was in a habit of taking a hot spring bath. This patient's symptoms were unusual for herpes simplex; he had no pain in the presence of diabetic neuropathy. The standard therapeutic dose of acyclovir was not effective in suppressing the lesions, and a higher dose was required to induce complete healing.

Topics: Acyclovir; Aged; Antiviral Agents; Cellulitis; Diabetic Foot; Diabetic Neuropathies; Foot Dermatoses; Herpes Simplex; Herpesvirus 1, Human; Humans; Hypesthesia; Male; Toes

Topics: Acyclovir; Antibodies, Viral; Antiviral Agents; DNA, Viral; Encephalitis, Varicella Zoster; Female; Headache; Herpesvirus 3, Human; Humans; Hypesthesia; Immunoglobulin G; Middle Aged; Skin

Topics: Acyclovir; Adult; Antiviral Agents; Female; Ganglia, Spinal; Herpes Simplex; Herpesvirus 2, Human; Humans; Hypesthesia; Leukocytosis; Myelitis; Radiculopathy; Sacrum; Syndrome; Urinary Retention

To determine the prognostic value of nasociliary skin lesions (Hutchinson's sign) for ocular inflammation and corneal sensory denervation in acute herpes zoster ophthalmicus.. A longitudinal observational study with a 2-month follow-up was performed involving 83 non-immunocompromised adults with acute herpes zoster ophthalmicus, with a skin rash duration of less than 7 days, referred by their general practitioner. All skin lesions at the tip, the side and the root of the nose, representing the dermatomes of the external nasal and infratrochlear branches of the nasociliary nerve, were documented by taking photographs and marking anatomical drawings. Ocular inflammatory signs were observed by slit-lamp biomicroscopy, and corneal sensitivity was measured with the Cochet-Bonnet esthesiometer at 2-month follow-up.. Hutchinson's sign was a powerful predictor of ocular inflammation and corneal denervation in herpes zoster ophthalmicus [relative risks: 3.35 (CI 95%: 1.82-6.15) and 4.02 (CI 95%:1.55-10.42), respectively]. The manifestation of herpes zoster skin lesions at the dermatomes of both nasociliary branches was invariably associated with the development of ocular inflammation.. Clinicians should be alert for early skin lesions within the complete nasociliary dermatome, because they are a reliable prognostic sign of sight-threatening ocular complications in acute herpes zoster ophthalmicus.

Topics: Acute Disease; Acyclovir; Aged; Antiviral Agents; Cornea; Cranial Nerve Diseases; Female; Herpes Zoster Ophthalmicus; Humans; Hypesthesia; Male; Neuralgia; Neurons, Afferent; Ophthalmic Nerve; Prognosis; Skin; Skin Diseases, Viral

Topics: Acyclovir; Administration, Oral; Adult; Antibodies, Viral; Antiviral Agents; Female; Follow-Up Studies; Herpesvirus 3, Human; Humans; Hypesthesia; Immunoglobulin G; Male; Simplexvirus; Trigeminal Nerve Diseases