acyclovir and Gingival-Diseases

Topics: Acyclovir; Anti-Bacterial Agents; Antiviral Agents; Exanthema; Facial Dermatoses; Floxacillin; Gingival Diseases; Herpes Zoster; Herpesvirus 3, Human; Humans; Male; Maxillary Diseases; Middle Aged; Mouth Mucosa; Osteonecrosis; Penicillin G; Virus Activation

Topics: Acyclovir; Adult; Antiviral Agents; Connective Tissue; Follow-Up Studies; Gingiva; Gingival Diseases; Gingival Recession; Graft Survival; Herpesvirus 1, Human; Humans; Male; Necrosis; Recurrence; Stomatitis, Herpetic; Treatment Failure

Erythema multiforme (EM) is a complex disease that may have cutaneous and/or mucosal involvement. The severity may range from mild to severe and potentially life threatening. The literature cites many factors including viruses, infections, and medications as causes. This report documents a patient who developed EM secondary to a herpes simplex viral (HSV) infection.. Two weeks following an eruption of herpes labialis, a 20-year-old white female patient developed acutely painful oral and labial ulcers accompanied by target skin lesions. A diagnosis of erythema multiforme (EM) was made. The patient was treated with antivirals, analgesics, and symptomatic therapy.. Nine days after the onset of symptoms, the oral and cutaneous lesions had started to heal and the patient no longer required pain medication.. Although the etiology of EM is still often unknown, infections with herpes simplex virus have been implicated as a possible precipitating factor. This case illustrates the association of the occurrence of EM with an HSV infection.

Topics: Acyclovir; Adult; Analgesics; Antiviral Agents; Erythema Multiforme; Female; Gingival Diseases; Herpes Labialis; Humans; Lip Diseases; Oral Ulcer; Recurrence; Stomatitis, Herpetic; Wound Healing

Four HIV-positive patients with herpes simplex virus and cytomegalovirus coinfected oral ulcers are presented. All patients had persistent oral pain associated with nonhealing mucosal ulcers. Lesions occurred on the palate, retromolar pad, tongue, and lip, and the clinical appearance of the ulcers was nonspecific. Histologic and immunohistochemical stains showed herpes simples virus alterations in keratinocyte nuclei and cytomegalovirus alterations in mesenchymal/endothelial cell nuclei and cytoplasm. Lesions in one patient responded to ganciclovir therapy. One patient improved with acyclovir, and another healed normally after excisional biopsy. Each virus alone has been described as causing oral ulcerations; their appearance together in the same lesion would suggest a synergistic relationship.

Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cell Nucleus; Cytomegalovirus; Cytomegalovirus Infections; Cytoplasm; Endothelium, Vascular; Follow-Up Studies; Ganciclovir; Gingival Diseases; HIV Seropositivity; Humans; Immunohistochemistry; Keratinocytes; Lip Diseases; Male; Mesoderm; Middle Aged; Mouth Diseases; Palate; Simplexvirus; Stomatitis, Herpetic; Tongue Diseases; Ulcer