acyclovir and Facial-Dermatoses

Osteonecrosis following herpes zoster infection is a rare but severe complication, and clinicians' awareness is important for early detection and management of this condition. A case of herpes zoster of the left maxillary division of the trigeminal nerve is reported in a young female having no concurrent predisposing factors, with accompanying rare complications of alveolar bone necrosis and rapid tooth exfoliation. Acyclovir was used to manage the case effectively. The previously reported similar cases in the literature have been reviewed and the pathophysiology of tooth exfoliation and osteonecrosis by varicella zoster viruses is discussed.

Topics: Acyclovir; Adult; Antiviral Agents; Cicatrix; Cranial Nerve Diseases; Facial Dermatoses; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Maxillary Diseases; Maxillary Nerve; Osteonecrosis; Tooth Loss; Virus Activation

Topics: Acyclovir; Antiviral Agents; Erythema; Facial Dermatoses; Facial Pain; Herpes Zoster Ophthalmicus; Humans; Immunocompetence; Intracranial Hemorrhages; Male; Middle Aged; Radiography; Treatment Outcome

Herpes is a pandemic infection in the human species. The purpose of this work was to conduct a critical analysis of the literature devoted to the pathophysiology and treatment of orofacial herpes an other localizations (genital herpes and neonatal herpes excluded).. We searched for articles in English and French devoted to orofacial herpes and other herpetic localizations indexed in Medline (1980-July 001), EmBase, and the Cochrane Library (1995-July 2001). Critical analysis was based on level of proof using the ANAES methodology.. More than 700 articles were identified. One hundred four were selected for this report. Primary HSV1 infection usually occurred before adulthood and involved acute gingivo-stomatitis in the majority of the cases. Several primary HIV1 infections were asymptomatic or aspecific and non-recognized. After the primary infection, the virus remains in the ganglion of the trigeminal nerve in a latent state and can be reactivated sporadically. Reactivation is associated with viral excretion and can be symptomatic (herpetic recrudescence) or not (recurrence). Recrudescence of orofacial herpes is typically labial. No currently available vaccine can prevent acquisition of HSV1. Treatment of acute gingivostomatitis has been standardized and is based on aciclovir. Inversely, the effectiveness of aciclovir and other nucleoside analogs with anti-herpes activity has not been clearly established for prevention or cure of recrudescence of orofacial herpes. Other localizations (hand, anus, diffuse skin localizations in contact sports, Kaposi-Juliusberg syndrome) are much more exceptional. Treatment has not been standardized.. Despite the abundance of the literature on orofacial herpes, consistent quality is lacking, particularly concerning therapeutic studies. The quality of these reports is generally inferior to those devoted to genital herpes. There has however been a general trend towards improved methodology over the last years. Very little has been reported on exceptional localizations of orofacial herpes.

Topics: Acyclovir; Administration, Oral; Administration, Topical; Antiviral Agents; Facial Dermatoses; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Immunocompetence; Stomatitis, Herpetic; Virus Activation

The eponym Kaposi's varicelliform eruption (KVE) describes a characteristic syndrome of disseminated vesicopustules that occasionally complicates a number of dermatoses. Among these, the most common is atopic dermatitis, and the inciting agent is most often herpes simplex virus (HSV). Very few reports of ocular herpetic disease exist among the many cases of KVE reported in the literature, despite extensive cutaneous involvement with herpetic lesions. We describe 10 patients with KVE, none of whom have developed evidence of herpetic ocular disease despite widespread facial involvement in all patients. All random conjunctival swab cultures performed in 3 patients were positive for growth of viable HSV. Although ocular exposure to HSV may commonly occur in KVE, ocular pathology due to this virus does not appear to be a common sequela.

Topics: Acyclovir; Adult; Child; Child, Preschool; Darier Disease; Dermatitis, Atopic; Facial Dermatoses; Female; Follow-Up Studies; Humans; Infant; Kaposi Varicelliform Eruption; Keratitis, Dendritic; Male; Middle Aged

The treatment of herpes simplex virus (HSV) infections in the past has been largely unsuccessful. Introduction of the drug acyclovir has been a positive development. Acyclovir has been extensively studied in the treatment of a a variety of HSV infections in immunocompromised patients and in otherwise healthy patients. The results have shown it to effectively inhibit HSV replication but to have no effect in preventing or eliminating the latent state of the virus. It has been shown to be very effective in certain instances and not so effective in others.

Topics: Acyclovir; Facial Dermatoses; Herpes Simplex; Humans; Recurrence; Stomatitis, Herpetic

Topics: Acyclovir; Autonomic Nervous System Diseases; Encephalitis; Esophagitis; Facial Dermatoses; Female; Fingers; Hepatitis, Viral, Human; Herpes Genitalis; Herpes Labialis; Herpes Simplex; Humans; Infant, Newborn; Keratitis, Dendritic; Male; Peripheral Nervous System Diseases; Recurrence; Respiratory Tract Infections; Stomatitis, Herpetic; Vaccination; Viral Vaccines

The objective of this multicenter, randomized, double-blind, noninferiority trial was to investigate valacyclovir as treatment for facial herpes simplex virus (HSV) outbreaks. In total, 308 otherwise healthy outpatients self-initiated therapy with valacyclovir, either 1000 mg twice daily for 1 day or 500 mg twice daily for 3 days, for treatment of one facial HSV episode. Aborted lesions were the primary end point. Secondary end points included episode and pain resolution and lesion healing. By regimen (1 or 3 days), aborted lesions occurred in 42.2% versus 46.7% of patients, treatment difference, -4.5% (95% confidence interval, -16.3% to 7.4%; P=.49). Subgroup findings showed that about half the episodes aborted when therapy started during the prodrome/macule stages or within 6 h of first symptoms. Episode and pain resolved rapidly, with results similar for both treatments. Adverse events were infrequent and similar for the two regimens.

Topics: Acyclovir; Administration, Oral; Adolescent; Adult; Aged; Antiviral Agents; Denmark; Double-Blind Method; Drug Administration Schedule; Facial Dermatoses; Female; Finland; Herpes Simplex; Humans; Lithuania; Male; Middle Aged; Norway; Prodrugs; Time Factors; Treatment Outcome; Valacyclovir; Valine

Herpes simplex facialis/labialis (HSFL) is a common infectious skin disorder, caused mainly by herpes simplex virus (HSV) type 1, for which the topical application of a cream containing an antiviral agent for treatment of the disease has been widely utilized.. To explore the efficacy of the topical application of 1% penciclovir cream in the treatment of HSFL, and to compare its efficacy and safety with 3% aciclovir cream.. A total of 248 patients with a diagnosis of HSFL were randomly allocated to one of the two treatment groups (n = 124 each), using stratified randomization based on a table of random numbers. Before treatment (day 0) and at every visit (days 3, 5 and 7) during the study, the sign and symptom scores were recorded by the same doctor.. Excluding 23 patients (10 in the penciclovir and 13 in the aciclovir groups), 225 completed the study, and no severe adverse events were noted with any of the treatment regimens. Results show that an encouraging improvement in the clinical course was found simultaneously for patients with each episode type and each treatment assignment. There were no significant differences in terms of efficacy endpoint, clinical cure rate, and safety between the two treatment arms, but there was a trend towards a shorter time to resolution of all symptoms, cessation of new blisters, and loss of crust (p

Topics: Acyclovir; Administration, Cutaneous; Adolescent; Adult; Aged; Antiviral Agents; Double-Blind Method; Drug Administration Schedule; Facial Dermatoses; Female; Guanine; Herpes Labialis; Herpes Simplex; Humans; Male; Middle Aged; Ointments; Pruritus; Treatment Outcome

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Topics: Acyclovir; Adolescent; Antiviral Agents; Asian People; Cellulitis; Facial Dermatoses; Herpes Simplex; Herpesvirus 1, Human; Humans; Male; Republic of Korea; Sports; Wrestling

Topics: Acyclovir; Administration, Oral; Administration, Topical; Adult; Antiviral Agents; Cicatrix; Dermatitis, Allergic Contact; Facial Dermatoses; Female; Gels; Herpes Labialis; Humans; Recurrence; Skin Cream

Topics: Acyclovir; Aged, 80 and over; Antiviral Agents; Dermatitis, Allergic Contact; Diagnosis, Differential; Facial Dermatoses; Glucocorticoids; Herpes Simplex; Herpes Zoster Oticus; Humans; Impetigo; Mouth Mucosa; Prednisone; Tongue

Topics: Acyclovir; Aged; Antiviral Agents; Breast Neoplasms; Diagnosis, Differential; Exanthema; Facial Dermatoses; Female; Forehead; Herpes Zoster; Humans; Immunocompromised Host; Lung Neoplasms; Neoplasms, Multiple Primary

We report a 48 -year-old woman witherythrokeratoderma variabilis, which is a rarehereditary disorder of keratinization, who developednew, painful, blisters within her skin lesions. Thediagnosis of herpes simplex virus infection was madebased on the clinical history and histopathologicfeatures. She was successfully treated withprophylactic valacyclovir, and her herpetic outbreakshave halted. This case serves as a reminder thateven among the most rare skin disorders, commonsecondary complications may be easily overlooked.

Topics: Abdomen; Acyclovir; Antiviral Agents; Arm; Erythrokeratodermia Variabilis; Facial Dermatoses; Female; Herpes Simplex; Humans; Leg; Middle Aged; Simplexvirus; Thoracic Wall; Valacyclovir; Valine

Rojas J. You're the flight surgeon: F-16 pilot with papular rash. Aerosp Med Hum Perform. 2016; 87(7):661-663.

Topics: Acyclovir; Adult; Analgesics, Opioid; Antiviral Agents; Erythema; Facial Dermatoses; Forehead; Herpes Zoster; Humans; Male; Military Personnel; Pain; Pilots; Vision Disorders

Herpes zoster (HZ) in immunocompetent children is quite uncommon. Initial exposure to the varicella-zoster virus (VZV) may be from a wild-type or vaccine-related strain. Either strain may cause a latent infection and subsequent eruption of HZ. We present a case of HZ in a 15-month-old boy after receiving the varicella vaccination at 12 months of age. A review of the literature regarding the incidence, clinical characteristics, and diagnosis of HZ in children also is provided.

Topics: Acyclovir; Antiviral Agents; Facial Dermatoses; Herpes Zoster; Herpes Zoster Ophthalmicus; Humans; Immunocompetence; Infant; Male; Polymerase Chain Reaction

Topics: Acyclovir; Administration, Oral; Adult; Antiviral Agents; Diagnosis, Differential; Facial Dermatoses; Female; Herpes Zoster; Humans; Valacyclovir; Valine

Topics: Acyclovir; Aged; Anti-Inflammatory Agents; Antiviral Agents; Earache; Exanthema; Facial Dermatoses; Facial Paralysis; Herpes Zoster Oticus; Humans; Male; Prednisolone; Treatment Outcome

Topics: Acyclovir; Anti-Bacterial Agents; Antiviral Agents; Exanthema; Facial Dermatoses; Floxacillin; Gingival Diseases; Herpes Zoster; Herpesvirus 3, Human; Humans; Male; Maxillary Diseases; Middle Aged; Mouth Mucosa; Osteonecrosis; Penicillin G; Virus Activation

A male university student, 24 years of age, presented to his general practitioner because of a facial rash. He had a past history of eczema but no other significant past medical history and no allergies. He was not taking any regular medications.

Topics: Acyclovir; Antiviral Agents; Diagnosis, Differential; Exanthema; Facial Dermatoses; Humans; Kaposi Varicelliform Eruption; Male; Valacyclovir; Valine; Young Adult

The following report describes a previously healthy 2-year-old girl with herpes zoster ophthalmicus (HZO). The child presented with a painless vesicular skin eruption covering the left forehead. There was only a history of household exposure to varicella zoster virus (VZV) and the child had not been vaccinated against VZV. PCR assays on vesicular fluid identified VZV DNA. Treatment with acyclovir was started early in the clinical course. In addition, the girl was treated with locally administered ophthalmological acyclovir ointment. Besides some dermal excoriations, a complete resolution of the HZO was achieved without sequelae.

Topics: Acyclovir; Antiviral Agents; Child, Preschool; Diagnosis, Differential; DNA, Viral; Facial Dermatoses; Female; Herpes Zoster Ophthalmicus; Herpesvirus 3, Human; Humans

A 68-year-old woman presented with unilateral herpetiform skin lesions of the face. She also showed reduced eye lid and mimic function as well as hearing loss. In addition grouped vesicles were seen in the outer ear canal. We diagnosed Ramsay Hunt syndrome and administered intravenous acyclovir, prednisolone and pentoxifylline. Within a few weeks, there was complete remission including the neurological symptoms.

Topics: Acyclovir; Aged; Anti-Inflammatory Agents; Antiviral Agents; Dermatitis Herpetiformis; Diagnosis, Differential; Eyelid Diseases; Facial Dermatoses; Female; Free Radical Scavengers; Hearing Loss, Sensorineural; Herpes Zoster Oticus; Humans; Neurologic Examination; Pentoxifylline; Prednisolone

Topics: Acyclovir; Adult; Antiviral Agents; Biopsy; Dermatitis, Atopic; Diagnosis, Differential; Exanthema; Facial Dermatoses; Herpesvirus 1, Human; Humans; Kaposi Varicelliform Eruption; Male; Skin; Social Stigma

A 29-year-old patient with HIV developed a facial angioedema hypersensitivity reaction to aciclovir when treated for acute retinal necrosis secondary to a herpes virus infection. She developed a similar reaction to famciclovir. Successful rapid desensitisation with oral aciclovir was performed and she became tolerant to aciclovir. She successfully completed 28 months of continuous treatment with no further reactions. However, 28 months later she experienced blurred vision and resumed taking oral aciclovir without a preceding desensitisation regimen. No allergic reaction occurred.

Topics: Acyclovir; Adult; Angioedema; Antiviral Agents; Desensitization, Immunologic; Drug Eruptions; Facial Dermatoses; Female; Humans

Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cidofovir; Cytosine; Drug Resistance, Viral; Facial Dermatoses; Herpes Simplex; Humans; Injections, Intralesional; Male; Organophosphonates

Topics: Acyclovir; Adult; Antiviral Agents; Facial Dermatoses; Female; Herpes Simplex; Herpesvirus 2, Human; Humans

A 33-year-old woman presented with a 5-year history of a relapsing erythematous, indurated plaque on the left cheek. Herpes simplex virus (HSV) immunostain revealed the presence of HSV in the follicular and perifollicular keratinocytes. After oral treatment with valaciclovir for a period of 3 months the lesion disappeared without leaving a scar. At the last check-up, no recurrence had occurred. Herpes folliculitis has various clinical presentations. In rare cases it mimics a pseudolymphoma, as was the case for this patient. A viral aetiology, such as HSV or varicella-zoster virus, should be considered in patients with folliculitis, especially when the condition does not respond to antibacterial and antifungal therapy.

Topics: Acyclovir; Adult; Antiviral Agents; Diagnosis, Differential; Facial Dermatoses; Female; Folliculitis; Herpes Simplex; Humans; Simplexvirus; Valacyclovir; Valine

A 60-year-old man presented with a plaque lesion on the upper right half of the face, which had developed after ophthalmic varicella zoster infection about 2 years previously. The lesion, which was burning and itchy, included a few tiny erythematous pustules, and was slightly squamous and infiltrated. The lesion covered the upper two-thirds of the right trigeminal nerve dermatome, involving half of the face with the forehead, the periorbital area, upper part of the cheek and the nose. The lesion became more marked after continuous topical anaesthetic and corticosteroid use. A standardized skin-surface biopsy was taken, and revealed a large number of Demodex folliculorum (38/cm(2)) in the lesion area. The lesions completely abated after topical 5% permethrin treatment, and no recurrence was observed during follow-up. Demodicosis may have atypical clinical presentations, other than the well-known classic forms. To our knowledge, this is the first unilateral trigeminal, pseudozoster presentation in the literature.

Topics: Acyclovir; Animals; Antiviral Agents; Diagnosis, Differential; Ectoparasitic Infestations; Facial Dermatoses; Herpes Zoster; Humans; Insecticides; Male; Middle Aged; Mite Infestations; Mites; Permethrin; Trigeminal Nerve; Trigeminal Nerve Diseases

A 35-year-old woman with a history of atopic diathesis presented to the emergency department with 2 weeks of widespread facial vesiculopustules and eroded vesicles. HSV-1 was found on viral culture and direct fluorescent antibody testing. She was diagnosed with eczema herpeticum, an uncommon and potentially life-threatening viral infection that arises in areas of pre-existing dermatosis. Antiviral treatment for eczema herpeticum is very effective, and should be instituted without delay to avoid significant morbidity and mortality.

Topics: Acyclovir; Adult; Antiviral Agents; Codeine; Dermatitis, Allergic Contact; Dermatitis, Atopic; Diagnostic Errors; Disease Susceptibility; Facial Dermatoses; Female; Floxacillin; Herpesvirus 1, Human; Humans; Kaposi Varicelliform Eruption; Morphine; Prednisone; Respiratory Hypersensitivity; Staphylococcal Skin Infections; Valacyclovir; Valine

Topics: Accidents, Traffic; Acyclovir; Antiviral Agents; Facial Dermatoses; Facial Injuries; Female; Fever; Herpes Labialis; Humans; Middle Aged; Saliva; Simplexvirus

A case of trigeminal herpes zoster (HZ) infection affecting the left maxillary and ophthalmic divisions of the fifth cranial nerve in an immuno-competent patient is presented. Extremely rare complications such as osteonecrosis, spontaneous tooth exfoliation, secondary osteomyelitis and facial scarring were observed. Sequestrectomy, aciclovir and erythromycin stearate were effectively used in managing the case.

Topics: Acyclovir; Adult; Anti-Bacterial Agents; Antiviral Agents; Cicatrix; Erythromycin; Facial Dermatoses; Herpes Zoster; Humans; Immunocompetence; Male; Maxillary Diseases; Osteomyelitis; Tooth Exfoliation; Trigeminal Nerve Diseases

Facial cellulitis and swellings of the head and neck are worrisome signs of odontogenic infection, which can be life threatening. Most head and neck infections are caused by bacterial pathogens. When treating such infections, dentists must also be aware of possible viral or fungal causes and their associated presentations. This report documents a case of viral infection that initially resembled a bacterial odontogenic infection. It is intended to familiarize dentists with the Ramsay Hunt syndrome and the need for prompt recognition and early definitive treatment.

Topics: Acyclovir; Adult; Antiviral Agents; Diagnosis, Differential; Facial Dermatoses; Female; Focal Infection, Dental; Herpes Zoster Oticus; Humans

Parthenium dermatitis is one of the most common causes of airborne contact dermatitis in India. Eczema herpeticum has been reported in association with various eczematous conditions, including Parthenium dermatitis. We report a case of eczema herpeticum in association with Parthenium dermatitis. Because Parthenium dermatitis is a common condition in this region, one should be aware of this complication so that appropriate treatment is not delayed.

Topics: Acyclovir; Agricultural Workers' Diseases; Allergens; Cistaceae; Dermatitis, Allergic Contact; Dermatitis, Occupational; Diagnosis, Differential; Facial Dermatoses; Humans; Kaposi Varicelliform Eruption; Male; Middle Aged; Patch Tests

A 60-year-old male athlete developed a folliculitis in the beard region after several competitions. After identification of herpes simplex antigen within the lesions, systemic therapy with acyclovir led to rapid improvement. In folliculitis resistant to antibiotic and anti-inflammatory therapy, viral and mycotic infections as well as eosinophilic folliculitis should be considered as differential diagnostic possibilities.

Topics: Acyclovir; Antiviral Agents; Conjunctivitis, Bacterial; Dermatitis, Perioral; Diagnosis, Differential; Disease Progression; Facial Dermatoses; Folliculitis; Herpes Simplex; Humans; Male; Middle Aged

Fulminant herpetic sycosis is a rare but well-known manifestation of herpes simplex virus (HSV) infection occurring in the context of viral recurrence in immunodepressed patients. We present here the case of a 32-year-old male patient, without notable medical history, who developed papulovesicular lesions of the beard accompanied by fever, painful cervical lymphadenopathy and odynophagia, with a clinical evolution that was initially unfavourable under antibiotic treatment. The diagnosis of herpetic sycosis was established by means of direct immunofluorescence and culture which confirmed positivity for HSV-1 and serologies compatible with a primary viral infection. No sign for a latent immune deficit was found at the time of investigations. The clinical evolution was rapidly favourable with administration of intravenous aciclovir for 1 week. To our knowledge, herpetic sycosis as a presentation of primary viral infection has not been reported previously. The possibility of a herpetic sycosis of the beard must be considered in the case of non-response to antibiotic or antifungal treatment.

Topics: Acyclovir; Adult; Antiviral Agents; Facial Dermatoses; Folliculitis; Herpes Simplex; Humans; Male

Topics: Acyclovir; Aged; Aged, 80 and over; Anti-Allergic Agents; Antiviral Agents; Clemastine; Facial Dermatoses; Female; Herpes Zoster; Humans; Time Factors; Treatment Outcome

Viral folliculitis is a rare disease usually caused by herpes simplex, herpes zoster and molluscum contagiosum in immune-compromised patients. An otherwise healthy 30 year old patient without history of herpes simplex contracted a folliculitis in the beard region after a flu-like illness. He had no oral or labial lesions but instead showed a crusty erythematous folliculitis confined to the beard region with small grouped vesicles on the neck and reactive cervical lymph nodes. Bacterial and mycological analysis from swabs were negative. The culture was positive for herpes simplex virus and the immune fluorescence showed HSV type 1. Systemic therapy with valaciclovir 2x 500 mg/d and lotio alba locally led to rapid improvement. When confronted with folliculitis, non-bacterial causes such as viral (herpes simplex, herpes zoster, molluscum contagiosum), mycological (pityrosporon, candida), demodex and eosinophilic follicultitis should be taken under consideration.

Topics: Acyclovir; Adult; Antiviral Agents; Facial Dermatoses; Fluorescent Antibody Technique; Folliculitis; Herpes Simplex; Humans; Male; Prodrugs; Skin; Valacyclovir; Valine

Allergic contact dermatitis caused by acyclovir is rare. We report the 5th case of systemic acyclovir reaction subsequent to acyclovir contact dermatitis, with investigations made to determine an alternative antiviral treatment. A 23-year-old woman, after dermatitis while using Zovirax cream, went on to develop urticaria after oral acyclovir. Patch tests were performed with the components of Zovirax cream (acyclovir, propylene glycol and sodium lauryl sulfate) and with other antiviral drugs. Patch tests were positive to Zovirax cream, acyclovir, valacyclovir and propylene glycol. Patch and prick tests with famciclovir were negative, but its oral administration caused an itchy erythematous dermatitis on the trunk and extremities. Our patient developed a systemic acyclovir reaction subsequent to acyclovir allergic contact dermatitis, with cross-reactions to valacyclovir and famciclovir. Their common chemical structure is the 2-aminopurine nucleus. It is probably this part of the molecule that provokes both contact allergy and systemic reactions. The only antiviral drugs not having this core are foscarnet and cidofovir, and these could therefore be alternatives.

Topics: Acyclovir; Administration, Cutaneous; Administration, Oral; Adult; Antiviral Agents; Dermatitis, Allergic Contact; Diagnosis, Differential; Facial Dermatoses; Female; Herpes Simplex; Humans; Lip Diseases; Patch Tests

The purpose of this survey was to ascertain current management practices of French dermatologists treating immunocompetent patients with cutaneomucosal herpes (ocular herpes excluded) as a prelude to the French consensus conference on this topic.. A random sample of French dermatologists were invited to respond to a telephone interview: 928 dermatologists were contacted.. The 216 dermatologists who responded to the telephone interview provided care for five persons per month (pregnancy excluded) who consulted for orofacial or genital herpes. Nearly half of the dermatologists stated they do not talk about herpes spontaneously with their patients. When a suspect lesion is seen for the first time, 48 p. 100 of the dermatologists order one or two complementary exams. Their advice on prevention between partners basically concerns use of preservatives. Therapeutic attitudes vary depending on the type of herpes or the number of recurrences per year: 84 p. 100 of the dermatologists prescribe a specific antiviral treatment for patients with solar herpes. Virological proof of infection is not acquired in 84 p. 100 of the cases before initiating a long-term treatment for recurrence. The most widely used agents are valaciclovir 500 and aciclovir 200.. This survey demonstrates a certain degree of divergence from the recommendations of the consensus conference. The participation rate appears to be satisfactory, but herpes serology is ordered too often and antiviral agents are not used in compliance with current guidelines. This survey will be redone after diffusion of the guidelines in order to evaluate their impact.

Topics: Acyclovir; Antiviral Agents; Dermatology; Drug Therapy, Combination; Facial Dermatoses; France; Health Care Surveys; Herpes Genitalis; Herpes Labialis; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Interviews as Topic; Practice Patterns, Physicians'; Surveys and Questionnaires; Valacyclovir; Valine

Increased mortality, extensive visceral involvement, and necrotizing tracheobronchitis associated with herpes viruses have been reported after burns. It is unclear whether herpes presenting as a facial rash results in outcome changes after burns.. A retrospective study characterizing the incidence, presentation, and outcome of 14 patients with facial herpes rashes out of 95 severely burned intubated adults was performed.. Facial rashes attributed to herpetic infections were found in at least 15% of patients. The problem was recognized during the second week after burn. There was no difference in mortality or length of stay noted between patients with or without the infection.. The course of this infection was relatively benign in this group of acyclovir-treated patients. Even so, the lesions clearly contributed to patient discomfort and often produced fevers requiring costly investigations. Early recognition could help prevent diffuse spread of the lesions, decreasing patient discomfort and improving patient care.

Topics: Acyclovir; Adult; Aged; Antiviral Agents; Body Surface Area; Boston; Burn Units; Burns; Facial Dermatoses; Herpes Simplex; Herpesvirus 1, Human; Hospitals, General; Humans; Incidence; Intubation, Intratracheal; Length of Stay; Middle Aged; Retrospective Studies; Survival Analysis; Treatment Outcome; Virus Activation

Topics: Acne Vulgaris; Acyclovir; Administration, Oral; Antiviral Agents; Diagnosis, Differential; Facial Dermatoses; Female; Folliculitis; Herpes Simplex; Humans; Middle Aged; Valacyclovir; Valine

Topics: Acyclovir; Aged; Antiviral Agents; Facial Dermatoses; Female; Herpes Simplex; Humans; Laser Therapy; Premedication; Rhytidoplasty; Valacyclovir; Valine; Virus Activation

Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Anti-HIV Agents; Child, Preschool; Cidofovir; Cytosine; Drug Resistance, Microbial; Facial Dermatoses; Foscarnet; Herpes Simplex; Humans; Male; Organophosphonates; Organophosphorus Compounds; Treatment Failure

Eleven female patients are reported who underwent full-face resurfacing. Three patients were treated for cosmetic rhytids, five for residual acne scarring, and three for photoaging. There were no complications or side effects in this group of patients. Reepithelialization was achieved in an average of 9.3 days, and erythema disappeared in an average of 8.9 weeks. The UltraPulse carbon dioxide laser with computerized pattern generator (CPG) scanner allows a rapid, uniform laserbrasion. The sequence of the procedure involves close application of adjacent squares at 60 W, 200 to 300 ml, at moderate density. Skin preparation with Retin-A and bleaching agents is important for best wound healing. Postoperative wound care includes maintenance of a moist environment and Zovirax for herpes prophylaxis.

Topics: Acne Vulgaris; Acyclovir; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antiviral Agents; Carbon Dioxide; Cicatrix; Dexamethasone; Epithelium; Erythema; Facial Dermatoses; Female; Follow-Up Studies; Glycolates; Herpesviridae Infections; Humans; Hydroquinones; Keratolytic Agents; Laser Therapy; Middle Aged; Radiation-Protective Agents; Rhytidoplasty; Skin Aging; Skin Care; Therapy, Computer-Assisted; Tretinoin; Wound Healing

Topics: Acyclovir; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antiviral Agents; Cranial Nerve Diseases; Facial Dermatoses; Herpes Simplex; Humans; Injections, Intralesional; Male; Neuritis; Skin Ulcer; Syndrome; Triamcinolone; Trigeminal Nerve

A 28-year-old man with Wiskott-Aldrich syndrome presented with ulcerative-proliferative lesions on his face from which herpes simplex type 1 (HSV-1) was isolated. He was initially treated with 10 mg/kg of acyclovir (Zovirax) intravenously every 8 h, but his skin lesions worsened. Clinical resistance to acyclovir was suspected, and therapy with this drug was intensified. The dosage of acyclovir was increased to 45 mg/kg, administered by continuous infusion, and the lesions subsequently resolved. The strain of HSV recovered from the patient showed acyclovir-resistance in vitro, using the colorimetric method with neutral red. Herpes simplex virus resistance to acyclovir is rare. It is more common in immunocompromised patients if subtherapeutic doses are administered in the treatment of chronic persistent forms of infection. Whenever clinical resistance to acyclovir is suspected, the dosage should be increased to 2 mg/kg per h administered via an infusion pump. If no improvement is observed in the patient's condition with this regimen, a phosphorylated medication whose mechanism of action is not dependent on viral thymidine kinase, such as foscarnet (phosphonoformic acid), should be substituted.

Topics: Acyclovir; Adult; Antiviral Agents; Drug Resistance; Facial Dermatoses; Herpes Simplex; Humans; Male; Wiskott-Aldrich Syndrome

Topics: Acyclovir; Adult; Edema; Eyelid Diseases; Facial Dermatoses; Herpes Simplex; Humans; Hypersensitivity, Immediate; Isotretinoin; Male

We report the case of an immunocompromised patient with AIDS in whom developed a perioral and several intraoral HSV 2 lesions that persisted for more than 1 year. The virus was resistant to acyclovir but was sensitive to foscarnet. Viral isolates were thymidine kinase negative. The lesions resolved with intravenous foscarnet therapy given over a 15-week period, and when last seen, 8 months after foscarnet was discontinued, the patient had not had a recurrence.

Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Antiviral Agents; Candidiasis, Oral; Drug Resistance, Microbial; Facial Dermatoses; Foscarnet; Herpes Simplex; Humans; Male; Organophosphorus Compounds; Phosphonoacetic Acid; Stomatitis, Herpetic

The authors report a case of chronic herpes virus infection of the face which developed in a 70-year old man already affected with chronic lymphocytic leukaemia of the B-cell type (CLL-B) with specific cutaneous localisations. Immunodepression was indicated only by marked hypogammaglobulinaemia. Cell-mediated immunity was preserved. The cutaneous lesions of the face were chronic and presented as pyodermatitis vegetans. A one-week course of acyclovir administered by intravenous infusion in doses of 5 mg/kg three times a day resulted in rapid and dramatic cure, but this result proved transient, since the virus infection relapsed 2 1/2 months later. The new episode also was successfully treated with a second course of acyclovir. The herpes virus infection had developed only on those skin areas that were specifically affected by the leukaemia; after treatment and eradication of the virus, massive lymphocytic infiltration of the dermis persisted in these areas. Involvement of the skin is rare in CLL-B and has been reported mainly in CLL-T. The lesions most frequently encountered are tuberous and papular lesions and infiltrated plaques on the forehead and ears. The pyodermatitis vegetans presentation is unusual. The reasons why viral skin lesions develop on those caused by leukaemia are unknown.

Topics: Acyclovir; Aged; B-Lymphocytes; Chronic Disease; Facial Dermatoses; Herpes Simplex; Humans; Immune Tolerance; Leukemia, Lymphoid; Male; Pyoderma; Skin Neoplasms

Topics: Acyclovir; Administration, Topical; Animals; Antiviral Agents; Cranial Nerve Diseases; Facial Dermatoses; Guanine; Herpes Simplex; Injections, Subcutaneous; Mice; Mice, Nude; Stomatitis, Herpetic; Trigeminal Nerve