acyclovir and Epilepsy--Tonic-Clonic

Topics: Acyclovir; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Humans; Keratoplasty, Penetrating; Male; Middle Aged; Mycophenolic Acid

Severe neurologic complications have been rarely reported during novel pandemic influenza A(H1N1) virus infections. We describe the case of an 10-year-old boy with new onset seizures and proven influenza A(H1N1) 2009 infection showing a reversible hyperintense lesion in the splenium of the corpus callosum on T2-weighted and FLAIR magnetic resonance images without contrast enhancement. Transient splenial lesions have been described in the context of virus encephalopathy and do not require specific treatment.

Topics: Acyclovir; Anticonvulsants; Antiviral Agents; Child; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Drug Therapy, Combination; Encephalitis, Viral; Epilepsy, Tonic-Clonic; Follow-Up Studies; Humans; Image Enhancement; Image Processing, Computer-Assisted; Influenza A Virus, H1N1 Subtype; Influenza, Human; Levetiracetam; Magnetic Resonance Imaging; Male; Oseltamivir; Pandemics; Piracetam; Reverse Transcriptase Polymerase Chain Reaction

This report describes a 9-year-old child with status epilepticus and cat scratch disease. This patient's focal seizures and electroencephalographic changes persisted for 18 months after status epilepticus. This patient represents the third reported case of persistent focal seizures or electroencephalographic changes after status epilepticus secondary to cat scratch disease. This finding suggests that cat scratch encephalopathy may be a cause of localization-related epilepsy, and should be investigated when evaluating a patient with new-onset partial seizures.

Topics: Acyclovir; Anti-Bacterial Agents; Anticonvulsants; Antiviral Agents; Cat-Scratch Disease; Ceftriaxone; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Male; Phenytoin; Status Epilepticus; Vancomycin

Topics: Acyclovir; Adult; Antiviral Agents; Encephalitis, Herpes Simplex; Epilepsy, Tonic-Clonic; Humans; Male; Melanoma; Meningeal Neoplasms; Paraparesis; Quadriplegia; Ventriculostomy

Four patients with typical manifestations of herpes simplex encephalitis were treated with Aciclovir. Infection with herpes simplex virus was confirmed in three of the four cases. Complete cure was achieved in each of the patients despite severe initial disease patterns. In view of these results in the treatment of a disease that had so far been partly lethal or produced severely defective states, the specific use of Aciclovir is emphasised.

Topics: Acyclovir; Adult; Cell Transformation, Viral; Cerebrospinal Fluid; Electroencephalography; Encephalitis; Epilepsy, Tonic-Clonic; Female; Herpes Simplex; Humans; Male; Middle Aged; Status Epilepticus