acyclovir and Edema

Topics: Acyclovir; Anti-Inflammatory Agents; Antirheumatic Agents; Antiviral Agents; Drug Substitution; Drug Therapy, Combination; Edema; Face; Female; Glucocorticoids; Humans; Hydrocortisone; Injections, Intravenous; Meningitis, Aseptic; Middle Aged; Neck; Prednisolone; Spondylitis, Ankylosing; Sulfasalazine; Treatment Outcome

Topics: Acyclovir; Aged; Antiviral Agents; Edema; Erythema; Exanthema; Face; Female; Folliculitis; Herpesviridae Infections; Humans; Treatment Outcome

A 73-year-old man presented to our hospital with a sore throat (left-sided) and hiccups. The patient had mucosal swelling and erosions affecting the left posterior pillar, base of tongue, epiglottis, arytenoid, and aryepiglottic fold. As the laryngeal mucosal edema became worse, herpetic vesicles and erosions developed on the left cavum conchae, external auditory canal, and palate. The patient was treated with acyclovir and a steroid. His hiccups were treated with metoclopramide, but it had little effect, and hiccups only subsided gradually after the disappearance of erosions. His hiccups relapsed transiently with vomiting, and then resolved completely. Elevation of the CF titer after 2 weeks confirmed the diagnosis of herpes zoster. This condition should be considered in patients with unilateral sore throat and intractable hiccups, and treatment with acyclovir should be provided.

Topics: Acyclovir; Administration, Oral; Aged; Anti-Inflammatory Agents; Antiviral Agents; Diarrhea; Edema; Herpes Zoster; Hiccup; Humans; Hydrocortisone; Infusions, Intravenous; Laryngeal Mucosa; Laryngitis; Male; Metoclopramide; Retreatment; Valacyclovir; Valine

A 63-year-old man with HZO presented with involvement of cranial nerves II, III, IV, V, and VI, with proptosis, raised intraocular pressure, and chemosis. With the aid of orbital imaging, a diagnosis of orbital apex inflammation secondary to HZO was confirmed, and he was treated with intravenous acyclovir and oral steroids. Despite this, he made a minimal recovery at eight months following presentation. Severe, irreversible orbital disease may develop following HZO, and an ischemic vasculitis may play a role in the pathogenesis of the disease.

Topics: Acyclovir; Antiviral Agents; Blepharoptosis; Conjunctival Diseases; Drug Therapy, Combination; Edema; Exophthalmos; Glucocorticoids; Herpes Zoster Ophthalmicus; Humans; Infusions, Intravenous; Intraocular Pressure; Magnetic Resonance Imaging; Male; Middle Aged; Ocular Hypertension; Orbital Diseases; Prednisolone; Tomography, X-Ray Computed

Topics: Acyclovir; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Bone Marrow Examination; Drug Therapy, Combination; Edema; Fatigue; Gait; Humans; Male; Methylprednisolone Hemisuccinate; Middle Aged; Paresthesia; Pigmentation Disorders; POEMS Syndrome; Prognosis; Remission Induction; Rituximab

The object of the present study was to review a series of surgically removed vestibular schwannoma tumours to establish the incidence of delayed facial palsy and to evaluate the course of recovery according to the possible etiology (surgical postoperative edema or viral reactivation) with reference to the time of onset.. The study group was composed of 98 patients with vestibular schwannoma. Sex, age, location, and extent of tumour and postoperative complications were all taken into consideration in the final evaluation. The course of each patient's postoperative facial function was graded according to House and Brackmann's six-grade scale. The incidence and the time of onset of the delayed facial palsy were also evaluated.. The deterioration in the facial function was found to be delayed in 25 of the 98 patients (26%); of these, it occurred in the first 5 days after surgery in 11 cases, between 6 and 13 days in 10 cases, and after 15 days in 14 patients. The incidence rate of the delayed facial dysfunction was not influenced by age, sex, or the size of the tumour. The prognosis of the facial dysfunction was favourable in the majority of cases, and, in fact, there were only five grade III to IV cases 1 year later. Facial dysfunction was over grade III in the majority of the latter five cases, and the period of recovery was long.. Eighty percent of our patients with delayed facial palsy following vestibular schwannoma resection were classified as having excellent or good function. In the remaining patients who had a less favourable recovery, the palsy was more severe, and the onset occurred after some time. This seems to agree with those who are of the opinion that the complication is due to viral reactivation. In these patients, it is advisable to start aggressive medical therapy with antiviral agents such as acyclovir as soon as possible.

Topics: Acyclovir; Adult; Aged; Antiviral Agents; Edema; Facial Nerve; Facial Paralysis; Female; Humans; Incidence; Male; Middle Aged; Neuroma, Acoustic; Neurosurgical Procedures; Postoperative Complications; Prognosis; Recovery of Function; Retrospective Studies; Steroids; Time Factors; Treatment Outcome; Virus Activation

We report a rare adult case of chronic active Epstein-Barr virus (EBV) infection. A 54-year-old woman was admitted to our hospital with intermittent fever, weight loss, hepatosplenomegaly, pancytopenia and liver disturbance. In serological tests for EBV, anti-virus capsid antigen (VCA)-IgG antibody and anti-early antigen (EA)-IgG antibody were markedly elevated and anti-EBV nuclear antigen (EBNA) antibody was negative. EBV genome was detected in the bone marrow nucleated cells and peripheral lymphocytes by Southern blot hybridization. The patient developed left facial edema, bilateral breast tumor and pneumonia. She died one year after admission in spite of the administration of prednisolone, interferon and acyclovir.

Topics: Acyclovir; Antigens, Viral; Blotting, Southern; Breast Neoplasms; Capsid Proteins; Chronic Disease; DNA-Binding Proteins; Edema; Epstein-Barr Virus Nuclear Antigens; Female; Hepatitis; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Interferon-alpha; Liver; Middle Aged; Prednisolone

Topics: Acyclovir; Administration, Oral; Edema; Female; Humans

Topics: Acyclovir; Adult; Edema; Eyelid Diseases; Facial Dermatoses; Herpes Simplex; Humans; Hypersensitivity, Immediate; Isotretinoin; Male

Topics: Acyclovir; Administration, Oral; Drug Eruptions; Edema; Female; Herpes Zoster; Humans; Middle Aged