acyclovir and Eczema

Aciclovir (ACV) is the most effective drug for the virostatic management of herpes simplex virus (HSV) infections, and the rate of side-effects is low. ACV resistance is rare, occurring only in highly immunocompromised patients (so far about 30 cases have been reported). Dosages and modes of application of ACV in different HSV infections are indicated and discussed.

Topics: Acyclovir; Antiviral Agents; Drug Resistance, Microbial; Eczema; Encephalitis; Herpes Genitalis; Herpes Labialis; Herpes Simplex; Humans

Topics: Acyclovir; Dermatitis, Atopic; Eczema; Humans; Janus Kinase 1; Janus Kinase Inhibitors

Eczema coxsackium (EC) can manifest in patients with underlying atopic dermatitis (AD) as a diffuse vesicular rash in a febrile child. The presentation overlaps clinically with the feared diagnosis of eczema herpeticum (EH), which makes differentiating between the conditions very important.. A 6-month-old girl with known AD presented with fever and rapidly spreading vesicular rash. The patient had multiple exposures including a new antibiotic prescription, introduction of new foods, 6-month vaccinations and a sick contact. She was treated empirically with acyclovir for EH until herpes simplex virus (HSV) polymerase chain reaction (PCR) returned negative and enterovirus PCR returned positive. Once the diagnosis of EC was confirmed, antiviral therapy was discontinued and she was treated successfully with supportive measures without sequelae.. Differentiating EC from EH is important clinically as EC is self-limiting and resolves spontaneously whereas EH may cause severe complications if not treated early. While morphology alone cannot reliably distinguish between the conditions, clinical suspicion based on history can prompt proper testing and improve patient outcomes.

Topics: Acyclovir; Antiviral Agents; Dermatitis, Atopic; Disease Progression; Eczema; Female; Humans; Infant; Kaposi Varicelliform Eruption; Risk Factors; Simplexvirus

A bath with scented soap prompted a flare of the boy's eczema. Days later, he was hospitalized with diffuse erosions covering 90% of his body. What was the cause?

Topics: Acyclovir; Anti-Bacterial Agents; Antiviral Agents; Child, Preschool; Eczema; Exanthema; Humans; Kaposi Varicelliform Eruption; Male; Mentha; Perfume; Simplexvirus; Soaps; Steroids; Tacrolimus; Tretoquinol

Topics: Acyclovir; Adrenal Cortex Hormones; Adult; Antiviral Agents; Cyclosporine; Dermatitis, Atopic; Eczema; Herpes Simplex; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; PUVA Therapy; Simplexvirus; Virus Activation

Topics: Acyclovir; Adult; Antiviral Agents; Drug Hypersensitivity; Eczema; Exanthema; Eye Diseases; Eyelids; Face; Humans; Kaposi Varicelliform Eruption; Male; Penicillins; Staphylococcal Infections

Two children aged 7 months with eczema herpeticum received treatment consisting of intravenous acyclovir and human plasma with a high titer of herpes simplex virus antibodies. One recovered following two recurrences, but the other died rapidly, suffering both septicemia due to Pseudomonas aeruginosa and herpetic encephalitis. In both cases, the virus involved was a herpes simplex virus type 1 (HSV 1). The various isolates obtained before, during and after treatment remained equally sensitive to acyclovir. These observations highlight three points: the unpredictable and sometimes dramatic development of eczema herpeticum in the young child; the urgency of early diagnosis and treatment; the role of environment in viral contamination.

Topics: Acyclovir; Antibodies, Viral; Blood Transfusion; Eczema; Female; Herpes Simplex; Humans; Infant; Male; Simplexvirus