acyclovir and Diabetic-Retinopathy

Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Cytomegalovirus Infections; Diabetic Retinopathy; Diagnosis, Differential; Foscarnet; Ganciclovir; Humans; Phosphonoacetic Acid; Pneumonia, Pneumocystis; Prognosis; Retinal Diseases; Retinitis; Zidovudine

Topics: Acyclovir; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antiviral Agents; Bevacizumab; Diabetic Retinopathy; DNA, Viral; Epithelium, Corneal; Herpesvirus 1, Human; Humans; Injections; Keratitis, Herpetic; Vascular Endothelial Growth Factor A; Vitreous Body

To report a case of herpetic epithelial keratitis that developed after intravitreal bevacizumab (Avastin) injection.. A 63-year-old man with diabetes with proliferative diabetic retinopathy and macular edema received intravitreal injection of bevacizumab (Avastin) in his right eye.. Three days after the injection, the patient presented with foreign body sensation, redness, tearing, photophobia, and decreased visual acuity in the right eye. The cornea showed an arborizing dendritic epithelial lesion with terminal bulb typical of herpes simplex virus (HSV) epithelial keratitis. HSV-DNA was detected in corneal scrapings using polymerase chain reaction. A diagnosis for herpes simplex epithelial keratitis was made. Topical acyclovir ointment therapy was initiated with good resolution of HSV signs and symptoms.. Herpes simplex epithelial keratitis can be a possible complication of intravitreal bevacizumab (Avastin) injection. To our knowledge, this case is the first report of herpetic epithelial keratitis after intravitreal bevacizumab (Avastin) injection.

Topics: Acyclovir; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antiviral Agents; Bevacizumab; Diabetic Retinopathy; DNA, Viral; Epithelium, Corneal; Herpesvirus 1, Human; Humans; Injections; Keratitis, Herpetic; Male; Middle Aged; Vascular Endothelial Growth Factor A; Vitreous Body

To report a case of recurrent herpes simplex virus (HSV) epithelial keratitis after intravitreal triamcinolone acetonide injection for the treatment of diabetic macular edema.. Case report.. We describe a case of a 59-year-old woman with a history of ocular HSV disease and severe proliferative diabetic retinopathy. She received an intravitreal injection of triamcinolone acetonide for macular edema in the right eye. One week later, she developed foreign body sensation, redness, and photophobia in the same eye. Slit-lamp examination revealed a corneal epithelial dendritic lesion. She was diagnosed with a recurrence of HSV epithelial keratitis and was treated with oral acyclovir 400 mg, 5 times a day, with good resolution of HSV signs and symptoms.. Intravitreal triamcinolone acetonide injection may result in reactivation of HSV keratitis.

Topics: Acyclovir; Antiviral Agents; Diabetic Retinopathy; Female; Glucocorticoids; Herpesvirus 1, Human; Humans; Injections; Keratitis, Herpetic; Macular Edema; Middle Aged; Recurrence; Triamcinolone Acetonide; Virus Activation; Vitreous Body