acyclovir and Diabetic-Nephropathies

Topics: Actuarial Analysis; Acyclovir; Cytomegalovirus Infections; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Graft Survival; Humans; Kidney Transplantation; Pancreas Transplantation; Retrospective Studies; Survival Rate

Viral infections are common complications following renal transplantation. However, there have been few reported cases of viral cystitis secondary to herpes simplex virus or adenovirus infection. Herein, we have reported four cases of hemorrhagic cystitis secondary to infections with herpes simplex virus and adenovirus following renal transplantation. The etiology was adenovirus in three cases and herpes simplex virus in the remaining case. In all four cases, the primary cause of the renal dysfunction was diabetic nephropathy. All four patients presented with a clinical profile characterized by dysuria, pollakiuria, macroscopic hematuria, and graft dysfunction. Three of the four patients developed these symptoms within the first 3 months after renal transplantation. In all four cases, there was an increase, albeit slight, in creatinine levels, which returned to normal or near-normal values upon resolution of the symptoms. Acute cellular rejection was observed in only one case. Although rare, hemorrhagic cystitis secondary to infection, which typically occurs early in the posttransplant period, causes pronounced symptoms. The infection appears to be self-limiting, resolving completely within 4 weeks.

Topics: Acyclovir; Adenovirus Infections, Human; Aged; Aged, 80 and over; Antiviral Agents; Cystitis; Diabetic Nephropathies; Herpes Simplex; Humans; Kidney Transplantation; Male; Middle Aged; Treatment Outcome; Valacyclovir; Valine